LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3Q8IAR5_LEIDO
TriTrypDb:
LdBPK_272240.1 , LdCL_270029800 , LDHU3_27.3390
Length:
247

Annotations

LeishMANIAdb annotations

A conserved but unique protein in Kinetoplastids (can also be organellar)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0016020 membrane 2 9
GO:0110165 cellular anatomical entity 1 9

Expansion

Sequence features

A0A3Q8IAR5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IAR5

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 15 17 PF00675 0.566
CLV_NRD_NRD_1 66 68 PF00675 0.491
CLV_NRD_NRD_1 76 78 PF00675 0.456
CLV_PCSK_KEX2_1 17 19 PF00082 0.559
CLV_PCSK_KEX2_1 187 189 PF00082 0.445
CLV_PCSK_PC1ET2_1 17 19 PF00082 0.559
CLV_PCSK_PC1ET2_1 187 189 PF00082 0.504
CLV_PCSK_SKI1_1 77 81 PF00082 0.518
DEG_Nend_UBRbox_2 1 3 PF02207 0.752
DOC_CYCLIN_yCln2_LP_2 131 137 PF00134 0.734
DOC_MAPK_gen_1 118 127 PF00069 0.705
DOC_MAPK_gen_1 187 195 PF00069 0.543
DOC_MAPK_gen_1 234 243 PF00069 0.713
DOC_MAPK_gen_1 77 84 PF00069 0.723
DOC_MAPK_HePTP_8 184 201 PF00069 0.380
DOC_MAPK_MEF2A_6 188 197 PF00069 0.548
DOC_MAPK_RevD_3 172 188 PF00069 0.344
DOC_PP1_RVXF_1 78 85 PF00149 0.695
DOC_PP2B_LxvP_1 131 134 PF13499 0.710
DOC_PP4_FxxP_1 139 142 PF00568 0.401
DOC_PP4_FxxP_1 209 212 PF00568 0.541
DOC_PP4_FxxP_1 84 87 PF00568 0.689
DOC_USP7_MATH_1 212 216 PF00917 0.401
DOC_WW_Pin1_4 158 163 PF00397 0.405
DOC_WW_Pin1_4 40 45 PF00397 0.736
LIG_14-3-3_CanoR_1 188 194 PF00244 0.475
LIG_14-3-3_CanoR_1 234 243 PF00244 0.653
LIG_BRCT_BRCA1_1 142 146 PF00533 0.408
LIG_Clathr_ClatBox_1 100 104 PF01394 0.768
LIG_CtBP_PxDLS_1 73 77 PF00389 0.701
LIG_deltaCOP1_diTrp_1 8 15 PF00928 0.732
LIG_FHA_1 192 198 PF00498 0.444
LIG_FHA_1 224 230 PF00498 0.418
LIG_FHA_1 27 33 PF00498 0.752
LIG_FHA_1 41 47 PF00498 0.666
LIG_LIR_Apic_2 83 87 PF02991 0.691
LIG_LIR_Gen_1 238 246 PF02991 0.682
LIG_LIR_Gen_1 7 15 PF02991 0.681
LIG_LIR_Nem_3 238 243 PF02991 0.659
LIG_LIR_Nem_3 7 12 PF02991 0.650
LIG_NRP_CendR_1 245 247 PF00754 0.494
LIG_Pex14_2 209 213 PF04695 0.365
LIG_SH2_STAP1 191 195 PF00017 0.429
LIG_SH2_STAT5 231 234 PF00017 0.598
LIG_SH3_1 18 24 PF00018 0.716
LIG_SH3_3 100 106 PF00018 0.769
LIG_SH3_3 171 177 PF00018 0.374
LIG_SH3_3 18 24 PF00018 0.789
LIG_SH3_3 83 89 PF00018 0.753
LIG_Sin3_3 151 158 PF02671 0.272
LIG_SUMO_SIM_anti_2 149 154 PF11976 0.444
LIG_SUMO_SIM_anti_2 215 220 PF11976 0.369
LIG_SUMO_SIM_anti_2 225 231 PF11976 0.334
LIG_SUMO_SIM_par_1 123 129 PF11976 0.688
LIG_SUMO_SIM_par_1 151 156 PF11976 0.372
LIG_SUMO_SIM_par_1 41 49 PF11976 0.699
LIG_UBA3_1 182 187 PF00899 0.485
LIG_WRC_WIRS_1 12 17 PF05994 0.754
LIG_WRC_WIRS_1 240 245 PF05994 0.691
LIG_WRC_WIRS_1 81 86 PF05994 0.696
LIG_WW_3 85 89 PF00397 0.742
MOD_CAAXbox 244 247 PF01239 0.721
MOD_CDK_SPxK_1 158 164 PF00069 0.484
MOD_CK1_1 110 116 PF00069 0.756
MOD_CK1_1 156 162 PF00069 0.494
MOD_CK1_1 30 36 PF00069 0.738
MOD_GlcNHglycan 142 145 PF01048 0.482
MOD_GSK3_1 235 242 PF00069 0.641
MOD_GSK3_1 26 33 PF00069 0.796
MOD_GSK3_1 34 41 PF00069 0.751
MOD_NEK2_1 153 158 PF00069 0.587
MOD_NEK2_1 222 227 PF00069 0.356
MOD_PKA_2 235 241 PF00069 0.653
MOD_PKB_1 234 242 PF00069 0.624
MOD_Plk_4 126 132 PF00069 0.665
MOD_Plk_4 212 218 PF00069 0.401
MOD_Plk_4 223 229 PF00069 0.418
MOD_Plk_4 236 242 PF00069 0.540
MOD_ProDKin_1 158 164 PF00069 0.407
MOD_ProDKin_1 40 46 PF00069 0.735
TRG_DiLeu_BaEn_2 97 103 PF01217 0.696
TRG_ENDOCYTIC_2 240 243 PF00928 0.688
TRG_ER_diArg_1 15 18 PF00400 0.768
TRG_ER_diArg_1 233 236 PF00400 0.671
TRG_NLS_Bipartite_1 67 81 PF00514 0.728
TRG_NLS_MonoExtN_4 74 81 PF00514 0.714

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IMI2 Leptomonas seymouri 65% 100%
A0A1X0NSH8 Trypanosomatidae 37% 100%
A0A3R7NGU7 Trypanosoma rangeli 32% 100%
A4HG09 Leishmania braziliensis 83% 100%
A4I328 Leishmania infantum 100% 100%
E9ACU9 Leishmania major 95% 100%
E9AZD8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
V5B3U0 Trypanosoma cruzi 34% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS