LeishMANIAdb
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Eukaryotic translation initiation factor 4 gamma, putative

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Eukaryotic translation initiation factor 4 gamma, putative
Gene product:
eukaryotic translation initiation factor 4 gamma 3
Species:
Leishmania donovani
UniProt:
A0A3Q8IAL0_LEIDO
TriTrypDb:
LdBPK_161700.1 * , LdCL_160022000 , LDHU3_16.2020
Length:
635

Annotations

LeishMANIAdb interaction annotations

by homology
Contact email: opmn@cpqam.biocruz.br
Publication title: Translation initiation in Leishmania major: characterisation of multiple eIF4F subunit homologues
Publication 1st author(s): Dhalia
Publication Identifier(s): 15694484
Host organism: -1
Interaction detection method(s): pull down
Interaction type: physical association
Identification method participant A: autoradiography
Identification method participant B: autoradiography
ID(s) interactor A: P60842
ID(s) interactor B: Q4QEK5
Taxid interactor A: Homo sapiens
Taxid interactor B: Leishmania major
Biological role(s) interactor A: unspecified role
Biological role(s) interactor B: unspecified role
Experimental role(s) interactor A: bait

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 12
NetGPI no yes: 0, no: 12
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0010494 cytoplasmic stress granule 5 1
GO:0016281 eukaryotic translation initiation factor 4F complex 2 1
GO:0032991 protein-containing complex 1 1
GO:0035770 ribonucleoprotein granule 3 1
GO:0036464 cytoplasmic ribonucleoprotein granule 4 1
GO:0043226 organelle 2 1
GO:0043228 non-membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043232 intracellular non-membrane-bounded organelle 4 1
GO:0099080 supramolecular complex 2 1
GO:0110165 cellular anatomical entity 1 2
GO:0016020 membrane 2 1

