Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved (fragment)

Species:

Leishmania donovani

UniProt:

A0A3Q8IAT2_LEIDO

TriTrypDb:

LdBPK_210570.1 , LdCL_210010500 , LDHU3_21.0610

Length:

551

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IAT2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IAT2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	50	54	PF00656	0.495
CLV_NRD_NRD_1	256	258	PF00675	0.517
CLV_NRD_NRD_1	451	453	PF00675	0.659
CLV_PCSK_KEX2_1	142	144	PF00082	0.427
CLV_PCSK_KEX2_1	450	452	PF00082	0.675
CLV_PCSK_KEX2_1	84	86	PF00082	0.721
CLV_PCSK_PC1ET2_1	142	144	PF00082	0.509
CLV_PCSK_PC1ET2_1	450	452	PF00082	0.772
CLV_PCSK_PC1ET2_1	84	86	PF00082	0.721
CLV_PCSK_SKI1_1	143	147	PF00082	0.427
CLV_PCSK_SKI1_1	29	33	PF00082	0.720
CLV_PCSK_SKI1_1	37	41	PF00082	0.608
CLV_PCSK_SKI1_1	400	404	PF00082	0.734
DEG_APCC_DBOX_1	142	150	PF00400	0.430
DEG_SCF_FBW7_1	148	154	PF00400	0.521
DOC_CDC14_PxL_1	131	139	PF14671	0.536
DOC_CDC14_PxL_1	192	200	PF14671	0.525
DOC_CDC14_PxL_1	404	412	PF14671	0.505
DOC_CKS1_1	148	153	PF01111	0.515
DOC_CKS1_1	517	522	PF01111	0.783
DOC_CYCLIN_yCln2_LP_2	198	204	PF00134	0.527
DOC_CYCLIN_yCln2_LP_2	430	436	PF00134	0.583
DOC_CYCLIN_yCln2_LP_2	456	462	PF00134	0.557
DOC_MAPK_gen_1	142	148	PF00069	0.423
DOC_MAPK_gen_1	398	407	PF00069	0.687
DOC_MAPK_MEF2A_6	400	409	PF00069	0.778
DOC_PP2B_LxvP_1	193	196	PF13499	0.489
DOC_PP4_MxPP_1	488	491	PF00568	0.661
DOC_USP7_MATH_1	10	14	PF00917	0.706
DOC_USP7_MATH_1	103	107	PF00917	0.606
DOC_USP7_MATH_1	112	116	PF00917	0.545
DOC_USP7_MATH_1	214	218	PF00917	0.693
DOC_USP7_MATH_1	320	324	PF00917	0.631
DOC_USP7_MATH_1	392	396	PF00917	0.634
DOC_USP7_MATH_1	463	467	PF00917	0.668
DOC_USP7_MATH_1	480	484	PF00917	0.770
DOC_WW_Pin1_4	147	152	PF00397	0.467
DOC_WW_Pin1_4	516	521	PF00397	0.791
DOC_WW_Pin1_4	77	82	PF00397	0.690
LIG_14-3-3_CanoR_1	37	45	PF00244	0.624
LIG_14-3-3_CanoR_1	451	455	PF00244	0.672
LIG_14-3-3_CanoR_1	8	13	PF00244	0.746
LIG_Actin_WH2_2	127	144	PF00022	0.579
LIG_BIR_II_1	1	5	PF00653	0.721
LIG_BRCT_BRCA1_1	304	308	PF00533	0.659
LIG_BRCT_BRCA1_1	79	83	PF00533	0.629
LIG_FHA_1	148	154	PF00498	0.486
LIG_FHA_1	219	225	PF00498	0.644
LIG_FHA_1	363	369	PF00498	0.608
LIG_FHA_1	411	417	PF00498	0.583
LIG_FHA_1	451	457	PF00498	0.617
LIG_FHA_1	61	67	PF00498	0.444
LIG_FHA_2	227	233	PF00498	0.587
LIG_FHA_2	38	44	PF00498	0.542
LIG_FHA_2	382	388	PF00498	0.707
LIG_GBD_Chelix_1	177	185	PF00786	0.325
LIG_LIR_Gen_1	109	119	PF02991	0.472
LIG_LIR_Gen_1	157	165	PF02991	0.490
LIG_LIR_Nem_3	157	162	PF02991	0.487
LIG_MYND_1	196	200	PF01753	0.525
LIG_MYND_3	134	138	PF01753	0.531
LIG_NRBOX	176	182	PF00104	0.454
LIG_NRBOX	223	229	PF00104	0.632
LIG_SH2_CRK	119	123	PF00017	0.506
LIG_SH2_NCK_1	304	308	PF00017	0.577
LIG_SH2_SRC	203	206	PF00017	0.569
LIG_SH2_STAP1	203	207	PF00017	0.563
LIG_SH2_STAP1	304	308	PF00017	0.674
LIG_SH2_STAP1	62	66	PF00017	0.506
LIG_SH2_STAT3	129	132	PF00017	0.471
