CRAL/TRIO domain family protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CRAL/TRIO domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IAR1_LEIDO

TriTrypDb:

LdBPK_220910.1 , LdCL_220016500 , LDHU3_22.1420

Length:

715

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IAR1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IAR1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	30	34	PF00656	0.534
CLV_C14_Caspase3-7	70	74	PF00656	0.556
CLV_NRD_NRD_1	183	185	PF00675	0.502
CLV_NRD_NRD_1	408	410	PF00675	0.650
CLV_NRD_NRD_1	612	614	PF00675	0.552
CLV_NRD_NRD_1	662	664	PF00675	0.534
CLV_NRD_NRD_1	97	99	PF00675	0.477
CLV_PCSK_FUR_1	180	184	PF00082	0.436
CLV_PCSK_FUR_1	610	614	PF00082	0.588
CLV_PCSK_FUR_1	95	99	PF00082	0.492
CLV_PCSK_KEX2_1	180	182	PF00082	0.509
CLV_PCSK_KEX2_1	183	185	PF00082	0.467
CLV_PCSK_KEX2_1	408	410	PF00082	0.650
CLV_PCSK_KEX2_1	610	612	PF00082	0.559
CLV_PCSK_KEX2_1	664	666	PF00082	0.555
CLV_PCSK_KEX2_1	95	97	PF00082	0.492
CLV_PCSK_PC1ET2_1	664	666	PF00082	0.555
CLV_PCSK_PC7_1	607	613	PF00082	0.586
CLV_PCSK_SKI1_1	132	136	PF00082	0.411
CLV_PCSK_SKI1_1	166	170	PF00082	0.436
CLV_PCSK_SKI1_1	456	460	PF00082	0.667
CLV_PCSK_SKI1_1	97	101	PF00082	0.459
DEG_COP1_1	533	542	PF00400	0.733
DEG_SCF_FBW7_1	472	478	PF00400	0.840
DEG_SPOP_SBC_1	283	287	PF00917	0.436
DEG_SPOP_SBC_1	32	36	PF00917	0.724
DEG_SPOP_SBC_1	706	710	PF00917	0.623
DOC_CKS1_1	472	477	PF01111	0.845
DOC_CYCLIN_RxL_1	163	173	PF00134	0.436
DOC_CYCLIN_yCln2_LP_2	262	268	PF00134	0.299
DOC_CYCLIN_yCln2_LP_2	392	398	PF00134	0.601
DOC_CYCLIN_yCln2_LP_2	459	465	PF00134	0.744
DOC_MAPK_gen_1	22	29	PF00069	0.538
DOC_MAPK_gen_1	408	419	PF00069	0.621
DOC_MAPK_gen_1	610	622	PF00069	0.698
DOC_MAPK_gen_1	78	87	PF00069	0.463
DOC_MAPK_gen_1	9	18	PF00069	0.466
DOC_MAPK_MEF2A_6	102	109	PF00069	0.462
DOC_MAPK_MEF2A_6	132	139	PF00069	0.411
DOC_MAPK_MEF2A_6	154	162	PF00069	0.389
DOC_MAPK_MEF2A_6	22	29	PF00069	0.480
DOC_MAPK_MEF2A_6	623	631	PF00069	0.608
DOC_MAPK_NFAT4_5	22	30	PF00069	0.542
DOC_PP2B_LxvP_1	25	28	PF13499	0.510
DOC_PP2B_LxvP_1	396	399	PF13499	0.571
DOC_PP2B_PxIxI_1	104	110	PF00149	0.481
DOC_PP4_FxxP_1	142	145	PF00568	0.411
DOC_USP7_MATH_1	116	120	PF00917	0.402
DOC_USP7_MATH_1	190	194	PF00917	0.431
DOC_USP7_MATH_1	32	36	PF00917	0.715
DOC_USP7_MATH_1	338	342	PF00917	0.409
DOC_USP7_MATH_1	386	390	PF00917	0.688
DOC_USP7_MATH_1	466	470	PF00917	0.754
DOC_USP7_MATH_1	547	551	PF00917	0.697
DOC_USP7_MATH_1	706	710	PF00917	0.637
DOC_WW_Pin1_4	107	112	PF00397	0.472
DOC_WW_Pin1_4	205	210	PF00397	0.338
DOC_WW_Pin1_4	435	440	PF00397	0.696
DOC_WW_Pin1_4	45	50	PF00397	0.699
DOC_WW_Pin1_4	458	463	PF00397	0.706
DOC_WW_Pin1_4	471	476	PF00397	0.741
DOC_WW_Pin1_4	686	691	PF00397	0.612
LIG_14-3-3_CanoR_1	291	295	PF00244	0.436
LIG_14-3-3_CanoR_1	468	475	PF00244	0.766
LIG_BIR_II_1	1	5	PF00653	0.572
LIG_BIR_III_4	382	386	PF00653	0.648
LIG_BRCT_BRCA1_1	118	122	PF00533	0.474
LIG_BRCT_BRCA1_1	191	195	PF00533	0.299
LIG_CtBP_PxDLS_1	312	316	PF00389	0.411
LIG_FHA_1	139	145	PF00498	0.424
LIG_FHA_1	226	232	PF00498	0.418
LIG_FHA_1	308	314	PF00498	0.363
LIG_FHA_1	487	493	PF00498	0.812
LIG_FHA_1	539	545	PF00498	0.818
LIG_FHA_1	62	68	PF00498	0.455
LIG_FHA_2	28	34	PF00498	0.510
LIG_FHA_2	472	478	PF00498	0.630
LIG_FHA_2	679	685	PF00498	0.636
LIG_FHA_2	68	74	PF00498	0.491
LIG_LIR_Apic_2	141	145	PF02991	0.389
LIG_LIR_Gen_1	119	129	PF02991	0.436
LIG_LIR_Gen_1	681	690	PF02991	0.555
LIG_LIR_LC3C_4	82	87	PF02991	0.365
LIG_LIR_Nem_3	119	125	PF02991	0.513
LIG_LIR_Nem_3	541	545	PF02991	0.809
LIG_LIR_Nem_3	60	65	PF02991	0.511
LIG_LIR_Nem_3	681	686	PF02991	0.525
LIG_LYPXL_yS_3	259	262	PF13949	0.411
LIG_MYND_3	144	148	PF01753	0.411
LIG_NRBOX	155	161	PF00104	0.389
LIG_NRBOX	671	677	PF00104	0.557
LIG_PCNA_PIPBox_1	69	78	PF02747	0.451
LIG_Pex3_1	672	683	PF04882	0.541
LIG_SH2_GRB2like	136	139	PF00017	0.411
LIG_SH2_NCK_1	545	549	PF00017	0.801
LIG_SH2_NCK_1	580	584	PF00017	0.650
LIG_SH2_PTP2	136	139	PF00017	0.513
LIG_SH2_PTP2	397	400	PF00017	0.565
LIG_SH2_SRC	136	139	PF00017	0.443
LIG_SH2_SRC	397	400	PF00017	0.565
LIG_SH2_STAT5	136	139	PF00017	0.355
LIG_SH2_STAT5	397	400	PF00017	0.565
LIG_SH2_STAT5	545	548	PF00017	0.753
LIG_SH2_STAT5	621	624	PF00017	0.649
LIG_SH2_STAT5	75	78	PF00017	0.438
LIG_SH2_STAT5	79	82	PF00017	0.450
LIG_SH3_2	441	446	PF14604	0.752
LIG_SH3_3	395	401	PF00018	0.563
LIG_SH3_3	433	439	PF00018	0.740
LIG_SH3_3	46	52	PF00018	0.721
LIG_SH3_3	469	475	PF00018	0.765
LIG_SUMO_SIM_anti_2	249	256	PF11976	0.490
LIG_SUMO_SIM_anti_2	423	431	PF11976	0.571
LIG_SUMO_SIM_par_1	105	110	PF11976	0.496
LIG_SUMO_SIM_par_1	145	151	PF11976	0.411
LIG_SUMO_SIM_par_1	155	161	PF11976	0.411
LIG_SUMO_SIM_par_1	227	234	PF11976	0.383
LIG_SUMO_SIM_par_1	674	679	PF11976	0.637
LIG_TRAF2_1	51	54	PF00917	0.697
LIG_TRAF2_1	588	591	PF00917	0.576
LIG_TYR_ITIM	134	139	PF00017	0.513
LIG_UBA3_1	251	257	PF00899	0.509
LIG_UBA3_1	76	83	PF00899	0.448
LIG_WRC_WIRS_1	139	144	PF05994	0.521
MOD_CAAXbox	712	715	PF01239	0.648
MOD_CDK_SPK_2	45	50	PF00069	0.741
MOD_CK1_1	34	40	PF00069	0.709
MOD_CK1_1	363	369	PF00069	0.635
MOD_CK1_1	425	431	PF00069	0.617
MOD_CK1_1	507	513	PF00069	0.794
MOD_CK1_1	578	584	PF00069	0.747
MOD_CK2_1	282	288	PF00069	0.408
MOD_CK2_1	338	344	PF00069	0.508
MOD_CK2_1	48	54	PF00069	0.588
MOD_CK2_1	585	591	PF00069	0.595
MOD_CK2_1	632	638	PF00069	0.565
MOD_CK2_1	678	684	PF00069	0.630
MOD_GlcNHglycan	1	4	PF01048	0.576
MOD_GlcNHglycan	118	121	PF01048	0.402
MOD_GlcNHglycan	192	195	PF01048	0.413
MOD_GlcNHglycan	323	326	PF01048	0.538
MOD_GlcNHglycan	36	39	PF01048	0.753
MOD_GlcNHglycan	362	365	PF01048	0.689
MOD_GlcNHglycan	424	427	PF01048	0.614
MOD_GlcNHglycan	450	453	PF01048	0.728
MOD_GlcNHglycan	506	509	PF01048	0.769
MOD_GlcNHglycan	536	539	PF01048	0.712
MOD_GlcNHglycan	563	566	PF01048	0.745
MOD_GlcNHglycan	583	586	PF01048	0.520
MOD_GSK3_1	105	112	PF00069	0.482
MOD_GSK3_1	186	193	PF00069	0.397
MOD_GSK3_1	246	253	PF00069	0.436
MOD_GSK3_1	27	34	PF00069	0.702
MOD_GSK3_1	353	360	PF00069	0.773
MOD_GSK3_1	421	428	PF00069	0.724
MOD_GSK3_1	431	438	PF00069	0.647
MOD_GSK3_1	466	473	PF00069	0.771
MOD_GSK3_1	530	537	PF00069	0.736
MOD_GSK3_1	543	550	PF00069	0.606
MOD_GSK3_1	581	588	PF00069	0.616
MOD_GSK3_1	61	68	PF00069	0.437
MOD_GSK3_1	684	691	PF00069	0.586
MOD_GSK3_1	706	713	PF00069	0.558
MOD_LATS_1	532	538	PF00433	0.739
MOD_N-GLC_1	246	251	PF02516	0.513
MOD_N-GLC_1	326	331	PF02516	0.476
MOD_N-GLC_1	466	471	PF02516	0.720
MOD_N-GLC_1	632	637	PF02516	0.565
MOD_N-GLC_1	684	689	PF02516	0.544
MOD_NEK2_1	100	105	PF00069	0.480
MOD_NEK2_1	240	245	PF00069	0.433
MOD_NEK2_1	306	311	PF00069	0.436
MOD_NEK2_1	337	342	PF00069	0.426
MOD_NEK2_1	403	408	PF00069	0.583
MOD_NEK2_1	422	427	PF00069	0.508
MOD_NEK2_1	551	556	PF00069	0.730
MOD_NEK2_1	561	566	PF00069	0.661
MOD_NEK2_1	575	580	PF00069	0.667
MOD_NEK2_1	67	72	PF00069	0.440
MOD_NEK2_1	676	681	PF00069	0.536
MOD_PIKK_1	338	344	PF00454	0.486
MOD_PIKK_1	403	409	PF00454	0.627
MOD_PIKK_1	478	484	PF00454	0.759
MOD_PK_1	632	638	PF00069	0.560
MOD_PKA_1	408	414	PF00069	0.526
MOD_PKA_2	290	296	PF00069	0.513
MOD_PKA_2	408	414	PF00069	0.526
MOD_PKA_2	467	473	PF00069	0.766
MOD_Plk_1	100	106	PF00069	0.489
MOD_Plk_1	246	252	PF00069	0.513
MOD_Plk_1	306	312	PF00069	0.430
MOD_Plk_1	632	638	PF00069	0.565
MOD_Plk_1	676	682	PF00069	0.529
MOD_Plk_2-3	498	504	PF00069	0.687
MOD_Plk_4	240	246	PF00069	0.375
MOD_Plk_4	247	253	PF00069	0.338
MOD_Plk_4	425	431	PF00069	0.725
MOD_Plk_4	575	581	PF00069	0.670
MOD_Plk_4	632	638	PF00069	0.560
MOD_ProDKin_1	107	113	PF00069	0.466
MOD_ProDKin_1	205	211	PF00069	0.338
MOD_ProDKin_1	435	441	PF00069	0.697
MOD_ProDKin_1	45	51	PF00069	0.686
MOD_ProDKin_1	458	464	PF00069	0.707
MOD_ProDKin_1	471	477	PF00069	0.744
MOD_ProDKin_1	686	692	PF00069	0.619
MOD_SUMO_for_1	657	660	PF00179	0.629
MOD_SUMO_rev_2	350	359	PF00179	0.761
TRG_DiLeu_BaEn_1	151	156	PF01217	0.383
TRG_DiLeu_BaLyEn_6	257	262	PF01217	0.436
TRG_DiLeu_LyEn_5	151	156	PF01217	0.383
TRG_ENDOCYTIC_2	136	139	PF00928	0.411
TRG_ENDOCYTIC_2	258	261	PF00928	0.427
TRG_ER_diArg_1	180	183	PF00400	0.509
TRG_ER_diArg_1	408	410	PF00400	0.650
TRG_ER_diArg_1	610	613	PF00400	0.560
TRG_ER_diArg_1	94	97	PF00400	0.481
TRG_NES_CRM1_1	640	654	PF08389	0.542
TRG_NLS_MonoExtC_3	662	667	PF00514	0.540
TRG_NLS_MonoExtN_4	663	668	PF00514	0.593
TRG_Pf-PMV_PEXEL_1	97	101	PF00026	0.357

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P818	Leptomonas seymouri	52%	100%
A4HCF0	Leishmania braziliensis	69%	98%
A4HZY1	Leishmania infantum	99%	100%
E9AVU1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QBN8	Leishmania major	89%	98%