DNAj-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

DNAj-like protein

Gene product:

DNAj-like protein

Species:

Leishmania donovani

UniProt:

A0A3Q8IAL4_LEIDO

TriTrypDb:

LdBPK_201150.1 , LdCL_200016200 , LDHU3_20.1420

Length:

653

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IAL4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IAL4

Function

Biological processes
Term	Name	Level	Count
GO:0006450	regulation of translational fidelity	3	11
GO:0006457	protein folding	2	11
GO:0006458	'de novo' protein folding	3	11
GO:0009987	cellular process	1	11
GO:0051083	'de novo' cotranslational protein folding	4	11
GO:0065007	biological regulation	1	11
GO:0065008	regulation of biological quality	2	11

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0005515	protein binding	2	11
GO:0030544	Hsp70 protein binding	4	11
GO:0031072	heat shock protein binding	3	11
GO:0043021	ribonucleoprotein complex binding	3	11
GO:0043022	ribosome binding	4	11
GO:0044877	protein-containing complex binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	89	93	PF00656	0.673
CLV_NRD_NRD_1	121	123	PF00675	0.551
CLV_NRD_NRD_1	161	163	PF00675	0.279
CLV_NRD_NRD_1	300	302	PF00675	0.397
CLV_NRD_NRD_1	314	316	PF00675	0.414
CLV_NRD_NRD_1	324	326	PF00675	0.441
CLV_NRD_NRD_1	353	355	PF00675	0.448
CLV_NRD_NRD_1	358	360	PF00675	0.463
CLV_NRD_NRD_1	410	412	PF00675	0.397
CLV_NRD_NRD_1	441	443	PF00675	0.521
CLV_PCSK_FUR_1	320	324	PF00082	0.414
CLV_PCSK_FUR_1	408	412	PF00082	0.489
CLV_PCSK_KEX2_1	160	162	PF00082	0.278
CLV_PCSK_KEX2_1	285	287	PF00082	0.424
CLV_PCSK_KEX2_1	300	302	PF00082	0.422
CLV_PCSK_KEX2_1	305	307	PF00082	0.375
CLV_PCSK_KEX2_1	322	324	PF00082	0.377
CLV_PCSK_KEX2_1	331	333	PF00082	0.452
CLV_PCSK_KEX2_1	352	354	PF00082	0.472
CLV_PCSK_KEX2_1	410	412	PF00082	0.421
CLV_PCSK_KEX2_1	441	443	PF00082	0.521
CLV_PCSK_PC1ET2_1	285	287	PF00082	0.406
CLV_PCSK_PC1ET2_1	305	307	PF00082	0.440
CLV_PCSK_PC1ET2_1	331	333	PF00082	0.462
CLV_PCSK_PC7_1	301	307	PF00082	0.470
CLV_PCSK_PC7_1	320	326	PF00082	0.367
CLV_PCSK_SKI1_1	125	129	PF00082	0.419
CLV_PCSK_SKI1_1	331	335	PF00082	0.513
CLV_PCSK_SKI1_1	431	435	PF00082	0.466
CLV_PCSK_SKI1_1	540	544	PF00082	0.487
CLV_PCSK_SKI1_1	613	617	PF00082	0.424
CLV_PCSK_SKI1_1	626	630	PF00082	0.386
CLV_PCSK_SKI1_1	634	638	PF00082	0.346
CLV_Separin_Metazoa	250	254	PF03568	0.479
DEG_Nend_UBRbox_3	1	3	PF02207	0.635
DOC_MAPK_gen_1	122	129	PF00069	0.448
DOC_MAPK_gen_1	305	311	PF00069	0.501
DOC_MAPK_gen_1	337	346	PF00069	0.526
DOC_PP1_RVXF_1	14	21	PF00149	0.676
DOC_USP7_MATH_1	197	201	PF00917	0.253
DOC_USP7_MATH_1	559	563	PF00917	0.527
DOC_USP7_MATH_1	582	586	PF00917	0.665
DOC_USP7_MATH_1	593	597	PF00917	0.721
DOC_USP7_UBL2_3	12	16	PF12436	0.655
DOC_USP7_UBL2_3	124	128	PF12436	0.438
DOC_USP7_UBL2_3	528	532	PF12436	0.416
DOC_USP7_UBL2_3	619	623	PF12436	0.421
DOC_WW_Pin1_4	243	248	PF00397	0.516
DOC_WW_Pin1_4	396	401	PF00397	0.541
DOC_WW_Pin1_4	580	585	PF00397	0.661
LIG_14-3-3_CanoR_1	116	126	PF00244	0.606
LIG_14-3-3_CanoR_1	549	558	PF00244	0.439
LIG_BIR_III_2	206	210	PF00653	0.517
LIG_BIR_III_2	35	39	PF00653	0.562
LIG_BRCT_BRCA1_1	200	204	PF00533	0.407
LIG_Clathr_ClatBox_1	273	277	PF01394	0.487
LIG_deltaCOP1_diTrp_1	256	264	PF00928	0.352
LIG_FHA_1	339	345	PF00498	0.337
LIG_FHA_1	399	405	PF00498	0.432
LIG_FHA_1	563	569	PF00498	0.451
LIG_FHA_1	61	67	PF00498	0.497
LIG_FHA_2	164	170	PF00498	0.278
LIG_FHA_2	517	523	PF00498	0.505
LIG_FHA_2	633	639	PF00498	0.489
LIG_LIR_Gen_1	137	144	PF02991	0.278
LIG_LIR_Gen_1	217	226	PF02991	0.340
LIG_LIR_Gen_1	246	255	PF02991	0.490
LIG_LIR_Gen_1	266	274	PF02991	0.263
LIG_LIR_Gen_1	539	548	PF02991	0.411
LIG_LIR_Gen_1	622	631	PF02991	0.377
LIG_LIR_Gen_1	638	646	PF02991	0.360
LIG_LIR_Nem_3	137	142	PF02991	0.284
LIG_LIR_Nem_3	176	182	PF02991	0.278
LIG_LIR_Nem_3	217	222	PF02991	0.360
LIG_LIR_Nem_3	246	251	PF02991	0.424
LIG_LIR_Nem_3	256	261	PF02991	0.326
LIG_LIR_Nem_3	263	267	PF02991	0.291
LIG_LIR_Nem_3	45	50	PF02991	0.621
LIG_LIR_Nem_3	539	544	PF02991	0.370
LIG_LIR_Nem_3	622	627	PF02991	0.374
LIG_LIR_Nem_3	638	643	PF02991	0.350
LIG_PCNA_PIPBox_1	383	392	PF02747	0.424
LIG_PCNA_yPIPBox_3	376	390	PF02747	0.433
LIG_Pex14_1	43	47	PF04695	0.613
LIG_Pex14_2	218	222	PF04695	0.351
LIG_Pex14_2	254	258	PF04695	0.329
LIG_SH2_CRK	47	51	PF00017	0.601
LIG_SH2_SRC	248	251	PF00017	0.497
LIG_SH2_STAP1	248	252	PF00017	0.414
LIG_SH3_3	233	239	PF00018	0.496
LIG_SH3_3	406	412	PF00018	0.390
LIG_Sin3_3	465	472	PF02671	0.496
LIG_SUMO_SIM_par_1	2	7	PF11976	0.658
LIG_SUMO_SIM_par_1	272	279	PF11976	0.482
LIG_TRAF2_1	347	350	PF00917	0.480
LIG_TRAF2_1	514	517	PF00917	0.570
LIG_TRAF2_1	87	90	PF00917	0.628
LIG_TYR_ITSM	244	251	PF00017	0.510
LIG_WRC_WIRS_1	219	224	PF05994	0.435
MOD_CDK_SPxxK_3	396	403	PF00069	0.547
MOD_CK1_1	240	246	PF00069	0.480
MOD_CK1_1	419	425	PF00069	0.474
MOD_CK1_1	562	568	PF00069	0.565
MOD_CK1_1	585	591	PF00069	0.685
MOD_CK2_1	592	598	PF00069	0.615
MOD_CK2_1	632	638	PF00069	0.501
MOD_GlcNHglycan	572	575	PF01048	0.583
MOD_GlcNHglycan	587	590	PF01048	0.652
MOD_GSK3_1	256	263	PF00069	0.477
MOD_GSK3_1	418	425	PF00069	0.424
MOD_GSK3_1	56	63	PF00069	0.574
MOD_GSK3_1	570	577	PF00069	0.581
MOD_GSK3_1	585	592	PF00069	0.655
MOD_N-GLC_1	172	177	PF02516	0.356
MOD_N-GLC_1	422	427	PF02516	0.560
MOD_N-GLC_1	598	603	PF02516	0.570
MOD_NEK2_1	218	223	PF00069	0.426
MOD_NEK2_1	418	423	PF00069	0.541
MOD_NEK2_1	56	61	PF00069	0.573
MOD_NEK2_1	645	650	PF00069	0.449
MOD_PIKK_1	20	26	PF00454	0.680
MOD_PIKK_1	61	67	PF00454	0.584
MOD_PK_1	231	237	PF00069	0.483
MOD_PKA_1	230	236	PF00069	0.389
MOD_PKA_2	256	262	PF00069	0.462
MOD_PKA_2	338	344	PF00069	0.335
MOD_PKA_2	550	556	PF00069	0.557
MOD_Plk_1	265	271	PF00069	0.375
MOD_Plk_1	276	282	PF00069	0.424
MOD_Plk_1	521	527	PF00069	0.452
MOD_Plk_1	598	604	PF00069	0.444
MOD_Plk_2-3	148	154	PF00069	0.298
MOD_ProDKin_1	243	249	PF00069	0.516
MOD_ProDKin_1	396	402	PF00069	0.542
MOD_ProDKin_1	580	586	PF00069	0.661
MOD_SUMO_for_1	142	145	PF00179	0.403
MOD_SUMO_rev_2	297	307	PF00179	0.528
MOD_SUMO_rev_2	326	333	PF00179	0.538
MOD_SUMO_rev_2	363	369	PF00179	0.483
TRG_DiLeu_BaEn_1	391	396	PF01217	0.511
TRG_DiLeu_BaEn_2	640	646	PF01217	0.489
TRG_DiLeu_BaEn_4	328	334	PF01217	0.443
TRG_DiLeu_BaLyEn_6	305	310	PF01217	0.494
TRG_ENDOCYTIC_2	139	142	PF00928	0.278
TRG_ENDOCYTIC_2	248	251	PF00928	0.497
TRG_ENDOCYTIC_2	47	50	PF00928	0.606
TRG_ER_diArg_1	159	162	PF00400	0.278
TRG_ER_diArg_1	306	309	PF00400	0.419
TRG_ER_diArg_1	319	322	PF00400	0.486
TRG_ER_diArg_1	323	325	PF00400	0.372
TRG_ER_diArg_1	352	354	PF00400	0.442
TRG_ER_diArg_1	408	411	PF00400	0.428
TRG_ER_diArg_1	441	444	PF00400	0.616
TRG_ER_diArg_1	548	551	PF00400	0.542
TRG_NES_CRM1_1	176	191	PF08389	0.357
TRG_NLS_MonoCore_2	121	126	PF00514	0.606
TRG_NLS_MonoExtN_4	122	127	PF00514	0.481
TRG_Pf-PMV_PEXEL_1	308	312	PF00026	0.419
TRG_Pf-PMV_PEXEL_1	334	338	PF00026	0.525
TRG_Pf-PMV_PEXEL_1	613	617	PF00026	0.424

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILT7	Leptomonas seymouri	73%	100%
A0A0S4KI36	Bodo saltans	48%	100%
A0A1X0NWB2	Trypanosomatidae	50%	97%
A0A422NLR6	Trypanosoma rangeli	53%	100%
A4HYV5	Leishmania infantum	100%	100%
C9ZID5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
E9AIG2	Leishmania braziliensis	86%	100%
E9AUQ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
P54103	Mus musculus	26%	100%
Q1RMH9	Bos taurus	27%	100%
Q4QCT3	Leishmania major	96%	100%
Q4R8H2	Macaca fascicularis	27%	100%
Q6NWJ4	Danio rerio	25%	100%
Q7TQ20	Rattus norvegicus	28%	100%
Q99543	Homo sapiens	27%	100%