Esterase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hydrolase-like protein

Species:

Leishmania donovani

UniProt:

A0A3Q8IAT8_LEIDO

TriTrypDb:

LdBPK_171160.1 , LdCL_170017700 , LDHU3_17.1640

Length:

724

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IAT8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IAT8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	5
GO:0016787	hydrolase activity	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	327	331	PF00656	0.672
CLV_C14_Caspase3-7	457	461	PF00656	0.655
CLV_C14_Caspase3-7	466	470	PF00656	0.580
CLV_NRD_NRD_1	173	175	PF00675	0.257
CLV_NRD_NRD_1	209	211	PF00675	0.425
CLV_NRD_NRD_1	216	218	PF00675	0.416
CLV_NRD_NRD_1	232	234	PF00675	0.231
CLV_NRD_NRD_1	471	473	PF00675	0.664
CLV_NRD_NRD_1	516	518	PF00675	0.607
CLV_NRD_NRD_1	700	702	PF00675	0.616
CLV_PCSK_KEX2_1	173	175	PF00082	0.273
CLV_PCSK_KEX2_1	208	210	PF00082	0.415
CLV_PCSK_KEX2_1	216	218	PF00082	0.302
CLV_PCSK_KEX2_1	232	234	PF00082	0.339
CLV_PCSK_KEX2_1	309	311	PF00082	0.561
CLV_PCSK_KEX2_1	437	439	PF00082	0.657
CLV_PCSK_KEX2_1	471	473	PF00082	0.627
CLV_PCSK_KEX2_1	516	518	PF00082	0.619
CLV_PCSK_KEX2_1	700	702	PF00082	0.616
CLV_PCSK_PC1ET2_1	208	210	PF00082	0.310
CLV_PCSK_PC1ET2_1	309	311	PF00082	0.561
CLV_PCSK_PC1ET2_1	437	439	PF00082	0.657
CLV_PCSK_SKI1_1	193	197	PF00082	0.307
CLV_PCSK_SKI1_1	209	213	PF00082	0.307
CLV_PCSK_SKI1_1	237	241	PF00082	0.308
CLV_PCSK_SKI1_1	266	270	PF00082	0.286
CLV_PCSK_SKI1_1	313	317	PF00082	0.635
CLV_PCSK_SKI1_1	451	455	PF00082	0.591
CLV_PCSK_SKI1_1	480	484	PF00082	0.639
CLV_PCSK_SKI1_1	541	545	PF00082	0.681
CLV_PCSK_SKI1_1	90	94	PF00082	0.352
DEG_APCC_DBOX_1	208	216	PF00400	0.329
DEG_SCF_FBW7_1	562	568	PF00400	0.600
DEG_SPOP_SBC_1	151	155	PF00917	0.307
DEG_SPOP_SBC_1	440	444	PF00917	0.649
DEG_SPOP_SBC_1	474	478	PF00917	0.554
DEG_SPOP_SBC_1	547	551	PF00917	0.626
DOC_CKS1_1	430	435	PF01111	0.640
DOC_CKS1_1	562	567	PF01111	0.599
DOC_CYCLIN_RxL_1	272	281	PF00134	0.307
DOC_CYCLIN_yCln2_LP_2	244	250	PF00134	0.307
DOC_MAPK_gen_1	208	215	PF00069	0.307
DOC_MAPK_gen_1	583	592	PF00069	0.521
DOC_MAPK_gen_1	79	87	PF00069	0.315
DOC_MAPK_MEF2A_6	586	594	PF00069	0.530
DOC_MAPK_MEF2A_6	79	87	PF00069	0.375
DOC_PP2B_LxvP_1	117	120	PF13499	0.307
DOC_PP2B_LxvP_1	139	142	PF13499	0.307
DOC_PP2B_LxvP_1	244	247	PF13499	0.307
DOC_PP2B_LxvP_1	85	88	PF13499	0.307