Expansion

Sequence features

A0A3Q8IAL0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IAL0

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 13
GO:0003723 RNA binding 4 13
GO:0003743 translation initiation factor activity 4 13
GO:0005488 binding 1 13
GO:0008135 translation factor activity, RNA binding 3 13
GO:0045182 translation regulator activity 1 13
GO:0090079 translation regulator activity, nucleic acid binding 2 13
GO:0097159 organic cyclic compound binding 2 13
GO:1901363 heterocyclic compound binding 2 13
GO:0003729 mRNA binding 5 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 329 333 PF00656 0.630
CLV_C14_Caspase3-7 456 460 PF00656 0.448
CLV_NRD_NRD_1 182 184 PF00675 0.232
CLV_NRD_NRD_1 281 283 PF00675 0.237
CLV_NRD_NRD_1 32 34 PF00675 0.490
CLV_NRD_NRD_1 456 458 PF00675 0.480
CLV_PCSK_FUR_1 182 186 PF00082 0.277
CLV_PCSK_FUR_1 30 34 PF00082 0.524
CLV_PCSK_KEX2_1 182 184 PF00082 0.231
CLV_PCSK_KEX2_1 283 285 PF00082 0.432
CLV_PCSK_KEX2_1 30 32 PF00082 0.435
CLV_PCSK_PC1ET2_1 184 186 PF00082 0.248
CLV_PCSK_PC1ET2_1 283 285 PF00082 0.595
CLV_PCSK_SKI1_1 103 107 PF00082 0.283
CLV_PCSK_SKI1_1 251 255 PF00082 0.314
CLV_PCSK_SKI1_1 291 295 PF00082 0.679
CLV_PCSK_SKI1_1 306 310 PF00082 0.614
CLV_PCSK_SKI1_1 32 36 PF00082 0.551
CLV_PCSK_SKI1_1 462 466 PF00082 0.430
CLV_PCSK_SKI1_1 81 85 PF00082 0.333
CLV_Separin_Metazoa 27 31 PF03568 0.480
DEG_APCC_DBOX_1 567 575 PF00400 0.522
DEG_Nend_UBRbox_3 1 3 PF02207 0.623
DEG_SPOP_SBC_1 344 348 PF00917 0.703
DEG_SPOP_SBC_1 368 372 PF00917 0.611
DEG_SPOP_SBC_1 452 456 PF00917 0.411
DOC_CYCLIN_RxL_1 81 92 PF00134 0.447
DOC_MAPK_gen_1 182 190 PF00069 0.426
DOC_MAPK_gen_1 270 278 PF00069 0.446
DOC_MAPK_MEF2A_6 388 397 PF00069 0.625
DOC_PP1_RVXF_1 268 274 PF00149 0.426
DOC_PP2B_LxvP_1 16 19 PF13499 0.487
DOC_SPAK_OSR1_1 272 276 PF12202 0.477
DOC_USP7_MATH_1 109 113 PF00917 0.474
DOC_USP7_MATH_1 324 328 PF00917 0.697
DOC_USP7_MATH_1 344 348 PF00917 0.735
DOC_USP7_MATH_1 383 387 PF00917 0.776
DOC_USP7_MATH_1 486 490 PF00917 0.310
DOC_USP7_MATH_1 541 545 PF00917 0.387
DOC_USP7_MATH_1 557 561 PF00917 0.392
DOC_USP7_UBL2_3 160 164 PF12436 0.464
DOC_USP7_UBL2_3 81 85 PF12436 0.527
DOC_WW_Pin1_4 358 363 PF00397 0.676
DOC_WW_Pin1_4 389 394 PF00397 0.656
DOC_WW_Pin1_4 537 542 PF00397 0.431
LIG_14-3-3_CanoR_1 138 147 PF00244 0.499
LIG_14-3-3_CanoR_1 214 222 PF00244 0.470
LIG_14-3-3_CanoR_1 251 257 PF00244 0.402
LIG_14-3-3_CanoR_1 31 40 PF00244 0.484
LIG_14-3-3_CanoR_1 355 362 PF00244 0.688
LIG_14-3-3_CanoR_1 403 408 PF00244 0.377
LIG_14-3-3_CanoR_1 505 510 PF00244 0.369
LIG_14-3-3_CanoR_1 532 536 PF00244 0.357
LIG_14-3-3_CanoR_1 593 599 PF00244 0.356
LIG_Actin_WH2_2 115 133 PF00022 0.578
LIG_APCC_ABBAyCdc20_2 520 526 PF00400 0.466
LIG_BH_BH3_1 226 242 PF00452 0.470
LIG_BRCT_BRCA1_1 202 206 PF00533 0.524
LIG_Clathr_ClatBox_1 397 401 PF01394 0.511
LIG_DLG_GKlike_1 505 512 PF00625 0.488
LIG_Dynein_DLC8_1 31 37 PF01221 0.502
LIG_EH1_1 272 280 PF00400 0.446
LIG_FHA_1 35 41 PF00498 0.510
LIG_FHA_1 364 370 PF00498 0.768
LIG_FHA_1 414 420 PF00498 0.556
LIG_FHA_1 82 88 PF00498 0.445
LIG_FHA_2 205 211 PF00498 0.502
LIG_FHA_2 234 240 PF00498 0.484
LIG_FHA_2 252 258 PF00498 0.341
LIG_FHA_2 454 460 PF00498 0.385
LIG_FHA_2 511 517 PF00498 0.441
LIG_FHA_2 52 58 PF00498 0.402
LIG_FHA_2 559 565 PF00498 0.575
LIG_GBD_Chelix_1 487 495 PF00786 0.385
LIG_Integrin_isoDGR_2 353 355 PF01839 0.648
LIG_LIR_Gen_1 174 181 PF02991 0.415
LIG_LIR_Gen_1 203 213 PF02991 0.537
LIG_LIR_Gen_1 250 259 PF02991 0.477
LIG_LIR_Gen_1 463 473 PF02991 0.342
LIG_LIR_Gen_1 504 512 PF02991 0.353
LIG_LIR_Gen_1 534 541 PF02991 0.438
LIG_LIR_Gen_1 551 559 PF02991 0.367
LIG_LIR_Gen_1 610 617 PF02991 0.451
LIG_LIR_LC3C_4 466 470 PF02991 0.464
LIG_LIR_Nem_3 112 118 PF02991 0.436
LIG_LIR_Nem_3 154 158 PF02991 0.561
LIG_LIR_Nem_3 17 23 PF02991 0.432
LIG_LIR_Nem_3 174 180 PF02991 0.341
LIG_LIR_Nem_3 250 256 PF02991 0.446
LIG_LIR_Nem_3 463 468 PF02991 0.317
LIG_LIR_Nem_3 477 483 PF02991 0.263
LIG_LIR_Nem_3 534 538 PF02991 0.379
LIG_LIR_Nem_3 551 556 PF02991 0.366
LIG_LIR_Nem_3 610 615 PF02991 0.449
LIG_NRBOX 229 235 PF00104 0.502
LIG_NRBOX 586 592 PF00104 0.470
LIG_PCNA_TLS_4 246 253 PF02747 0.481
LIG_PCNA_yPIPBox_3 415 424 PF02747 0.535
LIG_PCNA_yPIPBox_3 584 593 PF02747 0.460
LIG_Pex14_1 423 427 PF04695 0.355
LIG_Pex14_2 502 506 PF04695 0.312
LIG_PTB_Apo_2 96 103 PF02174 0.531
LIG_SH2_CRK 115 119 PF00017 0.426
LIG_SH2_SRC 15 18 PF00017 0.487
LIG_SH2_STAP1 125 129 PF00017 0.502
LIG_SH2_STAT5 15 18 PF00017 0.487
LIG_SH2_STAT5 195 198 PF00017 0.502
LIG_SH2_STAT5 252 255 PF00017 0.446
LIG_SH2_STAT5 524 527 PF00017 0.397
LIG_SH3_1 15 21 PF00018 0.521
LIG_SH3_3 15 21 PF00018 0.531
LIG_SH3_3 260 266 PF00018 0.495
LIG_SH3_3 390 396 PF00018 0.608
LIG_SH3_3 553 559 PF00018 0.434
LIG_SUMO_SIM_anti_2 223 231 PF11976 0.486
LIG_SUMO_SIM_anti_2 570 576 PF11976 0.521
LIG_TRAF2_1 169 172 PF00917 0.483
LIG_TRAF2_1 515 518 PF00917 0.620
LIG_TRAF2_1 54 57 PF00917 0.461
LIG_TRAF2_1 561 564 PF00917 0.617
LIG_TYR_ITIM 533 538 PF00017 0.405
LIG_UBA3_1 275 283 PF00899 0.460
LIG_UBA3_1 78 85 PF00899 0.452
LIG_WRC_WIRS_1 549 554 PF05994 0.484
LIG_WW_3 267 271 PF00397 0.477
MOD_CK1_1 216 222 PF00069 0.527
MOD_CK1_1 358 364 PF00069 0.675
MOD_CK1_1 451 457 PF00069 0.574
MOD_CK2_1 160 166 PF00069 0.452
MOD_CK2_1 21 27 PF00069 0.436
MOD_CK2_1 251 257 PF00069 0.569
MOD_CK2_1 433 439 PF00069 0.516
MOD_CK2_1 486 492 PF00069 0.331
MOD_CK2_1 51 57 PF00069 0.398
MOD_CK2_1 510 516 PF00069 0.437
MOD_CK2_1 557 563 PF00069 0.560
MOD_GlcNHglycan 321 324 PF01048 0.622
MOD_GlcNHglycan 358 361 PF01048 0.674
MOD_GlcNHglycan 371 374 PF01048 0.630
MOD_GlcNHglycan 450 453 PF01048 0.509
MOD_GlcNHglycan 484 487 PF01048 0.302
MOD_GlcNHglycan 488 491 PF01048 0.293
MOD_GlcNHglycan 542 546 PF01048 0.565
MOD_GSK3_1 156 163 PF00069 0.514
MOD_GSK3_1 200 207 PF00069 0.555
MOD_GSK3_1 209 216 PF00069 0.510
MOD_GSK3_1 363 370 PF00069 0.735
MOD_GSK3_1 373 380 PF00069 0.724
MOD_GSK3_1 448 455 PF00069 0.438
MOD_GSK3_1 48 55 PF00069 0.442
MOD_GSK3_1 482 489 PF00069 0.440
MOD_GSK3_1 512 519 PF00069 0.514
MOD_GSK3_1 537 544 PF00069 0.533
MOD_N-GLC_1 364 369 PF02516 0.717
MOD_N-GLC_2 428 430 PF02516 0.506
MOD_NEK2_1 200 205 PF00069 0.477
MOD_NEK2_1 209 214 PF00069 0.477
MOD_NEK2_1 233 238 PF00069 0.446
MOD_NEK2_1 34 39 PF00069 0.518
MOD_NEK2_1 369 374 PF00069 0.614
MOD_NEK2_1 510 515 PF00069 0.414
MOD_NEK2_1 531 536 PF00069 0.411
MOD_NEK2_1 63 68 PF00069 0.530
MOD_NEK2_2 383 388 PF00069 0.548
MOD_PIKK_1 138 144 PF00454 0.479
MOD_PIKK_1 32 38 PF00454 0.498
MOD_PKA_1 183 189 PF00069 0.525
MOD_PKA_1 32 38 PF00069 0.465
MOD_PKA_2 213 219 PF00069 0.470
MOD_PKA_2 32 38 PF00069 0.502
MOD_PKA_2 510 516 PF00069 0.436
MOD_PKA_2 531 537 PF00069 0.471
MOD_PKB_1 30 38 PF00069 0.474
MOD_Plk_1 209 215 PF00069 0.537
MOD_Plk_1 364 370 PF00069 0.714
MOD_Plk_1 541 547 PF00069 0.405
MOD_Plk_2-3 166 172 PF00069 0.460
MOD_Plk_4 201 207 PF00069 0.429
MOD_Plk_4 403 409 PF00069 0.434
MOD_Plk_4 505 511 PF00069 0.457
MOD_Plk_4 545 551 PF00069 0.375
MOD_Plk_4 594 600 PF00069 0.422
MOD_ProDKin_1 358 364 PF00069 0.675
MOD_ProDKin_1 389 395 PF00069 0.648
MOD_ProDKin_1 537 543 PF00069 0.432
MOD_SUMO_for_1 398 401 PF00179 0.566
MOD_SUMO_rev_2 161 169 PF00179 0.470
MOD_SUMO_rev_2 300 308 PF00179 0.645
MOD_SUMO_rev_2 72 77 PF00179 0.559
TRG_DiLeu_BaEn_1 225 230 PF01217 0.470
TRG_DiLeu_BaEn_2 462 468 PF01217 0.314
TRG_DiLeu_BaEn_3 72 78 PF01217 0.447
TRG_DiLeu_BaLyEn_6 58 63 PF01217 0.378
TRG_ENDOCYTIC_2 115 118 PF00928 0.428
TRG_ENDOCYTIC_2 20 23 PF00928 0.432
TRG_ENDOCYTIC_2 535 538 PF00928 0.332
TRG_ER_diArg_1 181 183 PF00400 0.442
TRG_ER_diArg_1 269 272 PF00400 0.455
TRG_ER_diArg_1 281 284 PF00400 0.428
TRG_ER_diArg_1 29 32 PF00400 0.476
TRG_NES_CRM1_1 547 562 PF08389 0.586
TRG_NES_CRM1_1 607 619 PF08389 0.507
TRG_NLS_MonoExtN_4 182 187 PF00514 0.448
TRG_Pf-PMV_PEXEL_1 104 108 PF00026 0.226
TRG_Pf-PMV_PEXEL_1 156 161 PF00026 0.270
TRG_Pf-PMV_PEXEL_1 189 193 PF00026 0.337
TRG_Pf-PMV_PEXEL_1 32 36 PF00026 0.479

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PDA5 Leptomonas seymouri 66% 100%
A0A0S4IUF0 Bodo saltans 33% 98%
A0A0S4KJH6 Bodo saltans 24% 100%
A0A1X0NZC7 Trypanosomatidae 41% 100%
A0A422NEE1 Trypanosoma rangeli 42% 100%
A4H8T8 Leishmania braziliensis 91% 100%
A4HX58 Leishmania infantum 100% 100%
C9ZVT3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 40% 100%
E9AQX3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 95% 100%
Q4QEK5 Leishmania major 96% 100%
V5DJ79 Trypanosoma cruzi 43% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS