LeishMANIAdb
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Diacylglycerol kinase (ATP)

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Diacylglycerol kinase (ATP)
Gene product:
diacylglycerol kinase, putative
Species:
Leishmania donovani
UniProt:
A0A3Q8IAN3_LEIDO
TriTrypDb:
LdBPK_161340.1 , LdCL_160018600 , LDHU3_16.1630
Length:
732

Annotations

Annotations by Jardim et al.

Phospholipid biosynthesis, diacylglycerol kinase

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Could not find GO cellular_component term for this entry.

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A0A3Q8IAN3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IAN3

Function

Biological processes
Term Name Level Count
GO:0006793 phosphorus metabolic process 3 10
GO:0006796 phosphate-containing compound metabolic process 4 10
GO:0007165 signal transduction 2 10
GO:0007186 G protein-coupled receptor signaling pathway 3 10
GO:0007205 protein kinase C-activating G protein-coupled receptor signaling pathway 4 10
GO:0008152 metabolic process 1 10
GO:0009987 cellular process 1 10
GO:0016310 phosphorylation 5 10
GO:0044237 cellular metabolic process 2 10
GO:0050789 regulation of biological process 2 10
GO:0050794 regulation of cellular process 3 10
GO:0065007 biological regulation 1 10
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 10
GO:0003824 catalytic activity 1 10
GO:0004143 diacylglycerol kinase activity 5 10
GO:0005488 binding 1 10
GO:0005524 ATP binding 5 10
GO:0016301 kinase activity 4 10
GO:0016740 transferase activity 2 10
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 10
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 10
GO:0017076 purine nucleotide binding 4 10
GO:0030554 adenyl nucleotide binding 5 10
GO:0032553 ribonucleotide binding 3 10
GO:0032555 purine ribonucleotide binding 4 10
GO:0032559 adenyl ribonucleotide binding 5 10
GO:0035639 purine ribonucleoside triphosphate binding 4 10
GO:0036094 small molecule binding 2 10
GO:0043167 ion binding 2 10
GO:0043168 anion binding 3 10
GO:0097159 organic cyclic compound binding 2 10
GO:0097367 carbohydrate derivative binding 2 10
GO:1901265 nucleoside phosphate binding 3 10
GO:1901363 heterocyclic compound binding 2 10

