Anti-silencing protein a-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

anti-silencing protein a-like protein

Species:

Leishmania donovani

UniProt:

A0A3Q8IAD9_LEIDO

TriTrypDb:

LdBPK_160010.1 , LdCL_160005000 , LDHU3_16.0010

Length:

185

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 19
NetGPI	no	yes: 0, no: 19

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	20
GO:0043226	organelle	2	20
GO:0043227	membrane-bounded organelle	3	20
GO:0043229	intracellular organelle	3	20
GO:0043231	intracellular membrane-bounded organelle	4	20
GO:0110165	cellular anatomical entity	1	20
GO:0005829	cytosol	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1

Expansion

Sequence features

A0A3Q8IAD9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IAD9

Function

Biological processes
Term	Name	Level	Count
GO:0006325	chromatin organization	4	20
GO:0009987	cellular process	1	20
GO:0016043	cellular component organization	3	20
GO:0071840	cellular component organization or biogenesis	2	20
GO:0006335	DNA replication-dependent chromatin assembly	5	2

Molecular functions
Term	Name	Level	Count
GO:0005198	structural molecule activity	1	20
GO:0030527	structural constituent of chromatin	2	20
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0042393	histone binding	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	159	163	PF00656	0.700
CLV_C14_Caspase3-7	168	172	PF00656	0.748
CLV_NRD_NRD_1	7	9	PF00675	0.408
CLV_PCSK_FUR_1	176	180	PF00082	0.541
CLV_PCSK_KEX2_1	175	177	PF00082	0.603
CLV_PCSK_KEX2_1	178	180	PF00082	0.588
CLV_PCSK_PC1ET2_1	175	177	PF00082	0.633
CLV_PCSK_PC1ET2_1	178	180	PF00082	0.627
CLV_PCSK_SKI1_1	175	179	PF00082	0.618
DEG_APCC_DBOX_1	3	11	PF00400	0.248
DOC_CKS1_1	20	25	PF01111	0.184
DOC_MAPK_gen_1	35	45	PF00069	0.393
DOC_MAPK_MEF2A_6	19	28	PF00069	0.434
DOC_MAPK_MEF2A_6	38	45	PF00069	0.151
DOC_MAPK_NFAT4_5	25	33	PF00069	0.251
DOC_PP1_RVXF_1	142	149	PF00149	0.393
DOC_PP4_FxxP_1	20	23	PF00568	0.248
DOC_PP4_FxxP_1	33	36	PF00568	0.248
DOC_USP7_MATH_1	15	19	PF00917	0.323
DOC_USP7_MATH_1	156	160	PF00917	0.676
DOC_USP7_UBL2_3	138	142	PF12436	0.221
DOC_WW_Pin1_4	149	154	PF00397	0.619
DOC_WW_Pin1_4	169	174	PF00397	0.446
DOC_WW_Pin1_4	19	24	PF00397	0.406
DOC_WW_Pin1_4	45	50	PF00397	0.314
LIG_Actin_WH2_2	129	146	PF00022	0.374
LIG_CSL_BTD_1	46	49	PF09270	0.307
LIG_FHA_1	131	137	PF00498	0.317
LIG_FHA_1	92	98	PF00498	0.296
LIG_FHA_2	1	7	PF00498	0.290
LIG_FHA_2	125	131	PF00498	0.367
LIG_LIR_Apic_2	145	151	PF02991	0.207
LIG_LIR_Apic_2	18	23	PF02991	0.325
LIG_LIR_Apic_2	31	36	PF02991	0.195
LIG_LIR_Apic_2	48	54	PF02991	0.342
LIG_LIR_Gen_1	105	114	PF02991	0.286
LIG_LIR_Nem_3	105	110	PF02991	0.300
LIG_LIR_Nem_3	44	50	PF02991	0.303
LIG_LYPXL_yS_3	140	143	PF13949	0.393
LIG_SH3_3	87	93	PF00018	0.268
LIG_SH3_3	9	15	PF00018	0.251
LIG_SUMO_SIM_par_1	28	34	PF11976	0.332
LIG_UBA3_1	96	101	PF00899	0.342
MOD_CDC14_SPxK_1	172	175	PF00782	0.587
MOD_CDK_SPxK_1	169	175	PF00069	0.447
MOD_CDK_SPxK_1	19	25	PF00069	0.184
MOD_CDK_SPxxK_3	169	176	PF00069	0.451
MOD_CK1_1	152	158	PF00069	0.673
MOD_CK1_1	169	175	PF00069	0.520
MOD_GlcNHglycan	127	130	PF01048	0.319
MOD_GlcNHglycan	168	171	PF01048	0.699
MOD_GSK3_1	15	22	PF00069	0.450
MOD_GSK3_1	152	159	PF00069	0.591
MOD_GSK3_1	162	169	PF00069	0.548
MOD_GSK3_1	41	48	PF00069	0.419
MOD_N-GLC_1	112	117	PF02516	0.225
MOD_NEK2_1	96	101	PF00069	0.285
MOD_Plk_1	112	118	PF00069	0.221
MOD_Plk_1	144	150	PF00069	0.312
MOD_Plk_1	41	47	PF00069	0.393
MOD_Plk_1	73	79	PF00069	0.331
MOD_ProDKin_1	149	155	PF00069	0.627
MOD_ProDKin_1	169	175	PF00069	0.447
MOD_ProDKin_1	19	25	PF00069	0.406
MOD_ProDKin_1	45	51	PF00069	0.314
MOD_SUMO_for_1	177	180	PF00179	0.536
TRG_ENDOCYTIC_2	140	143	PF00928	0.393
TRG_NLS_MonoExtC_3	174	179	PF00514	0.574
TRG_NLS_MonoExtN_4	173	179	PF00514	0.529

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0I1	Leptomonas seymouri	65%	100%
A0A0S4IIL8	Bodo saltans	31%	100%
A0A0S4JN61	Bodo saltans	46%	100%
A0A0S4JR86	Bodo saltans	56%	86%
A0A1X0NWK6	Trypanosomatidae	33%	100%
A0A1X0P1H0	Trypanosomatidae	62%	92%
A0A3Q8IBF3	Leishmania donovani	34%	100%
A0A3R7M8V4	Trypanosoma rangeli	30%	100%
A0A422ND92	Trypanosoma rangeli	66%	91%
A4H8C7	Leishmania braziliensis	79%	100%
A4HBH4	Leishmania braziliensis	31%	100%
A4HWP9	Leishmania infantum	99%	100%
A4HYJ8	Leishmania infantum	34%	100%
C9ZW62	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	83%
E9AQF6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
E9AUE5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
O74515	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	71%
P32447	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	66%
Q2GQS2	Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)	28%	67%
Q2KIG1	Bos taurus	30%	91%
Q4IR08	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	31%	66%
Q4QF20	Leishmania major	96%	100%
Q59MV1	Candida albicans (strain SC5314 / ATCC MYA-2876)	28%	75%
Q69DB9	Xenopus laevis	29%	92%
Q6BYE5	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	27%	70%
Q6CI62	Yarrowia lipolytica (strain CLIB 122 / E 150)	29%	70%
Q759F6	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	30%	67%
Q9BJ46	Leishmania major	33%	100%
V5B915	Trypanosoma cruzi	54%	92%
V5C0E3	Trypanosoma cruzi	32%	100%