LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Serine/threonine-protein kinase PLK

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Serine/threonine-protein kinase PLK
Gene product:
protein kinase, putative (fragment)
Species:
Leishmania donovani
UniProt:
A0A3Q8IAR8_LEIDO
TriTrypDb:
LdBPK_170770.1 * , LdCL_170013700 , LDHU3_17.1150
Length:
701

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. None of them appear to be TM.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0000922 spindle pole 2 1
GO:0005634 nucleus 5 1
GO:0005737 cytoplasm 2 1
GO:0005813 centrosome 3 1
GO:0005815 microtubule organizing center 2 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A0A3Q8IAR8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IAR8

Function

Biological processes
Term Name Level Count
GO:0006468 protein phosphorylation 5 11
GO:0006793 phosphorus metabolic process 3 11
GO:0006796 phosphate-containing compound metabolic process 4 11
GO:0006807 nitrogen compound metabolic process 2 11
GO:0008152 metabolic process 1 11
GO:0009987 cellular process 1 11
GO:0016310 phosphorylation 5 11
GO:0019538 protein metabolic process 3 11
GO:0036211 protein modification process 4 11
GO:0043170 macromolecule metabolic process 3 11
GO:0043412 macromolecule modification 4 11
GO:0044237 cellular metabolic process 2 11
GO:0044238 primary metabolic process 2 11
GO:0071704 organic substance metabolic process 2 11
GO:1901564 organonitrogen compound metabolic process 3 11
GO:0000278 mitotic cell cycle 3 1
GO:0007049 cell cycle 2 1
GO:0010564 regulation of cell cycle process 5 1
GO:0032465 regulation of cytokinesis 5 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0051302 regulation of cell division 4 1
GO:0051726 regulation of cell cycle 4 1
GO:0065007 biological regulation 1 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 11
GO:0003824 catalytic activity 1 11
GO:0004672 protein kinase activity 3 11
GO:0004674 protein serine/threonine kinase activity 4 10
GO:0005488 binding 1 11
GO:0005524 ATP binding 5 11
GO:0016301 kinase activity 4 11
GO:0016740 transferase activity 2 11
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 11
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 11
GO:0017076 purine nucleotide binding 4 11
GO:0030554 adenyl nucleotide binding 5 11
GO:0032553 ribonucleotide binding 3 11
GO:0032555 purine ribonucleotide binding 4 11
GO:0032559 adenyl ribonucleotide binding 5 11
GO:0035639 purine ribonucleoside triphosphate binding 4 11
GO:0036094 small molecule binding 2 11
GO:0043167 ion binding 2 11
GO:0043168 anion binding 3 11
GO:0097159 organic cyclic compound binding 2 11
GO:0097367 carbohydrate derivative binding 2 11
GO:0140096 catalytic activity, acting on a protein 2 11
GO:1901265 nucleoside phosphate binding 3 11
GO:1901363 heterocyclic compound binding 2 11

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 14 18 PF00656 0.428
CLV_C14_Caspase3-7 267 271 PF00656 0.329
CLV_C14_Caspase3-7 477 481 PF00656 0.538
CLV_NRD_NRD_1 138 140 PF00675 0.316
CLV_NRD_NRD_1 198 200 PF00675 0.237
CLV_NRD_NRD_1 345 347 PF00675 0.679
CLV_NRD_NRD_1 666 668 PF00675 0.285
CLV_NRD_NRD_1 99 101 PF00675 0.327
CLV_PCSK_KEX2_1 138 140 PF00082 0.319
CLV_PCSK_KEX2_1 200 202 PF00082 0.237
CLV_PCSK_KEX2_1 255 257 PF00082 0.254
CLV_PCSK_KEX2_1 345 347 PF00082 0.649
CLV_PCSK_KEX2_1 620 622 PF00082 0.306
CLV_PCSK_KEX2_1 665 667 PF00082 0.287
CLV_PCSK_KEX2_1 99 101 PF00082 0.254
CLV_PCSK_PC1ET2_1 200 202 PF00082 0.237
CLV_PCSK_PC1ET2_1 255 257 PF00082 0.370
CLV_PCSK_PC1ET2_1 620 622 PF00082 0.306
CLV_PCSK_SKI1_1 167 171 PF00082 0.237
CLV_PCSK_SKI1_1 362 366 PF00082 0.630
CLV_PCSK_SKI1_1 371 375 PF00082 0.537
CLV_PCSK_SKI1_1 555 559 PF00082 0.240
CLV_PCSK_SKI1_1 569 573 PF00082 0.175
CLV_PCSK_SKI1_1 575 579 PF00082 0.258
CLV_PCSK_SKI1_1 655 659 PF00082 0.203
CLV_PCSK_SKI1_1 689 693 PF00082 0.368
CLV_PCSK_SKI1_1 99 103 PF00082 0.314
CLV_Separin_Metazoa 372 376 PF03568 0.611
DEG_APCC_DBOX_1 286 294 PF00400 0.254
DEG_APCC_DBOX_1 370 378 PF00400 0.586
DEG_Nend_UBRbox_2 1 3 PF02207 0.683
DEG_SCF_FBW7_1 305 312 PF00400 0.496
DEG_SCF_FBW7_1 403 408 PF00400 0.541
DEG_SPOP_SBC_1 19 23 PF00917 0.532
DEG_SPOP_SBC_1 610 614 PF00917 0.513
DOC_CKS1_1 306 311 PF01111 0.538
DOC_CKS1_1 402 407 PF01111 0.542
DOC_CKS1_1 659 664 PF01111 0.428
DOC_CYCLIN_yCln2_LP_2 307 313 PF00134 0.556
DOC_MAPK_gen_1 114 123 PF00069 0.254
DOC_MAPK_gen_1 167 176 PF00069 0.337
DOC_MAPK_gen_1 620 631 PF00069 0.440
DOC_MAPK_gen_1 665 671 PF00069 0.499
DOC_MAPK_gen_1 99 109 PF00069 0.285
DOC_MAPK_MEF2A_6 345 352 PF00069 0.563
DOC_PP1_RVXF_1 518 524 PF00149 0.499
DOC_PP2B_LxvP_1 307 310 PF13499 0.462
DOC_PP2B_LxvP_1 318 321 PF13499 0.546
DOC_PP2B_LxvP_1 365 368 PF13499 0.571
DOC_PP4_FxxP_1 316 319 PF00568 0.661
DOC_SPAK_OSR1_1 139 143 PF12202 0.254
DOC_USP7_MATH_1 20 24 PF00917 0.651
DOC_USP7_MATH_1 32 36 PF00917 0.440
DOC_USP7_MATH_1 330 334 PF00917 0.584
DOC_USP7_MATH_1 610 614 PF00917 0.597
DOC_USP7_MATH_1 670 674 PF00917 0.390
DOC_USP7_UBL2_3 86 90 PF12436 0.279
DOC_WW_Pin1_4 203 208 PF00397 0.237
DOC_WW_Pin1_4 280 285 PF00397 0.393
DOC_WW_Pin1_4 299 304 PF00397 0.359
DOC_WW_Pin1_4 305 310 PF00397 0.415
DOC_WW_Pin1_4 387 392 PF00397 0.674
DOC_WW_Pin1_4 401 406 PF00397 0.608
DOC_WW_Pin1_4 417 422 PF00397 0.614
DOC_WW_Pin1_4 437 442 PF00397 0.662
DOC_WW_Pin1_4 584 589 PF00397 0.550
DOC_WW_Pin1_4 594 599 PF00397 0.355
DOC_WW_Pin1_4 658 663 PF00397 0.499
LIG_14-3-3_CanoR_1 138 143 PF00244 0.279
LIG_14-3-3_CanoR_1 294 299 PF00244 0.314
LIG_14-3-3_CanoR_1 435 441 PF00244 0.666
LIG_14-3-3_CanoR_1 464 470 PF00244 0.541
LIG_14-3-3_CanoR_1 555 561 PF00244 0.530
LIG_14-3-3_CanoR_1 583 588 PF00244 0.538
LIG_14-3-3_CanoR_1 606 610 PF00244 0.609
LIG_14-3-3_CanoR_1 655 660 PF00244 0.403
LIG_14-3-3_CanoR_1 665 670 PF00244 0.403
LIG_14-3-3_CanoR_1 686 692 PF00244 0.400
LIG_14-3-3_CanoR_1 79 83 PF00244 0.314
LIG_BRCT_BRCA1_1 612 616 PF00533 0.612
LIG_eIF4E_1 117 123 PF01652 0.370
LIG_EVH1_2 309 313 PF00568 0.547
LIG_FHA_1 143 149 PF00498 0.254
LIG_FHA_1 20 26 PF00498 0.563
LIG_FHA_1 226 232 PF00498 0.273
LIG_FHA_1 235 241 PF00498 0.201
LIG_FHA_1 275 281 PF00498 0.370
LIG_FHA_1 425 431 PF00498 0.761
LIG_FHA_1 517 523 PF00498 0.403
LIG_FHA_1 525 531 PF00498 0.403
LIG_FHA_1 635 641 PF00498 0.416
LIG_FHA_1 666 672 PF00498 0.436
LIG_FHA_1 686 692 PF00498 0.230
LIG_FHA_1 69 75 PF00498 0.333
LIG_FHA_2 110 116 PF00498 0.254
LIG_FHA_2 12 18 PF00498 0.465
LIG_FHA_2 128 134 PF00498 0.254
LIG_FHA_2 287 293 PF00498 0.237
LIG_FHA_2 610 616 PF00498 0.554
LIG_FHA_2 674 680 PF00498 0.566
LIG_LIR_Apic_2 206 212 PF02991 0.237
LIG_LIR_Apic_2 315 319 PF02991 0.715
LIG_LIR_Apic_2 658 662 PF02991 0.425
LIG_LIR_Gen_1 115 123 PF02991 0.314
LIG_LIR_Gen_1 144 155 PF02991 0.279
LIG_LIR_Gen_1 312 321 PF02991 0.610
LIG_LIR_Gen_1 531 541 PF02991 0.383
LIG_LIR_Gen_1 613 623 PF02991 0.499
LIG_LIR_Gen_1 690 701 PF02991 0.433
LIG_LIR_Nem_3 115 120 PF02991 0.254
LIG_LIR_Nem_3 144 150 PF02991 0.279
LIG_LIR_Nem_3 251 257 PF02991 0.249
LIG_LIR_Nem_3 312 316 PF02991 0.597
LIG_LIR_Nem_3 531 536 PF02991 0.383
LIG_LIR_Nem_3 574 580 PF02991 0.471
LIG_LIR_Nem_3 613 619 PF02991 0.505
LIG_LIR_Nem_3 651 657 PF02991 0.499
LIG_LIR_Nem_3 690 696 PF02991 0.409
LIG_MYND_1 305 309 PF01753 0.455
LIG_NRBOX 130 136 PF00104 0.370
LIG_NRBOX 234 240 PF00104 0.237
LIG_Pex14_2 109 113 PF04695 0.254
LIG_SH2_CRK 236 240 PF00017 0.252
LIG_SH2_CRK 254 258 PF00017 0.173
LIG_SH2_CRK 262 266 PF00017 0.237
LIG_SH2_CRK 533 537 PF00017 0.383
LIG_SH2_CRK 659 663 PF00017 0.428
LIG_SH2_CRK 693 697 PF00017 0.492
LIG_SH2_NCK_1 659 663 PF00017 0.425
LIG_SH2_PTP2 147 150 PF00017 0.314
LIG_SH2_PTP2 209 212 PF00017 0.237
LIG_SH2_STAP1 236 240 PF00017 0.292
LIG_SH2_STAP1 72 76 PF00017 0.279
LIG_SH2_STAT5 118 121 PF00017 0.339
LIG_SH2_STAT5 147 150 PF00017 0.314
LIG_SH2_STAT5 209 212 PF00017 0.237
LIG_SH2_STAT5 236 239 PF00017 0.280
LIG_SH2_STAT5 576 579 PF00017 0.324
LIG_SH2_STAT5 580 583 PF00017 0.341
LIG_SH2_STAT5 618 621 PF00017 0.294
LIG_SH2_STAT5 659 662 PF00017 0.403
LIG_SH3_2 601 606 PF14604 0.586
LIG_SH3_3 237 243 PF00018 0.237
LIG_SH3_3 300 306 PF00018 0.424
LIG_SH3_3 353 359 PF00018 0.685
LIG_SH3_3 370 376 PF00018 0.597
LIG_SH3_3 378 384 PF00018 0.570
LIG_SH3_3 385 391 PF00018 0.536
LIG_SH3_3 404 410 PF00018 0.706
LIG_SH3_3 481 487 PF00018 0.541
LIG_SH3_3 519 525 PF00018 0.416
LIG_SH3_3 595 601 PF00018 0.507
LIG_SH3_4 27 34 PF00018 0.506
LIG_SH3_CIN85_PxpxPR_1 601 606 PF14604 0.511
LIG_TRAF2_2 244 249 PF00917 0.237
LIG_TYR_ITIM 234 239 PF00017 0.254
LIG_TYR_ITIM 691 696 PF00017 0.478
LIG_UBA3_1 131 136 PF00899 0.279
LIG_WRC_WIRS_1 110 115 PF05994 0.254
LIG_WRC_WIRS_1 313 318 PF05994 0.627
LIG_WW_3 603 607 PF00397 0.518
MOD_CDC14_SPxK_1 587 590 PF00782 0.485
MOD_CDK_SPK_2 387 392 PF00069 0.714
MOD_CDK_SPK_2 417 422 PF00069 0.619
MOD_CDK_SPxK_1 584 590 PF00069 0.562
MOD_CDK_SPxxK_3 280 287 PF00069 0.370
MOD_CDK_SPxxK_3 658 665 PF00069 0.428
MOD_CK1_1 297 303 PF00069 0.601
MOD_CK1_1 312 318 PF00069 0.622
MOD_CK1_1 559 565 PF00069 0.543
MOD_CK1_1 634 640 PF00069 0.414
MOD_CK1_1 66 72 PF00069 0.370
MOD_CK1_1 673 679 PF00069 0.434
MOD_CK1_1 93 99 PF00069 0.314
MOD_CK2_1 138 144 PF00069 0.329
MOD_CK2_1 18 24 PF00069 0.611
MOD_CK2_1 32 38 PF00069 0.301
MOD_CK2_1 673 679 PF00069 0.607
MOD_Cter_Amidation 663 666 PF01082 0.299
MOD_DYRK1A_RPxSP_1 417 421 PF00069 0.614
MOD_GlcNHglycan 153 156 PF01048 0.295
MOD_GlcNHglycan 332 335 PF01048 0.708
MOD_GlcNHglycan 342 345 PF01048 0.585
MOD_GlcNHglycan 40 44 PF01048 0.523
MOD_GlcNHglycan 422 425 PF01048 0.694
MOD_GlcNHglycan 432 435 PF01048 0.589
MOD_GlcNHglycan 662 665 PF01048 0.259
MOD_GSK3_1 138 145 PF00069 0.266
MOD_GSK3_1 199 206 PF00069 0.237
MOD_GSK3_1 216 223 PF00069 0.370
MOD_GSK3_1 294 301 PF00069 0.328
MOD_GSK3_1 305 312 PF00069 0.405
MOD_GSK3_1 326 333 PF00069 0.641
MOD_GSK3_1 336 343 PF00069 0.533
MOD_GSK3_1 401 408 PF00069 0.661
MOD_GSK3_1 420 427 PF00069 0.684
MOD_GSK3_1 504 511 PF00069 0.499
MOD_GSK3_1 605 612 PF00069 0.590
MOD_N-GLC_1 515 520 PF02516 0.209
MOD_N-GLC_1 634 639 PF02516 0.216
MOD_NEK2_1 109 114 PF00069 0.254
MOD_NEK2_1 298 303 PF00069 0.568
MOD_NEK2_1 39 44 PF00069 0.554
MOD_NEK2_1 465 470 PF00069 0.387
MOD_NEK2_1 515 520 PF00069 0.409
MOD_NEK2_1 631 636 PF00069 0.403
MOD_NEK2_1 685 690 PF00069 0.455
MOD_NEK2_2 32 37 PF00069 0.486
MOD_PIKK_1 142 148 PF00454 0.264
MOD_PIKK_1 274 280 PF00454 0.386
MOD_PIKK_1 488 494 PF00454 0.457
MOD_PK_1 138 144 PF00069 0.225
MOD_PKA_1 138 144 PF00069 0.370
MOD_PKA_1 199 205 PF00069 0.237
MOD_PKA_1 569 575 PF00069 0.466
MOD_PKA_1 665 671 PF00069 0.499
MOD_PKA_2 138 144 PF00069 0.258
MOD_PKA_2 286 292 PF00069 0.237
MOD_PKA_2 504 510 PF00069 0.416
MOD_PKA_2 605 611 PF00069 0.605
MOD_PKA_2 631 637 PF00069 0.403
MOD_PKA_2 665 671 PF00069 0.403
MOD_PKA_2 685 691 PF00069 0.229
MOD_PKA_2 78 84 PF00069 0.314
MOD_Plk_1 250 256 PF00069 0.370
MOD_Plk_1 634 640 PF00069 0.416
MOD_Plk_1 93 99 PF00069 0.314
MOD_Plk_2-3 127 133 PF00069 0.370
MOD_Plk_4 127 133 PF00069 0.280
MOD_Plk_4 234 240 PF00069 0.254
MOD_Plk_4 286 292 PF00069 0.253
MOD_Plk_4 294 300 PF00069 0.237
MOD_Plk_4 32 38 PF00069 0.392
MOD_Plk_4 576 582 PF00069 0.350
MOD_Plk_4 687 693 PF00069 0.366
MOD_ProDKin_1 203 209 PF00069 0.237
MOD_ProDKin_1 280 286 PF00069 0.393
MOD_ProDKin_1 299 305 PF00069 0.359
MOD_ProDKin_1 387 393 PF00069 0.676
MOD_ProDKin_1 401 407 PF00069 0.604
MOD_ProDKin_1 417 423 PF00069 0.615
MOD_ProDKin_1 437 443 PF00069 0.664
MOD_ProDKin_1 584 590 PF00069 0.542
MOD_ProDKin_1 594 600 PF00069 0.367
MOD_ProDKin_1 658 664 PF00069 0.499
MOD_SUMO_for_1 536 539 PF00179 0.499
MOD_SUMO_for_1 551 554 PF00179 0.499
MOD_SUMO_rev_2 162 171 PF00179 0.373
MOD_SUMO_rev_2 192 202 PF00179 0.237
MOD_SUMO_rev_2 213 219 PF00179 0.370
MOD_SUMO_rev_2 562 572 PF00179 0.495
TRG_ENDOCYTIC_2 118 121 PF00928 0.261
TRG_ENDOCYTIC_2 147 150 PF00928 0.314
TRG_ENDOCYTIC_2 236 239 PF00928 0.306
TRG_ENDOCYTIC_2 254 257 PF00928 0.208
TRG_ENDOCYTIC_2 533 536 PF00928 0.383
TRG_ENDOCYTIC_2 693 696 PF00928 0.486
TRG_ER_diArg_1 137 139 PF00400 0.257
TRG_ER_diArg_1 665 667 PF00400 0.503
TRG_ER_diArg_1 99 101 PF00400 0.350
TRG_NES_CRM1_1 133 144 PF08389 0.370
TRG_NES_CRM1_1 179 192 PF08389 0.280
TRG_Pf-PMV_PEXEL_1 273 278 PF00026 0.370
TRG_Pf-PMV_PEXEL_1 621 626 PF00026 0.456

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I191 Leptomonas seymouri 73% 95%
A0A0S4JMY6 Bodo saltans 48% 91%
A0A1X0NTN5 Trypanosomatidae 50% 92%
A0A422N3U8 Trypanosoma rangeli 48% 97%
A4H913 Leishmania braziliensis 92% 99%
A4HXE5 Leishmania infantum 100% 100%
C9ZTW0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 48% 100%
E9AR40 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
P0C8M8 Zea mays 38% 100%
P32562 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 32% 99%
P50528 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 33% 100%
P53351 Mus musculus 30% 100%
Q4FZD7 Mus musculus 29% 100%
Q4QEC3 Leishmania major 97% 100%
Q9R012 Rattus norvegicus 30% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS