50S ribosomal protein L17, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

50S ribosomal protein L17, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IAE9_LEIDO

TriTrypDb:

LdBPK_160170.1 , LdCL_160006600 , LDHU3_16.0190

Length:

305

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	11
GO:0032991	protein-containing complex	1	12
GO:0043226	organelle	2	11
GO:0043228	non-membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043232	intracellular non-membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11
GO:1990904	ribonucleoprotein complex	2	12
GO:0015934	large ribosomal subunit	4	1
GO:0044391	ribosomal subunit	3	1

Expansion

Sequence features

A0A3Q8IAE9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IAE9

PDB structure(s): 7aih_I , 7am2_I , 7ane_I

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	12
GO:0006518	peptide metabolic process	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009058	biosynthetic process	2	12
GO:0009059	macromolecule biosynthetic process	4	12
GO:0009987	cellular process	1	12
GO:0019538	protein metabolic process	3	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	12
GO:0043043	peptide biosynthetic process	5	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043603	amide metabolic process	3	12
GO:0043604	amide biosynthetic process	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044249	cellular biosynthetic process	3	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0044271	cellular nitrogen compound biosynthetic process	4	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901566	organonitrogen compound biosynthetic process	4	12
GO:1901576	organic substance biosynthetic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003735	structural constituent of ribosome	2	12
GO:0005198	structural molecule activity	1	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	169	173	PF00656	0.383
CLV_NRD_NRD_1	134	136	PF00675	0.316
CLV_NRD_NRD_1	153	155	PF00675	0.297
CLV_NRD_NRD_1	71	73	PF00675	0.305
CLV_NRD_NRD_1	78	80	PF00675	0.297
CLV_PCSK_KEX2_1	134	136	PF00082	0.316
CLV_PCSK_KEX2_1	152	154	PF00082	0.297
CLV_PCSK_KEX2_1	20	22	PF00082	0.633
CLV_PCSK_KEX2_1	71	73	PF00082	0.305
CLV_PCSK_PC1ET2_1	20	22	PF00082	0.517
CLV_PCSK_PC7_1	148	154	PF00082	0.313
CLV_PCSK_SKI1_1	185	189	PF00082	0.383
CLV_PCSK_SKI1_1	228	232	PF00082	0.354
CLV_PCSK_SKI1_1	72	76	PF00082	0.306
DEG_Nend_Nbox_1	1	3	PF02207	0.567
DOC_CYCLIN_yCln2_LP_2	119	125	PF00134	0.297
DOC_MAPK_gen_1	79	85	PF00069	0.389
DOC_PP4_FxxP_1	186	189	PF00568	0.379
DOC_USP7_MATH_1	241	245	PF00917	0.413
DOC_USP7_MATH_1	264	268	PF00917	0.554
DOC_WW_Pin1_4	290	295	PF00397	0.727
DOC_WW_Pin1_4	59	64	PF00397	0.425
LIG_14-3-3_CanoR_1	152	161	PF00244	0.333
LIG_deltaCOP1_diTrp_1	210	216	PF00928	0.389
LIG_FHA_1	73	79	PF00498	0.297
LIG_FHA_2	249	255	PF00498	0.457
LIG_FXI_DFP_1	269	273	PF00024	0.623
LIG_LIR_Apic_2	184	190	PF02991	0.411
LIG_LIR_Gen_1	266	274	PF02991	0.511
LIG_LIR_Gen_1	81	90	PF02991	0.303
LIG_LIR_Nem_3	126	132	PF02991	0.297
LIG_LIR_Nem_3	266	272	PF02991	0.514
LIG_LIR_Nem_3	81	85	PF02991	0.303
LIG_Pex14_1	212	216	PF04695	0.376
LIG_Pex14_2	221	225	PF04695	0.362
LIG_SH2_NCK_1	279	283	PF00017	0.641
LIG_SH2_PTP2	82	85	PF00017	0.433
LIG_SH2_SRC	82	85	PF00017	0.389
LIG_SH2_STAT5	117	120	PF00017	0.313
LIG_SH2_STAT5	161	164	PF00017	0.297
LIG_SH2_STAT5	179	182	PF00017	0.418
LIG_SH2_STAT5	82	85	PF00017	0.297
LIG_SH3_3	237	243	PF00018	0.405
LIG_SUMO_SIM_par_1	121	126	PF11976	0.297
LIG_TRFH_1	186	190	PF08558	0.382
LIG_TYR_ITIM	232	237	PF00017	0.489
LIG_UBA3_1	145	150	PF00899	0.297
LIG_WW_3	188	192	PF00397	0.396
MOD_CDK_SPxxK_3	59	66	PF00069	0.413
MOD_CK1_1	292	298	PF00069	0.776
MOD_CK2_1	248	254	PF00069	0.442
MOD_CK2_1	264	270	PF00069	0.553
MOD_Cter_Amidation	150	153	PF01082	0.433
MOD_DYRK1A_RPxSP_1	59	63	PF00069	0.439
MOD_GlcNHglycan	294	297	PF01048	0.676
MOD_GSK3_1	211	218	PF00069	0.383
MOD_GSK3_1	288	295	PF00069	0.651
MOD_N-GLC_1	264	269	PF02516	0.669
MOD_NEK2_1	2	7	PF00069	0.555
MOD_PKA_1	152	158	PF00069	0.333
MOD_PKA_2	152	158	PF00069	0.333
MOD_PKA_2	2	8	PF00069	0.512
MOD_Plk_1	275	281	PF00069	0.535
MOD_Plk_2-3	275	281	PF00069	0.635
MOD_ProDKin_1	290	296	PF00069	0.726
MOD_ProDKin_1	59	65	PF00069	0.419
MOD_SUMO_for_1	216	219	PF00179	0.368
TRG_DiLeu_BaLyEn_6	3	8	PF01217	0.654
TRG_ENDOCYTIC_2	143	146	PF00928	0.315
TRG_ENDOCYTIC_2	234	237	PF00928	0.511
TRG_ENDOCYTIC_2	82	85	PF00928	0.297
TRG_ER_diArg_1	133	135	PF00400	0.315
TRG_ER_diArg_1	152	154	PF00400	0.313
TRG_ER_diArg_1	21	24	PF00400	0.634
TRG_ER_diArg_1	225	228	PF00400	0.367
TRG_ER_diArg_1	58	61	PF00400	0.416
TRG_ER_diArg_1	71	73	PF00400	0.277
TRG_ER_diArg_1	8	11	PF00400	0.608
TRG_Pf-PMV_PEXEL_1	94	98	PF00026	0.297

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I793	Leptomonas seymouri	89%	100%
A0A0S4JJ99	Bodo saltans	74%	98%
A0A1X0NHG6	Trypanosomatidae	85%	100%
A0A3R7KXR6	Trypanosoma rangeli	86%	100%
A4H8E3	Leishmania braziliensis	94%	100%
A4HWR5	Leishmania infantum	100%	100%
C9ZW59	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	85%	100%
E9AQH3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
Q4QF04	Leishmania major	98%	100%
V5B029	Trypanosoma cruzi	82%	100%