Gamma-glutamylcyclotransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

AIG2-like family, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IAR7_LEIDO

TriTrypDb:

LdBPK_200510.1 , LdCL_200009800 , LDHU3_20.0600

Length:

487

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IAR7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IAR7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0003839	gamma-glutamylcyclotransferase activity	5	7
GO:0016829	lyase activity	2	7
GO:0016840	carbon-nitrogen lyase activity	3	7
GO:0016842	amidine-lyase activity	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	16	20	PF00656	0.478
CLV_C14_Caspase3-7	277	281	PF00656	0.481
CLV_C14_Caspase3-7	418	422	PF00656	0.345
CLV_NRD_NRD_1	169	171	PF00675	0.505
CLV_NRD_NRD_1	332	334	PF00675	0.397
CLV_NRD_NRD_1	483	485	PF00675	0.666
CLV_PCSK_KEX2_1	332	334	PF00082	0.397
CLV_PCSK_KEX2_1	481	483	PF00082	0.650
CLV_PCSK_PC1ET2_1	481	483	PF00082	0.650
CLV_PCSK_SKI1_1	105	109	PF00082	0.334
CLV_PCSK_SKI1_1	333	337	PF00082	0.374
CLV_PCSK_SKI1_1	368	372	PF00082	0.390
CLV_PCSK_SKI1_1	42	46	PF00082	0.537
CLV_PCSK_SKI1_1	50	54	PF00082	0.398
CLV_PCSK_SKI1_1	97	101	PF00082	0.541
DEG_APCC_DBOX_1	104	112	PF00400	0.348
DOC_MAPK_gen_1	246	256	PF00069	0.459
DOC_MAPK_gen_1	332	343	PF00069	0.377
DOC_MAPK_MEF2A_6	116	123	PF00069	0.359
DOC_MAPK_MEF2A_6	249	256	PF00069	0.574
DOC_MAPK_NFAT4_5	249	257	PF00069	0.525
DOC_MAPK_RevD_3	156	171	PF00069	0.402
DOC_PP1_RVXF_1	48	54	PF00149	0.368
DOC_PP2B_LxvP_1	163	166	PF13499	0.467
DOC_USP7_MATH_1	269	273	PF00917	0.686
DOC_USP7_MATH_1	28	32	PF00917	0.483
DOC_USP7_MATH_1	312	316	PF00917	0.474
DOC_USP7_UBL2_3	481	485	PF12436	0.662
DOC_WW_Pin1_4	149	154	PF00397	0.467
DOC_WW_Pin1_4	201	206	PF00397	0.647
DOC_WW_Pin1_4	212	217	PF00397	0.637
DOC_WW_Pin1_4	473	478	PF00397	0.548
DOC_WW_Pin1_4	81	86	PF00397	0.736
LIG_14-3-3_CanoR_1	170	175	PF00244	0.541
LIG_BIR_II_1	1	5	PF00653	0.569
LIG_BRCT_BRCA1_1	151	155	PF00533	0.420
LIG_BRCT_BRCA1_1	5	9	PF00533	0.497
LIG_CtBP_PxDLS_1	70	74	PF00389	0.539
LIG_EH1_1	171	179	PF00400	0.470
LIG_FHA_1	306	312	PF00498	0.392
LIG_FHA_1	469	475	PF00498	0.438
LIG_FHA_1	78	84	PF00498	0.558
LIG_FHA_2	112	118	PF00498	0.384
LIG_FHA_2	14	20	PF00498	0.386
LIG_FHA_2	435	441	PF00498	0.318
LIG_LIR_Gen_1	152	163	PF02991	0.391
LIG_LIR_Gen_1	237	248	PF02991	0.538
LIG_LIR_Gen_1	250	258	PF02991	0.434
LIG_LIR_Gen_1	318	326	PF02991	0.434
LIG_LIR_Gen_1	428	434	PF02991	0.324
LIG_LIR_LC3C_4	157	160	PF02991	0.299
LIG_LIR_Nem_3	126	132	PF02991	0.454
LIG_LIR_Nem_3	152	158	PF02991	0.387
LIG_LIR_Nem_3	237	243	PF02991	0.556
LIG_LIR_Nem_3	245	251	PF02991	0.442
LIG_LIR_Nem_3	308	313	PF02991	0.363
LIG_LIR_Nem_3	318	322	PF02991	0.421
LIG_LIR_Nem_3	428	433	PF02991	0.324
LIG_LIR_Nem_3	6	12	PF02991	0.501
LIG_MYND_1	43	47	PF01753	0.482
LIG_PCNA_yPIPBox_3	187	201	PF02747	0.614
LIG_Pex14_1	309	313	PF04695	0.358
LIG_SH2_CRK	132	136	PF00017	0.411
LIG_SH2_CRK	240	244	PF00017	0.501
LIG_SH2_CRK	49	53	PF00017	0.417
LIG_SH2_GRB2like	359	362	PF00017	0.469
LIG_SH2_NCK_1	17	21	PF00017	0.337
LIG_SH2_PTP2	251	254	PF00017	0.441
LIG_SH2_PTP2	340	343	PF00017	0.356
LIG_SH2_SRC	17	20	PF00017	0.384
LIG_SH2_SRC	392	395	PF00017	0.324
LIG_SH2_STAP1	109	113	PF00017	0.420
LIG_SH2_STAP1	17	21	PF00017	0.337
LIG_SH2_STAP1	240	244	PF00017	0.429
LIG_SH2_STAP1	284	288	PF00017	0.541
LIG_SH2_STAP1	409	413	PF00017	0.370
LIG_SH2_STAT3	432	435	PF00017	0.314
LIG_SH2_STAT5	11	14	PF00017	0.368
LIG_SH2_STAT5	251	254	PF00017	0.539
LIG_SH2_STAT5	310	313	PF00017	0.353
LIG_SH2_STAT5	340	343	PF00017	0.356
LIG_SH2_STAT5	386	389	PF00017	0.324
LIG_SH2_STAT5	432	435	PF00017	0.324
LIG_SH2_STAT5	462	465	PF00017	0.425
LIG_SH3_1	467	473	PF00018	0.416
LIG_SH3_2	470	475	PF14604	0.503
LIG_SH3_3	112	118	PF00018	0.395
LIG_SH3_3	144	150	PF00018	0.530
LIG_SH3_3	215	221	PF00018	0.595
LIG_SH3_3	374	380	PF00018	0.496
LIG_SH3_3	467	473	PF00018	0.505
LIG_SUMO_SIM_par_1	363	369	PF11976	0.431
LIG_TRAF2_1	437	440	PF00917	0.296
LIG_TYR_ITIM	338	343	PF00017	0.473
LIG_WW_1	459	462	PF00397	0.303
MOD_CDC14_SPxK_1	84	87	PF00782	0.697
MOD_CDK_SPK_2	473	478	PF00069	0.595
MOD_CDK_SPxK_1	81	87	PF00069	0.692
MOD_CDK_SPxxK_3	212	219	PF00069	0.554
MOD_CK1_1	263	269	PF00069	0.697
MOD_CK1_1	272	278	PF00069	0.563
MOD_CK1_1	3	9	PF00069	0.524
MOD_CK1_1	300	306	PF00069	0.544
MOD_CK1_1	315	321	PF00069	0.433
MOD_CK1_1	420	426	PF00069	0.365
MOD_CK2_1	111	117	PF00069	0.376
MOD_CK2_1	434	440	PF00069	0.288
MOD_GlcNHglycan	110	114	PF01048	0.437
MOD_GlcNHglycan	272	275	PF01048	0.770
MOD_GlcNHglycan	277	280	PF01048	0.637
MOD_GlcNHglycan	30	33	PF01048	0.550
MOD_GlcNHglycan	39	42	PF01048	0.519
MOD_GlcNHglycan	56	59	PF01048	0.381
MOD_GSK3_1	201	208	PF00069	0.776
MOD_GSK3_1	263	270	PF00069	0.719
MOD_GSK3_1	345	352	PF00069	0.449
MOD_GSK3_1	77	84	PF00069	0.662
MOD_N-GLC_1	297	302	PF02516	0.671
MOD_N-GLC_1	315	320	PF02516	0.363
MOD_NEK2_1	111	116	PF00069	0.369
MOD_NEK2_1	154	159	PF00069	0.472
MOD_NEK2_1	23	28	PF00069	0.458
MOD_NEK2_1	283	288	PF00069	0.427
MOD_NEK2_2	133	138	PF00069	0.529
MOD_NEK2_2	228	233	PF00069	0.618
MOD_PIKK_1	234	240	PF00454	0.546
MOD_PIKK_1	300	306	PF00454	0.454
MOD_PIKK_1	392	398	PF00454	0.421
MOD_PK_1	170	176	PF00069	0.440
MOD_PKA_1	170	176	PF00069	0.496
MOD_PKA_2	414	420	PF00069	0.365
MOD_Plk_1	315	321	PF00069	0.477
MOD_Plk_4	154	160	PF00069	0.472
MOD_Plk_4	305	311	PF00069	0.408
MOD_Plk_4	69	75	PF00069	0.516
MOD_ProDKin_1	149	155	PF00069	0.455
MOD_ProDKin_1	201	207	PF00069	0.645
MOD_ProDKin_1	212	218	PF00069	0.628
MOD_ProDKin_1	473	479	PF00069	0.550
MOD_ProDKin_1	81	87	PF00069	0.738
MOD_SUMO_rev_2	164	173	PF00179	0.476
MOD_SUMO_rev_2	300	308	PF00179	0.497
MOD_SUMO_rev_2	363	373	PF00179	0.402
MOD_SUMO_rev_2	84	93	PF00179	0.667
TRG_DiLeu_BaLyEn_6	115	120	PF01217	0.407
TRG_ENDOCYTIC_2	132	135	PF00928	0.406
TRG_ENDOCYTIC_2	240	243	PF00928	0.545
TRG_ENDOCYTIC_2	251	254	PF00928	0.439
TRG_ENDOCYTIC_2	340	343	PF00928	0.356
TRG_ENDOCYTIC_2	359	362	PF00928	0.373
TRG_ENDOCYTIC_2	49	52	PF00928	0.415
TRG_ER_diArg_1	332	334	PF00400	0.438
TRG_NES_CRM1_1	164	175	PF08389	0.490

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P468	Leptomonas seymouri	56%	96%
A4HYM3	Leishmania infantum	99%	100%
E9AIA3	Leishmania braziliensis	73%	100%
E9AUI8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	99%
Q4QCZ6	Leishmania major	90%	100%