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 49 53 PF00656 0.622
CLV_NRD_NRD_1 256 258 PF00675 0.438
CLV_NRD_NRD_1 332 334 PF00675 0.447
CLV_NRD_NRD_1 477 479 PF00675 0.298
CLV_NRD_NRD_1 83 85 PF00675 0.642
CLV_PCSK_KEX2_1 195 197 PF00082 0.468
CLV_PCSK_KEX2_1 216 218 PF00082 0.418
CLV_PCSK_KEX2_1 256 258 PF00082 0.438
CLV_PCSK_KEX2_1 332 334 PF00082 0.447
CLV_PCSK_KEX2_1 477 479 PF00082 0.307
CLV_PCSK_KEX2_1 571 573 PF00082 0.411
CLV_PCSK_PC1ET2_1 195 197 PF00082 0.468
CLV_PCSK_PC1ET2_1 216 218 PF00082 0.396
CLV_PCSK_PC1ET2_1 571 573 PF00082 0.411
CLV_PCSK_PC7_1 212 218 PF00082 0.398
CLV_PCSK_PC7_1 328 334 PF00082 0.440
CLV_PCSK_SKI1_1 196 200 PF00082 0.337
CLV_PCSK_SKI1_1 578 582 PF00082 0.438
CLV_PCSK_SKI1_1 84 88 PF00082 0.669
DEG_APCC_DBOX_1 518 526 PF00400 0.340
DEG_COP1_1 102 110 PF00400 0.716
DEG_COP1_1 52 64 PF00400 0.520
DEG_Nend_UBRbox_3 1 3 PF02207 0.677
DEG_SCF_FBW7_1 587 592 PF00400 0.360
DEG_SCF_TRCP1_1 157 163 PF00400 0.456
DEG_SPOP_SBC_1 34 38 PF00917 0.720
DOC_CKS1_1 600 605 PF01111 0.371
DOC_CKS1_1 606 611 PF01111 0.336
DOC_CKS1_1 654 659 PF01111 0.435
DOC_CYCLIN_RxL_1 548 556 PF00134 0.438
DOC_MAPK_DCC_7 365 375 PF00069 0.437
DOC_MAPK_DCC_7 507 517 PF00069 0.361
DOC_MAPK_gen_1 506 517 PF00069 0.360
DOC_MAPK_gen_1 95 103 PF00069 0.604
DOC_MAPK_MEF2A_6 510 517 PF00069 0.334
DOC_MAPK_MEF2A_6 539 546 PF00069 0.396
DOC_MAPK_MEF2A_6 690 697 PF00069 0.445
DOC_PP2B_LxvP_1 544 547 PF13499 0.353
DOC_PP4_FxxP_1 205 208 PF00568 0.381
DOC_PP4_FxxP_1 298 301 PF00568 0.353
DOC_USP7_MATH_1 106 110 PF00917 0.562
DOC_USP7_MATH_1 118 122 PF00917 0.457
DOC_USP7_MATH_1 135 139 PF00917 0.667
DOC_USP7_MATH_1 15 19 PF00917 0.749
DOC_USP7_MATH_1 323 327 PF00917 0.527
DOC_USP7_MATH_1 359 363 PF00917 0.456
DOC_USP7_MATH_1 379 383 PF00917 0.436
DOC_USP7_MATH_1 411 415 PF00917 0.696
DOC_USP7_MATH_1 531 535 PF00917 0.345
DOC_USP7_MATH_1 64 68 PF00917 0.674
DOC_USP7_MATH_1 90 94 PF00917 0.712
DOC_USP7_UBL2_3 506 510 PF12436 0.341
DOC_WW_Pin1_4 137 142 PF00397 0.612
DOC_WW_Pin1_4 419 424 PF00397 0.660
DOC_WW_Pin1_4 585 590 PF00397 0.387
DOC_WW_Pin1_4 599 604 PF00397 0.238
DOC_WW_Pin1_4 605 610 PF00397 0.313
DOC_WW_Pin1_4 653 658 PF00397 0.405
DOC_WW_Pin1_4 78 83 PF00397 0.548
LIG_14-3-3_CanoR_1 196 201 PF00244 0.406
LIG_14-3-3_CanoR_1 500 504 PF00244 0.311
LIG_14-3-3_CanoR_1 578 583 PF00244 0.434
LIG_14-3-3_CanoR_1 690 694 PF00244 0.473
LIG_14-3-3_CanoR_1 724 731 PF00244 0.446
LIG_14-3-3_CanoR_1 95 101 PF00244 0.634
LIG_APCC_ABBA_1 275 280 PF00400 0.321
LIG_BRCT_BRCA1_1 38 42 PF00533 0.700
LIG_BRCT_BRCA1_1 52 56 PF00533 0.662
LIG_deltaCOP1_diTrp_1 330 334 PF00928 0.444
LIG_EH1_1 164 172 PF00400 0.368
LIG_FHA_1 192 198 PF00498 0.462
LIG_FHA_1 233 239 PF00498 0.268
LIG_FHA_1 284 290 PF00498 0.406
LIG_FHA_1 452 458 PF00498 0.417
LIG_FHA_1 586 592 PF00498 0.368
LIG_FHA_1 639 645 PF00498 0.344
LIG_FHA_1 717 723 PF00498 0.518
LIG_FHA_2 248 254 PF00498 0.395
LIG_FHA_2 308 314 PF00498 0.297
LIG_FHA_2 654 660 PF00498 0.435
LIG_FHA_2 97 103 PF00498 0.690
LIG_LIR_Apic_2 203 208 PF02991 0.445
