Ring finger domain containing protein, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ring finger domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IAL8_LEIDO

TriTrypDb:

LdBPK_170450.1 , LdCL_170010000 , LDHU3_17.0740

Length:

1057

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IAL8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IAL8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	509	513	PF00656	0.744
CLV_C14_Caspase3-7	608	612	PF00656	0.771
CLV_C14_Caspase3-7	866	870	PF00656	0.581
CLV_C14_Caspase3-7	9	13	PF00656	0.478
CLV_C14_Caspase3-7	93	97	PF00656	0.751
CLV_C14_Caspase3-7	966	970	PF00656	0.604
CLV_NRD_NRD_1	196	198	PF00675	0.779
CLV_NRD_NRD_1	291	293	PF00675	0.566
CLV_NRD_NRD_1	488	490	PF00675	0.770
CLV_NRD_NRD_1	52	54	PF00675	0.587
CLV_NRD_NRD_1	606	608	PF00675	0.785
CLV_NRD_NRD_1	713	715	PF00675	0.688
CLV_NRD_NRD_1	85	87	PF00675	0.714
CLV_PCSK_FUR_1	291	295	PF00082	0.721
CLV_PCSK_FUR_1	83	87	PF00082	0.637
CLV_PCSK_KEX2_1	195	197	PF00082	0.824
CLV_PCSK_KEX2_1	241	243	PF00082	0.734
CLV_PCSK_KEX2_1	291	293	PF00082	0.564
CLV_PCSK_KEX2_1	381	383	PF00082	0.597
CLV_PCSK_KEX2_1	45	47	PF00082	0.551
CLV_PCSK_KEX2_1	487	489	PF00082	0.771
CLV_PCSK_KEX2_1	52	54	PF00082	0.567
CLV_PCSK_KEX2_1	606	608	PF00082	0.785
CLV_PCSK_KEX2_1	713	715	PF00082	0.688
CLV_PCSK_KEX2_1	85	87	PF00082	0.714
CLV_PCSK_PC1ET2_1	241	243	PF00082	0.734
CLV_PCSK_PC1ET2_1	293	295	PF00082	0.629
CLV_PCSK_PC1ET2_1	381	383	PF00082	0.608
CLV_PCSK_PC1ET2_1	45	47	PF00082	0.600
CLV_PCSK_SKI1_1	1040	1044	PF00082	0.634
CLV_PCSK_SKI1_1	29	33	PF00082	0.704
CLV_PCSK_SKI1_1	378	382	PF00082	0.707
CLV_PCSK_SKI1_1	401	405	PF00082	0.572
CLV_PCSK_SKI1_1	458	462	PF00082	0.627
CLV_PCSK_SKI1_1	551	555	PF00082	0.733
CLV_PCSK_SKI1_1	886	890	PF00082	0.660
CLV_PCSK_SKI1_1	978	982	PF00082	0.556
CLV_Separin_Metazoa	427	431	PF03568	0.648
DEG_APCC_DBOX_1	28	36	PF00400	0.690
DEG_Nend_UBRbox_3	1	3	PF02207	0.721
DEG_ODPH_VHL_1	616	627	PF01847	0.736
DEG_SCF_TRCP1_1	722	727	PF00400	0.728
DEG_SPOP_SBC_1	225	229	PF00917	0.686
DOC_ANK_TNKS_1	7	14	PF00023	0.472
DOC_CKS1_1	113	118	PF01111	0.774
DOC_CYCLIN_RxL_1	241	252	PF00134	0.729
DOC_CYCLIN_RxL_1	26	34	PF00134	0.619
DOC_CYCLIN_yCln2_LP_2	692	698	PF00134	0.702
DOC_CYCLIN_yCln2_LP_2	767	773	PF00134	0.631
DOC_CYCLIN_yCln2_LP_2	912	918	PF00134	0.383
DOC_MAPK_gen_1	241	250	PF00069	0.736
DOC_MAPK_gen_1	378	388	PF00069	0.626
DOC_MAPK_MEF2A_6	381	388	PF00069	0.610
DOC_MAPK_RevD_3	30	45	PF00069	0.592
DOC_MAPK_RevD_3	698	714	PF00069	0.696
DOC_PP1_RVXF_1	711	718	PF00149	0.578
DOC_PP2B_LxvP_1	767	770	PF13499	0.640
DOC_PP2B_LxvP_1	845	848	PF13499	0.569
DOC_PP2B_LxvP_1	981	984	PF13499	0.595
DOC_PP4_FxxP_1	113	116	PF00568	0.771
DOC_PP4_FxxP_1	163	166	PF00568	0.734
DOC_PP4_FxxP_1	553	556	PF00568	0.743
DOC_PP4_MxPP_1	477	480	PF00568	0.702
DOC_USP7_MATH_1	123	127	PF00917	0.839
DOC_USP7_MATH_1	134	138	PF00917	0.841
DOC_USP7_MATH_1	327	331	PF00917	0.697
DOC_USP7_MATH_1	348	352	PF00917	0.740
DOC_USP7_MATH_1	81	85	PF00917	0.771
DOC_USP7_UBL2_3	660	664	PF12436	0.703
DOC_WW_Pin1_4	1050	1055	PF00397	0.769
DOC_WW_Pin1_4	112	117	PF00397	0.756
DOC_WW_Pin1_4	138	143	PF00397	0.659
DOC_WW_Pin1_4	162	167	PF00397	0.733
DOC_WW_Pin1_4	207	212	PF00397	0.713
DOC_WW_Pin1_4	504	509	PF00397	0.792
DOC_WW_Pin1_4	570	575	PF00397	0.560
DOC_WW_Pin1_4	576	581	PF00397	0.518
DOC_WW_Pin1_4	665	670	PF00397	0.577
DOC_WW_Pin1_4	802	807	PF00397	0.508
DOC_WW_Pin1_4	911	916	PF00397	0.383
LIG_14-3-3_CanoR_1	1040	1049	PF00244	0.547
LIG_14-3-3_CanoR_1	279	285	PF00244	0.588
LIG_14-3-3_CanoR_1	430	439	PF00244	0.583
LIG_14-3-3_CanoR_1	606	610	PF00244	0.785
LIG_14-3-3_CanoR_1	713	718	PF00244	0.568
LIG_14-3-3_CanoR_1	780	785	PF00244	0.465
LIG_14-3-3_CanoR_1	957	965	PF00244	0.567
LIG_Actin_WH2_2	381	398	PF00022	0.704
LIG_AP2alpha_1	609	613	PF02296	0.769
LIG_BIR_III_2	315	319	PF00653	0.592
LIG_BIR_III_4	184	188	PF00653	0.665
LIG_CtBP_PxDLS_1	442	446	PF00389	0.753
LIG_deltaCOP1_diTrp_1	257	262	PF00928	0.481
LIG_EH1_1	470	478	PF00400	0.611
LIG_eIF4E_1	16	22	PF01652	0.711
LIG_EVH1_1	845	849	PF00568	0.669
LIG_EVH1_2	109	113	PF00568	0.711
LIG_FHA_1	309	315	PF00498	0.685
LIG_FHA_1	677	683	PF00498	0.690
LIG_FHA_1	795	801	PF00498	0.593
LIG_FHA_1	836	842	PF00498	0.738
LIG_FHA_2	15	21	PF00498	0.582
LIG_FHA_2	179	185	PF00498	0.676
LIG_FHA_2	556	562	PF00498	0.617
LIG_FHA_2	586	592	PF00498	0.505
LIG_FHA_2	606	612	PF00498	0.718
LIG_FHA_2	864	870	PF00498	0.562
LIG_FHA_2	91	97	PF00498	0.721
LIG_FHA_2	964	970	PF00498	0.684
LIG_LIR_Apic_2	111	116	PF02991	0.766
LIG_LIR_Apic_2	161	166	PF02991	0.734
LIG_LIR_Apic_2	959	964	PF02991	0.661
LIG_LIR_Gen_1	405	412	PF02991	0.630
LIG_LIR_Gen_1	611	620	PF02991	0.652
LIG_LIR_Gen_1	716	725	PF02991	0.536
LIG_LIR_Nem_3	1027	1032	PF02991	0.518
LIG_LIR_Nem_3	275	281	PF02991	0.686
LIG_LIR_Nem_3	405	410	PF02991	0.516
LIG_LIR_Nem_3	437	441	PF02991	0.625
LIG_LIR_Nem_3	611	616	PF02991	0.661
LIG_LIR_Nem_3	716	720	PF02991	0.505
LIG_LIR_Nem_3	746	750	PF02991	0.519
LIG_Pex14_1	258	262	PF04695	0.510
LIG_Pex14_2	3	7	PF04695	0.691
LIG_Pex14_2	460	464	PF04695	0.567
LIG_Pex14_2	609	613	PF04695	0.769
LIG_Rb_LxCxE_1	596	611	PF01857	0.716
LIG_SH2_CRK	287	291	PF00017	0.705
LIG_SH2_CRK	407	411	PF00017	0.623
LIG_SH2_CRK	961	965	PF00017	0.652
LIG_SH2_GRB2like	1017	1020	PF00017	0.572
LIG_SH2_NCK_1	251	255	PF00017	0.507
LIG_SH2_STAP1	407	411	PF00017	0.623
LIG_SH2_STAP1	739	743	PF00017	0.652
LIG_SH2_STAT5	16	19	PF00017	0.655
LIG_SH2_STAT5	277	280	PF00017	0.588
LIG_SH2_STAT5	301	304	PF00017	0.752
LIG_SH2_STAT5	328	331	PF00017	0.714
LIG_SH2_STAT5	375	378	PF00017	0.716
LIG_SH3_3	103	109	PF00018	0.791
LIG_SH3_3	113	119	PF00018	0.662
LIG_SH3_3	137	143	PF00018	0.728
LIG_SH3_3	311	317	PF00018	0.593
LIG_SH3_3	383	389	PF00018	0.718
LIG_SH3_3	436	442	PF00018	0.620
LIG_SH3_3	477	483	PF00018	0.792
LIG_SH3_3	502	508	PF00018	0.625
LIG_SH3_3	843	849	PF00018	0.687
LIG_SUMO_SIM_anti_2	624	630	PF11976	0.725
LIG_SUMO_SIM_anti_2	677	682	PF11976	0.579
LIG_SUMO_SIM_anti_2	797	802	PF11976	0.593
LIG_TRAF2_1	306	309	PF00917	0.683
LIG_TRAF2_1	788	791	PF00917	0.561
LIG_TYR_ITIM	285	290	PF00017	0.700
LIG_UBA3_1	284	293	PF00899	0.708
MOD_CDK_SPK_2	207	212	PF00069	0.713
MOD_CDK_SPxxK_3	576	583	PF00069	0.630
MOD_CK1_1	111	117	PF00069	0.774
MOD_CK1_1	165	171	PF00069	0.745
MOD_CK1_1	178	184	PF00069	0.732
MOD_CK1_1	223	229	PF00069	0.801
MOD_CK1_1	330	336	PF00069	0.692
MOD_CK1_1	506	512	PF00069	0.754
MOD_CK1_1	84	90	PF00069	0.632
MOD_CK1_1	863	869	PF00069	0.617
MOD_CK2_1	14	20	PF00069	0.645
MOD_CK2_1	348	354	PF00069	0.777
MOD_CK2_1	520	526	PF00069	0.738
MOD_CK2_1	528	534	PF00069	0.717
MOD_CK2_1	555	561	PF00069	0.619
MOD_CK2_1	585	591	PF00069	0.501
MOD_CK2_1	61	67	PF00069	0.813
MOD_CK2_1	618	624	PF00069	0.630
MOD_CK2_1	784	790	PF00069	0.577
MOD_Cter_Amidation	193	196	PF01082	0.674
MOD_GlcNHglycan	100	103	PF01048	0.803
MOD_GlcNHglycan	159	163	PF01048	0.782
MOD_GlcNHglycan	184	188	PF01048	0.788
MOD_GlcNHglycan	223	226	PF01048	0.808
MOD_GlcNHglycan	54	57	PF01048	0.634
MOD_GlcNHglycan	543	546	PF01048	0.758
MOD_GlcNHglycan	722	725	PF01048	0.687
MOD_GlcNHglycan	786	789	PF01048	0.505
MOD_GlcNHglycan	823	827	PF01048	0.682
MOD_GSK3_1	1018	1025	PF00069	0.633
MOD_GSK3_1	1036	1043	PF00069	0.415
MOD_GSK3_1	1050	1057	PF00069	0.579
MOD_GSK3_1	108	115	PF00069	0.808
MOD_GSK3_1	123	130	PF00069	0.593
MOD_GSK3_1	134	141	PF00069	0.838
MOD_GSK3_1	158	165	PF00069	0.760
MOD_GSK3_1	175	182	PF00069	0.552
MOD_GSK3_1	219	226	PF00069	0.809
MOD_GSK3_1	326	333	PF00069	0.729
MOD_GSK3_1	344	351	PF00069	0.492
MOD_GSK3_1	402	409	PF00069	0.598
MOD_GSK3_1	430	437	PF00069	0.495
MOD_GSK3_1	499	506	PF00069	0.772
MOD_GSK3_1	720	727	PF00069	0.721
MOD_GSK3_1	780	787	PF00069	0.470
MOD_GSK3_1	859	866	PF00069	0.571
MOD_N-GLC_1	1018	1023	PF02516	0.560
MOD_N-GLC_1	499	504	PF02516	0.854
MOD_N-GLC_1	859	864	PF02516	0.560
MOD_N-GLC_2	951	953	PF02516	0.411
MOD_NEK2_1	1036	1041	PF00069	0.567
MOD_NEK2_1	150	155	PF00069	0.809
MOD_NEK2_1	31	36	PF00069	0.608
MOD_NEK2_1	326	331	PF00069	0.718
MOD_NEK2_1	395	400	PF00069	0.584
MOD_NEK2_1	402	407	PF00069	0.616
MOD_NEK2_1	690	695	PF00069	0.587
MOD_NEK2_1	971	976	PF00069	0.631
MOD_PIKK_1	108	114	PF00454	0.806
MOD_PIKK_1	618	624	PF00454	0.654
MOD_PK_1	780	786	PF00069	0.495
MOD_PKA_1	52	58	PF00069	0.627
MOD_PKA_1	713	719	PF00069	0.669
MOD_PKA_2	198	204	PF00069	0.764
MOD_PKA_2	219	225	PF00069	0.621
MOD_PKA_2	395	401	PF00069	0.657
MOD_PKA_2	52	58	PF00069	0.689
MOD_PKA_2	605	611	PF00069	0.781
MOD_PKA_2	713	719	PF00069	0.669
MOD_PKA_2	774	780	PF00069	0.550
MOD_PKA_2	84	90	PF00069	0.819
MOD_PKA_2	854	860	PF00069	0.548
MOD_PKA_2	956	962	PF00069	0.571
MOD_PKB_1	197	205	PF00069	0.745
MOD_Plk_1	676	682	PF00069	0.570
MOD_Plk_1	794	800	PF00069	0.604
MOD_Plk_1	859	865	PF00069	0.588
MOD_Plk_2-3	127	133	PF00069	0.637
MOD_Plk_2-3	605	611	PF00069	0.781
MOD_Plk_4	1006	1012	PF00069	0.493
MOD_Plk_4	280	286	PF00069	0.702
MOD_Plk_4	406	412	PF00069	0.525
MOD_Plk_4	471	477	PF00069	0.666
MOD_Plk_4	512	518	PF00069	0.739
MOD_Plk_4	593	599	PF00069	0.635
MOD_Plk_4	676	682	PF00069	0.578
MOD_Plk_4	743	749	PF00069	0.575
MOD_Plk_4	780	786	PF00069	0.420
MOD_Plk_4	860	866	PF00069	0.601
MOD_ProDKin_1	1050	1056	PF00069	0.768
MOD_ProDKin_1	112	118	PF00069	0.757
MOD_ProDKin_1	138	144	PF00069	0.660
MOD_ProDKin_1	162	168	PF00069	0.730
MOD_ProDKin_1	207	213	PF00069	0.712
MOD_ProDKin_1	504	510	PF00069	0.793
MOD_ProDKin_1	570	576	PF00069	0.558
MOD_ProDKin_1	665	671	PF00069	0.570
MOD_ProDKin_1	802	808	PF00069	0.514
MOD_ProDKin_1	911	917	PF00069	0.383
MOD_SUMO_rev_2	351	358	PF00179	0.642
MOD_SUMO_rev_2	377	383	PF00179	0.644
TRG_DiLeu_BaEn_1	677	682	PF01217	0.579
TRG_DiLeu_BaLyEn_6	171	176	PF01217	0.787
TRG_DiLeu_BaLyEn_6	753	758	PF01217	0.595
TRG_ENDOCYTIC_2	1030	1033	PF00928	0.513
TRG_ENDOCYTIC_2	287	290	PF00928	0.700
TRG_ENDOCYTIC_2	407	410	PF00928	0.510
TRG_ENDOCYTIC_2	807	810	PF00928	0.632
TRG_ENDOCYTIC_2	977	980	PF00928	0.555
TRG_ER_diArg_1	195	197	PF00400	0.819
TRG_ER_diArg_1	290	292	PF00400	0.551
TRG_ER_diArg_1	302	305	PF00400	0.602
TRG_ER_diArg_1	393	396	PF00400	0.685
TRG_ER_diArg_1	486	489	PF00400	0.804
TRG_ER_diArg_1	52	54	PF00400	0.651
TRG_ER_diArg_1	713	715	PF00400	0.688
TRG_ER_diArg_1	83	86	PF00400	0.637
TRG_NES_CRM1_1	624	638	PF08389	0.748
TRG_NES_CRM1_1	836	851	PF08389	0.709
TRG_Pf-PMV_PEXEL_1	463	467	PF00026	0.581
TRG_Pf-PMV_PEXEL_1	52	57	PF00026	0.666

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5H8	Leptomonas seymouri	38%	100%
A4H8Y3	Leishmania braziliensis	73%	100%
A4HXB3	Leishmania infantum	99%	100%
E9AR09	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4QEF4	Leishmania major	89%	100%