DOC_PP4_FxxP_1	22	25	PF00568	0.374
DOC_USP7_MATH_1	315	319	PF00917	0.630
DOC_USP7_MATH_1	426	430	PF00917	0.621
DOC_USP7_MATH_1	439	443	PF00917	0.637
DOC_USP7_MATH_1	498	502	PF00917	0.710
DOC_USP7_MATH_1	547	551	PF00917	0.665
DOC_USP7_MATH_1	553	557	PF00917	0.724
DOC_USP7_MATH_1	565	569	PF00917	0.520
DOC_USP7_MATH_1	617	621	PF00917	0.658
DOC_USP7_MATH_1	667	671	PF00917	0.621
DOC_USP7_MATH_1	691	695	PF00917	0.641
DOC_WW_Pin1_4	384	389	PF00397	0.510
DOC_WW_Pin1_4	429	434	PF00397	0.635
DOC_WW_Pin1_4	441	446	PF00397	0.553
DOC_WW_Pin1_4	484	489	PF00397	0.672
DOC_WW_Pin1_4	500	505	PF00397	0.498
DOC_WW_Pin1_4	561	566	PF00397	0.649
DOC_WW_Pin1_4	610	615	PF00397	0.568
DOC_WW_Pin1_4	660	665	PF00397	0.619
DOC_WW_Pin1_4	687	692	PF00397	0.635
LIG_14-3-3_CanoR_1	144	149	PF00244	0.307
LIG_14-3-3_CanoR_1	177	182	PF00244	0.375
LIG_14-3-3_CanoR_1	188	193	PF00244	0.252
LIG_14-3-3_CanoR_1	210	216	PF00244	0.439
LIG_14-3-3_CanoR_1	217	221	PF00244	0.307
LIG_14-3-3_CanoR_1	266	271	PF00244	0.286
LIG_14-3-3_CanoR_1	338	347	PF00244	0.562
LIG_14-3-3_CanoR_1	369	375	PF00244	0.544
LIG_14-3-3_CanoR_1	628	636	PF00244	0.629
LIG_Actin_WH2_2	182	199	PF00022	0.307
LIG_deltaCOP1_diTrp_1	164	170	PF00928	0.329
LIG_DLG_GKlike_1	188	195	PF00625	0.307
LIG_DLG_GKlike_1	216	224	PF00625	0.352
LIG_FHA_1	143	149	PF00498	0.302
LIG_FHA_1	425	431	PF00498	0.608
LIG_FHA_1	526	532	PF00498	0.592
LIG_FHA_1	641	647	PF00498	0.630
LIG_FHA_2	178	184	PF00498	0.371
LIG_FHA_2	325	331	PF00498	0.672
LIG_FHA_2	41	47	PF00498	0.329
LIG_FHA_2	593	599	PF00498	0.576
LIG_FHA_2	70	76	PF00498	0.307
LIG_LIR_Apic_2	376	380	PF02991	0.626
LIG_LIR_Gen_1	109	119	PF02991	0.306
LIG_LIR_Gen_1	16	25	PF02991	0.348
LIG_LIR_Gen_1	164	172	PF02991	0.329
LIG_LIR_Gen_1	423	433	PF02991	0.657
LIG_LIR_Gen_1	505	514	PF02991	0.594
LIG_LIR_Gen_1	597	606	PF02991	0.512
LIG_LIR_Gen_1	719	724	PF02991	0.658
LIG_LIR_Nem_3	109	114	PF02991	0.306
LIG_LIR_Nem_3	16	22	PF02991	0.338
LIG_LIR_Nem_3	164	169	PF02991	0.329
LIG_LIR_Nem_3	423	428	PF02991	0.645
LIG_LIR_Nem_3	505	510	PF02991	0.567
LIG_LIR_Nem_3	719	724	PF02991	0.613
LIG_NRBOX	191	197	PF00104	0.307
LIG_PCNA_yPIPBox_3	173	185	PF02747	0.307
LIG_PDZ_Class_1	719	724	PF00595	0.613
LIG_Pex14_1	45	49	PF04695	0.307
LIG_Pex14_2	286	290	PF04695	0.360
LIG_SH2_CRK	198	202	PF00017	0.375
LIG_SH2_CRK	273	277	PF00017	0.375
LIG_SH2_CRK	425	429	PF00017	0.657
LIG_SH2_GRB2like	63	66	PF00017	0.307
LIG_SH2_NCK_1	198	202	PF00017	0.375
LIG_SH2_NCK_1	425	429	PF00017	0.612
LIG_SH2_PTP2	377	380	PF00017	0.577
LIG_SH2_STAP1	273	277	PF00017	0.307
LIG_SH2_STAP1	70	74	PF00017	0.307
LIG_SH2_STAT5	206	209	PF00017	0.307
LIG_SH2_STAT5	285	288	PF00017	0.353
LIG_SH2_STAT5	311	314	PF00017	0.555
LIG_SH2_STAT5	377	380	PF00017	0.577
LIG_SH2_STAT5	59	62	PF00017	0.307
LIG_SH2_STAT5	599	602	PF00017	0.557
LIG_SH3_1	311	317	PF00018	0.534
LIG_SH3_3	155	161	PF00018	0.307
LIG_SH3_3	254	260	PF00018	0.306
LIG_SH3_3	311	317	PF00018	0.620
LIG_SH3_3	396	402	PF00018	0.584
LIG_SH3_3	405	411	PF00018	0.569
LIG_SH3_3	425	431	PF00018	0.469
LIG_SH3_3	559	565	PF00018	0.607
LIG_SH3_3	661	667	PF00018	0.570
LIG_SUMO_SIM_par_1	143	150	PF11976	0.240
LIG_SUMO_SIM_par_1	275	281	PF11976	0.307
LIG_SUMO_SIM_par_1	426	432	PF11976	0.541
LIG_SUMO_SIM_par_1	641	647	PF11976	0.614
LIG_TRAF2_1	320	323	PF00917	0.560
LIG_TRAF2_1	343	346	PF00917	0.612
LIG_TRAF2_1	595	598	PF00917	0.552
LIG_TRAF2_1	696	699	PF00917	0.642
LIG_TRAF2_2	100	105	PF00917	0.375
LIG_TRFH_1	198	202	PF08558	0.375
LIG_TYR_ITIM	271	276	PF00017	0.375
LIG_UBA3_1	276	280	PF00899	0.307
LIG_WW_3	174	178	PF00397	0.375
MOD_CDC14_SPxK_1	503	506	PF00782	0.548
MOD_CDK_SPxK_1	500	506	PF00069	0.553
MOD_CDK_SPxxK_3	384	391	PF00069	0.573
MOD_CK1_1	147	153	PF00069	0.307
MOD_CK1_1	429	435	PF00069	0.723
MOD_CK1_1	444	450	PF00069	0.550
MOD_CK1_1	476	482	PF00069	0.597
MOD_CK1_1	549	555	PF00069	0.623
MOD_CK1_1	610	616	PF00069	0.604
MOD_CK1_1	660	666	PF00069	0.684
MOD_CK1_1	690	696	PF00069	0.624
MOD_CK2_1	177	183	PF00069	0.371
MOD_CK2_1	317	323	PF00069	0.559
MOD_CK2_1	340	346	PF00069	0.615
MOD_CK2_1	370	376	PF00069	0.611
MOD_CK2_1	45	51	PF00069	0.329
MOD_CK2_1	488	494	PF00069	0.642
MOD_CK2_1	592	598	PF00069	0.575
MOD_CK2_1	69	75	PF00069	0.307
MOD_GlcNHglycan	262	265	PF01048	0.250
MOD_GlcNHglycan	317	320	PF01048	0.633
MOD_GlcNHglycan	330	333	PF01048	0.633
MOD_GlcNHglycan	340	343	PF01048	0.653
MOD_GlcNHglycan	353	359	PF01048	0.600
MOD_GlcNHglycan	530	534	PF01048	0.637
MOD_GlcNHglycan	537	540	PF01048	0.599
MOD_GlcNHglycan	551	554	PF01048	0.632
MOD_GlcNHglycan	555	558	PF01048	0.667
MOD_GlcNHglycan	567	570	PF01048	0.536
MOD_GlcNHglycan	609	612	PF01048	0.620
MOD_GlcNHglycan	659	662	PF01048	0.589
MOD_GlcNHglycan	685	688	PF01048	0.597
MOD_GSK3_1	142	149	PF00069	0.307
MOD_GSK3_1	211	218	PF00069	0.307
MOD_GSK3_1	260	267	PF00069	0.250
MOD_GSK3_1	324	331	PF00069	0.672
MOD_GSK3_1	440	447	PF00069	0.632
MOD_GSK3_1	45	52	PF00069	0.329
MOD_GSK3_1	451	458	PF00069	0.602
MOD_GSK3_1	484	491	PF00069	0.638
MOD_GSK3_1	498	505	PF00069	0.510
MOD_GSK3_1	525	532	PF00069	0.620
MOD_GSK3_1	535	542	PF00069	0.634
MOD_GSK3_1	547	554	PF00069	0.591
MOD_GSK3_1	561	568	PF00069	0.589
MOD_GSK3_1	613	620	PF00069	0.666
MOD_GSK3_1	640	647	PF00069	0.620
MOD_GSK3_1	683	690	PF00069	0.653
MOD_GSK3_1	716	723	PF00069	0.579
MOD_N-GLC_1	177	182	PF02516	0.307
MOD_NEK2_1	125	130	PF00069	0.307
MOD_NEK2_1	152	157	PF00069	0.290
MOD_NEK2_1	211	216	PF00069	0.439
MOD_NEK2_1	290	295	PF00069	0.356
MOD_NEK2_1	370	375	PF00069	0.538
MOD_NEK2_1	40	45	PF00069	0.357
MOD_NEK2_1	463	468	PF00069	0.661
MOD_NEK2_1	49	54	PF00069	0.264
MOD_NEK2_1	644	649	PF00069	0.577
MOD_NEK2_2	675	680	PF00069	0.624
MOD_PK_1	340	346	PF00069	0.615
MOD_PKA_1	216	222	PF00069	0.297
MOD_PKA_2	215	221	PF00069	0.310
MOD_PKA_2	535	541	PF00069	0.683
MOD_PKA_2	627	633	PF00069	0.630
MOD_Plk_1	142	148	PF00069	0.307
MOD_Plk_1	177	183	PF00069	0.307
MOD_Plk_1	45	51	PF00069	0.329
MOD_Plk_1	640	646	PF00069	0.615
MOD_Plk_4	147	153	PF00069	0.307
MOD_Plk_4	266	272	PF00069	0.286
MOD_Plk_4	290	296	PF00069	0.357
MOD_Plk_4	49	55	PF00069	0.307
MOD_ProDKin_1	384	390	PF00069	0.504
MOD_ProDKin_1	429	435	PF00069	0.637
MOD_ProDKin_1	441	447	PF00069	0.552
MOD_ProDKin_1	484	490	PF00069	0.670
MOD_ProDKin_1	500	506	PF00069	0.499
MOD_ProDKin_1	561	567	PF00069	0.650
MOD_ProDKin_1	610	616	PF00069	0.568
MOD_ProDKin_1	660	666	PF00069	0.618
MOD_ProDKin_1	687	693	PF00069	0.636
MOD_SUMO_rev_2	359	368	PF00179	0.607
TRG_DiLeu_BaLyEn_6	272	277	PF01217	0.375
TRG_ENDOCYTIC_2	19	22	PF00928	0.342
TRG_ENDOCYTIC_2	273	276	PF00928	0.307
TRG_ENDOCYTIC_2	425	428	PF00928	0.655
TRG_ENDOCYTIC_2	599	602	PF00928	0.586
TRG_ER_diArg_1	172	174	PF00400	0.273
TRG_ER_diArg_1	209	211	PF00400	0.446
TRG_ER_diArg_1	215	217	PF00400	0.420
TRG_ER_diArg_1	231	233	PF00400	0.231
TRG_ER_diArg_1	3	6	PF00400	0.336
TRG_Pf-PMV_PEXEL_1	93	97	PF00026	0.352

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBI2	Leptomonas seymouri	49%	90%
A4H961	Leishmania braziliensis	69%	97%
A4HXI3	Leishmania infantum	99%	100%
E9AR78	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	99%
Q4QE85	Leishmania major	92%	99%