LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3Q8IAR5_LEIDO
TriTrypDb:
LdBPK_272240.1 , LdCL_270029800 , LDHU3_27.3390
Length:
247

Annotations

LeishMANIAdb annotations

A conserved but unique protein in Kinetoplastids (can also be organellar)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
TermNameLevelCount
GO:0016020 membrane 2 9
GO:0110165 cellular anatomical entity 1 9
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Expansion

Sequence features

A0A3Q8IAR5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IAR5

Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_NRD_NRD_1 15 17 PF00675 0.566
CLV_NRD_NRD_1 66 68 PF00675 0.491
CLV_NRD_NRD_1 76 78 PF00675 0.456
CLV_PCSK_KEX2_1 17 19 PF00082 0.559
CLV_PCSK_KEX2_1 187 189 PF00082 0.445
CLV_PCSK_PC1ET2_1 17 19 PF00082 0.559
CLV_PCSK_PC1ET2_1 187 189 PF00082 0.504
CLV_PCSK_SKI1_1 77 81 PF00082 0.518
DEG_Nend_UBRbox_2 1 3 PF02207 0.752
DOC_CYCLIN_yCln2_LP_2 131 137 PF00134 0.734
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N1IMI2 Leptomonas seymouri 65% 100%
A0A1X0NSH8 Trypanosomatidae 37% 100%
A0A3R7NGU7 Trypanosoma rangeli 32% 100%
A4HG09 Leishmania braziliensis 83% 100%
A4I328 Leishmania infantum 100% 100%
E9ACU9 Leishmania major 95% 100%
E9AZD8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
V5B3U0 Trypanosoma cruzi 34% 100%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS