LeishMANIAdb
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Paraflagellar_rod_protein_1D_putative/GeneDB:LmjF.29.1750/GeneDB:LmjF.29.1760/GeneDB:LmjF.29.1770

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Paraflagellar_rod_protein_1D_putative/GeneDB:LmjF.29.1750/GeneDB:LmjF.29.1760/GeneDB:LmjF.29.1770
Gene product:
paraflagellar rod protein 2C
Species:
Leishmania donovani
UniProt:
A0A3Q8IAP5_LEIDO
TriTrypDb:
LdBPK_161510.1 , LdCL_160020100 , LdCL_160020200 , LdCL_160020300 , LDHU3_16.1790 , LDHU3_16.1800 , LDHU3_16.1810
Length:
599

Annotations

Annotations by Jardim et al.

Flagella, Paraflagellar rod 2C

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) yes yes: 8
Forrest at al. (procyclic) yes yes: 8
Silverman et al. no yes: 2
Pissara et al. yes yes: 28
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 8
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 24
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 48
NetGPI no yes: 0, no: 48
Cellular components
Term Name Level Count
GO:0005929 cilium 4 49
GO:0031514 motile cilium 5 49
GO:0042995 cell projection 2 49
GO:0043226 organelle 2 49
GO:0043227 membrane-bounded organelle 3 49
GO:0110165 cellular anatomical entity 1 49
GO:0120025 plasma membrane bounded cell projection 3 49
GO:0005737 cytoplasm 2 3
GO:0031974 membrane-enclosed lumen 2 3
GO:0031981 nuclear lumen 5 3
GO:0032838 plasma membrane bounded cell projection cytoplasm 4 3
GO:0043233 organelle lumen 3 3
GO:0070013 intracellular organelle lumen 4 3
GO:0097014 ciliary plasm 5 3
GO:0099568 cytoplasmic region 3 3
GO:0005930 axoneme 2 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A0A3Q8IAP5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IAP5

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0005488 binding 1 49
GO:0005515 protein binding 2 49
GO:0005516 calmodulin binding 3 49