LIG_SH2_STAT3	272	275	PF00017	0.351
LIG_SH2_STAT3	62	65	PF00017	0.544
LIG_SH2_STAT5	272	275	PF00017	0.525
LIG_SH2_STAT5	298	301	PF00017	0.687
LIG_SH2_STAT5	62	65	PF00017	0.521
LIG_SH3_3	145	151	PF00018	0.435
LIG_SH3_3	351	357	PF00018	0.540
LIG_SH3_3	402	408	PF00018	0.716
LIG_SH3_3	431	437	PF00018	0.633
LIG_SH3_3	465	471	PF00018	0.741
LIG_SH3_3	476	482	PF00018	0.644
LIG_SH3_3	495	501	PF00018	0.474
LIG_SH3_3	506	512	PF00018	0.631
LIG_SH3_3	514	520	PF00018	0.703
LIG_SH3_3	521	527	PF00018	0.723
LIG_SH3_3	528	534	PF00018	0.700
LIG_SH3_3	75	81	PF00018	0.556
LIG_Sin3_3	442	449	PF02671	0.760
LIG_SUMO_SIM_par_1	189	194	PF11976	0.566
LIG_SUMO_SIM_par_1	226	233	PF11976	0.602
LIG_TRAF2_1	136	139	PF00917	0.485
LIG_TRAF2_1	300	303	PF00917	0.642
LIG_TRAF2_1	40	43	PF00917	0.587
LIG_TYR_ITIM	117	122	PF00017	0.511
LIG_UBA3_1	133	142	PF00899	0.516
MOD_CDK_SPxxK_3	77	84	PF00069	0.708
MOD_CK1_1	240	246	PF00069	0.634
MOD_CK1_1	309	315	PF00069	0.710
MOD_CK1_1	35	41	PF00069	0.678
MOD_CK2_1	133	139	PF00069	0.588
MOD_CK2_1	151	157	PF00069	0.430
MOD_CK2_1	226	232	PF00069	0.680
MOD_CK2_1	297	303	PF00069	0.630
MOD_CK2_1	37	43	PF00069	0.553
MOD_GlcNHglycan	114	117	PF01048	0.525
MOD_GlcNHglycan	12	15	PF01048	0.728
MOD_GlcNHglycan	212	215	PF01048	0.636
MOD_GlcNHglycan	238	242	PF01048	0.716
MOD_GlcNHglycan	465	468	PF01048	0.677
MOD_GlcNHglycan	538	541	PF01048	0.696
MOD_GlcNHglycan	8	11	PF01048	0.723
MOD_GSK3_1	147	154	PF00069	0.518
MOD_GSK3_1	210	217	PF00069	0.624
MOD_GSK3_1	302	309	PF00069	0.589
MOD_GSK3_1	310	317	PF00069	0.679
MOD_GSK3_1	33	40	PF00069	0.621
MOD_GSK3_1	388	395	PF00069	0.717
MOD_GSK3_1	396	403	PF00069	0.698
MOD_GSK3_1	450	457	PF00069	0.622
MOD_GSK3_1	6	13	PF00069	0.727
MOD_N-GLC_1	388	393	PF02516	0.734
MOD_NEK2_1	164	169	PF00069	0.428
MOD_NEK2_1	180	185	PF00069	0.409
MOD_NEK2_1	32	37	PF00069	0.679
MOD_NEK2_1	360	365	PF00069	0.478
MOD_NEK2_1	381	386	PF00069	0.686
MOD_NEK2_1	97	102	PF00069	0.731
MOD_PIKK_1	382	388	PF00454	0.761
MOD_PIKK_1	392	398	PF00454	0.738
MOD_PIKK_1	60	66	PF00454	0.527
MOD_PK_1	8	14	PF00069	0.747
MOD_PKA_1	400	406	PF00069	0.731
MOD_PKA_1	450	456	PF00069	0.723
MOD_PKA_2	450	456	PF00069	0.729
MOD_Plk_4	180	186	PF00069	0.489
MOD_Plk_4	400	406	PF00069	0.546
MOD_ProDKin_1	147	153	PF00069	0.466
MOD_ProDKin_1	516	522	PF00069	0.791
MOD_ProDKin_1	77	83	PF00069	0.696
TRG_DiLeu_BaEn_1	187	192	PF01217	0.521
TRG_DiLeu_BaLyEn_6	377	382	PF01217	0.643
TRG_DiLeu_BaLyEn_6	405	410	PF01217	0.748
TRG_ENDOCYTIC_2	119	122	PF00928	0.507
TRG_NLS_MonoExtN_4	254	261	PF00514	0.514
TRG_NLS_MonoExtN_4	448	454	PF00514	0.769
TRG_Pf-PMV_PEXEL_1	260	264	PF00026	0.448

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAT9	Leptomonas seymouri	58%	93%
A4HBP8	Leishmania braziliensis	83%	100%
A4HZ50	Leishmania infantum	100%	100%
D0A1Q2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9AV18	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QCG4	Leishmania major	90%	100%
V5BKP0	Trypanosoma cruzi	29%	100%