Ribosomal RNA-processing protein 8

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ribosomal RNA-processing protein 8, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IAH5_LEIDO

TriTrypDb:

LdBPK_200490.1 , LdCL_200009600 , LDHU3_20.0580

Length:

372

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	12
GO:0043226	organelle	2	12
GO:0043228	non-membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043232	intracellular non-membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

A0A3Q8IAH5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IAH5

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006364	rRNA processing	8	12
GO:0006396	RNA processing	6	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0016072	rRNA metabolic process	7	12
GO:0032259	methylation	2	12
GO:0034470	ncRNA processing	7	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034660	ncRNA metabolic process	6	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0008168	methyltransferase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016741	transferase activity, transferring one-carbon groups	3	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	122	124	PF00675	0.505
CLV_NRD_NRD_1	201	203	PF00675	0.311
CLV_NRD_NRD_1	314	316	PF00675	0.333
CLV_NRD_NRD_1	48	50	PF00675	0.710
CLV_NRD_NRD_1	74	76	PF00675	0.627
CLV_NRD_NRD_1	8	10	PF00675	0.588
CLV_NRD_NRD_1	89	91	PF00675	0.589
CLV_PCSK_KEX2_1	121	123	PF00082	0.515
CLV_PCSK_KEX2_1	201	203	PF00082	0.287
CLV_PCSK_KEX2_1	299	301	PF00082	0.311
CLV_PCSK_KEX2_1	48	50	PF00082	0.715
CLV_PCSK_PC1ET2_1	299	301	PF00082	0.311
CLV_PCSK_PC1ET2_1	48	50	PF00082	0.715
CLV_PCSK_SKI1_1	122	126	PF00082	0.560
CLV_PCSK_SKI1_1	18	22	PF00082	0.562
CLV_PCSK_SKI1_1	287	291	PF00082	0.318
CLV_PCSK_SKI1_1	294	298	PF00082	0.269
CLV_PCSK_SKI1_1	299	303	PF00082	0.256
DEG_COP1_1	359	368	PF00400	0.416
DEG_Nend_Nbox_1	1	3	PF02207	0.591
DOC_AGCK_PIF_2	338	343	PF00069	0.296
DOC_CYCLIN_RxL_1	284	291	PF00134	0.330
DOC_CYCLIN_RxL_1	294	306	PF00134	0.251
DOC_MAPK_gen_1	294	304	PF00069	0.296
DOC_USP7_MATH_1	113	117	PF00917	0.674
DOC_USP7_MATH_1	251	255	PF00917	0.447
DOC_USP7_MATH_1	31	35	PF00917	0.729
DOC_USP7_MATH_1	58	62	PF00917	0.600
DOC_USP7_MATH_1	79	83	PF00917	0.664
DOC_USP7_UBL2_3	10	14	PF12436	0.563
DOC_USP7_UBL2_3	17	21	PF12436	0.541
DOC_USP7_UBL2_3	299	303	PF12436	0.311
DOC_USP7_UBL2_3	83	87	PF12436	0.676
LIG_14-3-3_CanoR_1	140	149	PF00244	0.318
LIG_Actin_WH2_2	289	305	PF00022	0.296
LIG_BRCT_BRCA1_1	245	249	PF00533	0.311
LIG_FHA_1	143	149	PF00498	0.296
LIG_FHA_1	189	195	PF00498	0.345
LIG_FHA_1	259	265	PF00498	0.381
LIG_FHA_1	281	287	PF00498	0.370
LIG_FHA_2	168	174	PF00498	0.296
LIG_FHA_2	255	261	PF00498	0.416
LIG_LIR_Apic_2	151	157	PF02991	0.330
LIG_LIR_Gen_1	246	255	PF02991	0.330
LIG_LIR_Gen_1	268	278	PF02991	0.416
LIG_LIR_Gen_1	288	298	PF02991	0.301
LIG_LIR_Gen_1	327	338	PF02991	0.367
LIG_LIR_Nem_3	144	149	PF02991	0.298
LIG_LIR_Nem_3	168	174	PF02991	0.300
LIG_LIR_Nem_3	246	252	PF02991	0.330
LIG_LIR_Nem_3	268	273	PF02991	0.368
LIG_LIR_Nem_3	288	293	PF02991	0.268
LIG_LIR_Nem_3	327	333	PF02991	0.319
LIG_LIR_Nem_3	336	341	PF02991	0.264
LIG_NRP_CendR_1	370	372	PF00754	0.296
LIG_Pex14_2	313	317	PF04695	0.443
LIG_SH2_CRK	154	158	PF00017	0.330
LIG_SH2_CRK	98	102	PF00017	0.674
LIG_SH2_NCK_1	154	158	PF00017	0.381
LIG_SH2_NCK_1	330	334	PF00017	0.382
LIG_SH2_PTP2	270	273	PF00017	0.400
LIG_SH2_SRC	270	273	PF00017	0.229
LIG_SH2_STAP1	330	334	PF00017	0.416
LIG_SH2_STAT3	178	181	PF00017	0.296
LIG_SH2_STAT5	242	245	PF00017	0.311
LIG_SH2_STAT5	270	273	PF00017	0.382
LIG_SH2_STAT5	285	288	PF00017	0.304
LIG_SH2_STAT5	337	340	PF00017	0.298
LIG_SH3_3	183	189	PF00018	0.297
LIG_SH3_3	308	314	PF00018	0.353
LIG_SH3_3	360	366	PF00018	0.353
LIG_SH3_3	75	81	PF00018	0.499
LIG_SUMO_SIM_anti_2	277	284	PF11976	0.296
LIG_SUMO_SIM_par_1	190	196	PF11976	0.345
LIG_SUMO_SIM_par_1	254	262	PF11976	0.418
LIG_SUMO_SIM_par_1	303	309	PF11976	0.296
LIG_TYR_ITIM	328	333	PF00017	0.404
LIG_WRC_WIRS_1	244	249	PF05994	0.296
MOD_CK1_1	254	260	PF00069	0.326
MOD_CK1_1	35	41	PF00069	0.741
MOD_CK1_1	68	74	PF00069	0.626
MOD_CK2_1	285	291	PF00069	0.366
MOD_CK2_1	79	85	PF00069	0.566
MOD_GlcNHglycan	116	119	PF01048	0.536
MOD_GlcNHglycan	35	38	PF01048	0.693
MOD_GlcNHglycan	70	73	PF01048	0.591
MOD_GSK3_1	155	162	PF00069	0.416
MOD_GSK3_1	254	261	PF00069	0.381
MOD_GSK3_1	276	283	PF00069	0.296
MOD_GSK3_1	31	38	PF00069	0.736
MOD_N-GLC_1	141	146	PF02516	0.412
MOD_NEK2_1	141	146	PF00069	0.296
MOD_NEK2_1	276	281	PF00069	0.303
MOD_NEK2_2	285	290	PF00069	0.416
MOD_PIKK_1	21	27	PF00454	0.694
MOD_PIKK_1	351	357	PF00454	0.416
MOD_PKA_1	21	27	PF00069	0.635
MOD_PKA_2	68	74	PF00069	0.598
MOD_Plk_1	141	147	PF00069	0.412
MOD_Plk_1	167	173	PF00069	0.404
MOD_Plk_2-3	167	173	PF00069	0.296
MOD_Plk_4	188	194	PF00069	0.413
MOD_Plk_4	217	223	PF00069	0.311
MOD_Plk_4	251	257	PF00069	0.429
MOD_Plk_4	276	282	PF00069	0.296
MOD_Plk_4	285	291	PF00069	0.296
MOD_Plk_4	364	370	PF00069	0.296
MOD_SUMO_rev_2	82	88	PF00179	0.534
TRG_DiLeu_BaLyEn_6	144	149	PF01217	0.296
TRG_DiLeu_BaLyEn_6	160	165	PF01217	0.296
TRG_DiLeu_BaLyEn_6	297	302	PF01217	0.296
TRG_ENDOCYTIC_2	270	273	PF00928	0.400
TRG_ENDOCYTIC_2	330	333	PF00928	0.382
TRG_ENDOCYTIC_2	98	101	PF00928	0.672
TRG_ER_diArg_1	121	123	PF00400	0.595
TRG_ER_diArg_1	201	204	PF00400	0.296
TRG_ER_diArg_1	307	310	PF00400	0.296
TRG_Pf-PMV_PEXEL_1	123	127	PF00026	0.630
TRG_Pf-PMV_PEXEL_1	147	151	PF00026	0.283
TRG_Pf-PMV_PEXEL_1	163	167	PF00026	0.285
TRG_Pf-PMV_PEXEL_1	287	291	PF00026	0.353

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD61	Leptomonas seymouri	81%	100%
A0A0S4J2L3	Bodo saltans	54%	71%
A0A1X0NWQ8	Trypanosomatidae	59%	100%
A0A422NCI5	Trypanosoma rangeli	58%	100%
A4HYM5	Leishmania infantum	99%	100%
A8XI07	Caenorhabditis briggsae	36%	100%
C9ZI63	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	100%
E9AIA1	Leishmania braziliensis	89%	100%
E9AUI6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
O44410	Caenorhabditis elegans	33%	100%
Q10257	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	33%	100%
Q4QCZ8	Leishmania major	94%	100%
Q54CP1	Dictyostelium discoideum	34%	95%
Q84JC0	Arabidopsis thaliana	35%	100%
V5C0A6	Trypanosoma cruzi	62%	100%