Ribonucleotide reductase, small chain family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ribonucleoside-diphosphate reductase small chain, putative (fragment)

Species:

Leishmania donovani

UniProt:

A0A3Q8IAS1_LEIDO

TriTrypDb:

LdBPK_221112.1 , LdCL_220018500 , LDHU3_22.1640

Length:

392

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 35

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 17
NetGPI	no	yes: 0, no: 17

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

A0A3Q8IAS1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IAS1

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	18
GO:0006725	cellular aromatic compound metabolic process	3	18
GO:0006753	nucleoside phosphate metabolic process	4	18
GO:0006793	phosphorus metabolic process	3	18
GO:0006796	phosphate-containing compound metabolic process	4	18
GO:0006807	nitrogen compound metabolic process	2	18
GO:0008152	metabolic process	1	18
GO:0009058	biosynthetic process	2	18
GO:0009117	nucleotide metabolic process	5	18
GO:0009165	nucleotide biosynthetic process	6	18
GO:0009262	deoxyribonucleotide metabolic process	4	18
GO:0009263	deoxyribonucleotide biosynthetic process	5	18
GO:0009987	cellular process	1	18
GO:0018130	heterocycle biosynthetic process	4	18
GO:0019438	aromatic compound biosynthetic process	4	18
GO:0019637	organophosphate metabolic process	3	18
GO:0034641	cellular nitrogen compound metabolic process	3	18
GO:0034654	nucleobase-containing compound biosynthetic process	4	18
GO:0044237	cellular metabolic process	2	18
GO:0044238	primary metabolic process	2	18
GO:0044249	cellular biosynthetic process	3	18
GO:0044271	cellular nitrogen compound biosynthetic process	4	18
GO:0044281	small molecule metabolic process	2	18
GO:0046483	heterocycle metabolic process	3	18
GO:0055086	nucleobase-containing small molecule metabolic process	3	18
GO:0071704	organic substance metabolic process	2	18
GO:0090407	organophosphate biosynthetic process	4	18
GO:1901135	carbohydrate derivative metabolic process	3	18
GO:1901137	carbohydrate derivative biosynthetic process	4	18
GO:1901293	nucleoside phosphate biosynthetic process	5	18
GO:1901360	organic cyclic compound metabolic process	3	18
GO:1901362	organic cyclic compound biosynthetic process	4	18
GO:1901576	organic substance biosynthetic process	3	18

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	18
GO:0004748	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	6	11
GO:0016491	oxidoreductase activity	2	18
GO:0016725	oxidoreductase activity, acting on CH or CH2 groups	3	11
GO:0016728	oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor	4	11
GO:0061731	ribonucleoside-diphosphate reductase activity	5	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	120	124	PF00656	0.434
CLV_C14_Caspase3-7	6	10	PF00656	0.602
CLV_NRD_NRD_1	93	95	PF00675	0.343
CLV_PCSK_KEX2_1	16	18	PF00082	0.569
CLV_PCSK_KEX2_1	249	251	PF00082	0.437
CLV_PCSK_PC1ET2_1	16	18	PF00082	0.569
CLV_PCSK_PC1ET2_1	249	251	PF00082	0.437
CLV_PCSK_SKI1_1	130	134	PF00082	0.255
CLV_PCSK_SKI1_1	62	66	PF00082	0.522
CLV_PCSK_SKI1_1	81	85	PF00082	0.302
DEG_APCC_DBOX_1	80	88	PF00400	0.512
DEG_COP1_1	153	160	PF00400	0.472
DEG_COP1_1	31	40	PF00400	0.575
DOC_MAPK_gen_1	285	294	PF00069	0.248
DOC_MAPK_MEF2A_6	249	258	PF00069	0.237
DOC_MAPK_MEF2A_6	288	296	PF00069	0.343
DOC_PP1_RVXF_1	223	230	PF00149	0.437
DOC_PP1_RVXF_1	79	86	PF00149	0.437
DOC_USP7_MATH_1	28	32	PF00917	0.759
LIG_14-3-3_CanoR_1	150	158	PF00244	0.472
LIG_14-3-3_CanoR_1	332	338	PF00244	0.272
LIG_14-3-3_CanoR_1	344	348	PF00244	0.272
LIG_BIR_II_1	1	5	PF00653	0.754
LIG_BIR_III_2	308	312	PF00653	0.247
LIG_BRCT_BRCA1_1	218	222	PF00533	0.543
LIG_BRCT_BRCA1_1	237	241	PF00533	0.278
LIG_BRCT_BRCA1_1	382	386	PF00533	0.477
LIG_BRCT_BRCA1_1	388	392	PF00533	0.472
LIG_deltaCOP1_diTrp_1	210	215	PF00928	0.453
LIG_FHA_1	175	181	PF00498	0.443
LIG_FHA_1	53	59	PF00498	0.742
LIG_FHA_2	103	109	PF00498	0.442
LIG_FHA_2	118	124	PF00498	0.451
LIG_FHA_2	185	191	PF00498	0.490
LIG_FHA_2	4	10	PF00498	0.595
LIG_FHA_2	40	46	PF00498	0.617
LIG_FHA_2	65	71	PF00498	0.653
LIG_GBD_Chelix_1	329	337	PF00786	0.438
LIG_LIR_Gen_1	117	125	PF02991	0.439
LIG_LIR_Gen_1	175	186	PF02991	0.441
LIG_LIR_Gen_1	238	247	PF02991	0.278
LIG_LIR_Gen_1	271	278	PF02991	0.255
LIG_LIR_Gen_1	346	357	PF02991	0.325
LIG_LIR_Nem_3	117	121	PF02991	0.460
LIG_LIR_Nem_3	175	181	PF02991	0.439
LIG_LIR_Nem_3	238	244	PF02991	0.278
LIG_LIR_Nem_3	271	276	PF02991	0.255
LIG_LIR_Nem_3	91	96	PF02991	0.437
LIG_PDZ_Class_3	387	392	PF00595	0.525
LIG_Pex14_2	237	241	PF04695	0.278
LIG_REV1ctd_RIR_1	361	371	PF16727	0.383
LIG_SH2_CRK	178	182	PF00017	0.442
LIG_SH2_STAP1	178	182	PF00017	0.437
LIG_SH2_STAT3	164	167	PF00017	0.437
LIG_SH2_STAT3	96	99	PF00017	0.543
LIG_SH2_STAT5	185	188	PF00017	0.439
LIG_SH2_STAT5	325	328	PF00017	0.254
LIG_SH2_STAT5	82	85	PF00017	0.437
LIG_SH3_3	152	158	PF00018	0.442
LIG_SH3_3	24	30	PF00018	0.641
LIG_SH3_3	44	50	PF00018	0.776
LIG_SH3_3	80	86	PF00018	0.471
LIG_SUMO_SIM_par_1	333	340	PF11976	0.310
LIG_TRAF2_1	105	108	PF00917	0.447
LIG_TRAF2_1	221	224	PF00917	0.543
LIG_TRAF2_1	69	72	PF00917	0.651
LIG_TRAF2_2	86	91	PF00917	0.507
LIG_TRFH_1	82	86	PF08558	0.512
LIG_TYR_ITIM	87	92	PF00017	0.437
LIG_UBA3_1	244	249	PF00899	0.278
LIG_UBA3_1	333	341	PF00899	0.343
LIG_UBA3_1	354	360	PF00899	0.357
MOD_CK1_1	218	224	PF00069	0.441
MOD_CK1_1	39	45	PF00069	0.630
MOD_CK2_1	102	108	PF00069	0.442
MOD_CK2_1	184	190	PF00069	0.490
MOD_CK2_1	218	224	PF00069	0.490
MOD_CK2_1	261	267	PF00069	0.237
MOD_CK2_1	333	339	PF00069	0.336
MOD_CK2_1	38	44	PF00069	0.601
MOD_CK2_1	384	390	PF00069	0.530
MOD_CK2_1	64	70	PF00069	0.672
MOD_GlcNHglycan	1	4	PF01048	0.413
MOD_GlcNHglycan	218	221	PF01048	0.345
MOD_GlcNHglycan	237	240	PF01048	0.283
MOD_GlcNHglycan	30	33	PF01048	0.496
MOD_GSK3_1	172	179	PF00069	0.441
MOD_GSK3_1	375	382	PF00069	0.418
MOD_GSK3_1	52	59	PF00069	0.582
MOD_GSK3_1	98	105	PF00069	0.437
MOD_NEK2_1	181	186	PF00069	0.446
MOD_NEK2_1	237	242	PF00069	0.278
MOD_NEK2_1	277	282	PF00069	0.343
MOD_NEK2_1	333	338	PF00069	0.256
MOD_PIKK_1	343	349	PF00454	0.343
MOD_PKA_1	384	390	PF00069	0.530
MOD_PKA_2	28	34	PF00069	0.666
MOD_PKA_2	343	349	PF00069	0.215
MOD_Plk_2-3	117	123	PF00069	0.524
MOD_Plk_4	176	182	PF00069	0.442
MOD_SUMO_rev_2	153	158	PF00179	0.507
MOD_SUMO_rev_2	188	193	PF00179	0.544
TRG_DiLeu_BaEn_1	191	196	PF01217	0.458
TRG_DiLeu_BaLyEn_6	222	227	PF01217	0.543
TRG_DiLeu_BaLyEn_6	310	315	PF01217	0.246
TRG_DiLeu_BaLyEn_6	329	334	PF01217	0.175
TRG_DiLeu_LyEn_5	191	196	PF01217	0.458
TRG_ENDOCYTIC_2	178	181	PF00928	0.442
TRG_ENDOCYTIC_2	325	328	PF00928	0.254
TRG_ENDOCYTIC_2	82	85	PF00928	0.437
TRG_ENDOCYTIC_2	89	92	PF00928	0.437
TRG_NES_CRM1_1	145	159	PF08389	0.437
TRG_NES_CRM1_1	324	339	PF08389	0.307
TRG_NLS_MonoExtC_3	15	21	PF00514	0.735
TRG_NLS_MonoExtN_4	14	20	PF00514	0.640

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8G9	Leptomonas seymouri	86%	100%
A0A0S4JI02	Bodo saltans	67%	97%
A0A1X0NN82	Trypanosomatidae	81%	100%
A0A3R7N6N4	Trypanosoma rangeli	75%	100%
A0A3S7X0X6	Leishmania donovani	94%	100%
A4HCG7	Leishmania braziliensis	93%	100%
A4HFY2	Leishmania braziliensis	92%	100%
A4I2X5	Leishmania infantum	94%	100%
D0A9F7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	77%	100%
D0A9F8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	80%	100%
D0A9F9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	79%	100%
E9ADI5	Leishmania major	94%	100%
E9AGZ9	Leishmania infantum	100%	100%
E9AVW1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
E9AZB1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
F5HAW0	Human herpesvirus 8 type P (isolate GK18)	30%	100%
O15910	Trypanosoma brucei brucei	77%	100%
O30601	Bacillus subtilis (strain 168)	25%	100%
O36410	Alcelaphine herpesvirus 1 (strain C500)	29%	100%
O46310	Leishmania amazonensis	98%	100%
O57175	Vaccinia virus (strain Ankara)	65%	100%
O64174	Bacillus phage SPbeta	25%	100%
O83092	Treponema pallidum (strain Nichols)	25%	100%
O84835	Chlamydia trachomatis (strain D/UW-3/Cx)	29%	100%
P06474	Human herpesvirus 1 (strain KOS)	30%	100%
P07201	Spisula solidissima	63%	100%
P09247	Varicella-zoster virus (strain Dumas)	30%	100%
P09938	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	61%	98%
P0C701	Epstein-Barr virus (strain GD1)	32%	100%
P0C8I0	African swine fever virus (isolate Pig/Kenya/KEN-50/1950)	39%	100%
P0C8I1	African swine fever virus (isolate Tick/South Africa/Pretoriuskop Pr4/1996)	39%	100%
P0C8I2	African swine fever virus (isolate Warthog/Namibia/Wart80/1980)	39%	100%
P0CAP6	Epstein-Barr virus (strain B95-8)	32%	100%
P0CAP7	Epstein-Barr virus (strain AG876)	32%	100%
P0DKH3	Arabidopsis thaliana	65%	100%
P0DSS7	Variola virus (isolate Human/India/Ind3/1967)	64%	100%
P0DSS8	Variola virus	65%	100%
P10224	Human herpesvirus 1 (strain 17)	30%	100%
P11157	Mus musculus	63%	100%
P11158	Vaccinia virus (strain Western Reserve)	65%	100%
P20493	Vaccinia virus (strain Copenhagen)	64%	100%
P26713	African swine fever virus (isolate Tick/Malawi/Lil 20-1/1983)	39%	100%
P28847	Equine herpesvirus 1 (strain Ab4p)	28%	100%
P29883	Vaccinia virus (strain L-IVP)	64%	100%
P31350	Homo sapiens	59%	100%
P32209	Swinepox virus (strain Kasza)	63%	100%
P36603	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	62%	100%
P42170	Caenorhabditis elegans	55%	100%
P42492	African swine fever virus (strain Badajoz 1971 Vero-adapted)	39%	100%
P42521	Dictyostelium discoideum	64%	100%
P48592	Drosophila melanogaster	58%	100%
P49723	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	44%	100%
P49730	Nicotiana tabacum	66%	100%
P50644	Equine herpesvirus 4 (strain 1942)	28%	100%
P50645	Suid herpesvirus 1 (strain Kaplan)	30%	100%
P50649	Plasmodium falciparum (isolate FCR-3 / Gambia)	58%	100%
P50650	Plasmodium falciparum (isolate Dd2)	55%	100%
P50651	Arabidopsis thaliana	65%	100%
P55983	Helicobacter pylori (strain ATCC 700392 / 26695)	24%	100%
P69520	Human herpesvirus 2 (strain 333)	29%	100%
P69521	Human herpesvirus 2 (strain HG52)	29%	100%
P69924	Escherichia coli (strain K12)	24%	100%
P69925	Escherichia coli O157:H7	24%	100%
P79733	Danio rerio	62%	100%
Q01038	Saimiriine herpesvirus 2 (strain 11)	29%	100%
Q01319	Bovine herpesvirus 1.1 (strain Cooper)	28%	100%
Q4JQV7	Varicella-zoster virus (strain Oka vaccine)	30%	100%
Q4KLN6	Rattus norvegicus	60%	100%
Q4QBL8	Leishmania major	96%	100%
Q4R741	Macaca fascicularis	59%	100%
Q4R7Q7	Macaca fascicularis	58%	100%
Q5R9G0	Pongo abelii	59%	100%
Q60561	Mesocricetus auratus	58%	100%
Q66662	Equine herpesvirus 2 (strain 86/87)	29%	100%
Q6PEE3	Mus musculus	59%	100%
Q6R7K3	Ostreid herpesvirus 1 (isolate France)	29%	68%
Q6UDJ1	Psittacid herpesvirus 1 (isolate Amazon parrot/-/97-0001/1997)	31%	100%
Q77MS0	Gallid herpesvirus 2 (strain Chicken/Md5/ATCC VR-987)	30%	100%
Q7LG56	Homo sapiens	59%	100%
Q7T6Y9	Acanthamoeba polyphaga mimivirus	45%	94%
Q8SRR2	Encephalitozoon cuniculi (strain GB-M1)	60%	100%
Q91FE8	Invertebrate iridescent virus 6	23%	100%
Q9C167	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	68%	96%
Q9DHU2	Yaba-like disease virus	61%	100%
Q9KFH7	Halalkalibacterium halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)	22%	100%
Q9LSD0	Arabidopsis thaliana	67%	100%
Q9PL92	Chlamydia muridarum (strain MoPn / Nigg)	28%	100%
Q9QTF2	Red sea bream iridovirus	50%	100%
Q9Z6S4	Chlamydia pneumoniae	28%	100%
Q9ZKC3	Helicobacter pylori (strain J99 / ATCC 700824)	25%	100%
V5ASN2	Trypanosoma cruzi	78%	100%