Thioredoxin domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3Q8IAS7_LEIDO

TriTrypDb:

LdBPK_170240.1 , LdCL_170007900 , LDHU3_17.0460

Length:

867

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 6, no: 0
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IAS7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IAS7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	323	327	PF00656	0.497
CLV_C14_Caspase3-7	505	509	PF00656	0.577
CLV_C14_Caspase3-7	510	514	PF00656	0.593
CLV_C14_Caspase3-7	578	582	PF00656	0.454
CLV_C14_Caspase3-7	614	618	PF00656	0.712
CLV_C14_Caspase3-7	817	821	PF00656	0.604
CLV_MEL_PAP_1	499	505	PF00089	0.530
CLV_NRD_NRD_1	140	142	PF00675	0.475
CLV_NRD_NRD_1	389	391	PF00675	0.458
CLV_NRD_NRD_1	434	436	PF00675	0.519
CLV_NRD_NRD_1	536	538	PF00675	0.633
CLV_NRD_NRD_1	638	640	PF00675	0.625
CLV_NRD_NRD_1	709	711	PF00675	0.568
CLV_NRD_NRD_1	719	721	PF00675	0.576
CLV_NRD_NRD_1	732	734	PF00675	0.493
CLV_NRD_NRD_1	740	742	PF00675	0.571
CLV_NRD_NRD_1	790	792	PF00675	0.633
CLV_NRD_NRD_1	806	808	PF00675	0.659
CLV_NRD_NRD_1	832	834	PF00675	0.533
CLV_PCSK_FUR_1	707	711	PF00082	0.495
CLV_PCSK_FUR_1	738	742	PF00082	0.603
CLV_PCSK_FUR_1	829	833	PF00082	0.549
CLV_PCSK_KEX2_1	140	142	PF00082	0.475
CLV_PCSK_KEX2_1	389	391	PF00082	0.563
CLV_PCSK_KEX2_1	434	436	PF00082	0.519
CLV_PCSK_KEX2_1	535	537	PF00082	0.665
CLV_PCSK_KEX2_1	638	640	PF00082	0.625
CLV_PCSK_KEX2_1	709	711	PF00082	0.566
CLV_PCSK_KEX2_1	719	721	PF00082	0.553
CLV_PCSK_KEX2_1	730	732	PF00082	0.505
CLV_PCSK_KEX2_1	740	742	PF00082	0.568
CLV_PCSK_KEX2_1	790	792	PF00082	0.633
CLV_PCSK_KEX2_1	806	808	PF00082	0.659
CLV_PCSK_KEX2_1	829	831	PF00082	0.570
CLV_PCSK_KEX2_1	832	834	PF00082	0.560
CLV_PCSK_PC1ET2_1	719	721	PF00082	0.566
CLV_PCSK_PC1ET2_1	730	732	PF00082	0.448
CLV_PCSK_PC7_1	705	711	PF00082	0.501
CLV_PCSK_SKI1_1	162	166	PF00082	0.495
CLV_PCSK_SKI1_1	239	243	PF00082	0.549
CLV_PCSK_SKI1_1	248	252	PF00082	0.520
CLV_PCSK_SKI1_1	409	413	PF00082	0.388
CLV_PCSK_SKI1_1	570	574	PF00082	0.506
CLV_PCSK_SKI1_1	657	661	PF00082	0.591
CLV_PCSK_SKI1_1	850	854	PF00082	0.639
DEG_SPOP_SBC_1	311	315	PF00917	0.582
DOC_CDC14_PxL_1	216	224	PF14671	0.470
DOC_CKS1_1	179	184	PF01111	0.509
DOC_CYCLIN_yCln2_LP_2	11	17	PF00134	0.515
