LeishMANIAdb
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Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Hypothetical_protein_conserved
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3Q8IAG5_LEIDO
TriTrypDb:
LdBPK_211890.1 , LdCL_210024600 , LDHU3_21.2260
Length:
146

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IAG5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IAG5

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 139 141 PF00675 0.790
CLV_NRD_NRD_1 20 22 PF00675 0.679
CLV_NRD_NRD_1 29 31 PF00675 0.695
CLV_PCSK_KEX2_1 101 103 PF00082 0.606
CLV_PCSK_KEX2_1 139 141 PF00082 0.794
CLV_PCSK_KEX2_1 20 22 PF00082 0.679
CLV_PCSK_KEX2_1 29 31 PF00082 0.695
CLV_PCSK_PC1ET2_1 101 103 PF00082 0.569
CLV_PCSK_SKI1_1 101 105 PF00082 0.530
DEG_ODPH_VHL_1 7 19 PF01847 0.569
DEG_SPOP_SBC_1 52 56 PF00917 0.727
DOC_MAPK_gen_1 36 43 PF00069 0.586
DOC_MAPK_MEF2A_6 36 43 PF00069 0.586
DOC_PP1_RVXF_1 121 128 PF00149 0.565
DOC_USP7_MATH_1 13 17 PF00917 0.749
DOC_USP7_MATH_1 25 29 PF00917 0.552
DOC_USP7_MATH_1 59 63 PF00917 0.732
DOC_WW_Pin1_4 63 68 PF00397 0.773
LIG_14-3-3_CanoR_1 120 126 PF00244 0.560
LIG_FHA_2 45 51 PF00498 0.601
LIG_LIR_Gen_1 115 125 PF02991 0.551
LIG_LIR_Nem_3 115 121 PF02991 0.522
LIG_SH2_CRK 93 97 PF00017 0.609
LIG_SH3_3 19 25 PF00018 0.766
LIG_SH3_3 3 9 PF00018 0.635
LIG_SH3_3 71 77 PF00018 0.677
LIG_TRAF2_1 85 88 PF00917 0.448
MOD_CK2_1 110 116 PF00069 0.539
MOD_Cter_Amidation 137 140 PF01082 0.759
MOD_GlcNHglycan 112 115 PF01048 0.487
MOD_GlcNHglycan 61 64 PF01048 0.681
MOD_GSK3_1 121 128 PF00069 0.590
MOD_GSK3_1 50 57 PF00069 0.688
MOD_GSK3_1 59 66 PF00069 0.791
MOD_NEK2_1 97 102 PF00069 0.493
MOD_PKA_2 138 144 PF00069 0.712
MOD_ProDKin_1 63 69 PF00069 0.769
TRG_ENDOCYTIC_2 93 96 PF00928 0.608
TRG_ER_diArg_1 19 21 PF00400 0.704
TRG_ER_diArg_1 29 31 PF00400 0.621
TRG_ER_diArg_1 36 39 PF00400 0.590
TRG_Pf-PMV_PEXEL_1 84 88 PF00026 0.521

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P3J6 Leptomonas seymouri 51% 70%
A4HC11 Leishmania braziliensis 73% 99%
A4HZF2 Leishmania infantum 99% 100%
E9AVE8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
Q4QC31 Leishmania major 90% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS