Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3Q8IAM5_LEIDO

TriTrypDb:

LdBPK_201300.1 , LdCL_200017600 , LDHU3_20.1610

Length:

838

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 8

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IAM5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IAM5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	199	203	PF00656	0.576
CLV_C14_Caspase3-7	358	362	PF00656	0.701
CLV_C14_Caspase3-7	71	75	PF00656	0.490
CLV_C14_Caspase3-7	778	782	PF00656	0.632
CLV_NRD_NRD_1	263	265	PF00675	0.579
CLV_NRD_NRD_1	334	336	PF00675	0.704
CLV_NRD_NRD_1	369	371	PF00675	0.578
CLV_NRD_NRD_1	48	50	PF00675	0.553
CLV_NRD_NRD_1	666	668	PF00675	0.613
CLV_NRD_NRD_1	71	73	PF00675	0.498
CLV_NRD_NRD_1	711	713	PF00675	0.632
CLV_PCSK_FUR_1	367	371	PF00082	0.592
CLV_PCSK_KEX2_1	258	260	PF00082	0.607
CLV_PCSK_KEX2_1	262	264	PF00082	0.567
CLV_PCSK_KEX2_1	369	371	PF00082	0.587
CLV_PCSK_KEX2_1	48	50	PF00082	0.553
CLV_PCSK_KEX2_1	666	668	PF00082	0.575
CLV_PCSK_KEX2_1	711	713	PF00082	0.632
CLV_PCSK_KEX2_1	83	85	PF00082	0.567
CLV_PCSK_KEX2_1	87	89	PF00082	0.634
CLV_PCSK_PC1ET2_1	258	260	PF00082	0.603
CLV_PCSK_PC1ET2_1	262	264	PF00082	0.575
CLV_PCSK_PC1ET2_1	83	85	PF00082	0.567
CLV_PCSK_PC1ET2_1	87	89	PF00082	0.634
CLV_PCSK_PC7_1	259	265	PF00082	0.587
CLV_PCSK_SKI1_1	385	389	PF00082	0.462
CLV_PCSK_SKI1_1	480	484	PF00082	0.488
CLV_PCSK_SKI1_1	620	624	PF00082	0.648
CLV_PCSK_SKI1_1	73	77	PF00082	0.453
DEG_APCC_DBOX_1	368	376	PF00400	0.759
DEG_APCC_DBOX_1	580	588	PF00400	0.621
DEG_SCF_FBW7_2	494	500	PF00400	0.579
DEG_SPOP_SBC_1	295	299	PF00917	0.547
DOC_CKS1_1	188	193	PF01111	0.714
DOC_CKS1_1	319	324	PF01111	0.752
DOC_CKS1_1	494	499	PF01111	0.578
DOC_CKS1_1	559	564	PF01111	0.552
DOC_CYCLIN_RxL_1	379	392	PF00134	0.509
DOC_CYCLIN_RxL_1	708	717	PF00134	0.628
DOC_CYCLIN_yCln2_LP_2	543	549	PF00134	0.393
DOC_MAPK_DCC_7	474	484	PF00069	0.445
DOC_MAPK_gen_1	367	377	PF00069	0.567
DOC_MAPK_gen_1	577	587	PF00069	0.752
DOC_MAPK_MEF2A_6	539	547	PF00069	0.633
DOC_MIT_MIM_1	534	543	PF04212	0.459
DOC_PP1_RVXF_1	383	390	PF00149	0.450
DOC_PP2B_LxvP_1	543	546	PF13499	0.476
DOC_PP2B_LxvP_1	688	691	PF13499	0.670
DOC_PP4_FxxP_1	654	657	PF00568	0.637
DOC_PP4_FxxP_1	742	745	PF00568	0.574
DOC_USP7_MATH_1	159	163	PF00917	0.710
DOC_USP7_MATH_1	170	174	PF00917	0.642
DOC_USP7_MATH_1	208	212	PF00917	0.585
DOC_USP7_MATH_1	254	258	PF00917	0.700
DOC_USP7_MATH_1	294	298	PF00917	0.794
DOC_USP7_MATH_1	320	324	PF00917	0.640
DOC_USP7_MATH_1	344	348	PF00917	0.647
DOC_USP7_MATH_1	397	401	PF00917	0.506
DOC_USP7_MATH_1	549	553	PF00917	0.390
DOC_USP7_MATH_1	60	64	PF00917	0.525
DOC_USP7_MATH_1	621	625	PF00917	0.604
DOC_USP7_MATH_1	635	639	PF00917	0.651
DOC_USP7_MATH_1	65	69	PF00917	0.550
DOC_USP7_MATH_1	673	677	PF00917	0.654
DOC_USP7_MATH_1	753	757	PF00917	0.616
DOC_USP7_MATH_1	805	809	PF00917	0.640
DOC_USP7_UBL2_3	258	262	PF12436	0.588
DOC_USP7_UBL2_3	281	285	PF12436	0.637
DOC_USP7_UBL2_3	569	573	PF12436	0.418
DOC_USP7_UBL2_3	73	77	PF12436	0.467
DOC_USP7_UBL2_3	83	87	PF12436	0.549
DOC_WW_Pin1_4	155	160	PF00397	0.653
DOC_WW_Pin1_4	166	171	PF00397	0.686
DOC_WW_Pin1_4	183	188	PF00397	0.488
DOC_WW_Pin1_4	250	255	PF00397	0.715
DOC_WW_Pin1_4	318	323	PF00397	0.680
DOC_WW_Pin1_4	361	366	PF00397	0.655
DOC_WW_Pin1_4	411	416	PF00397	0.655
DOC_WW_Pin1_4	434	439	PF00397	0.754
DOC_WW_Pin1_4	447	452	PF00397	0.534
DOC_WW_Pin1_4	493	498	PF00397	0.684
DOC_WW_Pin1_4	558	563	PF00397	0.488
DOC_WW_Pin1_4	675	680	PF00397	0.651
LIG_14-3-3_CanoR_1	171	175	PF00244	0.610
LIG_14-3-3_CanoR_1	374	378	PF00244	0.612
LIG_14-3-3_CanoR_1	379	387	PF00244	0.539
LIG_14-3-3_CanoR_1	581	585	PF00244	0.598
LIG_14-3-3_CanoR_1	711	716	PF00244	0.649
LIG_Actin_WH2_2	365	381	PF00022	0.595
LIG_APCC_ABBAyCdc20_2	385	391	PF00400	0.455
LIG_BIR_III_2	765	769	PF00653	0.569
LIG_BRCT_BRCA1_1	118	122	PF00533	0.556
LIG_BRCT_BRCA1_1	650	654	PF00533	0.645
LIG_Clathr_ClatBox_1	544	548	PF01394	0.528
LIG_eIF4E_1	538	544	PF01652	0.461
LIG_FHA_1	188	194	PF00498	0.579
LIG_FHA_1	231	237	PF00498	0.663
LIG_FHA_1	287	293	PF00498	0.640
LIG_FHA_1	319	325	PF00498	0.676
LIG_FHA_1	382	388	PF00498	0.678
LIG_FHA_1	486	492	PF00498	0.559
LIG_FHA_1	493	499	PF00498	0.569
LIG_FHA_1	525	531	PF00498	0.428
LIG_FHA_1	540	546	PF00498	0.443
LIG_FHA_1	628	634	PF00498	0.669
LIG_FHA_1	829	835	PF00498	0.594
LIG_FHA_2	137	143	PF00498	0.583
LIG_FHA_2	307	313	PF00498	0.673
LIG_FHA_2	494	500	PF00498	0.687
LIG_FHA_2	650	656	PF00498	0.644
LIG_FHA_2	91	97	PF00498	0.531
LIG_IBAR_NPY_1	738	740	PF08397	0.602
LIG_Integrin_RGD_1	200	202	PF01839	0.668
LIG_Integrin_RGD_1	816	818	PF01839	0.652
LIG_LIR_Apic_2	651	657	PF02991	0.640
LIG_LIR_Apic_2	741	745	PF02991	0.615
LIG_LIR_Gen_1	384	391	PF02991	0.549
LIG_LIR_Gen_1	473	484	PF02991	0.500
LIG_LIR_Gen_1	517	526	PF02991	0.404
LIG_LIR_Nem_3	161	167	PF02991	0.650
LIG_LIR_Nem_3	384	389	PF02991	0.511
LIG_LIR_Nem_3	473	479	PF02991	0.509
LIG_LIR_Nem_3	517	522	PF02991	0.394
LIG_MYND_1	112	116	PF01753	0.556
LIG_NRBOX	539	545	PF00104	0.465
LIG_PDZ_Class_2	833	838	PF00595	0.675
LIG_PTB_Apo_2	137	144	PF02174	0.554
LIG_PTB_Phospho_1	137	143	PF10480	0.558
LIG_SH2_PTP2	476	479	PF00017	0.538
LIG_SH2_SRC	476	479	PF00017	0.538
LIG_SH2_STAT3	405	408	PF00017	0.481
LIG_SH2_STAT5	476	479	PF00017	0.622
LIG_SH2_STAT5	529	532	PF00017	0.508
LIG_SH3_3	13	19	PF00018	0.769
LIG_SH3_3	185	191	PF00018	0.700
LIG_SH3_3	245	251	PF00018	0.675
LIG_SH3_3	412	418	PF00018	0.642
LIG_SH3_3	422	428	PF00018	0.596
LIG_SH3_3	44	50	PF00018	0.526
LIG_SH3_3	491	497	PF00018	0.619
LIG_SH3_3	518	524	PF00018	0.404
LIG_SH3_3	677	683	PF00018	0.627
LIG_SUMO_SIM_anti_2	373	379	PF11976	0.650
LIG_SUMO_SIM_par_1	480	485	PF11976	0.442
LIG_SUMO_SIM_par_1	797	803	PF11976	0.557
LIG_TRAF2_1	420	423	PF00917	0.640
LIG_TRAF2_1	497	500	PF00917	0.588
LIG_TRAF2_1	93	96	PF00917	0.493
LIG_UBA3_1	584	589	PF00899	0.564
LIG_WRC_WIRS_1	287	292	PF05994	0.641
MOD_CDC14_SPxK_1	186	189	PF00782	0.651
MOD_CDC14_SPxK_1	364	367	PF00782	0.652
MOD_CDC14_SPxK_1	414	417	PF00782	0.648
MOD_CDK_SPK_2	166	171	PF00069	0.686
MOD_CDK_SPK_2	558	563	PF00069	0.491
MOD_CDK_SPxK_1	183	189	PF00069	0.649
MOD_CDK_SPxK_1	361	367	PF00069	0.655
MOD_CDK_SPxK_1	411	417	PF00069	0.635
MOD_CK1_1	117	123	PF00069	0.629
MOD_CK1_1	158	164	PF00069	0.613
MOD_CK1_1	169	175	PF00069	0.669
MOD_CK1_1	203	209	PF00069	0.619
MOD_CK1_1	3	9	PF00069	0.620
MOD_CK1_1	323	329	PF00069	0.599
MOD_CK1_1	373	379	PF00069	0.605
MOD_CK1_1	381	387	PF00069	0.509
MOD_CK1_1	429	435	PF00069	0.661
MOD_CK1_1	453	459	PF00069	0.720
MOD_CK1_1	466	472	PF00069	0.636
MOD_CK1_1	558	564	PF00069	0.638
MOD_CK1_1	637	643	PF00069	0.734
MOD_CK1_1	68	74	PF00069	0.563
MOD_CK1_1	714	720	PF00069	0.615
MOD_CK1_1	820	826	PF00069	0.604
MOD_CK1_1	828	834	PF00069	0.565
MOD_CK1_1	90	96	PF00069	0.482
MOD_CK2_1	136	142	PF00069	0.613
MOD_CK2_1	203	209	PF00069	0.654
MOD_CK2_1	308	314	PF00069	0.583
MOD_CK2_1	472	478	PF00069	0.664
MOD_CK2_1	493	499	PF00069	0.550
MOD_CK2_1	649	655	PF00069	0.646
MOD_CK2_1	89	95	PF00069	0.567
MOD_GlcNHglycan	12	16	PF01048	0.621
MOD_GlcNHglycan	2	5	PF01048	0.614
MOD_GlcNHglycan	205	208	PF01048	0.830
MOD_GlcNHglycan	241	244	PF01048	0.724
MOD_GlcNHglycan	344	347	PF01048	0.644
MOD_GlcNHglycan	357	360	PF01048	0.563
MOD_GlcNHglycan	391	394	PF01048	0.531
MOD_GlcNHglycan	428	431	PF01048	0.691
MOD_GlcNHglycan	602	605	PF01048	0.660
MOD_GlcNHglycan	612	615	PF01048	0.699
MOD_GlcNHglycan	623	626	PF01048	0.516
MOD_GlcNHglycan	675	678	PF01048	0.689
MOD_GlcNHglycan	722	727	PF01048	0.812
MOD_GlcNHglycan	777	780	PF01048	0.636
MOD_GlcNHglycan	791	794	PF01048	0.515
MOD_GlcNHglycan	8	11	PF01048	0.633
MOD_GlcNHglycan	811	815	PF01048	0.592
MOD_GSK3_1	110	117	PF00069	0.558
MOD_GSK3_1	151	158	PF00069	0.678
MOD_GSK3_1	166	173	PF00069	0.631
MOD_GSK3_1	179	186	PF00069	0.781
MOD_GSK3_1	224	231	PF00069	0.784
MOD_GSK3_1	250	257	PF00069	0.741
MOD_GSK3_1	355	362	PF00069	0.609
MOD_GSK3_1	429	436	PF00069	0.722
MOD_GSK3_1	452	459	PF00069	0.699
MOD_GSK3_1	463	470	PF00069	0.590
MOD_GSK3_1	569	576	PF00069	0.577
MOD_GSK3_1	6	13	PF00069	0.628
MOD_GSK3_1	610	617	PF00069	0.649
MOD_GSK3_1	671	678	PF00069	0.629
MOD_GSK3_1	744	751	PF00069	0.577
MOD_GSK3_1	800	807	PF00069	0.641
MOD_GSK3_1	817	824	PF00069	0.575
MOD_N-GLC_1	151	156	PF02516	0.640
MOD_N-GLC_1	179	184	PF02516	0.633
MOD_N-GLC_1	389	394	PF02516	0.666
MOD_N-GLC_2	730	732	PF02516	0.662
MOD_NEK2_1	151	156	PF00069	0.680
MOD_NEK2_1	179	184	PF00069	0.689
MOD_NEK2_1	224	229	PF00069	0.624
MOD_NEK2_1	286	291	PF00069	0.665
MOD_NEK2_1	389	394	PF00069	0.492
MOD_NEK2_1	452	457	PF00069	0.624
MOD_NEK2_1	506	511	PF00069	0.570
MOD_NEK2_1	547	552	PF00069	0.484
MOD_NEK2_1	610	615	PF00069	0.778
MOD_NEK2_1	648	653	PF00069	0.704
MOD_NEK2_2	43	48	PF00069	0.625
MOD_NEK2_2	524	529	PF00069	0.491
MOD_NMyristoyl	1	7	PF02799	0.620
MOD_PIKK_1	209	215	PF00454	0.714
MOD_PIKK_1	463	469	PF00454	0.567
MOD_PIKK_1	753	759	PF00454	0.558
MOD_PIKK_1	828	834	PF00454	0.545
MOD_PKA_1	262	268	PF00069	0.593
MOD_PKA_1	569	575	PF00069	0.486
MOD_PKA_1	711	717	PF00069	0.630
MOD_PKA_1	87	93	PF00069	0.503
MOD_PKA_2	170	176	PF00069	0.634
MOD_PKA_2	209	215	PF00069	0.643
MOD_PKA_2	262	268	PF00069	0.593
MOD_PKA_2	334	340	PF00069	0.688
MOD_PKA_2	373	379	PF00069	0.644
MOD_PKA_2	580	586	PF00069	0.596
MOD_PKA_2	608	614	PF00069	0.617
MOD_PKA_2	711	717	PF00069	0.634
MOD_PKA_2	87	93	PF00069	0.503
MOD_Plk_1	381	387	PF00069	0.562
MOD_Plk_1	817	823	PF00069	0.673
MOD_Plk_2-3	308	314	PF00069	0.564
MOD_Plk_4	110	116	PF00069	0.569
MOD_Plk_4	170	176	PF00069	0.754
MOD_Plk_4	224	230	PF00069	0.613
MOD_Plk_4	323	329	PF00069	0.599
MOD_Plk_4	397	403	PF00069	0.381
MOD_Plk_4	524	530	PF00069	0.491
MOD_Plk_4	539	545	PF00069	0.531
MOD_Plk_4	555	561	PF00069	0.378
MOD_Plk_4	580	586	PF00069	0.595
MOD_Plk_4	649	655	PF00069	0.598
MOD_ProDKin_1	155	161	PF00069	0.655
MOD_ProDKin_1	166	172	PF00069	0.683
MOD_ProDKin_1	183	189	PF00069	0.492
MOD_ProDKin_1	250	256	PF00069	0.717
MOD_ProDKin_1	318	324	PF00069	0.678
MOD_ProDKin_1	361	367	PF00069	0.655
MOD_ProDKin_1	411	417	PF00069	0.659
MOD_ProDKin_1	434	440	PF00069	0.751
MOD_ProDKin_1	447	453	PF00069	0.536
MOD_ProDKin_1	493	499	PF00069	0.683
MOD_ProDKin_1	558	564	PF00069	0.485
MOD_ProDKin_1	675	681	PF00069	0.654
MOD_SUMO_for_1	695	698	PF00179	0.577
MOD_SUMO_rev_2	499	509	PF00179	0.515
MOD_SUMO_rev_2	68	78	PF00179	0.509
MOD_SUMO_rev_2	778	785	PF00179	0.632
MOD_SUMO_rev_2	820	829	PF00179	0.629
TRG_DiLeu_BaEn_1	130	135	PF01217	0.753
TRG_DiLeu_BaLyEn_6	133	138	PF01217	0.600
TRG_ENDOCYTIC_2	24	27	PF00928	0.661
TRG_ENDOCYTIC_2	476	479	PF00928	0.538
TRG_ER_diArg_1	263	266	PF00400	0.624
TRG_ER_diArg_1	367	370	PF00400	0.598
TRG_ER_diArg_1	383	386	PF00400	0.482
TRG_ER_diArg_1	47	49	PF00400	0.561
TRG_ER_diArg_1	711	713	PF00400	0.647
TRG_NES_CRM1_1	371	382	PF08389	0.509
TRG_NES_CRM1_1	534	548	PF08389	0.466
TRG_NLS_Bipartite_1	72	90	PF00514	0.576
TRG_NLS_MonoExtC_3	261	266	PF00514	0.584
TRG_NLS_MonoExtC_3	568	573	PF00514	0.423
TRG_NLS_MonoExtC_3	82	87	PF00514	0.586
TRG_NLS_MonoExtN_4	259	266	PF00514	0.590
TRG_NLS_MonoExtN_4	569	574	PF00514	0.483
TRG_NLS_MonoExtN_4	83	90	PF00514	0.590

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0G6	Leptomonas seymouri	34%	100%
A4HYW9	Leishmania infantum	98%	100%
E9AII1	Leishmania braziliensis	56%	93%
E9AUR6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	99%
Q4QCS0	Leishmania major	84%	99%