DOC_MAPK_gen_1	140	148	PF00069	0.469
DOC_MAPK_gen_1	535	543	PF00069	0.458
DOC_MAPK_MEF2A_6	140	147	PF00069	0.541
DOC_MAPK_MEF2A_6	535	543	PF00069	0.458
DOC_MAPK_MEF2A_6	86	95	PF00069	0.492
DOC_MAPK_NFAT4_5	140	148	PF00069	0.545
DOC_PP1_RVXF_1	407	413	PF00149	0.360
DOC_PP2B_LxvP_1	11	14	PF13499	0.514
DOC_PP2B_LxvP_1	335	338	PF13499	0.629
DOC_PP2B_PxIxI_1	538	544	PF00149	0.390
DOC_PP4_FxxP_1	179	182	PF00568	0.764
DOC_PP4_FxxP_1	52	55	PF00568	0.514
DOC_USP7_MATH_1	101	105	PF00917	0.408
DOC_USP7_MATH_1	189	193	PF00917	0.578
DOC_USP7_MATH_1	244	248	PF00917	0.590
DOC_USP7_MATH_1	253	257	PF00917	0.491
DOC_USP7_MATH_1	273	277	PF00917	0.503
DOC_USP7_MATH_1	311	315	PF00917	0.535
DOC_USP7_MATH_1	330	334	PF00917	0.557
DOC_USP7_MATH_1	41	45	PF00917	0.687
DOC_USP7_MATH_1	449	453	PF00917	0.599
DOC_USP7_MATH_1	498	502	PF00917	0.470
DOC_USP7_MATH_1	526	530	PF00917	0.655
DOC_USP7_MATH_1	577	581	PF00917	0.506
DOC_USP7_MATH_1	588	592	PF00917	0.396
DOC_USP7_MATH_1	622	626	PF00917	0.655
DOC_USP7_MATH_1	82	86	PF00917	0.607
DOC_WW_Pin1_4	174	179	PF00397	0.637
DOC_WW_Pin1_4	185	190	PF00397	0.626
DOC_WW_Pin1_4	224	229	PF00397	0.611
DOC_WW_Pin1_4	3	8	PF00397	0.546
DOC_WW_Pin1_4	333	338	PF00397	0.563
DOC_WW_Pin1_4	383	388	PF00397	0.472
DOC_WW_Pin1_4	460	465	PF00397	0.521
DOC_WW_Pin1_4	661	666	PF00397	0.594
DOC_WW_Pin1_4	695	700	PF00397	0.671
DOC_WW_Pin1_4	78	83	PF00397	0.637
LIG_14-3-3_CanoR_1	115	125	PF00244	0.455
LIG_14-3-3_CanoR_1	434	443	PF00244	0.531
LIG_14-3-3_CanoR_1	609	619	PF00244	0.590
LIG_14-3-3_CanoR_1	692	699	PF00244	0.699
LIG_14-3-3_CanoR_1	850	855	PF00244	0.612
LIG_Actin_RPEL_3	828	847	PF02755	0.466
LIG_Actin_WH2_2	394	411	PF00022	0.441
LIG_Actin_WH2_2	539	555	PF00022	0.491
LIG_AP2alpha_2	538	540	PF02296	0.471
LIG_APCC_ABBA_1	93	98	PF00400	0.426
LIG_BRCT_BRCA1_1	220	224	PF00533	0.483
LIG_BRCT_BRCA1_1	324	328	PF00533	0.643
LIG_BRCT_BRCA1_1	43	47	PF00533	0.597
LIG_BRCT_BRCA1_1	588	592	PF00533	0.430
LIG_CaM_IQ_9	401	417	PF13499	0.409
LIG_EH1_1	15	23	PF00400	0.495
LIG_FHA_1	153	159	PF00498	0.501
LIG_FHA_1	179	185	PF00498	0.637
LIG_FHA_1	213	219	PF00498	0.655
LIG_FHA_1	232	238	PF00498	0.548
LIG_FHA_1	383	389	PF00498	0.636
LIG_FHA_1	443	449	PF00498	0.423
LIG_FHA_1	79	85	PF00498	0.718
LIG_FHA_1	87	93	PF00498	0.476
LIG_FHA_2	341	347	PF00498	0.618