LIG_LIR_Gen_1 161 171 PF02991 0.389
LIG_LIR_Gen_1 442 448 PF02991 0.370
LIG_LIR_Gen_1 538 547 PF02991 0.364
LIG_LIR_Gen_1 647 657 PF02991 0.361
LIG_LIR_Gen_1 668 675 PF02991 0.540
LIG_LIR_Nem_3 161 167 PF02991 0.395
LIG_LIR_Nem_3 260 266 PF02991 0.370
LIG_LIR_Nem_3 329 334 PF02991 0.598
LIG_LIR_Nem_3 442 446 PF02991 0.367
LIG_LIR_Nem_3 454 458 PF02991 0.339
LIG_LIR_Nem_3 538 544 PF02991 0.364
LIG_LIR_Nem_3 647 653 PF02991 0.325
LIG_LIR_Nem_3 668 673 PF02991 0.542
LIG_MYND_1 301 305 PF01753 0.396
LIG_PCNA_yPIPBox_3 485 497 PF02747 0.400
LIG_Pex14_2 320 324 PF04695 0.396
LIG_SH2_CRK 164 168 PF00017 0.429
LIG_SH2_CRK 222 226 PF00017 0.420
LIG_SH2_CRK 455 459 PF00017 0.314
LIG_SH2_CRK 509 513 PF00017 0.263
LIG_SH2_CRK 577 581 PF00017 0.377
LIG_SH2_CRK 630 634 PF00017 0.396
LIG_SH2_CRK 670 674 PF00017 0.506
LIG_SH2_GRB2like 314 317 PF00017 0.321
LIG_SH2_STAP1 152 156 PF00017 0.481
LIG_SH2_STAP1 314 318 PF00017 0.321
LIG_SH2_STAP1 679 683 PF00017 0.506
LIG_SH2_STAT5 152 155 PF00017 0.452
LIG_SH2_STAT5 166 169 PF00017 0.255
LIG_SH2_STAT5 297 300 PF00017 0.396
LIG_SH2_STAT5 460 463 PF00017 0.297
LIG_SH2_STAT5 468 471 PF00017 0.297
LIG_SH2_STAT5 630 633 PF00017 0.438
LIG_SH2_STAT5 670 673 PF00017 0.501
LIG_SH3_2 397 402 PF14604 0.552
LIG_SH3_2 567 572 PF14604 0.360
LIG_SH3_3 105 111 PF00018 0.659
LIG_SH3_3 353 359 PF00018 0.357
LIG_SH3_3 394 400 PF00018 0.611
LIG_SH3_3 512 518 PF00018 0.362
LIG_SH3_3 564 570 PF00018 0.396
LIG_SH3_3 597 603 PF00018 0.294
LIG_SH3_3 65 71 PF00018 0.685
LIG_SH3_3 698 704 PF00018 0.373
LIG_SUMO_SIM_anti_2 250 256 PF11976 0.399
LIG_SUMO_SIM_par_1 610 616 PF11976 0.396
LIG_SUMO_SIM_par_1 99 104 PF11976 0.718
LIG_TRAF2_2 145 150 PF00917 0.501
LIG_TYR_ITIM 220 225 PF00017 0.301
LIG_TYR_ITIM 458 463 PF00017 0.297
LIG_TYR_ITIM 575 580 PF00017 0.396
LIG_TYR_ITIM 628 633 PF00017 0.396
LIG_WW_3 81 85 PF00397 0.580
MOD_CDC14_SPxK_1 81 84 PF00782 0.542
MOD_CDK_SPxK_1 78 84 PF00069 0.547
MOD_CDK_SPxxK_3 78 85 PF00069 0.546
MOD_CK1_1 155 161 PF00069 0.457
MOD_CK1_1 175 181 PF00069 0.474
MOD_CK1_1 32 38 PF00069 0.649
MOD_CK1_1 326 332 PF00069 0.597
MOD_CK1_1 382 388 PF00069 0.603
MOD_CK1_1 534 540 PF00069 0.319
MOD_CK1_1 562 568 PF00069 0.404
MOD_CK1_1 638 644 PF00069 0.438
MOD_CK1_1 668 674 PF00069 0.451
MOD_CK1_1 685 691 PF00069 0.537
MOD_CK2_1 155 161 PF00069 0.488
MOD_CK2_1 5 11 PF00069 0.653
MOD_CK2_1 678 684 PF00069 0.523
MOD_CK2_1 96 102 PF00069 0.674
MOD_GlcNHglycan 126 129 PF01048 0.635
MOD_GlcNHglycan 13 16 PF01048 0.673
MOD_GlcNHglycan 137 140 PF01048 0.611
MOD_GlcNHglycan 157 160 PF01048 0.424
MOD_GlcNHglycan 17 20 PF01048 0.683
MOD_GlcNHglycan 174 177 PF01048 0.430
MOD_GlcNHglycan 280 284 PF01048 0.345
MOD_GlcNHglycan 413 416 PF01048 0.666
MOD_GlcNHglycan 448 451 PF01048 0.449
MOD_GlcNHglycan 522 525 PF01048 0.439
MOD_GlcNHglycan 56 59 PF01048 0.667
MOD_GlcNHglycan 561 564 PF01048 0.424
MOD_GlcNHglycan 595 598 PF01048 0.438
MOD_GlcNHglycan 62 65 PF01048 0.694
MOD_GlcNHglycan 663 666 PF01048 0.531
MOD_GlcNHglycan 667 670 PF01048 0.484
