Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IAT9_LEIDO

TriTrypDb:

LdBPK_221420.1 , LdCL_220021500 , LDHU3_22.2050

Length:

363

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IAT9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IAT9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	191	195	PF00656	0.728
CLV_C14_Caspase3-7	222	226	PF00656	0.735
CLV_C14_Caspase3-7	252	256	PF00656	0.537
CLV_NRD_NRD_1	121	123	PF00675	0.519
CLV_NRD_NRD_1	145	147	PF00675	0.574
CLV_NRD_NRD_1	187	189	PF00675	0.782
CLV_NRD_NRD_1	59	61	PF00675	0.690
CLV_NRD_NRD_1	74	76	PF00675	0.643
CLV_PCSK_FUR_1	143	147	PF00082	0.604
CLV_PCSK_KEX2_1	145	147	PF00082	0.574
CLV_PCSK_KEX2_1	177	179	PF00082	0.656
CLV_PCSK_KEX2_1	187	189	PF00082	0.769
CLV_PCSK_KEX2_1	59	61	PF00082	0.719
CLV_PCSK_KEX2_1	74	76	PF00082	0.745
CLV_PCSK_PC1ET2_1	177	179	PF00082	0.590
CLV_PCSK_PC1ET2_1	59	61	PF00082	0.719
CLV_PCSK_SKI1_1	145	149	PF00082	0.632
CLV_PCSK_SKI1_1	187	191	PF00082	0.642
CLV_PCSK_SKI1_1	258	262	PF00082	0.612
CLV_Separin_Metazoa	285	289	PF03568	0.585
DEG_COP1_1	261	270	PF00400	0.547
DEG_Nend_UBRbox_4	1	3	PF02207	0.576
DEG_SPOP_SBC_1	53	57	PF00917	0.673
DEG_SPOP_SBC_1	66	70	PF00917	0.493
DOC_CYCLIN_RxL_1	139	152	PF00134	0.585
DOC_CYCLIN_RxL_1	22	36	PF00134	0.721
DOC_MAPK_gen_1	122	129	PF00069	0.619
DOC_PP2B_LxvP_1	265	268	PF13499	0.629
DOC_USP7_MATH_1	183	187	PF00917	0.747
DOC_USP7_MATH_1	211	215	PF00917	0.582
DOC_USP7_MATH_1	256	260	PF00917	0.658
DOC_USP7_MATH_1	326	330	PF00917	0.666
DOC_USP7_MATH_1	53	57	PF00917	0.754
DOC_USP7_MATH_1	66	70	PF00917	0.692
DOC_USP7_MATH_1	78	82	PF00917	0.656
DOC_USP7_UBL2_3	59	63	PF12436	0.730
DOC_WW_Pin1_4	189	194	PF00397	0.749
DOC_WW_Pin1_4	20	25	PF00397	0.731
DOC_WW_Pin1_4	62	67	PF00397	0.664
LIG_14-3-3_CanoR_1	11	16	PF00244	0.514
LIG_14-3-3_CanoR_1	18	25	PF00244	0.652
LIG_14-3-3_CanoR_1	187	193	PF00244	0.761
LIG_14-3-3_CanoR_1	280	287	PF00244	0.527
LIG_14-3-3_CanoR_1	325	332	PF00244	0.493
LIG_14-3-3_CanoR_1	42	49	PF00244	0.617
LIG_14-3-3_CanoR_1	97	105	PF00244	0.499
LIG_BRCT_BRCA1_1	45	49	PF00533	0.690
LIG_FHA_1	262	268	PF00498	0.564
LIG_FHA_2	250	256	PF00498	0.674
LIG_FHA_2	315	321	PF00498	0.702
LIG_FHA_2	97	103	PF00498	0.566
LIG_IBAR_NPY_1	179	181	PF08397	0.582
LIG_LIR_Gen_1	113	121	PF02991	0.513
LIG_LIR_Gen_1	229	237	PF02991	0.551
LIG_LIR_Nem_3	113	118	PF02991	0.562
LIG_LIR_Nem_3	229	235	PF02991	0.553
LIG_PDZ_Class_2	358	363	PF00595	0.672
LIG_SH2_NCK_1	348	352	PF00017	0.608
LIG_SH2_STAP1	232	236	PF00017	0.580
LIG_SH2_STAP1	293	297	PF00017	0.518
LIG_SH2_STAP1	348	352	PF00017	0.653
LIG_SH2_STAT5	348	351	PF00017	0.642
LIG_SH3_3	310	316	PF00018	0.608
LIG_SUMO_SIM_par_1	263	269	PF11976	0.549
LIG_TRAF2_1	135	138	PF00917	0.593
LIG_TRAF2_1	92	95	PF00917	0.555
LIG_UBA3_1	169	177	PF00899	0.595
LIG_WRC_WIRS_1	232	237	PF05994	0.585
MOD_CK1_1	113	119	PF00069	0.584
MOD_CK1_1	292	298	PF00069	0.742
MOD_CK1_1	301	307	PF00069	0.699
MOD_CK1_1	45	51	PF00069	0.650
MOD_CK1_1	52	58	PF00069	0.687
MOD_CK1_1	65	71	PF00069	0.581
MOD_CK1_1	73	79	PF00069	0.668
MOD_CK2_1	225	231	PF00069	0.661
MOD_CK2_1	244	250	PF00069	0.441
MOD_CK2_1	79	85	PF00069	0.707
MOD_GlcNHglycan	213	216	PF01048	0.668
MOD_GlcNHglycan	238	241	PF01048	0.573
MOD_GlcNHglycan	258	261	PF01048	0.588
MOD_GlcNHglycan	300	303	PF01048	0.656
MOD_GlcNHglycan	51	54	PF01048	0.614
MOD_GSK3_1	106	113	PF00069	0.546
MOD_GSK3_1	183	190	PF00069	0.703
MOD_GSK3_1	236	243	PF00069	0.641
MOD_GSK3_1	26	33	PF00069	0.640
MOD_GSK3_1	320	327	PF00069	0.721
MOD_GSK3_1	45	52	PF00069	0.453
MOD_GSK3_1	62	69	PF00069	0.661
MOD_GSK3_1	9	16	PF00069	0.666
MOD_LATS_1	26	32	PF00433	0.618
MOD_NEK2_1	110	115	PF00069	0.563
MOD_NEK2_1	206	211	PF00069	0.564
MOD_NEK2_1	236	241	PF00069	0.601
MOD_NEK2_1	30	35	PF00069	0.694
MOD_NEK2_1	49	54	PF00069	0.717
MOD_NEK2_2	268	273	PF00069	0.636
MOD_NEK2_2	34	39	PF00069	0.625
MOD_PIKK_1	13	19	PF00454	0.603
MOD_PIKK_1	206	212	PF00454	0.576
MOD_PKA_1	187	193	PF00069	0.767
MOD_PKA_2	17	23	PF00069	0.656
MOD_PKA_2	187	193	PF00069	0.705
MOD_PKA_2	324	330	PF00069	0.613
MOD_PKA_2	49	55	PF00069	0.709
MOD_PKA_2	73	79	PF00069	0.721
MOD_PKA_2	96	102	PF00069	0.506
MOD_Plk_1	151	157	PF00069	0.580
MOD_Plk_1	268	274	PF00069	0.507
MOD_Plk_1	346	352	PF00069	0.698
MOD_Plk_2-3	225	231	PF00069	0.600
MOD_Plk_4	231	237	PF00069	0.588
MOD_Plk_4	268	274	PF00069	0.602
MOD_ProDKin_1	189	195	PF00069	0.745
MOD_ProDKin_1	20	26	PF00069	0.733
MOD_ProDKin_1	62	68	PF00069	0.665
TRG_DiLeu_BaEn_2	230	236	PF01217	0.518
TRG_DiLeu_BaLyEn_6	143	148	PF01217	0.635
TRG_DiLeu_BaLyEn_6	153	158	PF01217	0.542
TRG_DiLeu_BaLyEn_6	168	173	PF01217	0.629
TRG_ENDOCYTIC_2	232	235	PF00928	0.535
TRG_ER_diArg_1	143	146	PF00400	0.494
TRG_NLS_MonoExtC_3	58	63	PF00514	0.749
TRG_NLS_MonoExtN_4	59	64	PF00514	0.762
TRG_Pf-PMV_PEXEL_1	145	149	PF00026	0.632
TRG_Pf-PMV_PEXEL_1	156	161	PF00026	0.559

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4X3	Leptomonas seymouri	39%	97%
A0A1X0NTI1	Trypanosomatidae	32%	100%
A0A422N4X5	Trypanosoma rangeli	31%	100%
A4HCJ6	Leishmania braziliensis	74%	100%
A4I016	Leishmania infantum	100%	100%
C9ZQ77	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9AVY9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4QBJ0	Leishmania major	91%	100%
V5ARZ4	Trypanosoma cruzi	30%	100%