LeishMANIAdb
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Palmitoyltransferase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Palmitoyltransferase
Gene product:
zinc finger domain-like protein
Species:
Leishmania donovani
UniProt:
A0A3Q8IAF5_LEIDO
TriTrypDb:
LdBPK_211640.1 * , LdCL_210022000 , LDHU3_21.1950
Length:
708

Annotations

LeishMANIAdb annotations

Palmitoyltransferase. Leishmaniids have +2 extra TM segments at the N-terminus while all other Kinetoplastids typically only have the 4 core ones.. Localization: ER (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0005789 endoplasmic reticulum membrane 4 2
GO:0016020 membrane 2 7
GO:0031090 organelle membrane 3 2
GO:0110165 cellular anatomical entity 1 7
GO:0005783 endoplasmic reticulum 5 2
GO:0005794 Golgi apparatus 5 2
GO:0043226 organelle 2 2
GO:0043227 membrane-bounded organelle 3 2
GO:0043229 intracellular organelle 3 2
GO:0043231 intracellular membrane-bounded organelle 4 2

Expansion

Sequence features

A0A3Q8IAF5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IAF5

Function

Biological processes
Term Name Level Count
GO:0006497 protein lipidation 5 2
GO:0006605 protein targeting 5 2
GO:0006612 protein targeting to membrane 5 2
GO:0006807 nitrogen compound metabolic process 2 2
GO:0006810 transport 3 2
GO:0006886 intracellular protein transport 4 2
GO:0006897 endocytosis 5 2
GO:0008104 protein localization 4 2
GO:0008152 metabolic process 1 2
GO:0009987 cellular process 1 2
GO:0015031 protein transport 4 2
GO:0016192 vesicle-mediated transport 4 2
GO:0018193 peptidyl-amino acid modification 5 2
GO:0018198 peptidyl-cysteine modification 6 2
GO:0018230 peptidyl-L-cysteine S-palmitoylation 7 2
GO:0018231 peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine 7 2
GO:0018345 protein palmitoylation 6 2
GO:0019538 protein metabolic process 3 2
GO:0033036 macromolecule localization 2 2
GO:0036211 protein modification process 4 2
GO:0043170 macromolecule metabolic process 3 2
GO:0043412 macromolecule modification 4 2
GO:0043543 protein acylation 5 2
GO:0044238 primary metabolic process 2 2
GO:0045184 establishment of protein localization 3 2
GO:0046907 intracellular transport 3 2
GO:0051179 localization 1 2
GO:0051234 establishment of localization 2 2
GO:0051641 cellular localization 2 2
GO:0051649 establishment of localization in cell 3 2
GO:0051668 localization within membrane 3 2
GO:0070727 cellular macromolecule localization 3 2
GO:0071702 organic substance transport 4 2
GO:0071704 organic substance metabolic process 2 2
GO:0071705 nitrogen compound transport 4 2
GO:0072657 protein localization to membrane 4 2
GO:0090150 establishment of protein localization to membrane 4 2
GO:1901564 organonitrogen compound metabolic process 3 2
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 7
GO:0016409 palmitoyltransferase activity 5 7
GO:0016417 S-acyltransferase activity 5 7
GO:0016740 transferase activity 2 7
GO:0016746 acyltransferase activity 3 7
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 4 7
GO:0019706 protein-cysteine S-palmitoyltransferase activity 4 7
GO:0019707 protein-cysteine S-acyltransferase activity 3 7
GO:0140096 catalytic activity, acting on a protein 2 7

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 111 115 PF00656 0.555
CLV_C14_Caspase3-7 238 242 PF00656 0.690
CLV_C14_Caspase3-7 341 345 PF00656 0.710
CLV_NRD_NRD_1 104 106 PF00675 0.407
CLV_NRD_NRD_1 107 109 PF00675 0.422
CLV_NRD_NRD_1 125 127 PF00675 0.429
CLV_NRD_NRD_1 285 287 PF00675 0.467
CLV_NRD_NRD_1 363 365 PF00675 0.471
CLV_NRD_NRD_1 435 437 PF00675 0.352
CLV_NRD_NRD_1 442 444 PF00675 0.297
CLV_NRD_NRD_1 511 513 PF00675 0.523
CLV_NRD_NRD_1 514 516 PF00675 0.497
CLV_NRD_NRD_1 640 642 PF00675 0.469
CLV_NRD_NRD_1 663 665 PF00675 0.427
CLV_PCSK_FUR_1 105 109 PF00082 0.409
CLV_PCSK_FUR_1 512 516 PF00082 0.434
CLV_PCSK_KEX2_1 106 108 PF00082 0.418
CLV_PCSK_KEX2_1 125 127 PF00082 0.429
CLV_PCSK_KEX2_1 285 287 PF00082 0.467
CLV_PCSK_KEX2_1 363 365 PF00082 0.471
CLV_PCSK_KEX2_1 435 437 PF00082 0.327
CLV_PCSK_KEX2_1 442 444 PF00082 0.283
CLV_PCSK_KEX2_1 511 513 PF00082 0.505
CLV_PCSK_KEX2_1 514 516 PF00082 0.517
CLV_PCSK_KEX2_1 574 576 PF00082 0.306
CLV_PCSK_KEX2_1 592 594 PF00082 0.340
CLV_PCSK_KEX2_1 640 642 PF00082 0.446
CLV_PCSK_KEX2_1 663 665 PF00082 0.427
CLV_PCSK_PC1ET2_1 106 108 PF00082 0.412
CLV_PCSK_PC1ET2_1 574 576 PF00082 0.296
CLV_PCSK_PC1ET2_1 592 594 PF00082 0.351
CLV_PCSK_PC7_1 103 109 PF00082 0.409
CLV_PCSK_SKI1_1 120 124 PF00082 0.426
CLV_PCSK_SKI1_1 368 372 PF00082 0.459
CLV_PCSK_SKI1_1 442 446 PF00082 0.327
CLV_PCSK_SKI1_1 479 483 PF00082 0.269
CLV_PCSK_SKI1_1 575 579 PF00082 0.427
CLV_PCSK_SKI1_1 629 633 PF00082 0.500
CLV_PCSK_SKI1_1 640 644 PF00082 0.418
DEG_APCC_DBOX_1 125 133 PF00400 0.631
DEG_APCC_DBOX_1 478 486 PF00400 0.469
DEG_APCC_DBOX_1 623 631 PF00400 0.634
DEG_Nend_UBRbox_1 1 4 PF02207 0.585
DEG_SPOP_SBC_1 50 54 PF00917 0.617
DOC_CKS1_1 179 184 PF01111 0.415
DOC_CYCLIN_RxL_1 571 582 PF00134 0.346
DOC_CYCLIN_RxL_1 609 618 PF00134 0.607
DOC_CYCLIN_yCln2_LP_2 299 305 PF00134 0.655
DOC_CYCLIN_yCln2_LP_2 536 542 PF00134 0.327
DOC_MAPK_gen_1 125 132 PF00069 0.670
DOC_MAPK_gen_1 424 433 PF00069 0.618
DOC_MAPK_gen_1 663 671 PF00069 0.627
DOC_MAPK_HePTP_8 661 673 PF00069 0.557
DOC_MAPK_MEF2A_6 125 134 PF00069 0.665
DOC_MAPK_MEF2A_6 420 427 PF00069 0.616
DOC_MAPK_MEF2A_6 664 673 PF00069 0.648
DOC_MAPK_RevD_3 349 364 PF00069 0.677
DOC_PP1_RVXF_1 148 155 PF00149 0.504
DOC_PP1_RVXF_1 610 617 PF00149 0.609
DOC_PP2B_LxvP_1 431 434 PF13499 0.647
DOC_PP2B_LxvP_1 444 447 PF13499 0.444
DOC_PP2B_LxvP_1 536 539 PF13499 0.327
DOC_PP4_FxxP_1 281 284 PF00568 0.721
DOC_USP7_MATH_1 24 28 PF00917 0.553
DOC_USP7_MATH_1 51 55 PF00917 0.619
DOC_USP7_MATH_1 583 587 PF00917 0.504
DOC_USP7_UBL2_3 629 633 PF12436 0.631
DOC_WW_Pin1_4 178 183 PF00397 0.420
DOC_WW_Pin1_4 254 259 PF00397 0.744
DOC_WW_Pin1_4 280 285 PF00397 0.746
DOC_WW_Pin1_4 301 306 PF00397 0.757
DOC_WW_Pin1_4 38 43 PF00397 0.584
DOC_WW_Pin1_4 52 57 PF00397 0.615
DOC_WW_Pin1_4 520 525 PF00397 0.334
DOC_WW_Pin1_4 95 100 PF00397 0.604
LIG_14-3-3_CanoR_1 376 385 PF00244 0.655
LIG_14-3-3_CanoR_1 398 403 PF00244 0.676
LIG_14-3-3_CanoR_1 60 67 PF00244 0.614
LIG_14-3-3_CanoR_1 640 647 PF00244 0.673
LIG_AP2alpha_1 616 620 PF02296 0.597
LIG_BRCT_BRCA1_1 207 211 PF00533 0.520
LIG_BRCT_BRCA1_1 26 30 PF00533 0.555
LIG_BRCT_BRCA1_1 36 40 PF00533 0.560
LIG_BRCT_BRCA1_1 381 385 PF00533 0.664
LIG_BRCT_BRCA1_1 598 602 PF00533 0.654
LIG_CaM_NSCaTE_8 489 496 PF13499 0.346
LIG_Clathr_ClatBox_1 408 412 PF01394 0.635
LIG_deltaCOP1_diTrp_1 652 658 PF00928 0.634
LIG_DLG_GKlike_1 363 370 PF00625 0.618
LIG_EH1_1 555 563 PF00400 0.330
LIG_eIF4E_1 571 577 PF01652 0.378
LIG_eIF4E_1 691 697 PF01652 0.671
LIG_FHA_1 147 153 PF00498 0.509
LIG_FHA_1 163 169 PF00498 0.261
LIG_FHA_1 262 268 PF00498 0.656
LIG_FHA_1 311 317 PF00498 0.733
LIG_FHA_1 324 330 PF00498 0.638
LIG_FHA_1 348 354 PF00498 0.743
LIG_FHA_1 494 500 PF00498 0.346
LIG_FHA_1 546 552 PF00498 0.327
LIG_FHA_1 553 559 PF00498 0.280
LIG_FHA_1 579 585 PF00498 0.527
LIG_FHA_1 691 697 PF00498 0.755
LIG_FHA_1 96 102 PF00498 0.601
LIG_FHA_2 109 115 PF00498 0.630
LIG_FHA_2 296 302 PF00498 0.738
LIG_FHA_2 458 464 PF00498 0.504
LIG_FHA_2 580 586 PF00498 0.527
LIG_FHA_2 620 626 PF00498 0.618
LIG_HP1_1 186 190 PF01393 0.265
LIG_IBAR_NPY_1 606 608 PF08397 0.516
LIG_Integrin_RGD_1 338 340 PF01839 0.505
LIG_LIR_Apic_2 221 227 PF02991 0.710
LIG_LIR_Apic_2 603 607 PF02991 0.553
LIG_LIR_Gen_1 165 172 PF02991 0.378
LIG_LIR_Gen_1 184 195 PF02991 0.206
LIG_LIR_Gen_1 29 40 PF02991 0.561
LIG_LIR_Gen_1 567 577 PF02991 0.378
LIG_LIR_Gen_1 693 702 PF02991 0.667
LIG_LIR_Gen_1 72 82 PF02991 0.599
LIG_LIR_Nem_3 165 169 PF02991 0.378
LIG_LIR_Nem_3 184 190 PF02991 0.206
LIG_LIR_Nem_3 198 202 PF02991 0.253
LIG_LIR_Nem_3 29 35 PF02991 0.559
LIG_LIR_Nem_3 325 331 PF02991 0.731
LIG_LIR_Nem_3 496 501 PF02991 0.378
LIG_LIR_Nem_3 567 572 PF02991 0.378
LIG_LIR_Nem_3 676 681 PF02991 0.659
LIG_LIR_Nem_3 693 697 PF02991 0.579
LIG_LIR_Nem_3 72 78 PF02991 0.601
LIG_LYPXL_SIV_4 539 547 PF13949 0.327
LIG_NRBOX 189 195 PF00104 0.346
LIG_NRBOX 404 410 PF00104 0.650
LIG_Pex14_1 674 678 PF04695 0.648
LIG_Pex14_2 141 145 PF04695 0.657
LIG_Pex14_2 616 620 PF04695 0.597
LIG_SH2_CRK 224 228 PF00017 0.689
LIG_SH2_CRK 501 505 PF00017 0.378
LIG_SH2_CRK 604 608 PF00017 0.599
LIG_SH2_GRB2like 202 205 PF00017 0.378
LIG_SH2_GRB2like 237 240 PF00017 0.658
LIG_SH2_GRB2like 571 574 PF00017 0.378
LIG_SH2_PTP2 187 190 PF00017 0.346
LIG_SH2_PTP2 75 78 PF00017 0.606
LIG_SH2_SRC 237 240 PF00017 0.716
LIG_SH2_STAP1 228 232 PF00017 0.682
LIG_SH2_STAT3 121 124 PF00017 0.597
LIG_SH2_STAT5 128 131 PF00017 0.629
LIG_SH2_STAT5 187 190 PF00017 0.354
LIG_SH2_STAT5 202 205 PF00017 0.268
LIG_SH2_STAT5 222 225 PF00017 0.588
LIG_SH2_STAT5 228 231 PF00017 0.657
LIG_SH2_STAT5 437 440 PF00017 0.536
LIG_SH2_STAT5 480 483 PF00017 0.431
LIG_SH2_STAT5 503 506 PF00017 0.422
LIG_SH2_STAT5 550 553 PF00017 0.457
LIG_SH2_STAT5 571 574 PF00017 0.378
LIG_SH2_STAT5 588 591 PF00017 0.519
LIG_SH2_STAT5 75 78 PF00017 0.606
LIG_SH3_3 288 294 PF00018 0.744
LIG_SH3_3 299 305 PF00018 0.698
LIG_SH3_3 315 321 PF00018 0.672
LIG_SH3_3 393 399 PF00018 0.680
LIG_SH3_3 536 542 PF00018 0.327
LIG_SH3_3 64 70 PF00018 0.591
LIG_SH3_3 686 692 PF00018 0.700
LIG_SUMO_SIM_par_1 406 412 PF11976 0.639
LIG_TYR_ITIM 185 190 PF00017 0.378
LIG_TYR_ITIM 499 504 PF00017 0.346
LIG_ULM_U2AF65_1 105 110 PF00076 0.490
LIG_WRC_WIRS_1 142 147 PF05994 0.559
LIG_WRC_WIRS_1 163 168 PF05994 0.378
LIG_WRC_WIRS_1 196 201 PF05994 0.378
LIG_WRC_WIRS_1 678 683 PF05994 0.585
LIG_WRC_WIRS_1 691 696 PF05994 0.487
LIG_WW_1 219 222 PF00397 0.598
LIG_WW_2 321 324 PF00397 0.659
LIG_WW_3 421 425 PF00397 0.511
MOD_CDC14_SPxK_1 283 286 PF00782 0.680
MOD_CDC14_SPxK_1 523 526 PF00782 0.388
MOD_CDK_SPK_2 254 259 PF00069 0.585
MOD_CDK_SPK_2 280 285 PF00069 0.571
MOD_CDK_SPK_2 301 306 PF00069 0.620
MOD_CDK_SPxK_1 280 286 PF00069 0.672
MOD_CDK_SPxK_1 520 526 PF00069 0.388
MOD_CK1_1 240 246 PF00069 0.704
MOD_CK1_1 34 40 PF00069 0.428
MOD_CK1_1 366 372 PF00069 0.595
MOD_CK1_1 549 555 PF00069 0.330
MOD_CK1_1 93 99 PF00069 0.492
MOD_CK2_1 579 585 PF00069 0.386
MOD_CMANNOS 486 489 PF00535 0.378
MOD_GlcNHglycan 244 248 PF01048 0.599
MOD_GlcNHglycan 340 344 PF01048 0.719
MOD_GlcNHglycan 379 382 PF01048 0.556
MOD_GlcNHglycan 698 701 PF01048 0.657
MOD_GSK3_1 141 148 PF00069 0.560
MOD_GSK3_1 177 184 PF00069 0.470
MOD_GSK3_1 205 212 PF00069 0.451
MOD_GSK3_1 239 246 PF00069 0.650
MOD_GSK3_1 261 268 PF00069 0.658
MOD_GSK3_1 31 38 PF00069 0.425
MOD_GSK3_1 375 382 PF00069 0.582
MOD_GSK3_1 40 47 PF00069 0.481
MOD_GSK3_1 489 496 PF00069 0.430
MOD_GSK3_1 545 552 PF00069 0.344
MOD_GSK3_1 579 586 PF00069 0.351
MOD_GSK3_1 59 66 PF00069 0.491
MOD_GSK3_1 596 603 PF00069 0.407
MOD_GSK3_1 673 680 PF00069 0.551
MOD_LATS_1 85 91 PF00433 0.500
MOD_N-GLC_1 145 150 PF02516 0.529
MOD_N-GLC_1 579 584 PF02516 0.378
MOD_N-GLC_1 600 605 PF02516 0.421
MOD_N-GLC_2 456 458 PF02516 0.338
MOD_N-GLC_2 470 472 PF02516 0.293
MOD_NEK2_1 141 146 PF00069 0.538
MOD_NEK2_1 206 211 PF00069 0.484
MOD_NEK2_1 295 300 PF00069 0.696
MOD_NEK2_1 31 36 PF00069 0.420
MOD_NEK2_1 377 382 PF00069 0.476
MOD_NEK2_1 493 498 PF00069 0.378
MOD_NEK2_1 546 551 PF00069 0.481
MOD_NEK2_1 556 561 PF00069 0.341
MOD_NEK2_1 564 569 PF00069 0.375
MOD_NEK2_1 578 583 PF00069 0.356
MOD_NEK2_1 59 64 PF00069 0.503
MOD_NEK2_1 619 624 PF00069 0.486
MOD_NEK2_2 583 588 PF00069 0.346
MOD_PIKK_1 261 267 PF00454 0.662
MOD_PIKK_1 316 322 PF00454 0.646
MOD_PKA_1 363 369 PF00069 0.524
MOD_PKA_1 640 646 PF00069 0.576
MOD_PKA_2 363 369 PF00069 0.589
MOD_PKA_2 375 381 PF00069 0.476
MOD_PKA_2 504 510 PF00069 0.330
MOD_PKA_2 59 65 PF00069 0.501
MOD_PKA_2 640 646 PF00069 0.547
MOD_Plk_1 220 226 PF00069 0.587
MOD_Plk_1 265 271 PF00069 0.590
MOD_Plk_1 295 301 PF00069 0.712
MOD_Plk_1 579 585 PF00069 0.378
MOD_Plk_1 600 606 PF00069 0.442
MOD_Plk_4 26 32 PF00069 0.422
MOD_Plk_4 35 41 PF00069 0.427
MOD_Plk_4 489 495 PF00069 0.378
MOD_Plk_4 546 552 PF00069 0.356
MOD_Plk_4 556 562 PF00069 0.305
MOD_Plk_4 564 570 PF00069 0.434
MOD_Plk_4 583 589 PF00069 0.274
MOD_Plk_4 70 76 PF00069 0.467
MOD_ProDKin_1 178 184 PF00069 0.500
MOD_ProDKin_1 254 260 PF00069 0.681
MOD_ProDKin_1 280 286 PF00069 0.688
MOD_ProDKin_1 301 307 PF00069 0.700
MOD_ProDKin_1 38 44 PF00069 0.462
MOD_ProDKin_1 52 58 PF00069 0.502
MOD_ProDKin_1 520 526 PF00069 0.388
MOD_ProDKin_1 95 101 PF00069 0.485
MOD_SUMO_for_1 632 635 PF00179 0.523
TRG_DiLeu_BaLyEn_6 426 431 PF01217 0.394
TRG_DiLeu_LyEn_5 701 706 PF01217 0.600
TRG_ENDOCYTIC_2 187 190 PF00928 0.378
TRG_ENDOCYTIC_2 480 483 PF00928 0.459
TRG_ENDOCYTIC_2 501 504 PF00928 0.378
TRG_ENDOCYTIC_2 691 694 PF00928 0.609
TRG_ENDOCYTIC_2 75 78 PF00928 0.489
TRG_ER_diArg_1 104 107 PF00400 0.493
TRG_ER_diArg_1 284 286 PF00400 0.571
TRG_ER_diArg_1 423 426 PF00400 0.522
TRG_ER_diArg_1 434 436 PF00400 0.298
TRG_ER_diArg_1 442 444 PF00400 0.226
TRG_ER_diArg_1 511 513 PF00400 0.354
TRG_ER_diArg_1 514 516 PF00400 0.361
TRG_ER_diArg_1 663 665 PF00400 0.518
TRG_NES_CRM1_1 266 278 PF08389 0.622
TRG_NLS_MonoCore_2 104 109 PF00514 0.492
TRG_NLS_MonoExtC_3 105 110 PF00514 0.490
TRG_NLS_MonoExtN_4 103 110 PF00514 0.491
TRG_Pf-PMV_PEXEL_1 213 217 PF00026 0.535
TRG_Pf-PMV_PEXEL_1 514 519 PF00026 0.378
TRG_Pf-PMV_PEXEL_1 663 667 PF00026 0.551

Homologs

Protein Taxonomy Sequence identity Coverage
A4HC51 Leishmania braziliensis 69% 100%
A4HZD7 Leishmania infantum 100% 100%
E9AVC4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 100%
Q4QC55 Leishmania major 92% 100%
Q4QC56 Leishmania major 91% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS