COP9 signalosome complex subunit 5, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

COP9 signalosome complex subunit 5, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IAE8_LEIDO

TriTrypDb:

LdBPK_160850.1 , LdCL_160013800 , LDHU3_16.1020

Length:

491

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0008180	COP9 signalosome	3	7
GO:0032991	protein-containing complex	1	7
GO:0140513	nuclear protein-containing complex	2	7
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IAE8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IAE8

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0019538	protein metabolic process	3	7
GO:0043170	macromolecule metabolic process	3	7
GO:0044238	primary metabolic process	2	7
GO:0071704	organic substance metabolic process	2	7
GO:1901564	organonitrogen compound metabolic process	3	7
GO:0000338	protein deneddylation	6	1
GO:0036211	protein modification process	4	1
GO:0043412	macromolecule modification	4	1
GO:0070646	protein modification by small protein removal	5	1
GO:0070647	protein modification by small protein conjugation or removal	5	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004175	endopeptidase activity	4	7
GO:0004222	metalloendopeptidase activity	5	7
GO:0005488	binding	1	7
GO:0008233	peptidase activity	3	7
GO:0008237	metallopeptidase activity	4	7
GO:0016787	hydrolase activity	2	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0140096	catalytic activity, acting on a protein	2	7
GO:0019783	ubiquitin-like protein peptidase activity	4	1
GO:0019784	deNEDDylase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	179	183	PF00656	0.222
CLV_C14_Caspase3-7	230	234	PF00656	0.601
CLV_C14_Caspase3-7	281	285	PF00656	0.419
CLV_C14_Caspase3-7	373	377	PF00656	0.678
CLV_NRD_NRD_1	149	151	PF00675	0.288
CLV_NRD_NRD_1	349	351	PF00675	0.740
CLV_NRD_NRD_1	463	465	PF00675	0.539
CLV_NRD_NRD_1	474	476	PF00675	0.485
CLV_NRD_NRD_1	489	491	PF00675	0.408
CLV_NRD_NRD_1	55	57	PF00675	0.373
CLV_PCSK_KEX2_1	149	151	PF00082	0.288
CLV_PCSK_KEX2_1	349	351	PF00082	0.740
CLV_PCSK_KEX2_1	437	439	PF00082	0.666
CLV_PCSK_KEX2_1	463	465	PF00082	0.539
CLV_PCSK_KEX2_1	489	491	PF00082	0.422
CLV_PCSK_KEX2_1	55	57	PF00082	0.373
CLV_PCSK_PC1ET2_1	437	439	PF00082	0.646
CLV_PCSK_SKI1_1	79	83	PF00082	0.376
CLV_Separin_Metazoa	397	401	PF03568	0.460
DEG_SCF_FBW7_1	20	26	PF00400	0.590
DOC_ANK_TNKS_1	211	218	PF00023	0.374
DOC_CKS1_1	20	25	PF01111	0.677
DOC_CKS1_1	43	48	PF01111	0.422
DOC_CYCLIN_yCln2_LP_2	302	308	PF00134	0.454
DOC_MAPK_gen_1	31	38	PF00069	0.423
DOC_MAPK_gen_1	58	67	PF00069	0.395
DOC_MAPK_HePTP_8	290	302	PF00069	0.507
DOC_MAPK_MEF2A_6	270	278	PF00069	0.379
DOC_MAPK_MEF2A_6	293	302	PF00069	0.508
DOC_PP4_FxxP_1	120	123	PF00568	0.288
DOC_USP7_MATH_1	13	17	PF00917	0.634
DOC_USP7_MATH_1	227	231	PF00917	0.614
DOC_USP7_MATH_1	23	27	PF00917	0.697
DOC_USP7_MATH_1	244	248	PF00917	0.614
DOC_USP7_MATH_1	331	335	PF00917	0.514
DOC_USP7_MATH_1	343	347	PF00917	0.439
DOC_USP7_MATH_1	37	41	PF00917	0.354
DOC_USP7_MATH_1	89	93	PF00917	0.288
DOC_WW_Pin1_4	19	24	PF00397	0.546
DOC_WW_Pin1_4	237	242	PF00397	0.551
DOC_WW_Pin1_4	337	342	PF00397	0.617
DOC_WW_Pin1_4	4	9	PF00397	0.677
DOC_WW_Pin1_4	42	47	PF00397	0.487
LIG_14-3-3_CanoR_1	223	232	PF00244	0.638
LIG_14-3-3_CanoR_1	277	287	PF00244	0.384
LIG_14-3-3_CanoR_1	33	37	PF00244	0.405
LIG_Actin_WH2_2	187	204	PF00022	0.322
LIG_AP2alpha_2	188	190	PF02296	0.357
LIG_BIR_II_1	1	5	PF00653	0.680
LIG_BRCT_BRCA1_1	300	304	PF00533	0.433
LIG_BRCT_BRCA1_1	456	460	PF00533	0.646
LIG_BRCT_BRCA1_1	63	67	PF00533	0.442
LIG_CtBP_PxDLS_1	297	301	PF00389	0.420
LIG_deltaCOP1_diTrp_1	41	48	PF00928	0.483
LIG_EH1_1	98	106	PF00400	0.288
LIG_FHA_1	393	399	PF00498	0.520
LIG_FHA_2	177	183	PF00498	0.248
LIG_FHA_2	211	217	PF00498	0.363
LIG_FHA_2	246	252	PF00498	0.611
LIG_HP1_1	189	193	PF01393	0.339
LIG_LIR_Apic_2	117	123	PF02991	0.288
LIG_LIR_Apic_2	250	256	PF02991	0.593
LIG_LIR_Apic_2	40	46	PF02991	0.394
LIG_LIR_Gen_1	188	198	PF02991	0.342
LIG_LIR_Gen_1	404	414	PF02991	0.600
LIG_LIR_Gen_1	45	54	PF02991	0.504
LIG_LIR_Gen_1	453	460	PF02991	0.615
LIG_LIR_Gen_1	64	75	PF02991	0.179
LIG_LIR_Nem_3	188	193	PF02991	0.349
LIG_LIR_Nem_3	404	409	PF02991	0.596
LIG_LIR_Nem_3	453	459	PF02991	0.613
LIG_LIR_Nem_3	64	70	PF02991	0.433
LIG_MLH1_MIPbox_1	63	67	PF16413	0.436
LIG_PCNA_PIPBox_1	102	111	PF02747	0.288
LIG_Pex14_1	44	48	PF04695	0.482
LIG_Pex14_2	456	460	PF04695	0.622
LIG_Pex14_2	62	66	PF04695	0.403
LIG_SH2_CRK	253	257	PF00017	0.653
LIG_SH2_STAP1	168	172	PF00017	0.288
LIG_SH2_STAT5	144	147	PF00017	0.288
LIG_SH3_3	191	197	PF00018	0.333
LIG_SH3_3	302	308	PF00018	0.514
LIG_SUMO_SIM_par_1	296	301	PF11976	0.419
LIG_SUMO_SIM_par_1	390	395	PF11976	0.556
LIG_TRAF2_1	467	470	PF00917	0.665
LIG_TRFH_1	253	257	PF08558	0.444
MOD_CDK_SPxxK_3	4	11	PF00069	0.636
MOD_CK1_1	16	22	PF00069	0.556
MOD_CK1_1	240	246	PF00069	0.641
MOD_CK1_1	247	253	PF00069	0.525
MOD_CK1_1	352	358	PF00069	0.508
MOD_CK1_1	4	10	PF00069	0.636
MOD_CK1_1	443	449	PF00069	0.654
MOD_CK1_1	455	461	PF00069	0.675
MOD_CK2_1	107	113	PF00069	0.446
MOD_CK2_1	124	130	PF00069	0.213
MOD_CK2_1	210	216	PF00069	0.341
MOD_GlcNHglycan	172	175	PF01048	0.288
MOD_GlcNHglycan	225	228	PF01048	0.712
MOD_GlcNHglycan	229	232	PF01048	0.646
MOD_GlcNHglycan	242	245	PF01048	0.659
MOD_GlcNHglycan	280	283	PF01048	0.471
MOD_GlcNHglycan	3	6	PF01048	0.605
MOD_GlcNHglycan	316	319	PF01048	0.550
MOD_GlcNHglycan	324	327	PF01048	0.459
MOD_GlcNHglycan	367	370	PF01048	0.620
MOD_GlcNHglycan	372	375	PF01048	0.565
MOD_GlcNHglycan	376	380	PF01048	0.494
MOD_GSK3_1	114	121	PF00069	0.298
MOD_GSK3_1	166	173	PF00069	0.293
MOD_GSK3_1	176	183	PF00069	0.312
MOD_GSK3_1	18	25	PF00069	0.704
MOD_GSK3_1	200	207	PF00069	0.428
MOD_GSK3_1	223	230	PF00069	0.695
MOD_GSK3_1	240	247	PF00069	0.650
MOD_GSK3_1	296	303	PF00069	0.427
MOD_GSK3_1	333	340	PF00069	0.572
MOD_GSK3_1	345	352	PF00069	0.498
MOD_GSK3_1	439	446	PF00069	0.625
MOD_GSK3_1	454	461	PF00069	0.667
MOD_GSK3_1	66	73	PF00069	0.322
MOD_GSK3_1	9	16	PF00069	0.631
MOD_N-GLC_2	314	316	PF02516	0.426
MOD_NEK2_1	1	6	PF00069	0.638
MOD_NEK2_1	116	121	PF00069	0.288
MOD_NEK2_1	298	303	PF00069	0.435
MOD_NEK2_1	32	37	PF00069	0.574
MOD_NEK2_1	359	364	PF00069	0.727
MOD_NEK2_1	459	464	PF00069	0.631
MOD_NEK2_1	66	71	PF00069	0.379
MOD_NEK2_1	74	79	PF00069	0.261
MOD_NEK2_1	82	87	PF00069	0.222
MOD_NEK2_2	166	171	PF00069	0.288
MOD_NEK2_2	197	202	PF00069	0.350
MOD_NEK2_2	204	209	PF00069	0.428
MOD_PIKK_1	13	19	PF00454	0.631
MOD_PIKK_1	134	140	PF00454	0.288
MOD_PIKK_1	176	182	PF00454	0.288
MOD_PIKK_1	89	95	PF00454	0.288
MOD_PK_1	349	355	PF00069	0.515
MOD_PKA_1	349	355	PF00069	0.515
MOD_PKA_2	180	186	PF00069	0.227
MOD_PKA_2	32	38	PF00069	0.409
MOD_PKA_2	349	355	PF00069	0.567
MOD_PKB_1	223	231	PF00069	0.624
MOD_PKB_1	400	408	PF00069	0.515
MOD_Plk_1	129	135	PF00069	0.284
MOD_Plk_1	452	458	PF00069	0.653
MOD_Plk_4	455	461	PF00069	0.619
MOD_Plk_4	61	67	PF00069	0.479
MOD_ProDKin_1	19	25	PF00069	0.543
MOD_ProDKin_1	237	243	PF00069	0.552
MOD_ProDKin_1	337	343	PF00069	0.617
MOD_ProDKin_1	4	10	PF00069	0.678
MOD_ProDKin_1	42	48	PF00069	0.489
TRG_AP2beta_CARGO_1	453	463	PF09066	0.578
TRG_DiLeu_BaEn_1	100	105	PF01217	0.288
TRG_DiLeu_BaEn_1	404	409	PF01217	0.508
TRG_DiLeu_BaLyEn_6	354	359	PF01217	0.525
TRG_DiLeu_BaLyEn_6	387	392	PF01217	0.568
TRG_ENDOCYTIC_2	168	171	PF00928	0.288
TRG_ENDOCYTIC_2	271	274	PF00928	0.376
TRG_ER_diArg_1	149	151	PF00400	0.288
TRG_ER_diArg_1	399	402	PF00400	0.480

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD30	Leptomonas seymouri	59%	100%
A4H8K9	Leishmania braziliensis	79%	100%
A4HWY1	Leishmania infantum	100%	100%
E9AQP4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4P804	Ustilago maydis (strain 521 / FGSC 9021)	31%	100%
Q4QET4	Leishmania major	94%	100%