LIG_FHA_2	791	797	PF00498	0.596
LIG_FHA_2	851	857	PF00498	0.612
LIG_GBD_Chelix_1	428	436	PF00786	0.390
LIG_LIR_Apic_2	130	134	PF02991	0.458
LIG_LIR_Apic_2	177	182	PF02991	0.637
LIG_LIR_Apic_2	49	55	PF02991	0.599
LIG_LIR_Gen_1	192	203	PF02991	0.461
LIG_LIR_Gen_1	215	224	PF02991	0.494
LIG_LIR_Nem_3	192	198	PF02991	0.513
LIG_LIR_Nem_3	215	219	PF02991	0.492
LIG_LIR_Nem_3	256	262	PF02991	0.493
LIG_LIR_Nem_3	459	465	PF02991	0.527
LIG_LIR_Nem_3	538	543	PF02991	0.445
LIG_LIR_Nem_3	637	643	PF02991	0.586
LIG_NRBOX	141	147	PF00104	0.536
LIG_SH2_CRK	259	263	PF00017	0.519
LIG_SH2_CRK	549	553	PF00017	0.496
LIG_SH2_GRB2like	319	322	PF00017	0.626
LIG_SH2_PTP2	131	134	PF00017	0.462
LIG_SH2_PTP2	210	213	PF00017	0.504
LIG_SH2_SRC	131	134	PF00017	0.462
LIG_SH2_SRC	210	213	PF00017	0.487
LIG_SH2_SRC	319	322	PF00017	0.577
LIG_SH2_STAT3	655	658	PF00017	0.574
LIG_SH2_STAT5	131	134	PF00017	0.462
LIG_SH2_STAT5	195	198	PF00017	0.627
LIG_SH2_STAT5	210	213	PF00017	0.434
LIG_SH2_STAT5	319	322	PF00017	0.550
LIG_SH2_STAT5	598	601	PF00017	0.498
LIG_SH2_STAT5	633	636	PF00017	0.636
LIG_SH2_STAT5	655	658	PF00017	0.627
LIG_SH3_1	808	814	PF00018	0.586
LIG_SH3_3	1	7	PF00018	0.699
LIG_SH3_3	222	228	PF00018	0.584
LIG_SH3_3	34	40	PF00018	0.758
LIG_SH3_3	571	577	PF00018	0.457
LIG_SH3_3	786	792	PF00018	0.614
LIG_SH3_3	808	814	PF00018	0.586
LIG_SH3_3	85	91	PF00018	0.552
LIG_SUMO_SIM_anti_2	144	149	PF11976	0.544
LIG_SUMO_SIM_anti_2	492	498	PF11976	0.377
LIG_SUMO_SIM_anti_2	59	67	PF11976	0.477
LIG_SUMO_SIM_par_1	284	292	PF11976	0.516
LIG_SUMO_SIM_par_1	91	99	PF11976	0.432
LIG_TRAF2_1	528	531	PF00917	0.686
LIG_TRAF2_1	711	714	PF00917	0.527
LIG_TRAF2_1	767	770	PF00917	0.525
LIG_TRFH_1	216	220	PF08558	0.494
LIG_UBA3_1	397	402	PF00899	0.419
MOD_CDC14_SPxK_1	386	389	PF00782	0.426
MOD_CDK_SPxK_1	383	389	PF00069	0.465
MOD_CDK_SPxxK_3	383	390	PF00069	0.455
MOD_CDK_SPxxK_3	460	467	PF00069	0.483
MOD_CK1_1	172	178	PF00069	0.585
MOD_CK1_1	276	282	PF00069	0.525
MOD_CK1_1	322	328	PF00069	0.558
MOD_CK1_1	333	339	PF00069	0.545
MOD_CK1_1	340	346	PF00069	0.485
MOD_CK1_1	42	48	PF00069	0.679
MOD_CK1_1	6	12	PF00069	0.526
MOD_CK1_1	625	631	PF00069	0.567
MOD_CK1_1	671	677	PF00069	0.653
MOD_CK1_1	78	84	PF00069	0.773
MOD_CK1_1	861	867	PF00069	0.691
MOD_CK2_1	133	139	PF00069	0.445
MOD_CK2_1	191	197	PF00069	0.529
MOD_CK2_1	224	230	PF00069	0.574
MOD_CK2_1	340	346	PF00069	0.642
MOD_CK2_1	453	459	PF00069	0.642
MOD_CK2_1	565	571	PF00069	0.570
MOD_CK2_1	671	677	PF00069	0.642
MOD_CK2_1	695	701	PF00069	0.739
MOD_CK2_1	779	785	PF00069	0.747
MOD_CK2_1	850	856	PF00069	0.534
MOD_CK2_1	861	867	PF00069	0.698
MOD_Cter_Amidation	804	807	PF01082	0.670
MOD_DYRK1A_RPxSP_1	460	464	PF00069	0.506
MOD_GlcNHglycan	135	138	PF01048	0.534
MOD_GlcNHglycan	174	177	PF01048	0.590
MOD_GlcNHglycan	191	194	PF01048	0.642
MOD_GlcNHglycan	291	294	PF01048	0.520
MOD_GlcNHglycan	322	325	PF01048	0.716
MOD_GlcNHglycan	353	356	PF01048	0.668
MOD_GlcNHglycan	392	395	PF01048	0.462
MOD_GlcNHglycan	41	44	PF01048	0.616
MOD_GlcNHglycan	567	570	PF01048	0.609
MOD_GlcNHglycan	588	591	PF01048	0.516
MOD_GlcNHglycan	624	627	PF01048	0.722
MOD_GlcNHglycan	686	689	PF01048	0.751
MOD_GlcNHglycan	695	698	PF01048	0.712
MOD_GSK3_1	116	123	PF00069	0.485
MOD_GSK3_1	148	155	PF00069	0.654
MOD_GSK3_1	174	181	PF00069	0.585
MOD_GSK3_1	185	192	PF00069	0.669
MOD_GSK3_1	197	204	PF00069	0.489
MOD_GSK3_1	242	249	PF00069	0.601
MOD_GSK3_1	260	267	PF00069	0.439
MOD_GSK3_1	272	279	PF00069	0.530
MOD_GSK3_1	333	340	PF00069	0.552
MOD_GSK3_1	35	42	PF00069	0.712
MOD_GSK3_1	449	456	PF00069	0.621
MOD_GSK3_1	485	492	PF00069	0.564
MOD_GSK3_1	596	603	PF00069	0.628
MOD_GSK3_1	622	629	PF00069	0.760
MOD_GSK3_1	63	70	PF00069	0.560
MOD_GSK3_1	691	698	PF00069	0.760
MOD_GSK3_1	76	83	PF00069	0.585
MOD_LATS_1	690	696	PF00433	0.663
MOD_N-GLC_1	320	325	PF02516	0.564
MOD_N-GLC_1	382	387	PF02516	0.486
MOD_N-GLC_1	443	448	PF02516	0.453
MOD_N-GLC_1	660	665	PF02516	0.590
MOD_N-GLC_2	849	851	PF02516	0.581
MOD_NEK2_1	184	189	PF00069	0.539
MOD_NEK2_1	260	265	PF00069	0.488
MOD_NEK2_1	320	325	PF00069	0.641
MOD_NEK2_1	328	333	PF00069	0.594
MOD_NEK2_1	382	387	PF00069	0.549
MOD_NEK2_1	436	441	PF00069	0.559
MOD_NEK2_1	442	447	PF00069	0.400
MOD_NEK2_1	485	490	PF00069	0.537
MOD_NEK2_1	586	591	PF00069	0.498
MOD_NEK2_1	596	601	PF00069	0.493
MOD_NEK2_1	660	665	PF00069	0.590
MOD_NEK2_1	96	101	PF00069	0.522
MOD_NEK2_2	361	366	PF00069	0.503
MOD_PIKK_1	276	282	PF00454	0.497
MOD_PIKK_1	485	491	PF00454	0.526
MOD_PIKK_1	600	606	PF00454	0.468
MOD_PIKK_1	779	785	PF00454	0.643
MOD_PIKK_1	818	824	PF00454	0.591
MOD_PKA_1	790	796	PF00069	0.675
MOD_PKA_2	260	266	PF00069	0.507
MOD_PKA_2	414	420	PF00069	0.461
MOD_PKA_2	691	697	PF00069	0.692
MOD_PKA_2	790	796	PF00069	0.713
MOD_Plk_1	303	309	PF00069	0.543
MOD_Plk_1	443	449	PF00069	0.459
MOD_Plk_1	458	464	PF00069	0.542
MOD_Plk_4	121	127	PF00069	0.452
MOD_Plk_4	169	175	PF00069	0.558
MOD_Plk_4	191	197	PF00069	0.518
MOD_Plk_4	284	290	PF00069	0.593
MOD_Plk_4	437	443	PF00069	0.593
MOD_Plk_4	489	495	PF00069	0.423
MOD_Plk_4	56	62	PF00069	0.469
MOD_Plk_4	588	594	PF00069	0.457
MOD_Plk_4	6	12	PF00069	0.568
MOD_Plk_4	858	864	PF00069	0.577
MOD_ProDKin_1	174	180	PF00069	0.636
MOD_ProDKin_1	185	191	PF00069	0.628
MOD_ProDKin_1	224	230	PF00069	0.610
MOD_ProDKin_1	3	9	PF00069	0.545
MOD_ProDKin_1	333	339	PF00069	0.556
MOD_ProDKin_1	383	389	PF00069	0.465
MOD_ProDKin_1	460	466	PF00069	0.507
MOD_ProDKin_1	661	667	PF00069	0.596
MOD_ProDKin_1	695	701	PF00069	0.668
MOD_ProDKin_1	78	84	PF00069	0.637
MOD_SUMO_for_1	765	768	PF00179	0.618
TRG_DiLeu_BaEn_1	233	238	PF01217	0.448
TRG_DiLeu_BaEn_4	713	719	PF01217	0.527
TRG_DiLeu_BaLyEn_6	138	143	PF01217	0.546
TRG_ENDOCYTIC_2	195	198	PF00928	0.513
TRG_ENDOCYTIC_2	259	262	PF00928	0.502
TRG_ENDOCYTIC_2	549	552	PF00928	0.419
TRG_ENDOCYTIC_2	633	636	PF00928	0.560
TRG_ENDOCYTIC_2	640	643	PF00928	0.592
TRG_ER_diArg_1	140	142	PF00400	0.475
TRG_ER_diArg_1	388	390	PF00400	0.567
TRG_ER_diArg_1	434	436	PF00400	0.519
TRG_ER_diArg_1	455	458	PF00400	0.657
TRG_ER_diArg_1	534	537	PF00400	0.580
TRG_ER_diArg_1	638	640	PF00400	0.587
TRG_ER_diArg_1	706	709	PF00400	0.599
TRG_ER_diArg_1	731	733	PF00400	0.521
TRG_ER_diArg_1	738	741	PF00400	0.567
TRG_ER_diArg_1	789	791	PF00400	0.655
TRG_ER_diArg_1	828	831	PF00400	0.584
TRG_ER_diArg_1	832	835	PF00400	0.580
TRG_NES_CRM1_1	476	489	PF08389	0.453
TRG_NLS_Bipartite_1	709	723	PF00514	0.514
TRG_NLS_Bipartite_1	790	811	PF00514	0.551
TRG_NLS_MonoExtC_3	806	811	PF00514	0.561
TRG_NLS_MonoExtN_4	806	811	PF00514	0.561
TRG_Pf-PMV_PEXEL_1	140	144	PF00026	0.469

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2L9	Leptomonas seymouri	51%	100%
A4H8W2	Leishmania braziliensis	74%	100%
A4HXA9	Leishmania infantum	100%	100%
E9AQY8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4QEH5	Leishmania major	91%	100%