LeishMANIAdb
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Leucine Rich repeats (2 copies) family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Leucine Rich repeats (2 copies) family protein
Gene product:
Leucine Rich repeats (2 copies), putative
Species:
Leishmania donovani
UniProt:
A0A3Q8IAE2_LEIDO
TriTrypDb:
LdBPK_191670.1 * , LdCL_050021400 , LdCL_190022700 , LDHU3_05.1410
Length:
629

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0005929 cilium 4 10
GO:0042995 cell projection 2 10
GO:0043226 organelle 2 10
GO:0043227 membrane-bounded organelle 3 10
GO:0110165 cellular anatomical entity 1 10
GO:0120025 plasma membrane bounded cell projection 3 10
GO:0000151 ubiquitin ligase complex 3 1
GO:0019005 SCF ubiquitin ligase complex 5 1
GO:0031461 cullin-RING ubiquitin ligase complex 4 1
GO:0032991 protein-containing complex 1 1
GO:0140535 intracellular protein-containing complex 2 1
GO:1902494 catalytic complex 2 1
GO:1990234 transferase complex 3 1

Expansion

Sequence features

A0A3Q8IAE2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IAE2

Function

Biological processes
Term Name Level Count
GO:0006508 proteolysis 4 1
GO:0006511 ubiquitin-dependent protein catabolic process 7 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0008152 metabolic process 1 1
GO:0009056 catabolic process 2 1
GO:0009057 macromolecule catabolic process 4 1
GO:0009987 cellular process 1 1
GO:0010498 proteasomal protein catabolic process 5 1
GO:0019538 protein metabolic process 3 1
GO:0019941 modification-dependent protein catabolic process 6 1
GO:0030163 protein catabolic process 4 1
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process 7 1
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process 6 1
GO:0043170 macromolecule metabolic process 3 1
GO:0043632 modification-dependent macromolecule catabolic process 5 1
GO:0044237 cellular metabolic process 2 1
GO:0044238 primary metabolic process 2 1
GO:0044248 cellular catabolic process 3 1
GO:0044260 obsolete cellular macromolecule metabolic process 3 1
GO:0044265 obsolete cellular macromolecule catabolic process 4 1
GO:0051603 proteolysis involved in protein catabolic process 5 1
GO:0071704 organic substance metabolic process 2 1
GO:1901564 organonitrogen compound metabolic process 3 1
GO:1901565 organonitrogen compound catabolic process 4 1
GO:1901575 organic substance catabolic process 3 1
GO:0006950 response to stress 2 1
GO:0006952 defense response 3 1
GO:0050896 response to stimulus 1 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 4
GO:0016787 hydrolase activity 2 4