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 166 170 PF00656 0.442
CLV_NRD_NRD_1 287 289 PF00675 0.335
CLV_NRD_NRD_1 30 32 PF00675 0.532
CLV_NRD_NRD_1 340 342 PF00675 0.338
CLV_NRD_NRD_1 363 365 PF00675 0.342
CLV_NRD_NRD_1 374 376 PF00675 0.322
CLV_NRD_NRD_1 447 449 PF00675 0.321
CLV_NRD_NRD_1 552 554 PF00675 0.324
CLV_PCSK_KEX2_1 273 275 PF00082 0.491
CLV_PCSK_KEX2_1 286 288 PF00082 0.299
CLV_PCSK_KEX2_1 316 318 PF00082 0.327
CLV_PCSK_KEX2_1 362 364 PF00082 0.335
CLV_PCSK_KEX2_1 373 375 PF00082 0.351
CLV_PCSK_KEX2_1 447 449 PF00082 0.328
CLV_PCSK_KEX2_1 462 464 PF00082 0.333
CLV_PCSK_KEX2_1 552 554 PF00082 0.338
CLV_PCSK_KEX2_1 579 581 PF00082 0.515
CLV_PCSK_PC1ET2_1 273 275 PF00082 0.507
CLV_PCSK_PC1ET2_1 286 288 PF00082 0.304
CLV_PCSK_PC1ET2_1 316 318 PF00082 0.333
CLV_PCSK_PC1ET2_1 362 364 PF00082 0.337
CLV_PCSK_PC1ET2_1 462 464 PF00082 0.334
CLV_PCSK_PC1ET2_1 579 581 PF00082 0.515
CLV_PCSK_PC7_1 370 376 PF00082 0.360
CLV_PCSK_PC7_1 575 581 PF00082 0.513
CLV_PCSK_SKI1_1 273 277 PF00082 0.482
CLV_PCSK_SKI1_1 287 291 PF00082 0.328
CLV_PCSK_SKI1_1 317 321 PF00082 0.424
CLV_PCSK_SKI1_1 389 393 PF00082 0.343
CLV_PCSK_SKI1_1 595 599 PF00082 0.685
CLV_PCSK_SKI1_1 86 90 PF00082 0.645
DOC_CYCLIN_RxL_1 386 395 PF00134 0.345
DOC_MAPK_gen_1 31 40 PF00069 0.516
DOC_MAPK_gen_1 389 396 PF00069 0.339
DOC_MAPK_gen_1 469 478 PF00069 0.334
DOC_MAPK_MEF2A_6 389 396 PF00069 0.339
DOC_MAPK_MEF2A_6 472 480 PF00069 0.345
DOC_MAPK_NFAT4_5 389 397 PF00069 0.345
DOC_PP4_FxxP_1 538 541 PF00568 0.333
DOC_USP7_MATH_1 20 24 PF00917 0.636
DOC_USP7_MATH_1 80 84 PF00917 0.615
DOC_USP7_UBL2_3 113 117 PF12436 0.500
DOC_USP7_UBL2_3 286 290 PF12436 0.310
DOC_USP7_UBL2_3 497 501 PF12436 0.315
LIG_14-3-3_CanoR_1 141 146 PF00244 0.468
LIG_14-3-3_CanoR_1 448 454 PF00244 0.325
LIG_14-3-3_CanoR_1 469 478 PF00244 0.309
LIG_14-3-3_CanoR_1 590 595 PF00244 0.564
LIG_14-3-3_CterR_2 595 599 PF00244 0.461
LIG_Actin_WH2_2 149 166 PF00022 0.447
LIG_Actin_WH2_2 389 406 PF00022 0.455
LIG_APCC_ABBA_1 436 441 PF00400 0.345
LIG_APCC_ABBAyCdc20_2 435 441 PF00400 0.345
LIG_BIR_II_1 1 5 PF00653 0.615
LIG_CtBP_PxDLS_1 103 109 PF00389 0.490
LIG_EH1_1 92 100 PF00400 0.466
LIG_eIF4E_1 235 241 PF01652 0.403
LIG_eIF4E_1 93 99 PF01652 0.473
LIG_FHA_1 138 144 PF00498 0.492
LIG_FHA_1 277 283 PF00498 0.371
LIG_FHA_1 40 46 PF00498 0.483
LIG_FHA_1 471 477 PF00498 0.292
LIG_FHA_1 579 585 PF00498 0.667
LIG_FHA_1 73 79 PF00498 0.606
LIG_FHA_2 127 133 PF00498 0.443
LIG_FHA_2 256 262 PF00498 0.446
LIG_FHA_2 318 324 PF00498 0.346
LIG_FHA_2 420 426 PF00498 0.326
LIG_LIR_Apic_2 537 541 PF02991 0.331
LIG_LIR_Gen_1 264 269 PF02991 0.573
LIG_LIR_Gen_1 355 365 PF02991 0.344
LIG_LIR_Gen_1 377 384 PF02991 0.292
LIG_LIR_Nem_3 250 255 PF02991 0.382
LIG_LIR_Nem_3 264 268 PF02991 0.467
LIG_LIR_Nem_3 337 343 PF02991 0.323
LIG_LIR_Nem_3 355 361 PF02991 0.346
LIG_LIR_Nem_3 377 381 PF02991 0.292
LIG_LIR_Nem_3 444 449 PF02991 0.322
LIG_PTB_Apo_2 44 51 PF02174 0.469
LIG_SH2_CRK 450 454 PF00017 0.351
LIG_SH2_SRC 442 445 PF00017 0.370
LIG_SH2_STAT3 318 321 PF00017 0.429
LIG_SH2_STAT3 93 96 PF00017 0.541
LIG_SH2_STAT5 235 238 PF00017 0.389
LIG_SH2_STAT5 442 445 PF00017 0.323
LIG_SH3_3 173 179 PF00018 0.532
LIG_SH3_4 113 120 PF00018 0.487
LIG_SUMO_SIM_par_1 140 146 PF11976 0.594
LIG_SUMO_SIM_par_1 390 395 PF11976 0.345
LIG_TRAF2_1 159 162 PF00917 0.542
LIG_TRAF2_1 275 278 PF00917 0.469
LIG_TRAF2_1 427 430 PF00917 0.323
LIG_TRAF2_1 46 49 PF00917 0.482
LIG_TRAF2_1 541 544 PF00917 0.335
LIG_TRAF2_1 564 567 PF00917 0.498
LIG_WRC_WIRS_1 482 487 PF05994 0.314
MOD_CK1_1 23 29 PF00069 0.573
MOD_CK1_1 57 63 PF00069 0.542
MOD_CK2_1 104 110 PF00069 0.477
MOD_CK2_1 126 132 PF00069 0.417
MOD_CK2_1 255 261 PF00069 0.407
MOD_CK2_1 317 323 PF00069 0.341
MOD_CK2_1 424 430 PF00069 0.300
MOD_CK2_1 43 49 PF00069 0.485
MOD_Cter_Amidation 284 287 PF01082 0.443
MOD_GlcNHglycan 405 408 PF01048 0.362
MOD_GlcNHglycan 417 420 PF01048 0.309
MOD_GlcNHglycan 82 85 PF01048 0.564
MOD_GSK3_1 137 144 PF00069 0.490
MOD_GSK3_1 39 46 PF00069 0.478
MOD_GSK3_1 415 422 PF00069 0.359
MOD_N-GLC_1 137 142 PF02516 0.497
MOD_N-GLC_1 188 193 PF02516 0.424
MOD_N-GLC_1 261 266 PF02516 0.482
MOD_NEK2_1 104 109 PF00069 0.473
MOD_NEK2_1 126 131 PF00069 0.442
MOD_NEK2_1 163 168 PF00069 0.457
MOD_NEK2_1 188 193 PF00069 0.419
MOD_NEK2_1 276 281 PF00069 0.351
MOD_NEK2_1 392 397 PF00069 0.323
MOD_NEK2_1 403 408 PF00069 0.318
MOD_NEK2_1 449 454 PF00069 0.320
MOD_NEK2_1 578 583 PF00069 0.528
MOD_PIKK_1 163 169 PF00454 0.463
MOD_PIKK_1 268 274 PF00454 0.519
MOD_PIKK_1 317 323 PF00454 0.354
MOD_PIKK_1 583 589 PF00454 0.547
MOD_PIKK_1 59 65 PF00454 0.553
MOD_PKA_1 490 496 PF00069 0.351
MOD_PKA_2 163 169 PF00069 0.463
MOD_PKA_2 403 409 PF00069 0.359
MOD_PKA_2 471 477 PF00069 0.320
MOD_PKA_2 551 557 PF00069 0.328
MOD_Plk_1 104 110 PF00069 0.524
MOD_Plk_1 188 194 PF00069 0.443
MOD_Plk_1 23 29 PF00069 0.560
MOD_Plk_1 261 267 PF00069 0.532
MOD_Plk_1 392 398 PF00069 0.355
MOD_Plk_2-3 261 267 PF00069 0.361
MOD_Plk_2-3 296 302 PF00069 0.417
MOD_Plk_4 188 194 PF00069 0.463
MOD_Plk_4 392 398 PF00069 0.341
MOD_SUMO_for_1 154 157 PF00179 0.475
MOD_SUMO_for_1 495 498 PF00179 0.349
MOD_SUMO_for_1 564 567 PF00179 0.496
MOD_SUMO_rev_2 110 118 PF00179 0.487
MOD_SUMO_rev_2 259 265 PF00179 0.422
MOD_SUMO_rev_2 567 572 PF00179 0.459
MOD_SUMO_rev_2 574 581 PF00179 0.433
TRG_DiLeu_BaEn_2 376 382 PF01217 0.345
TRG_DiLeu_BaEn_3 507 513 PF01217 0.346
TRG_DiLeu_BaEn_4 429 435 PF01217 0.388
TRG_DiLeu_BaEn_4 508 514 PF01217 0.331
TRG_ENDOCYTIC_2 378 381 PF00928 0.281
TRG_ENDOCYTIC_2 450 453 PF00928 0.323
TRG_ER_diArg_1 287 289 PF00400 0.326
TRG_ER_diArg_1 363 365 PF00400 0.332
TRG_ER_diArg_1 373 375 PF00400 0.336
TRG_ER_diArg_1 446 448 PF00400 0.344
TRG_NES_CRM1_1 242 257 PF08389 0.387
TRG_NES_CRM1_1 96 110 PF08389 0.548
TRG_NLS_Bipartite_1 273 290 PF00514 0.351
TRG_NLS_MonoExtC_3 285 290 PF00514 0.345
TRG_NLS_MonoExtN_4 283 290 PF00514 0.345
TRG_Pf-PMV_PEXEL_1 128 132 PF00026 0.480
TRG_Pf-PMV_PEXEL_1 253 257 PF00026 0.437
TRG_Pf-PMV_PEXEL_1 298 302 PF00026 0.337
TRG_Pf-PMV_PEXEL_1 341 345 PF00026 0.339
TRG_Pf-PMV_PEXEL_1 363 367 PF00026 0.324
TRG_Pf-PMV_PEXEL_1 389 393 PF00026 0.337
TRG_Pf-PMV_PEXEL_1 462 466 PF00026 0.335
TRG_Pf-PMV_PEXEL_1 595 599 PF00026 0.487

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P2I5 Leptomonas seymouri 66% 100%
A0A0N0P5J5 Leptomonas seymouri 26% 75%
A0A0N1IFZ5 Leptomonas seymouri 95% 100%
A0A0S4IW44 Bodo saltans 25% 90%
A0A0S4IZY8 Bodo saltans 84% 100%
A0A0S4J013 Bodo saltans 25% 91%
A0A0S4J193 Bodo saltans 28% 97%
A0A0S4J561 Bodo saltans 30% 85%
A0A0S4JS20 Bodo saltans 69% 100%
A0A1X0NR57 Trypanosomatidae 26% 76%
A0A1X0NYU4 Trypanosomatidae 85% 100%
A0A1X0P0B7 Trypanosomatidae 69% 100%
A0A381MH18 Leishmania infantum 100% 100%
A0A381MN58 Leishmania infantum 67% 100%
A0A3Q8IEH2 Leishmania donovani 67% 100%
A0A3R7KDB9 Trypanosoma rangeli 84% 100%
A0A3S5IRI8 Trypanosoma rangeli 69% 100%
A0A3S7WQV4 Leishmania donovani 22% 99%
A0A3S7X0V5 Leishmania donovani 24% 77%
A0A3S7X2K1 Leishmania donovani 67% 100%
A0A422NJR9 Trypanosoma rangeli 25% 81%
A4H5W0 Leishmania braziliensis 24% 100%
A4H8S1 Leishmania braziliensis 94% 100%
A4HFV9 Leishmania braziliensis 25% 100%
A4HIY0 Leishmania braziliensis 66% 100%
A4HU55 Leishmania infantum 21% 100%
A4HX40 Leishmania infantum 100% 100%
A4I2Z1 Leishmania infantum 24% 100%
C9ZJD8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 26% 79%
C9ZLC1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 68% 100%
C9ZLC2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 66% 100%
C9ZU76 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 28% 87%
C9ZVV0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 83% 100%
E9ADG3 Leishmania major 25% 100%
E9AE36 Leishmania major 67% 100%
E9AE37 Leishmania major 67% 100%
E9AHJ2 Leishmania infantum 67% 100%
E9ALP7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 66% 100%
E9ALP8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 66% 100%
E9AMY4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 22% 100%
E9AQV6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 97% 100%
E9AZ87 Leishmania mexicana (strain MHOM/GT/2001/U1103) 25% 100%
P22225 Trypanosoma brucei brucei 83% 100%
Q26789 Trypanosoma brucei brucei 67% 100%
Q4QEM2 Leishmania major 99% 100%
Q4QHP3 Leishmania major 22% 99%
V5ARJ3 Trypanosoma cruzi 28% 86%
V5BDW8 Trypanosoma cruzi 69% 100%
V5BIN9 Trypanosoma cruzi 27% 81%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS