Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3Q8IAS9_LEIDO

TriTrypDb:

LdBPK_170960.1 , LdCL_170015600 , LDHU3_17.1380

Length:

144

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IAS9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IAS9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	82	86	PF00656	0.710
CLV_PCSK_KEX2_1	69	71	PF00082	0.675
CLV_PCSK_PC1ET2_1	69	71	PF00082	0.738
CLV_PCSK_SKI1_1	28	32	PF00082	0.689
DEG_MDM2_SWIB_1	7	14	PF02201	0.739
DOC_CKS1_1	120	125	PF01111	0.720
DOC_USP7_MATH_1	57	61	PF00917	0.759
DOC_USP7_MATH_1	68	72	PF00917	0.607
DOC_USP7_MATH_1	79	83	PF00917	0.651
DOC_USP7_MATH_1	90	94	PF00917	0.609
DOC_USP7_UBL2_3	20	24	PF12436	0.702
DOC_WW_Pin1_4	119	124	PF00397	0.722
LIG_14-3-3_CanoR_1	28	35	PF00244	0.719
LIG_14-3-3_CanoR_1	56	62	PF00244	0.724
LIG_14-3-3_CanoR_1	70	75	PF00244	0.578
LIG_BIR_II_1	1	5	PF00653	0.735
LIG_BRCT_BRCA1_1	3	7	PF00533	0.645
LIG_BRCT_BRCA1_1	70	74	PF00533	0.719
LIG_FHA_1	16	22	PF00498	0.761
LIG_FHA_2	14	20	PF00498	0.750
LIG_LIR_Apic_2	33	38	PF02991	0.778
LIG_LIR_Gen_1	106	116	PF02991	0.709
LIG_LIR_Nem_3	94	100	PF02991	0.710
LIG_Pex14_2	3	7	PF04695	0.723
LIG_PTB_Apo_2	36	43	PF02174	0.534
LIG_PTB_Phospho_1	36	42	PF10480	0.538
LIG_SH2_CRK	140	144	PF00017	0.754
LIG_SH2_CRK	35	39	PF00017	0.762
LIG_SH2_CRK	42	46	PF00017	0.640
LIG_SH2_CRK	97	101	PF00017	0.715
LIG_SH2_GRB2like	35	38	PF00017	0.770
LIG_SH2_NCK_1	35	39	PF00017	0.762
LIG_SH2_SRC	35	38	PF00017	0.694
LIG_SH2_STAP1	105	109	PF00017	0.690
LIG_SH2_STAT3	127	130	PF00017	0.835
LIG_SH2_STAT5	105	108	PF00017	0.725
LIG_SH2_STAT5	121	124	PF00017	0.621
LIG_SH2_STAT5	127	130	PF00017	0.700
MOD_CK1_1	13	19	PF00069	0.744
MOD_CK1_1	2	8	PF00069	0.729
MOD_CK1_1	47	53	PF00069	0.772
MOD_CK2_1	13	19	PF00069	0.744
MOD_GlcNHglycan	57	60	PF01048	0.623
MOD_GlcNHglycan	81	84	PF01048	0.775
MOD_GSK3_1	47	54	PF00069	0.625
MOD_GSK3_1	57	64	PF00069	0.681
MOD_N-GLC_1	79	84	PF02516	0.728
MOD_NEK2_1	1	6	PF00069	0.734
MOD_NEK2_1	55	60	PF00069	0.681
MOD_NEK2_1	61	66	PF00069	0.635
MOD_PIKK_1	103	109	PF00454	0.643
MOD_PK_1	44	50	PF00069	0.688
MOD_PKA_2	51	57	PF00069	0.642
MOD_ProDKin_1	119	125	PF00069	0.721
TRG_DiLeu_BaEn_1	25	30	PF01217	0.772
TRG_ENDOCYTIC_2	109	112	PF00928	0.616
TRG_ENDOCYTIC_2	140	143	PF00928	0.756
TRG_ENDOCYTIC_2	97	100	PF00928	0.731

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4H950	Leishmania braziliensis	53%	89%
A4HXG4	Leishmania infantum	99%	100%
E9AR59	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4QEA4	Leishmania major	89%	100%