GO:0005488 binding 1 1
GO:0043167 ion binding 2 1
GO:0043169 cation binding 3 1
GO:0046872 metal ion binding 4 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 307 311 PF00656 0.511
CLV_C14_Caspase3-7 55 59 PF00656 0.521
CLV_NRD_NRD_1 227 229 PF00675 0.528
CLV_NRD_NRD_1 359 361 PF00675 0.288
CLV_PCSK_KEX2_1 227 229 PF00082 0.532
CLV_PCSK_KEX2_1 359 361 PF00082 0.288
CLV_PCSK_SKI1_1 227 231 PF00082 0.467
CLV_PCSK_SKI1_1 379 383 PF00082 0.331
CLV_PCSK_SKI1_1 449 453 PF00082 0.514
CLV_PCSK_SKI1_1 72 76 PF00082 0.434
CLV_Separin_Metazoa 546 550 PF03568 0.291
DEG_APCC_DBOX_1 359 367 PF00400 0.267
DEG_APCC_KENBOX_2 139 143 PF00400 0.329
DEG_Nend_Nbox_1 1 3 PF02207 0.528
DEG_SCF_FBW7_1 20 26 PF00400 0.485
DOC_ANK_TNKS_1 60 67 PF00023 0.448
DOC_CDC14_PxL_1 516 524 PF14671 0.483
DOC_CKS1_1 20 25 PF01111 0.491
DOC_CYCLIN_RxL_1 275 284 PF00134 0.339
DOC_CYCLIN_RxL_1 379 392 PF00134 0.270
DOC_CYCLIN_RxL_1 520 531 PF00134 0.415
DOC_CYCLIN_yClb5_NLxxxL_5 406 415 PF00134 0.270
DOC_MAPK_gen_1 138 146 PF00069 0.378
DOC_MAPK_gen_1 227 237 PF00069 0.343
DOC_MAPK_gen_1 356 366 PF00069 0.296
DOC_MAPK_gen_1 379 389 PF00069 0.427
DOC_MAPK_gen_1 446 456 PF00069 0.314
DOC_MAPK_MEF2A_6 132 139 PF00069 0.351
DOC_MAPK_MEF2A_6 169 176 PF00069 0.381
DOC_MAPK_MEF2A_6 227 236 PF00069 0.383
DOC_MAPK_MEF2A_6 540 547 PF00069 0.380
DOC_MAPK_NFAT4_5 227 235 PF00069 0.350
DOC_MIT_MIM_1 224 232 PF04212 0.354
DOC_PP2B_LxvP_1 198 201 PF13499 0.429
DOC_PP2B_LxvP_1 586 589 PF13499 0.457
DOC_PP4_FxxP_1 322 325 PF00568 0.347
DOC_USP7_MATH_1 153 157 PF00917 0.464
DOC_USP7_MATH_1 315 319 PF00917 0.366
DOC_USP7_MATH_1 377 381 PF00917 0.336
DOC_USP7_MATH_1 521 525 PF00917 0.397
DOC_USP7_MATH_1 53 57 PF00917 0.509
DOC_USP7_MATH_1 622 626 PF00917 0.521
DOC_WW_Pin1_4 19 24 PF00397 0.506
DOC_WW_Pin1_4 30 35 PF00397 0.515
DOC_WW_Pin1_4 333 338 PF00397 0.360
DOC_WW_Pin1_4 39 44 PF00397 0.481
DOC_WW_Pin1_4 46 51 PF00397 0.479
DOC_WW_Pin1_4 508 513 PF00397 0.420
DOC_WW_Pin1_4 579 584 PF00397 0.485
LIG_14-3-3_CanoR_1 169 175 PF00244 0.408
LIG_14-3-3_CanoR_1 257 261 PF00244 0.361
LIG_14-3-3_CanoR_1 287 293 PF00244 0.484
LIG_14-3-3_CanoR_1 317 322 PF00244 0.508
LIG_14-3-3_CanoR_1 348 353 PF00244 0.492
LIG_14-3-3_CanoR_1 416 421 PF00244 0.386
LIG_14-3-3_CanoR_1 6 10 PF00244 0.511
LIG_Actin_WH2_2 438 454 PF00022 0.382
LIG_Actin_WH2_2 555 571 PF00022 0.472
LIG_BIR_III_2 149 153 PF00653 0.402
LIG_BIR_III_2 272 276 PF00653 0.356
LIG_BIR_III_2 518 522 PF00653 0.410
LIG_BRCT_BRCA1_1 23 27 PF00533 0.526
LIG_DLG_GKlike_1 348 355 PF00625 0.328
LIG_DLG_GKlike_1 416 423 PF00625 0.270
LIG_FHA_1 109 115 PF00498 0.447
LIG_FHA_1 171 177 PF00498 0.494
LIG_FHA_1 266 272 PF00498 0.444
LIG_FHA_1 30 36 PF00498 0.498
LIG_FHA_1 594 600 PF00498 0.398
LIG_FHA_1 608 614 PF00498 0.498
LIG_FHA_2 219 225 PF00498 0.511
LIG_FHA_2 31 37 PF00498 0.530
LIG_FHA_2 402 408 PF00498 0.354
LIG_FHA_2 435 441 PF00498 0.402
LIG_FHA_2 473 479 PF00498 0.369
LIG_FHA_2 480 486 PF00498 0.318
LIG_Integrin_RGD_1 46 48 PF01839 0.532
LIG_LIR_Apic_2 320 325 PF02991 0.337
LIG_LIR_Apic_2 509 513 PF02991 0.381
LIG_LIR_Gen_1 478 487 PF02991 0.322
LIG_LIR_Gen_1 73 83 PF02991 0.373
LIG_LIR_Nem_3 149 154 PF02991 0.421
LIG_LIR_Nem_3 478 484 PF02991 0.356
LIG_LIR_Nem_3 73 78 PF02991 0.418
LIG_LYPXL_yS_3 151 154 PF13949 0.406
LIG_RPA_C_Fungi 343 355 PF08784 0.291
LIG_SH2_CRK 510 514 PF00017 0.397
LIG_SH2_SRC 18 21 PF00017 0.517
LIG_SH2_STAT5 182 185 PF00017 0.456
LIG_SH2_STAT5 386 389 PF00017 0.428
LIG_SH2_STAT5 77 80 PF00017 0.486
LIG_SH3_3 17 23 PF00018 0.482
LIG_SH3_3 212 218 PF00018 0.356
LIG_SH3_3 47 53 PF00018 0.495
LIG_Sin3_3 143 150 PF02671 0.324
LIG_SUMO_SIM_anti_2 557 564 PF11976 0.483
LIG_SUMO_SIM_par_1 233 239 PF11976 0.353
LIG_SUMO_SIM_par_1 569 574 PF11976 0.351
LIG_TRAF2_1 302 305 PF00917 0.541
LIG_TRAF2_2 43 48 PF00917 0.497
LIG_TYR_ITIM 384 389 PF00017 0.331
LIG_WW_3 541 545 PF00397 0.351
MOD_CDC14_SPxK_1 582 585 PF00782 0.403
MOD_CDK_SPxK_1 579 585 PF00069 0.404
MOD_CDK_SPxxK_3 333 340 PF00069 0.372
MOD_CDK_SPxxK_3 39 46 PF00069 0.495
MOD_CK1_1 170 176 PF00069 0.493
MOD_CK1_1 21 27 PF00069 0.523
MOD_CK1_1 299 305 PF00069 0.605
MOD_CK1_1 401 407 PF00069 0.473
MOD_CK1_1 419 425 PF00069 0.174
MOD_CK1_1 435 441 PF00069 0.304
MOD_CK1_1 472 478 PF00069 0.486
MOD_CK1_1 49 55 PF00069 0.535
MOD_CK1_1 531 537 PF00069 0.383
MOD_CK1_1 557 563 PF00069 0.381
MOD_CK1_1 577 583 PF00069 0.291
MOD_CK2_1 299 305 PF00069 0.638
MOD_CK2_1 401 407 PF00069 0.357
MOD_CK2_1 434 440 PF00069 0.323
MOD_CK2_1 491 497 PF00069 0.555
MOD_CK2_1 5 11 PF00069 0.515
MOD_CK2_1 531 537 PF00069 0.476
MOD_DYRK1A_RPxSP_1 579 583 PF00069 0.405
MOD_GlcNHglycan 106 109 PF01048 0.487
MOD_GlcNHglycan 305 309 PF01048 0.632
MOD_GlcNHglycan 333 336 PF01048 0.527
MOD_GlcNHglycan 379 382 PF01048 0.403
MOD_GlcNHglycan 455 459 PF01048 0.290
MOD_GlcNHglycan 493 496 PF01048 0.332
MOD_GlcNHglycan 563 566 PF01048 0.553
MOD_GSK3_1 102 109 PF00069 0.483
MOD_GSK3_1 14 21 PF00069 0.508
MOD_GSK3_1 22 29 PF00069 0.481
MOD_GSK3_1 299 306 PF00069 0.589
MOD_GSK3_1 434 441 PF00069 0.398
MOD_GSK3_1 49 56 PF00069 0.540
MOD_GSK3_1 491 498 PF00069 0.407
MOD_GSK3_1 5 12 PF00069 0.527
MOD_GSK3_1 521 528 PF00069 0.350
MOD_GSK3_1 557 564 PF00069 0.483
MOD_GSK3_1 573 580 PF00069 0.331
MOD_GSK3_1 593 600 PF00069 0.336
MOD_GSK3_1 66 73 PF00069 0.344
MOD_N-GLC_1 528 533 PF02516 0.437
MOD_N-GLC_1 574 579 PF02516 0.490
MOD_N-GLC_2 412 414 PF02516 0.242
MOD_N-GLC_2 551 553 PF02516 0.351
MOD_NEK2_1 102 107 PF00069 0.640
MOD_NEK2_1 167 172 PF00069 0.485
MOD_NEK2_1 265 270 PF00069 0.466
MOD_NEK2_1 291 296 PF00069 0.478
MOD_NEK2_1 303 308 PF00069 0.736
MOD_NEK2_1 387 392 PF00069 0.440
MOD_NEK2_1 432 437 PF00069 0.323
MOD_NEK2_1 479 484 PF00069 0.424
MOD_NEK2_1 525 530 PF00069 0.323
MOD_NEK2_1 573 578 PF00069 0.446
MOD_NEK2_1 607 612 PF00069 0.602
MOD_NEK2_1 70 75 PF00069 0.425
MOD_NEK2_2 209 214 PF00069 0.359
MOD_NEK2_2 495 500 PF00069 0.319
MOD_NEK2_2 66 71 PF00069 0.388
MOD_OFUCOSY 166 171 PF10250 0.391
MOD_PIKK_1 291 297 PF00454 0.461
MOD_PIKK_1 398 404 PF00454 0.365
MOD_PIKK_1 469 475 PF00454 0.349
MOD_PK_1 317 323 PF00069 0.284
MOD_PKA_2 256 262 PF00069 0.434
MOD_PKA_2 286 292 PF00069 0.393
MOD_PKA_2 347 353 PF00069 0.417
MOD_PKA_2 435 441 PF00069 0.297
MOD_PKA_2 5 11 PF00069 0.515
MOD_Plk_1 167 173 PF00069 0.468
MOD_Plk_1 477 483 PF00069 0.453
MOD_Plk_1 485 491 PF00069 0.380
MOD_Plk_1 528 534 PF00069 0.449
MOD_Plk_1 557 563 PF00069 0.385
MOD_Plk_1 573 579 PF00069 0.383
MOD_Plk_1 597 603 PF00069 0.518
MOD_Plk_1 66 72 PF00069 0.401
MOD_Plk_2-3 256 262 PF00069 0.285
MOD_Plk_4 23 29 PF00069 0.497
MOD_Plk_4 317 323 PF00069 0.420
MOD_Plk_4 438 444 PF00069 0.373
MOD_Plk_4 9 15 PF00069 0.529
MOD_ProDKin_1 19 25 PF00069 0.506
MOD_ProDKin_1 30 36 PF00069 0.514
MOD_ProDKin_1 333 339 PF00069 0.353
MOD_ProDKin_1 39 45 PF00069 0.480
MOD_ProDKin_1 46 52 PF00069 0.479
MOD_ProDKin_1 508 514 PF00069 0.434
MOD_ProDKin_1 579 585 PF00069 0.492
TRG_DiLeu_LyEn_5 250 255 PF01217 0.352
TRG_ENDOCYTIC_2 151 154 PF00928 0.466
TRG_ENDOCYTIC_2 386 389 PF00928 0.331
TRG_ENDOCYTIC_2 493 496 PF00928 0.347
TRG_ER_diArg_1 226 228 PF00400 0.542
TRG_ER_diArg_1 359 361 PF00400 0.358
TRG_ER_diArg_1 415 418 PF00400 0.315
TRG_ER_diArg_1 499 502 PF00400 0.321
TRG_ER_diArg_1 567 570 PF00400 0.401
TRG_Pf-PMV_PEXEL_1 228 233 PF00026 0.532

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1P921 Leptomonas seymouri 25% 77%
A4HCY0 Leishmania braziliensis 26% 100%
C9ZK22 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 24% 77%
C9ZZI9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 23% 100%
E9AEF0 Leishmania major 26% 81%
E9AGT5 Leishmania infantum 100% 100%
Q4QD45 Leishmania major 82% 100%
Q4QJ80 Leishmania major 81% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS