Hypothetical_protein_conserved

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3Q8IAT4_LEIDO

TriTrypDb:

LdBPK_200810.1 , LdCL_200012800 , LDHU3_20.1000

Length:

358

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IAT4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IAT4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	150	154	PF00656	0.619
CLV_NRD_NRD_1	23	25	PF00675	0.591
CLV_NRD_NRD_1	303	305	PF00675	0.464
CLV_NRD_NRD_1	44	46	PF00675	0.586
CLV_NRD_NRD_1	70	72	PF00675	0.602
CLV_PCSK_KEX2_1	23	25	PF00082	0.591
CLV_PCSK_KEX2_1	43	45	PF00082	0.455
CLV_PCSK_KEX2_1	72	74	PF00082	0.621
CLV_PCSK_PC1ET2_1	72	74	PF00082	0.550
CLV_PCSK_SKI1_1	273	277	PF00082	0.439
CLV_PCSK_SKI1_1	64	68	PF00082	0.565
CLV_PCSK_SKI1_1	75	79	PF00082	0.488
DOC_CYCLIN_RxL_1	270	278	PF00134	0.416
DOC_MAPK_JIP1_4	317	323	PF00069	0.499
DOC_USP7_MATH_1	198	202	PF00917	0.733
DOC_USP7_UBL2_3	346	350	PF12436	0.491
DOC_WW_Pin1_4	16	21	PF00397	0.618
DOC_WW_Pin1_4	278	283	PF00397	0.517
DOC_WW_Pin1_4	4	9	PF00397	0.682
LIG_14-3-3_CanoR_1	304	310	PF00244	0.475
LIG_APCC_ABBAyCdc20_2	75	81	PF00400	0.443
LIG_BIR_III_2	156	160	PF00653	0.623
LIG_eIF4E_1	207	213	PF01652	0.515
LIG_FHA_1	290	296	PF00498	0.481
LIG_FHA_2	46	52	PF00498	0.537
LIG_RPA_C_Fungi	125	137	PF08784	0.514
LIG_SH2_STAT5	248	251	PF00017	0.532
LIG_SH3_CIN85_PxpxPR_1	6	11	PF14604	0.586
LIG_SUMO_SIM_anti_2	319	326	PF11976	0.498
LIG_SUMO_SIM_par_1	292	298	PF11976	0.416
LIG_TRAF2_1	120	123	PF00917	0.684
LIG_TRAF2_1	208	211	PF00917	0.607
LIG_TRAF2_1	258	261	PF00917	0.499
MOD_CDK_SPK_2	6	11	PF00069	0.644
MOD_CDK_SPxK_1	278	284	PF00069	0.521
MOD_CDK_SPxxK_3	16	23	PF00069	0.551
MOD_CDK_SPxxK_3	4	11	PF00069	0.655
MOD_CK1_1	201	207	PF00069	0.540
MOD_CK1_1	308	314	PF00069	0.466
MOD_CK1_1	4	10	PF00069	0.688
MOD_CK2_1	329	335	PF00069	0.529
MOD_CK2_1	351	357	PF00069	0.502
MOD_CK2_1	45	51	PF00069	0.543
MOD_GlcNHglycan	153	156	PF01048	0.591
MOD_GlcNHglycan	184	187	PF01048	0.645
MOD_GlcNHglycan	3	6	PF01048	0.625
MOD_GSK3_1	198	205	PF00069	0.557
MOD_N-GLC_1	198	203	PF02516	0.635
MOD_NEK2_1	1	6	PF00069	0.700
MOD_NEK2_1	300	305	PF00069	0.481
MOD_NEK2_2	198	203	PF00069	0.635
MOD_PIKK_1	329	335	PF00454	0.488
MOD_PIKK_1	9	15	PF00454	0.721
MOD_PK_1	305	311	PF00069	0.430
MOD_PKB_1	43	51	PF00069	0.531
MOD_Plk_1	198	204	PF00069	0.561
MOD_Plk_2-3	158	164	PF00069	0.618
MOD_Plk_4	158	164	PF00069	0.652
MOD_Plk_4	319	325	PF00069	0.497
MOD_ProDKin_1	16	22	PF00069	0.613
MOD_ProDKin_1	278	284	PF00069	0.521
MOD_ProDKin_1	4	10	PF00069	0.683
MOD_SUMO_for_1	344	347	PF00179	0.451
MOD_SUMO_rev_2	331	340	PF00179	0.391
TRG_DiLeu_BaEn_1	296	301	PF01217	0.411
TRG_DiLeu_BaEn_4	121	127	PF01217	0.545
TRG_ER_diArg_1	42	45	PF00400	0.560

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCL3	Leptomonas seymouri	56%	100%
A4HYN8	Leishmania infantum	100%	100%
E9AID1	Leishmania braziliensis	73%	95%
E9AUL8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QCW6	Leishmania major	93%	100%