Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IAS3_LEIDO

TriTrypDb:

LdBPK_090560.1 , LdCL_090010700 , LDHU3_09.0690

Length:

415

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IAS3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IAS3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	239	243	PF00656	0.598
CLV_NRD_NRD_1	106	108	PF00675	0.702
CLV_NRD_NRD_1	164	166	PF00675	0.626
CLV_NRD_NRD_1	168	170	PF00675	0.636
CLV_NRD_NRD_1	188	190	PF00675	0.681
CLV_NRD_NRD_1	197	199	PF00675	0.686
CLV_NRD_NRD_1	258	260	PF00675	0.764
CLV_NRD_NRD_1	55	57	PF00675	0.432
CLV_NRD_NRD_1	81	83	PF00675	0.477
CLV_PCSK_KEX2_1	108	110	PF00082	0.786
CLV_PCSK_KEX2_1	164	166	PF00082	0.626
CLV_PCSK_KEX2_1	168	170	PF00082	0.636
CLV_PCSK_KEX2_1	188	190	PF00082	0.681
CLV_PCSK_KEX2_1	257	259	PF00082	0.786
CLV_PCSK_KEX2_1	55	57	PF00082	0.432
CLV_PCSK_KEX2_1	81	83	PF00082	0.507
CLV_PCSK_PC1ET2_1	108	110	PF00082	0.786
CLV_PCSK_PC1ET2_1	257	259	PF00082	0.771
CLV_PCSK_PC7_1	104	110	PF00082	0.776
CLV_PCSK_PC7_1	164	170	PF00082	0.585
CLV_PCSK_SKI1_1	136	140	PF00082	0.401
CLV_PCSK_SKI1_1	307	311	PF00082	0.761
CLV_PCSK_SKI1_1	411	415	PF00082	0.616
CLV_PCSK_SKI1_1	82	86	PF00082	0.413
DEG_SCF_FBW7_1	284	291	PF00400	0.769
DOC_CKS1_1	285	290	PF01111	0.775
DOC_CYCLIN_RxL_1	133	143	PF00134	0.578
DOC_MAPK_gen_1	55	63	PF00069	0.423
DOC_MAPK_gen_1	81	88	PF00069	0.484
DOC_MAPK_MEF2A_6	19	26	PF00069	0.412
DOC_MAPK_MEF2A_6	56	65	PF00069	0.422
DOC_PP1_RVXF_1	134	140	PF00149	0.445
DOC_PP2B_LxvP_1	63	66	PF13499	0.437
DOC_PP4_FxxP_1	32	35	PF00568	0.518
DOC_PP4_FxxP_1	84	87	PF00568	0.464
DOC_USP7_MATH_1	15	19	PF00917	0.526
DOC_USP7_MATH_1	206	210	PF00917	0.740
DOC_USP7_MATH_1	288	292	PF00917	0.780
DOC_USP7_MATH_1	317	321	PF00917	0.611
DOC_USP7_MATH_1	340	344	PF00917	0.578
DOC_USP7_MATH_1	4	8	PF00917	0.502
DOC_USP7_MATH_1	45	49	PF00917	0.488
DOC_WW_Pin1_4	146	151	PF00397	0.490
DOC_WW_Pin1_4	264	269	PF00397	0.794
DOC_WW_Pin1_4	284	289	PF00397	0.754
DOC_WW_Pin1_4	298	303	PF00397	0.615
DOC_WW_Pin1_4	34	39	PF00397	0.557
LIG_14-3-3_CanoR_1	19	23	PF00244	0.328
LIG_14-3-3_CanoR_1	198	203	PF00244	0.777
LIG_14-3-3_CanoR_1	205	213	PF00244	0.685
LIG_14-3-3_CanoR_1	259	269	PF00244	0.758
LIG_14-3-3_CanoR_1	316	325	PF00244	0.507
LIG_14-3-3_CanoR_1	44	50	PF00244	0.485
LIG_BIR_II_1	1	5	PF00653	0.496
LIG_BRCT_BRCA1_1	175	179	PF00533	0.750
LIG_CtBP_PxDLS_1	237	241	PF00389	0.678
LIG_EH_1	176	180	PF12763	0.671
LIG_FHA_1	115	121	PF00498	0.537
LIG_FHA_1	132	138	PF00498	0.529
LIG_FHA_1	151	157	PF00498	0.415
LIG_FHA_1	19	25	PF00498	0.354
LIG_FHA_1	222	228	PF00498	0.623
LIG_FHA_1	353	359	PF00498	0.576
LIG_FHA_2	128	134	PF00498	0.643
LIG_FHA_2	294	300	PF00498	0.754
LIG_FHA_2	401	407	PF00498	0.662
LIG_FHA_2	65	71	PF00498	0.558
LIG_LIR_Apic_2	29	35	PF02991	0.494
LIG_LIR_Apic_2	83	87	PF02991	0.461
LIG_LIR_Gen_1	117	127	PF02991	0.501
LIG_LIR_Gen_1	328	338	PF02991	0.443
LIG_LIR_Nem_3	117	122	PF02991	0.502
LIG_LIR_Nem_3	157	162	PF02991	0.468
LIG_LIR_Nem_3	176	182	PF02991	0.622
LIG_LIR_Nem_3	328	333	PF02991	0.449
LIG_LIR_Nem_3	85	91	PF02991	0.466
LIG_MAD2	280	288	PF02301	0.613
LIG_Pex14_2	84	88	PF04695	0.489
LIG_PTB_Apo_2	74	81	PF02174	0.525
LIG_PTB_Phospho_1	74	80	PF10480	0.521
LIG_REV1ctd_RIR_1	411	415	PF16727	0.670
LIG_SH2_CRK	175	179	PF00017	0.672
LIG_SH2_CRK	330	334	PF00017	0.431
LIG_SH2_GRB2like	175	178	PF00017	0.668
LIG_SH2_GRB2like	90	93	PF00017	0.579
LIG_SH2_NCK_1	175	179	PF00017	0.740
LIG_SH2_NCK_1	330	334	PF00017	0.431
LIG_SH2_STAP1	116	120	PF00017	0.527
LIG_SH2_STAP1	223	227	PF00017	0.602
LIG_SH2_STAP1	330	334	PF00017	0.431
LIG_SH2_STAT5	116	119	PF00017	0.492
LIG_SH2_STAT5	223	226	PF00017	0.621
LIG_SH2_STAT5	352	355	PF00017	0.487
LIG_SH2_STAT5	372	375	PF00017	0.256
LIG_SH2_STAT5	39	42	PF00017	0.509
LIG_SH2_STAT5	46	49	PF00017	0.407
LIG_SH2_STAT5	90	93	PF00017	0.475
LIG_SH3_3	231	237	PF00018	0.648
LIG_SH3_3	265	271	PF00018	0.723
LIG_SH3_3	32	38	PF00018	0.483
LIG_SH3_3	359	365	PF00018	0.520
LIG_SUMO_SIM_anti_2	379	385	PF11976	0.568
LIG_SUMO_SIM_par_1	152	157	PF11976	0.437
LIG_SUMO_SIM_par_1	2	10	PF11976	0.571
LIG_SUMO_SIM_par_1	331	337	PF11976	0.479
LIG_TRAF2_1	229	232	PF00917	0.632
LIG_TRAF2_1	403	406	PF00917	0.629
LIG_TYR_ITSM	115	122	PF00017	0.539
MOD_CK1_1	18	24	PF00069	0.426
MOD_CK1_1	253	259	PF00069	0.725
MOD_CK1_1	263	269	PF00069	0.759
MOD_CK1_1	293	299	PF00069	0.721
MOD_CK1_1	345	351	PF00069	0.546
MOD_CK1_1	7	13	PF00069	0.428
MOD_CK2_1	340	346	PF00069	0.538
MOD_CK2_1	400	406	PF00069	0.622
MOD_CK2_1	64	70	PF00069	0.544
MOD_GlcNHglycan	101	104	PF01048	0.717
MOD_GlcNHglycan	2	5	PF01048	0.522
MOD_GlcNHglycan	208	211	PF01048	0.734
MOD_GlcNHglycan	262	265	PF01048	0.807
MOD_GlcNHglycan	292	295	PF01048	0.693
MOD_GlcNHglycan	341	345	PF01048	0.589
MOD_GSK3_1	127	134	PF00069	0.567
MOD_GSK3_1	146	153	PF00069	0.453
MOD_GSK3_1	253	260	PF00069	0.685
MOD_GSK3_1	284	291	PF00069	0.742
MOD_GSK3_1	340	347	PF00069	0.600
MOD_GSK3_1	400	407	PF00069	0.636
MOD_GSK3_1	45	52	PF00069	0.524
MOD_N-GLC_1	114	119	PF02516	0.561
MOD_N-GLC_1	127	132	PF02516	0.570
MOD_NEK2_1	26	31	PF00069	0.388
MOD_NEK2_1	50	55	PF00069	0.409
MOD_PIKK_1	257	263	PF00454	0.822
MOD_PKA_1	198	204	PF00069	0.696
MOD_PKA_1	257	263	PF00069	0.739
MOD_PKA_2	18	24	PF00069	0.333
MOD_PKA_2	197	203	PF00069	0.762
MOD_PKA_2	257	263	PF00069	0.754
MOD_PKA_2	315	321	PF00069	0.540
MOD_PKB_1	196	204	PF00069	0.689
MOD_Plk_1	132	138	PF00069	0.581
MOD_Plk_1	250	256	PF00069	0.567
MOD_Plk_1	328	334	PF00069	0.448
MOD_Plk_1	345	351	PF00069	0.288
MOD_Plk_1	82	88	PF00069	0.391
MOD_Plk_4	150	156	PF00069	0.418
MOD_Plk_4	328	334	PF00069	0.448
MOD_Plk_4	45	51	PF00069	0.463
MOD_ProDKin_1	146	152	PF00069	0.482
MOD_ProDKin_1	264	270	PF00069	0.796
MOD_ProDKin_1	284	290	PF00069	0.751
MOD_ProDKin_1	298	304	PF00069	0.619
MOD_ProDKin_1	34	40	PF00069	0.554
MOD_SUMO_for_1	353	356	PF00179	0.544
MOD_SUMO_rev_2	405	413	PF00179	0.735
TRG_DiLeu_BaEn_1	328	333	PF01217	0.451
TRG_DiLeu_BaLyEn_6	354	359	PF01217	0.537
TRG_ENDOCYTIC_2	119	122	PF00928	0.529
TRG_ENDOCYTIC_2	159	162	PF00928	0.513
TRG_ENDOCYTIC_2	223	226	PF00928	0.621
TRG_ENDOCYTIC_2	330	333	PF00928	0.424
TRG_ER_diArg_1	168	170	PF00400	0.592
TRG_ER_diArg_1	188	190	PF00400	0.668
TRG_ER_diArg_1	202	205	PF00400	0.744
TRG_ER_diArg_1	278	281	PF00400	0.776
TRG_ER_diArg_1	54	56	PF00400	0.430
TRG_ER_diArg_1	80	82	PF00400	0.537
TRG_NLS_MonoExtN_4	104	111	PF00514	0.733
TRG_Pf-PMV_PEXEL_1	136	141	PF00026	0.429
TRG_Pf-PMV_PEXEL_1	168	172	PF00026	0.710

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB46	Leptomonas seymouri	62%	100%
A0A1X0NNC7	Trypanosomatidae	32%	100%
A4H5M8	Leishmania braziliensis	78%	96%
A4HTW5	Leishmania infantum	97%	97%
E9AMQ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	94%
Q4QHX3	Leishmania major	93%	100%