Iron-sulfur assembly protein 1, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Iron-sulfur assembly protein 1, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IAJ0_LEIDO

TriTrypDb:

LdBPK_160830.1 , LdCL_160013600 , LDHU3_16.1000

Length:

293

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IAJ0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IAJ0

Function

Biological processes
Term	Name	Level	Count
GO:0006790	sulfur compound metabolic process	3	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016043	cellular component organization	3	11
GO:0016226	iron-sulfur cluster assembly	4	11
GO:0022607	cellular component assembly	4	11
GO:0031163	metallo-sulfur cluster assembly	5	11
GO:0044237	cellular metabolic process	2	11
GO:0071840	cellular component organization or biogenesis	2	11
GO:0006807	nitrogen compound metabolic process	2	1
GO:0019538	protein metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044238	primary metabolic process	2	1
GO:0051604	protein maturation	4	1
GO:0071704	organic substance metabolic process	2	1
GO:0097428	protein maturation by iron-sulfur cluster transfer	5	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0051536	iron-sulfur cluster binding	3	11
GO:0051540	metal cluster binding	2	11
GO:0051537	2 iron, 2 sulfur cluster binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	153	155	PF00675	0.447
CLV_NRD_NRD_1	193	195	PF00675	0.236
CLV_NRD_NRD_1	220	222	PF00675	0.275
CLV_PCSK_KEX2_1	134	136	PF00082	0.447
CLV_PCSK_KEX2_1	153	155	PF00082	0.340
CLV_PCSK_KEX2_1	17	19	PF00082	0.536
CLV_PCSK_KEX2_1	192	194	PF00082	0.237
CLV_PCSK_PC1ET2_1	134	136	PF00082	0.560
CLV_PCSK_PC1ET2_1	17	19	PF00082	0.514
CLV_PCSK_PC7_1	188	194	PF00082	0.249
CLV_PCSK_SKI1_1	142	146	PF00082	0.422
CLV_PCSK_SKI1_1	153	157	PF00082	0.406
CLV_PCSK_SKI1_1	17	21	PF00082	0.719
CLV_PCSK_SKI1_1	215	219	PF00082	0.267
DEG_COP1_1	177	187	PF00400	0.400
DEG_Nend_UBRbox_3	1	3	PF02207	0.538
DEG_SCF_TRCP1_1	43	49	PF00400	0.540
DEG_SPOP_SBC_1	28	32	PF00917	0.680
DOC_CKS1_1	146	151	PF01111	0.457
DOC_CYCLIN_RxL_1	14	23	PF00134	0.541
DOC_CYCLIN_RxL_1	153	163	PF00134	0.481
DOC_PP1_RVXF_1	133	140	PF00149	0.497
DOC_PP2B_LxvP_1	106	109	PF13499	0.513
DOC_PP4_FxxP_1	267	270	PF00568	0.436
DOC_USP7_MATH_1	113	117	PF00917	0.556
DOC_USP7_MATH_1	174	178	PF00917	0.663
DOC_USP7_MATH_1	210	214	PF00917	0.509
DOC_USP7_MATH_1	217	221	PF00917	0.532
DOC_USP7_MATH_1	46	50	PF00917	0.683
DOC_USP7_MATH_1	95	99	PF00917	0.711
DOC_USP7_UBL2_3	264	268	PF12436	0.482
DOC_USP7_UBL2_3	63	67	PF12436	0.601
DOC_WW_Pin1_4	127	132	PF00397	0.460
DOC_WW_Pin1_4	145	150	PF00397	0.350
DOC_WW_Pin1_4	170	175	PF00397	0.557
DOC_WW_Pin1_4	215	220	PF00397	0.531
DOC_WW_Pin1_4	69	74	PF00397	0.714
LIG_BIR_III_2	120	124	PF00653	0.626
LIG_FHA_1	1	7	PF00498	0.544
LIG_FHA_1	56	62	PF00498	0.596
LIG_FHA_1	69	75	PF00498	0.662
LIG_FHA_2	250	256	PF00498	0.436
LIG_FHA_2	257	263	PF00498	0.436
LIG_LIR_Apic_2	266	270	PF02991	0.436
LIG_LIR_Apic_2	77	81	PF02991	0.588
LIG_LIR_LC3C_4	228	232	PF02991	0.465
LIG_LIR_Nem_3	244	250	PF02991	0.492
LIG_LIR_Nem_3	280	285	PF02991	0.377
LIG_SH2_CRK	162	166	PF00017	0.331
LIG_SH2_CRK	62	66	PF00017	0.608
LIG_SH2_SRC	248	251	PF00017	0.436
LIG_SH2_STAP1	199	203	PF00017	0.436
LIG_SH2_STAT5	157	160	PF00017	0.342
LIG_SH2_STAT5	201	204	PF00017	0.436
LIG_SH2_STAT5	206	209	PF00017	0.436
LIG_SH2_STAT5	248	251	PF00017	0.436
LIG_SH2_STAT5	256	259	PF00017	0.436
LIG_SH3_3	143	149	PF00018	0.564
LIG_SxIP_EBH_1	67	79	PF03271	0.577
LIG_TRFH_1	145	149	PF08558	0.347
MOD_CDK_SPxK_1	215	221	PF00069	0.513
MOD_CDK_SPxxK_3	127	134	PF00069	0.454
MOD_CDK_SPxxK_3	215	222	PF00069	0.482
MOD_CDK_SPxxK_3	69	76	PF00069	0.615
MOD_CK1_1	177	183	PF00069	0.530
MOD_CK1_1	197	203	PF00069	0.383
MOD_CK1_1	38	44	PF00069	0.762
MOD_CK1_1	49	55	PF00069	0.635
MOD_CK2_1	113	119	PF00069	0.557
MOD_CK2_1	256	262	PF00069	0.534
MOD_CK2_1	74	80	PF00069	0.630
MOD_DYRK1A_RPxSP_1	127	131	PF00069	0.444
MOD_GlcNHglycan	166	169	PF01048	0.551
MOD_GlcNHglycan	184	187	PF01048	0.165
MOD_GlcNHglycan	196	199	PF01048	0.202
MOD_GlcNHglycan	208	211	PF01048	0.236
MOD_GlcNHglycan	212	215	PF01048	0.236
MOD_GlcNHglycan	43	46	PF01048	0.670
MOD_GlcNHglycan	48	51	PF01048	0.684
MOD_GlcNHglycan	90	93	PF01048	0.608
MOD_GlcNHglycan	97	100	PF01048	0.543
MOD_GSK3_1	160	167	PF00069	0.443
MOD_GSK3_1	170	177	PF00069	0.497
MOD_GSK3_1	206	213	PF00069	0.504
MOD_GSK3_1	28	35	PF00069	0.651
MOD_GSK3_1	48	55	PF00069	0.513
MOD_N-GLC_1	36	41	PF02516	0.749
MOD_N-GLC_1	46	51	PF02516	0.524
MOD_NEK2_1	1	6	PF00069	0.665
MOD_NEK2_1	19	24	PF00069	0.736
MOD_NEK2_1	61	66	PF00069	0.684
MOD_PIKK_1	55	61	PF00454	0.614
MOD_PKA_2	113	119	PF00069	0.552
MOD_PKA_2	39	45	PF00069	0.632
MOD_PKA_2	68	74	PF00069	0.667
MOD_PKB_1	192	200	PF00069	0.449
MOD_Plk_1	52	58	PF00069	0.500
MOD_Plk_4	1	7	PF00069	0.567
MOD_Plk_4	278	284	PF00069	0.518
MOD_ProDKin_1	127	133	PF00069	0.457
MOD_ProDKin_1	145	151	PF00069	0.342
MOD_ProDKin_1	170	176	PF00069	0.559
MOD_ProDKin_1	215	221	PF00069	0.531
MOD_ProDKin_1	69	75	PF00069	0.716
TRG_ENDOCYTIC_2	162	165	PF00928	0.329
TRG_ENDOCYTIC_2	62	65	PF00928	0.675
TRG_ER_diArg_1	152	154	PF00400	0.358
TRG_ER_diArg_1	191	194	PF00400	0.449
TRG_ER_diArg_1	83	86	PF00400	0.596

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6U6	Leptomonas seymouri	66%	100%
A0A1X0NZ22	Trypanosomatidae	60%	100%
A0A422NDJ9	Trypanosoma rangeli	51%	100%
A4H8K7	Leishmania braziliensis	78%	100%
A4HWY0	Leishmania infantum	100%	100%
C9ZW24	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9AQP2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QET6	Leishmania major	93%	100%
V5BHL1	Trypanosoma cruzi	47%	91%