MOD_GlcNHglycan 726 729 PF01048 0.468
MOD_GSK3_1 137 144 PF00069 0.541
MOD_GSK3_1 243 250 PF00069 0.360
MOD_GSK3_1 279 286 PF00069 0.404
MOD_GSK3_1 29 36 PF00069 0.780
MOD_GSK3_1 479 486 PF00069 0.381
MOD_GSK3_1 5 12 PF00069 0.670
MOD_GSK3_1 50 57 PF00069 0.634
MOD_GSK3_1 531 538 PF00069 0.320
MOD_GSK3_1 585 592 PF00069 0.359
MOD_GSK3_1 60 67 PF00069 0.722
MOD_GSK3_1 661 668 PF00069 0.458
MOD_GSK3_1 678 685 PF00069 0.531
MOD_LATS_1 576 582 PF00433 0.360
MOD_N-GLC_1 29 34 PF02516 0.786
MOD_N-GLC_1 50 55 PF02516 0.636
MOD_N-GLC_2 615 617 PF02516 0.321
MOD_NEK2_1 247 252 PF00069 0.371
MOD_NEK2_1 267 272 PF00069 0.420
MOD_NEK2_1 284 289 PF00069 0.438
MOD_NEK2_1 324 329 PF00069 0.524
MOD_NEK2_1 473 478 PF00069 0.332
MOD_NEK2_1 553 558 PF00069 0.297
MOD_NEK2_1 628 633 PF00069 0.396
MOD_NEK2_1 637 642 PF00069 0.375
MOD_NEK2_2 90 95 PF00069 0.509
MOD_PIKK_1 247 253 PF00454 0.376
MOD_PIKK_1 267 273 PF00454 0.415
MOD_PIKK_1 382 388 PF00454 0.634
MOD_PIKK_1 389 395 PF00454 0.571
MOD_PIKK_1 668 674 PF00454 0.488
MOD_PK_1 726 732 PF00069 0.504
MOD_PKA_2 232 238 PF00069 0.297
MOD_PKA_2 429 435 PF00069 0.440
MOD_PKA_2 499 505 PF00069 0.349
MOD_PKA_2 689 695 PF00069 0.468
MOD_PKA_2 96 102 PF00069 0.611
MOD_PKB_1 724 732 PF00069 0.492
MOD_Plk_1 160 166 PF00069 0.475
MOD_Plk_1 279 285 PF00069 0.436
MOD_Plk_1 366 372 PF00069 0.425
MOD_Plk_1 685 691 PF00069 0.488
MOD_Plk_1 706 712 PF00069 0.540
MOD_Plk_4 232 238 PF00069 0.297
MOD_Plk_4 243 249 PF00069 0.297
MOD_Plk_4 366 372 PF00069 0.420
MOD_Plk_4 64 70 PF00069 0.685
MOD_Plk_4 706 712 PF00069 0.450
MOD_Plk_4 726 732 PF00069 0.219
MOD_Plk_4 96 102 PF00069 0.740
MOD_ProDKin_1 137 143 PF00069 0.600
MOD_ProDKin_1 419 425 PF00069 0.653
MOD_ProDKin_1 585 591 PF00069 0.387
MOD_ProDKin_1 599 605 PF00069 0.238
MOD_ProDKin_1 653 659 PF00069 0.405
MOD_ProDKin_1 78 84 PF00069 0.547
TRG_DiLeu_BaEn_2 261 267 PF01217 0.389
TRG_DiLeu_BaEn_2 279 285 PF01217 0.389
TRG_DiLeu_BaEn_2 647 653 PF01217 0.321
TRG_DiLeu_BaLyEn_6 209 214 PF01217 0.455
TRG_ENDOCYTIC_2 164 167 PF00928 0.404
TRG_ENDOCYTIC_2 222 225 PF00928 0.322
TRG_ENDOCYTIC_2 297 300 PF00928 0.396
TRG_ENDOCYTIC_2 455 458 PF00928 0.326
TRG_ENDOCYTIC_2 460 463 PF00928 0.322
TRG_ENDOCYTIC_2 494 497 PF00928 0.382
TRG_ENDOCYTIC_2 509 512 PF00928 0.353
TRG_ENDOCYTIC_2 577 580 PF00928 0.377
TRG_ENDOCYTIC_2 630 633 PF00928 0.396
TRG_ENDOCYTIC_2 670 673 PF00928 0.503
TRG_ER_diArg_1 255 257 PF00400 0.438
TRG_ER_diArg_1 331 333 PF00400 0.443
TRG_ER_diArg_1 723 726 PF00400 0.389
TRG_NLS_MonoExtN_4 570 575 PF00514 0.360
TRG_Pf-PMV_PEXEL_1 257 261 PF00026 0.324

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HRI7 Leptomonas seymouri 51% 98%
A0A3R7MJ80 Trypanosoma rangeli 32% 100%
A4H8Q7 Leishmania braziliensis 72% 96%
A4HX26 Leishmania infantum 100% 100%
C9ZVX0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 31% 100%
E9AQU0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 86% 100%
Q4QEN8 Leishmania major 91% 99%
V5DJ39 Trypanosoma cruzi 33% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS