Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IAR6_LEIDO

TriTrypDb:

LdBPK_171170.1 , LdCL_170017800 , LDHU3_17.1650

Length:

528

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

A0A3Q8IAR6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IAR6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	55	59	PF00656	0.714
CLV_NRD_NRD_1	125	127	PF00675	0.499
CLV_NRD_NRD_1	203	205	PF00675	0.481
CLV_PCSK_KEX2_1	125	127	PF00082	0.499
CLV_PCSK_KEX2_1	203	205	PF00082	0.481
CLV_PCSK_SKI1_1	196	200	PF00082	0.476
CLV_PCSK_SKI1_1	206	210	PF00082	0.417
CLV_PCSK_SKI1_1	222	226	PF00082	0.409
CLV_PCSK_SKI1_1	32	36	PF00082	0.518
CLV_PCSK_SKI1_1	420	424	PF00082	0.633
CLV_PCSK_SKI1_1	477	481	PF00082	0.370
CLV_PCSK_SKI1_1	91	95	PF00082	0.531
DEG_SCF_FBW7_1	514	521	PF00400	0.452
DEG_SPOP_SBC_1	180	184	PF00917	0.656
DOC_CDC14_PxL_1	497	505	PF14671	0.332
DOC_CKS1_1	2	7	PF01111	0.702
DOC_CKS1_1	33	38	PF01111	0.718
DOC_CKS1_1	67	72	PF01111	0.700
DOC_CYCLIN_RxL_1	203	211	PF00134	0.680
DOC_MAPK_gen_1	203	209	PF00069	0.678
DOC_PP1_RVXF_1	204	210	PF00149	0.661
DOC_PP1_RVXF_1	382	389	PF00149	0.585
DOC_PP2B_LxvP_1	243	246	PF13499	0.675
DOC_PP2B_LxvP_1	307	310	PF13499	0.690
DOC_PP2B_LxvP_1	455	458	PF13499	0.368
DOC_USP7_MATH_1	180	184	PF00917	0.656
DOC_USP7_MATH_1	273	277	PF00917	0.732
DOC_USP7_MATH_1	332	336	PF00917	0.706
DOC_USP7_MATH_1	367	371	PF00917	0.645
DOC_USP7_MATH_1	405	409	PF00917	0.368
DOC_USP7_MATH_1	488	492	PF00917	0.439
DOC_WW_Pin1_4	1	6	PF00397	0.706
DOC_WW_Pin1_4	169	174	PF00397	0.641
DOC_WW_Pin1_4	17	22	PF00397	0.649
DOC_WW_Pin1_4	32	37	PF00397	0.662
DOC_WW_Pin1_4	514	519	PF00397	0.449
DOC_WW_Pin1_4	66	71	PF00397	0.708
LIG_14-3-3_CanoR_1	105	112	PF00244	0.681
LIG_14-3-3_CanoR_1	155	163	PF00244	0.671
LIG_14-3-3_CanoR_1	196	205	PF00244	0.677
LIG_14-3-3_CanoR_1	45	54	PF00244	0.688
LIG_14-3-3_CanoR_1	74	81	PF00244	0.734
LIG_14-3-3_CanoR_1	91	99	PF00244	0.659
LIG_BRCT_BRCA1_1	275	279	PF00533	0.720
LIG_CSL_BTD_1	243	246	PF09270	0.624
LIG_FHA_1	18	24	PF00498	0.713
LIG_FHA_1	223	229	PF00498	0.644
LIG_FHA_1	240	246	PF00498	0.568
LIG_FHA_1	282	288	PF00498	0.744
LIG_FHA_1	439	445	PF00498	0.385
LIG_FHA_1	519	525	PF00498	0.517
LIG_FHA_1	94	100	PF00498	0.685
LIG_FHA_2	13	19	PF00498	0.715
LIG_FHA_2	141	147	PF00498	0.709
LIG_FHA_2	197	203	PF00498	0.673
LIG_FHA_2	488	494	PF00498	0.368
LIG_FHA_2	53	59	PF00498	0.711
LIG_Integrin_isoDGR_2	30	32	PF01839	0.529
LIG_LIR_Apic_2	251	256	PF02991	0.658
LIG_LIR_Gen_1	115	123	PF02991	0.724
LIG_LIR_Nem_3	172	178	PF02991	0.738
LIG_LYPXL_yS_3	240	243	PF13949	0.663
LIG_LYPXL_yS_3	80	83	PF13949	0.704
LIG_MYND_1	354	358	PF01753	0.669
LIG_PDZ_Class_2	523	528	PF00595	0.492
LIG_Pex14_1	265	269	PF04695	0.685
LIG_Pex14_1	474	478	PF04695	0.561
LIG_PTAP_UEV_1	315	320	PF05743	0.686
LIG_PTAP_UEV_1	53	58	PF05743	0.684
LIG_PTB_Apo_2	110	117	PF02174	0.705
LIG_PTB_Apo_2	247	254	PF02174	0.664
LIG_PTB_Phospho_1	247	253	PF10480	0.663
LIG_RPA_C_Fungi	335	347	PF08784	0.598
LIG_SH2_CRK	253	257	PF00017	0.599
LIG_SH2_CRK	322	326	PF00017	0.636
LIG_SH2_CRK	464	468	PF00017	0.368
LIG_SH3_3	124	130	PF00018	0.651
LIG_SH3_3	19	25	PF00018	0.617
LIG_SH3_3	221	227	PF00018	0.568
LIG_SH3_3	30	36	PF00018	0.608
LIG_SH3_3	313	319	PF00018	0.649
LIG_SH3_3	348	354	PF00018	0.717
LIG_SH3_3	51	57	PF00018	0.610
LIG_SH3_3	64	70	PF00018	0.583
LIG_SUMO_SIM_anti_2	490	496	PF11976	0.406
LIG_SUMO_SIM_par_1	448	454	PF11976	0.354
LIG_TRAF2_1	199	202	PF00917	0.582
LIG_TYR_ITIM	238	243	PF00017	0.544
MOD_CDK_SPxxK_3	169	176	PF00069	0.526
MOD_CK1_1	131	137	PF00069	0.660
MOD_CK1_1	282	288	PF00069	0.627
MOD_CK1_1	378	384	PF00069	0.536
MOD_CK2_1	12	18	PF00069	0.642
MOD_CK2_1	140	146	PF00069	0.635
MOD_CK2_1	154	160	PF00069	0.531
MOD_CK2_1	196	202	PF00069	0.569
MOD_CK2_1	277	283	PF00069	0.603
MOD_CK2_1	367	373	PF00069	0.593
MOD_CK2_1	374	380	PF00069	0.531
MOD_CK2_1	436	442	PF00069	0.497
MOD_DYRK1A_RPxSP_1	32	36	PF00069	0.645
MOD_GlcNHglycan	115	119	PF01048	0.619
MOD_GlcNHglycan	271	274	PF01048	0.604
MOD_GlcNHglycan	279	282	PF01048	0.590
MOD_GlcNHglycan	295	299	PF01048	0.619
MOD_GlcNHglycan	334	337	PF01048	0.628
MOD_GlcNHglycan	359	362	PF01048	0.616
MOD_GlcNHglycan	468	471	PF01048	0.371
MOD_GSK3_1	180	187	PF00069	0.550
MOD_GSK3_1	251	258	PF00069	0.619
MOD_GSK3_1	269	276	PF00069	0.659
MOD_GSK3_1	277	284	PF00069	0.679
MOD_GSK3_1	310	317	PF00069	0.602
MOD_GSK3_1	374	381	PF00069	0.530
MOD_GSK3_1	422	429	PF00069	0.476
MOD_GSK3_1	434	441	PF00069	0.440
MOD_GSK3_1	514	521	PF00069	0.670
MOD_GSK3_1	87	94	PF00069	0.651
MOD_N-GLC_1	390	395	PF02516	0.497
MOD_N-GLC_1	514	519	PF02516	0.549
MOD_NEK2_1	208	213	PF00069	0.598
MOD_NEK2_1	248	253	PF00069	0.537
MOD_NEK2_1	269	274	PF00069	0.610
MOD_NEK2_1	331	336	PF00069	0.662
MOD_NEK2_1	374	379	PF00069	0.535
MOD_NEK2_1	487	492	PF00069	0.371
MOD_NEK2_1	6	11	PF00069	0.641
MOD_NEK2_1	92	97	PF00069	0.662
MOD_NEK2_2	422	427	PF00069	0.482
MOD_PIKK_1	405	411	PF00454	0.368
MOD_PIKK_1	73	79	PF00454	0.621
MOD_PKA_2	104	110	PF00069	0.580
MOD_PKA_2	131	137	PF00069	0.672
MOD_PKA_2	154	160	PF00069	0.606
MOD_PKA_2	248	254	PF00069	0.574
MOD_PKA_2	73	79	PF00069	0.634
MOD_PKA_2	87	93	PF00069	0.584
MOD_PKB_1	220	228	PF00069	0.532
MOD_Plk_1	107	113	PF00069	0.590
MOD_Plk_1	114	120	PF00069	0.593
MOD_Plk_1	282	288	PF00069	0.621
MOD_Plk_1	390	396	PF00069	0.482
MOD_Plk_1	518	524	PF00069	0.571
MOD_Plk_4	107	113	PF00069	0.550
MOD_Plk_4	239	245	PF00069	0.535
MOD_Plk_4	248	254	PF00069	0.540
MOD_Plk_4	256	262	PF00069	0.499
MOD_Plk_4	282	288	PF00069	0.634
MOD_Plk_4	422	428	PF00069	0.485
MOD_ProDKin_1	1	7	PF00069	0.629
MOD_ProDKin_1	169	175	PF00069	0.539
MOD_ProDKin_1	17	23	PF00069	0.552
MOD_ProDKin_1	32	38	PF00069	0.568
MOD_ProDKin_1	514	520	PF00069	0.552
MOD_ProDKin_1	66	72	PF00069	0.632
TRG_DiLeu_BaLyEn_6	203	208	PF01217	0.576
TRG_ENDOCYTIC_2	240	243	PF00928	0.568
TRG_ENDOCYTIC_2	397	400	PF00928	0.368
TRG_ENDOCYTIC_2	464	467	PF00928	0.368
TRG_ENDOCYTIC_2	484	487	PF00928	0.368
TRG_ENDOCYTIC_2	80	83	PF00928	0.625
TRG_ER_diArg_1	125	127	PF00400	0.618
TRG_ER_diArg_1	203	206	PF00400	0.594
TRG_ER_diArg_1	212	215	PF00400	0.539
TRG_ER_diArg_1	220	223	PF00400	0.488
TRG_ER_diArg_1	480	483	PF00400	0.456

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4H962	Leishmania braziliensis	64%	100%
A4HXI4	Leishmania infantum	100%	100%
E9AR79	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4QE84	Leishmania major	87%	100%