Cilia- and flagella-associated protein 206

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IAK5_LEIDO

TriTrypDb:

LdBPK_170260.1 , LdCL_170008100 , LDHU3_17.0500

Length:

707

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	9
GO:0005856	cytoskeleton	5	8
GO:0005929	cilium	4	8
GO:0042995	cell projection	2	8
GO:0043226	organelle	2	8
GO:0043227	membrane-bounded organelle	3	8
GO:0043228	non-membrane-bounded organelle	3	8
GO:0043229	intracellular organelle	3	8
GO:0043232	intracellular non-membrane-bounded organelle	4	8
GO:0110165	cellular anatomical entity	1	9
GO:0120025	plasma membrane bounded cell projection	3	8
GO:0005815	microtubule organizing center	2	1
GO:0005930	axoneme	2	1
GO:0036064	ciliary basal body	3	1

Expansion

Sequence features

A0A3Q8IAK5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IAK5

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	9
GO:0016043	cellular component organization	3	9
GO:0030030	cell projection organization	4	9
GO:0071840	cellular component organization or biogenesis	2	9
GO:0003352	regulation of cilium movement	6	1
GO:0003356	regulation of cilium beat frequency	7	1
GO:0032886	regulation of microtubule-based process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0060632	regulation of microtubule-based movement	5	1
GO:0065007	biological regulation	1	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	364	368	PF00656	0.446
CLV_NRD_NRD_1	201	203	PF00675	0.358
CLV_NRD_NRD_1	522	524	PF00675	0.539
CLV_NRD_NRD_1	630	632	PF00675	0.380
CLV_NRD_NRD_1	655	657	PF00675	0.534
CLV_NRD_NRD_1	664	666	PF00675	0.562
CLV_NRD_NRD_1	701	703	PF00675	0.540
CLV_NRD_NRD_1	94	96	PF00675	0.443
CLV_PCSK_KEX2_1	201	203	PF00082	0.371
CLV_PCSK_KEX2_1	522	524	PF00082	0.539
CLV_PCSK_KEX2_1	630	632	PF00082	0.380
CLV_PCSK_KEX2_1	655	657	PF00082	0.571
CLV_PCSK_KEX2_1	94	96	PF00082	0.359
CLV_PCSK_SKI1_1	255	259	PF00082	0.434
CLV_PCSK_SKI1_1	356	360	PF00082	0.521
CLV_PCSK_SKI1_1	387	391	PF00082	0.470
CLV_PCSK_SKI1_1	631	635	PF00082	0.390
CLV_Separin_Metazoa	574	578	PF03568	0.465
DEG_APCC_DBOX_1	74	82	PF00400	0.424
DEG_Nend_UBRbox_2	1	3	PF02207	0.402
DEG_SCF_FBW7_2	229	235	PF00400	0.469
DEG_SPOP_SBC_1	502	506	PF00917	0.458
DOC_CKS1_1	229	234	PF01111	0.464
DOC_CYCLIN_RxL_1	252	262	PF00134	0.487
DOC_CYCLIN_RxL_1	522	536	PF00134	0.471
DOC_CYCLIN_RxL_1	571	582	PF00134	0.502
DOC_MAPK_DCC_7	440	449	PF00069	0.408
DOC_MAPK_gen_1	107	115	PF00069	0.461
DOC_MAPK_gen_1	201	209	PF00069	0.360
DOC_MAPK_gen_1	440	449	PF00069	0.505
DOC_MAPK_gen_1	450	457	PF00069	0.535
DOC_MAPK_gen_1	630	636	PF00069	0.389
DOC_MAPK_MEF2A_6	107	115	PF00069	0.443
DOC_MAPK_MEF2A_6	440	449	PF00069	0.408
DOC_PP1_RVXF_1	199	206	PF00149	0.323
DOC_PP1_RVXF_1	353	360	PF00149	0.519
DOC_PP1_RVXF_1	526	533	PF00149	0.425
DOC_PP2B_LxvP_1	492	495	PF13499	0.484
DOC_USP7_MATH_1	118	122	PF00917	0.537
DOC_USP7_MATH_1	23	27	PF00917	0.516
DOC_USP7_MATH_1	308	312	PF00917	0.519
DOC_USP7_MATH_1	331	335	PF00917	0.665
DOC_USP7_MATH_1	389	393	PF00917	0.498
DOC_USP7_MATH_1	419	423	PF00917	0.539
DOC_USP7_MATH_1	502	506	PF00917	0.633
DOC_USP7_UBL2_3	103	107	PF12436	0.541
DOC_WW_Pin1_4	228	233	PF00397	0.512
DOC_WW_Pin1_4	257	262	PF00397	0.370
DOC_WW_Pin1_4	338	343	PF00397	0.639
DOC_WW_Pin1_4	503	508	PF00397	0.678
LIG_14-3-3_CanoR_1	387	396	PF00244	0.526
LIG_14-3-3_CanoR_1	643	652	PF00244	0.477
LIG_14-3-3_CanoR_1	691	701	PF00244	0.442
LIG_14-3-3_CanoR_1	75	79	PF00244	0.503
LIG_Actin_WH2_2	81	96	PF00022	0.439
LIG_AP2alpha_2	546	548	PF02296	0.382
LIG_Clathr_ClatBox_1	119	123	PF01394	0.497
LIG_deltaCOP1_diTrp_1	130	140	PF00928	0.431
LIG_eIF4E_1	277	283	PF01652	0.399
LIG_eIF4E_1	478	484	PF01652	0.331
LIG_FHA_1	181	187	PF00498	0.524
LIG_FHA_1	260	266	PF00498	0.521
LIG_FHA_1	27	33	PF00498	0.368
LIG_FHA_1	487	493	PF00498	0.497
LIG_FHA_1	589	595	PF00498	0.655
LIG_FHA_1	609	615	PF00498	0.529
LIG_FHA_1	647	653	PF00498	0.483
LIG_FHA_1	693	699	PF00498	0.457
LIG_FHA_1	81	87	PF00498	0.308
LIG_FHA_2	225	231	PF00498	0.481
LIG_FHA_2	401	407	PF00498	0.459
LIG_FHA_2	658	664	PF00498	0.557
LIG_GBD_Chelix_1	586	594	PF00786	0.713
LIG_HCF-1_HBM_1	619	622	PF13415	0.484
LIG_KLC1_Yacidic_2	578	582	PF13176	0.441
LIG_LIR_Gen_1	130	141	PF02991	0.431
LIG_LIR_Gen_1	275	283	PF02991	0.436
LIG_LIR_Nem_3	130	136	PF02991	0.372
LIG_LIR_Nem_3	275	280	PF02991	0.439
LIG_LIR_Nem_3	546	551	PF02991	0.367
LIG_NRBOX	31	37	PF00104	0.417
LIG_NRBOX	68	74	PF00104	0.411
LIG_Pex14_2	623	627	PF04695	0.511
LIG_SH2_CRK	309	313	PF00017	0.438
LIG_SH2_CRK	478	482	PF00017	0.434
LIG_SH2_SRC	550	553	PF00017	0.447
LIG_SH2_SRC	580	583	PF00017	0.467
LIG_SH2_SRC	617	620	PF00017	0.540
LIG_SH2_STAP1	309	313	PF00017	0.380
LIG_SH2_STAP1	396	400	PF00017	0.538
LIG_SH2_STAP1	694	698	PF00017	0.480
LIG_SH2_STAT3	15	18	PF00017	0.483
LIG_SH2_STAT5	478	481	PF00017	0.430
LIG_SH2_STAT5	531	534	PF00017	0.487
LIG_SH2_STAT5	550	553	PF00017	0.282
LIG_SH2_STAT5	580	583	PF00017	0.394
LIG_SH2_STAT5	617	620	PF00017	0.513
LIG_SH2_STAT5	622	625	PF00017	0.480
LIG_SH2_STAT5	686	689	PF00017	0.444
LIG_SH2_STAT5	694	697	PF00017	0.482
LIG_SH2_STAT5	71	74	PF00017	0.358
LIG_SH3_3	226	232	PF00018	0.504
LIG_SH3_3	258	264	PF00018	0.461
LIG_SH3_3	302	308	PF00018	0.493
LIG_SH3_3	354	360	PF00018	0.467
LIG_SH3_3	413	419	PF00018	0.576
LIG_SH3_3	496	502	PF00018	0.498
LIG_TRAF2_1	404	407	PF00917	0.518
LIG_TRAF2_1	96	99	PF00917	0.440
LIG_UBA3_1	35	43	PF00899	0.402
MOD_CDC14_SPxK_1	506	509	PF00782	0.537
MOD_CDK_SPxK_1	503	509	PF00069	0.539
MOD_CK1_1	149	155	PF00069	0.624
MOD_CK1_1	159	165	PF00069	0.634
MOD_CK1_1	171	177	PF00069	0.435
MOD_CK1_1	224	230	PF00069	0.428
MOD_CK1_1	26	32	PF00069	0.419
MOD_CK1_1	334	340	PF00069	0.663
MOD_CK1_1	436	442	PF00069	0.456
MOD_CK1_1	500	506	PF00069	0.679
MOD_CK1_1	508	514	PF00069	0.532
MOD_CK1_1	592	598	PF00069	0.536
MOD_CK1_1	606	612	PF00069	0.594
MOD_CK1_1	646	652	PF00069	0.476
MOD_CK1_1	77	83	PF00069	0.444
MOD_CK2_1	162	168	PF00069	0.538
MOD_CK2_1	400	406	PF00069	0.421
MOD_CK2_1	693	699	PF00069	0.480
MOD_CK2_1	93	99	PF00069	0.519
MOD_CMANNOS	624	627	PF00535	0.386
MOD_GlcNHglycan	127	130	PF01048	0.476
MOD_GlcNHglycan	151	154	PF01048	0.592
MOD_GlcNHglycan	158	161	PF01048	0.570
MOD_GlcNHglycan	170	173	PF01048	0.405
MOD_GlcNHglycan	25	28	PF01048	0.532
MOD_GlcNHglycan	333	336	PF01048	0.677
MOD_GlcNHglycan	337	340	PF01048	0.707
MOD_GlcNHglycan	391	394	PF01048	0.565
MOD_GlcNHglycan	421	424	PF01048	0.592
MOD_GlcNHglycan	516	520	PF01048	0.538
MOD_GlcNHglycan	595	598	PF01048	0.525
MOD_GlcNHglycan	695	698	PF01048	0.453
MOD_GSK3_1	142	149	PF00069	0.469
MOD_GSK3_1	158	165	PF00069	0.622
MOD_GSK3_1	221	228	PF00069	0.475
MOD_GSK3_1	330	337	PF00069	0.589
MOD_GSK3_1	396	403	PF00069	0.406
MOD_GSK3_1	456	463	PF00069	0.555
MOD_GSK3_1	497	504	PF00069	0.624
MOD_GSK3_1	588	595	PF00069	0.508
MOD_GSK3_1	665	672	PF00069	0.700
MOD_GSK3_1	89	96	PF00069	0.475
MOD_NEK2_1	223	228	PF00069	0.439
MOD_NEK2_1	381	386	PF00069	0.359
MOD_NEK2_1	515	520	PF00069	0.331
MOD_NEK2_1	690	695	PF00069	0.460
MOD_PIKK_1	606	612	PF00454	0.549
MOD_PIKK_1	644	650	PF00454	0.474
MOD_PIKK_1	657	663	PF00454	0.541
MOD_PIKK_1	675	681	PF00454	0.574
MOD_PKA_1	665	671	PF00069	0.575
MOD_PKA_2	251	257	PF00069	0.440
MOD_PKA_2	486	492	PF00069	0.537
MOD_PKA_2	588	594	PF00069	0.640
MOD_PKA_2	603	609	PF00069	0.646
MOD_PKA_2	690	696	PF00069	0.468
MOD_PKA_2	74	80	PF00069	0.429
MOD_PKA_2	93	99	PF00069	0.446
MOD_Plk_1	396	402	PF00069	0.472
MOD_Plk_1	535	541	PF00069	0.258
MOD_Plk_4	308	314	PF00069	0.388
MOD_Plk_4	381	387	PF00069	0.377
MOD_Plk_4	54	60	PF00069	0.460
MOD_Plk_4	563	569	PF00069	0.396
MOD_Plk_4	613	619	PF00069	0.580
MOD_ProDKin_1	228	234	PF00069	0.516
MOD_ProDKin_1	257	263	PF00069	0.371
MOD_ProDKin_1	338	344	PF00069	0.643
MOD_ProDKin_1	503	509	PF00069	0.674
MOD_SUMO_for_1	106	109	PF00179	0.457
MOD_SUMO_for_1	238	241	PF00179	0.396
MOD_SUMO_for_1	273	276	PF00179	0.414
MOD_SUMO_rev_2	235	240	PF00179	0.468
TRG_DiLeu_BaEn_1	276	281	PF01217	0.389
TRG_DiLeu_BaEn_1	315	320	PF01217	0.401
TRG_DiLeu_BaEn_1	429	434	PF01217	0.463
TRG_DiLeu_BaEn_4	406	412	PF01217	0.426
TRG_ENDOCYTIC_2	144	147	PF00928	0.445
TRG_ENDOCYTIC_2	277	280	PF00928	0.427
TRG_ENDOCYTIC_2	309	312	PF00928	0.468
TRG_ENDOCYTIC_2	478	481	PF00928	0.430
TRG_ENDOCYTIC_2	531	534	PF00928	0.398
TRG_ER_diArg_1	200	202	PF00400	0.369
TRG_ER_diArg_1	440	443	PF00400	0.529
TRG_ER_diArg_1	522	524	PF00400	0.518
TRG_ER_diArg_1	629	631	PF00400	0.376
TRG_ER_diArg_1	654	656	PF00400	0.520
TRG_ER_diArg_1	93	95	PF00400	0.310
TRG_NES_CRM1_1	199	213	PF08389	0.454
TRG_NES_CRM1_1	31	44	PF08389	0.434
TRG_Pf-PMV_PEXEL_1	577	582	PF00026	0.449

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWJ8	Leptomonas seymouri	60%	96%
A0A0S4J344	Bodo saltans	29%	100%
A0A1X0NSZ8	Trypanosomatidae	36%	100%
A1A5Q4	Rattus norvegicus	24%	100%
A4H8W4	Leishmania braziliensis	81%	100%
C9ZTV6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
Q23H79	Tetrahymena thermophila (strain SB210)	21%	100%
Q29RL1	Bos taurus	22%	100%
Q4QEH3	Leishmania major	94%	100%
Q6PE87	Mus musculus	24%	100%
Q8IYR0	Homo sapiens	23%	100%
Q95JU3	Macaca fascicularis	23%	100%
V5BH83	Trypanosoma cruzi	35%	100%