Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IAD7_LEIDO

TriTrypDb:

LdBPK_160740.1 , LdCL_160012600 , LDHU3_16.0890

Length:

740

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IAD7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IAD7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	297	301	PF00656	0.678
CLV_C14_Caspase3-7	329	333	PF00656	0.600
CLV_C14_Caspase3-7	571	575	PF00656	0.541
CLV_NRD_NRD_1	114	116	PF00675	0.475
CLV_NRD_NRD_1	169	171	PF00675	0.584
CLV_NRD_NRD_1	31	33	PF00675	0.630
CLV_NRD_NRD_1	490	492	PF00675	0.583
CLV_NRD_NRD_1	586	588	PF00675	0.553
CLV_NRD_NRD_1	619	621	PF00675	0.543
CLV_NRD_NRD_1	623	625	PF00675	0.572
CLV_PCSK_FUR_1	111	115	PF00082	0.589
CLV_PCSK_KEX2_1	113	115	PF00082	0.514
CLV_PCSK_KEX2_1	169	171	PF00082	0.584
CLV_PCSK_KEX2_1	31	33	PF00082	0.630
CLV_PCSK_KEX2_1	386	388	PF00082	0.626
CLV_PCSK_KEX2_1	490	492	PF00082	0.583
CLV_PCSK_KEX2_1	586	588	PF00082	0.553
CLV_PCSK_KEX2_1	619	621	PF00082	0.543
CLV_PCSK_KEX2_1	623	625	PF00082	0.572
CLV_PCSK_PC1ET2_1	386	388	PF00082	0.690
CLV_PCSK_PC7_1	615	621	PF00082	0.520
CLV_PCSK_SKI1_1	337	341	PF00082	0.416
CLV_PCSK_SKI1_1	615	619	PF00082	0.512
CLV_PCSK_SKI1_1	668	672	PF00082	0.607
DEG_APCC_DBOX_1	336	344	PF00400	0.416
DEG_Nend_Nbox_1	1	3	PF02207	0.681
DEG_SCF_FBW7_1	681	687	PF00400	0.672
DEG_SPOP_SBC_1	513	517	PF00917	0.659
DEG_SPOP_SBC_1	55	59	PF00917	0.622
DOC_ANK_TNKS_1	423	430	PF00023	0.509
DOC_CKS1_1	537	542	PF01111	0.567
DOC_CKS1_1	681	686	PF01111	0.629
DOC_MAPK_DCC_7	88	97	PF00069	0.498
DOC_MAPK_gen_1	251	260	PF00069	0.503
DOC_MAPK_gen_1	640	650	PF00069	0.455
DOC_MAPK_MEF2A_6	254	262	PF00069	0.560
DOC_MAPK_MEF2A_6	651	658	PF00069	0.501
DOC_MAPK_MEF2A_6	88	97	PF00069	0.498
DOC_PP2B_LxvP_1	232	235	PF13499	0.563
DOC_PP2B_LxvP_1	493	496	PF13499	0.655
DOC_PP4_FxxP_1	713	716	PF00568	0.520
DOC_SPAK_OSR1_1	170	174	PF12202	0.496
DOC_USP7_MATH_1	131	135	PF00917	0.427
DOC_USP7_MATH_1	192	196	PF00917	0.655
DOC_USP7_MATH_1	228	232	PF00917	0.752
DOC_USP7_MATH_1	294	298	PF00917	0.677
DOC_USP7_MATH_1	301	305	PF00917	0.707
DOC_USP7_MATH_1	326	330	PF00917	0.628
DOC_USP7_MATH_1	363	367	PF00917	0.575
DOC_USP7_MATH_1	506	510	PF00917	0.752
DOC_USP7_MATH_1	55	59	PF00917	0.726
DOC_USP7_MATH_1	550	554	PF00917	0.604
DOC_USP7_MATH_1	578	582	PF00917	0.642
DOC_USP7_MATH_1	627	631	PF00917	0.603
DOC_USP7_MATH_1	719	723	PF00917	0.549
DOC_USP7_MATH_2	66	72	PF00917	0.581
DOC_WW_Pin1_4	140	145	PF00397	0.438
DOC_WW_Pin1_4	188	193	PF00397	0.664
DOC_WW_Pin1_4	236	241	PF00397	0.577
DOC_WW_Pin1_4	330	335	PF00397	0.536
DOC_WW_Pin1_4	367	372	PF00397	0.558
DOC_WW_Pin1_4	436	441	PF00397	0.571
DOC_WW_Pin1_4	536	541	PF00397	0.579
DOC_WW_Pin1_4	59	64	PF00397	0.671
DOC_WW_Pin1_4	680	685	PF00397	0.665
DOC_WW_Pin1_4	712	717	PF00397	0.616
DOC_WW_Pin1_4	73	78	PF00397	0.615
LIG_14-3-3_CanoR_1	113	119	PF00244	0.473
LIG_14-3-3_CanoR_1	130	139	PF00244	0.435
LIG_14-3-3_CanoR_1	285	294	PF00244	0.530
LIG_14-3-3_CanoR_1	31	38	PF00244	0.689
LIG_14-3-3_CanoR_1	337	347	PF00244	0.431
LIG_14-3-3_CanoR_1	348	353	PF00244	0.508
LIG_14-3-3_CanoR_1	378	383	PF00244	0.550
LIG_14-3-3_CanoR_1	445	455	PF00244	0.579
LIG_14-3-3_CanoR_1	468	476	PF00244	0.590
LIG_14-3-3_CanoR_1	557	566	PF00244	0.598
LIG_14-3-3_CanoR_1	724	730	PF00244	0.446
LIG_Clathr_ClatBox_1	479	483	PF01394	0.617
LIG_eIF4E_1	733	739	PF01652	0.406
LIG_EVH1_1	493	497	PF00568	0.575
LIG_FHA_1	141	147	PF00498	0.552
LIG_FHA_1	21	27	PF00498	0.645
LIG_FHA_1	279	285	PF00498	0.436
LIG_FHA_1	301	307	PF00498	0.598
LIG_FHA_1	340	346	PF00498	0.416
LIG_FHA_1	354	360	PF00498	0.583
LIG_FHA_1	524	530	PF00498	0.773
LIG_FHA_1	651	657	PF00498	0.502
LIG_FHA_1	665	671	PF00498	0.398
LIG_FHA_2	339	345	PF00498	0.410
LIG_FHA_2	352	358	PF00498	0.549
LIG_FHA_2	596	602	PF00498	0.811
LIG_Integrin_isoDGR_2	252	254	PF01839	0.524
LIG_LIR_Apic_2	710	716	PF02991	0.528
LIG_LIR_Gen_1	404	415	PF02991	0.518
LIG_LIR_Nem_3	168	174	PF02991	0.505
LIG_LIR_Nem_3	241	247	PF02991	0.439
LIG_LIR_Nem_3	404	410	PF02991	0.527
LIG_LIR_Nem_3	459	464	PF02991	0.545
LIG_LIR_Nem_3	730	736	PF02991	0.460
LIG_LYPXL_yS_3	733	736	PF13949	0.406
LIG_PCNA_yPIPBox_3	726	739	PF02747	0.422
LIG_PDZ_Class_2	735	740	PF00595	0.419
LIG_Pex14_1	665	669	PF04695	0.472
LIG_Pex14_2	430	434	PF04695	0.557
LIG_SH2_CRK	244	248	PF00017	0.409
LIG_SH2_STAP1	51	55	PF00017	0.602
LIG_SH2_STAT3	674	677	PF00017	0.561
LIG_SH2_STAT5	174	177	PF00017	0.487
LIG_SH2_STAT5	461	464	PF00017	0.552
LIG_SH2_STAT5	669	672	PF00017	0.499
LIG_SH3_1	491	497	PF00018	0.578
LIG_SH3_1	74	80	PF00018	0.695
LIG_SH3_1	88	94	PF00018	0.461
LIG_SH3_3	156	162	PF00018	0.604
LIG_SH3_3	197	203	PF00018	0.691
LIG_SH3_3	486	492	PF00018	0.743
LIG_SH3_3	494	500	PF00018	0.808
LIG_SH3_3	60	66	PF00018	0.607
LIG_SH3_3	601	607	PF00018	0.614
LIG_SH3_3	646	652	PF00018	0.447
LIG_SH3_3	74	80	PF00018	0.684
LIG_SH3_3	84	90	PF00018	0.563
LIG_SUMO_SIM_par_1	134	143	PF11976	0.410
LIG_SUMO_SIM_par_1	280	286	PF11976	0.500
LIG_SUMO_SIM_par_1	341	346	PF11976	0.420
LIG_SUMO_SIM_par_1	652	657	PF11976	0.497
LIG_SUMO_SIM_par_1	93	99	PF11976	0.435
LIG_TRAF2_1	117	120	PF00917	0.453
LIG_TRAF2_1	441	444	PF00917	0.580
LIG_WW_1	64	67	PF00397	0.583
LIG_WW_3	161	165	PF00397	0.639
LIG_WW_3	85	89	PF00397	0.587
MOD_CDK_SPK_2	712	717	PF00069	0.578
MOD_CDK_SPxxK_3	236	243	PF00069	0.554
MOD_CDK_SPxxK_3	330	337	PF00069	0.546
MOD_CK1_1	105	111	PF00069	0.529
MOD_CK1_1	188	194	PF00069	0.715
MOD_CK1_1	230	236	PF00069	0.618
MOD_CK1_1	238	244	PF00069	0.452
MOD_CK1_1	286	292	PF00069	0.508
MOD_CK1_1	308	314	PF00069	0.670
MOD_CK1_1	351	357	PF00069	0.536
MOD_CK1_1	370	376	PF00069	0.563
MOD_CK1_1	380	386	PF00069	0.606
MOD_CK1_1	517	523	PF00069	0.724
MOD_CK1_1	53	59	PF00069	0.619
MOD_CK1_1	546	552	PF00069	0.695
MOD_CK1_1	703	709	PF00069	0.607
MOD_CK1_1	712	718	PF00069	0.548
MOD_CK1_1	75	81	PF00069	0.622
MOD_CK1_1	96	102	PF00069	0.414
MOD_CK2_1	114	120	PF00069	0.521
MOD_CK2_1	139	145	PF00069	0.433
MOD_CK2_1	351	357	PF00069	0.581
MOD_CK2_1	578	584	PF00069	0.671
MOD_CK2_1	656	662	PF00069	0.531
MOD_DYRK1A_RPxSP_1	436	440	PF00069	0.564
MOD_GlcNHglycan	103	107	PF01048	0.550
MOD_GlcNHglycan	188	191	PF01048	0.669
MOD_GlcNHglycan	194	197	PF01048	0.626
MOD_GlcNHglycan	288	291	PF01048	0.532
MOD_GlcNHglycan	316	319	PF01048	0.637
MOD_GlcNHglycan	365	368	PF01048	0.651
MOD_GlcNHglycan	382	385	PF01048	0.511
MOD_GlcNHglycan	42	45	PF01048	0.621
MOD_GlcNHglycan	508	511	PF01048	0.838
MOD_GlcNHglycan	516	519	PF01048	0.565
MOD_GlcNHglycan	548	551	PF01048	0.605
MOD_GlcNHglycan	559	562	PF01048	0.581
MOD_GlcNHglycan	580	583	PF01048	0.741
MOD_GlcNHglycan	598	601	PF01048	0.509
MOD_GlcNHglycan	629	632	PF01048	0.647
MOD_GlcNHglycan	633	636	PF01048	0.534
MOD_GlcNHglycan	657	661	PF01048	0.668
MOD_GlcNHglycan	678	681	PF01048	0.560
MOD_GlcNHglycan	684	687	PF01048	0.641
MOD_GSK3_1	186	193	PF00069	0.655
MOD_GSK3_1	301	308	PF00069	0.802
MOD_GSK3_1	309	316	PF00069	0.613
MOD_GSK3_1	326	333	PF00069	0.580
MOD_GSK3_1	339	346	PF00069	0.353
MOD_GSK3_1	363	370	PF00069	0.579
MOD_GSK3_1	373	380	PF00069	0.598
MOD_GSK3_1	50	57	PF00069	0.751
MOD_GSK3_1	513	520	PF00069	0.685
MOD_GSK3_1	546	553	PF00069	0.569
MOD_GSK3_1	573	580	PF00069	0.647
MOD_GSK3_1	596	603	PF00069	0.674
MOD_GSK3_1	627	634	PF00069	0.653
MOD_GSK3_1	664	671	PF00069	0.482
MOD_GSK3_1	676	683	PF00069	0.537
MOD_GSK3_1	68	75	PF00069	0.528
MOD_LATS_1	184	190	PF00433	0.548
MOD_LATS_1	666	672	PF00433	0.440
MOD_N-GLC_1	312	317	PF02516	0.600
MOD_N-GLC_2	448	450	PF02516	0.591
MOD_NEK2_1	139	144	PF00069	0.528
MOD_NEK2_1	30	35	PF00069	0.694
MOD_NEK2_1	343	348	PF00069	0.489
MOD_NEK2_1	430	435	PF00069	0.572
MOD_NEK2_1	556	561	PF00069	0.678
MOD_NEK2_2	485	490	PF00069	0.587
MOD_PIKK_1	373	379	PF00454	0.588
MOD_PIKK_1	673	679	PF00454	0.496
MOD_PIKK_1	700	706	PF00454	0.634
MOD_PIKK_1	75	81	PF00454	0.691
MOD_PK_1	263	269	PF00069	0.486
MOD_PK_1	573	579	PF00069	0.542
MOD_PKA_1	114	120	PF00069	0.460
MOD_PKA_2	114	120	PF00069	0.461
MOD_PKA_2	185	191	PF00069	0.617
MOD_PKA_2	286	292	PF00069	0.530
MOD_PKA_2	30	36	PF00069	0.605
MOD_PKA_2	377	383	PF00069	0.552
MOD_PKA_2	444	450	PF00069	0.581
MOD_PKA_2	546	552	PF00069	0.614
MOD_PKA_2	556	562	PF00069	0.545
MOD_PKA_2	650	656	PF00069	0.558
MOD_PKA_2	719	725	PF00069	0.514
MOD_PKA_2	9	15	PF00069	0.705
MOD_Plk_1	343	349	PF00069	0.477
MOD_Plk_1	430	436	PF00069	0.577
MOD_Plk_1	600	606	PF00069	0.596
MOD_Plk_1	67	73	PF00069	0.583
MOD_Plk_4	263	269	PF00069	0.418
MOD_Plk_4	430	436	PF00069	0.577
MOD_Plk_4	524	530	PF00069	0.605
MOD_Plk_4	734	740	PF00069	0.414
MOD_Plk_4	93	99	PF00069	0.435
MOD_ProDKin_1	140	146	PF00069	0.435
MOD_ProDKin_1	188	194	PF00069	0.662
MOD_ProDKin_1	236	242	PF00069	0.556
MOD_ProDKin_1	330	336	PF00069	0.518
MOD_ProDKin_1	367	373	PF00069	0.564
MOD_ProDKin_1	436	442	PF00069	0.575
MOD_ProDKin_1	536	542	PF00069	0.578
MOD_ProDKin_1	59	65	PF00069	0.673
MOD_ProDKin_1	680	686	PF00069	0.668
MOD_ProDKin_1	712	718	PF00069	0.612
MOD_ProDKin_1	73	79	PF00069	0.616
TRG_DiLeu_BaEn_2	256	262	PF01217	0.395
TRG_DiLeu_BaLyEn_6	731	736	PF01217	0.419
TRG_ENDOCYTIC_2	244	247	PF00928	0.411
TRG_ENDOCYTIC_2	407	410	PF00928	0.530
TRG_ENDOCYTIC_2	461	464	PF00928	0.552
TRG_ENDOCYTIC_2	733	736	PF00928	0.451
TRG_ER_diArg_1	111	114	PF00400	0.545
TRG_ER_diArg_1	169	171	PF00400	0.584
TRG_ER_diArg_1	2	5	PF00400	0.649
TRG_ER_diArg_1	284	287	PF00400	0.437
TRG_ER_diArg_1	30	32	PF00400	0.580
TRG_ER_diArg_1	452	455	PF00400	0.552
TRG_ER_diArg_1	489	491	PF00400	0.587
TRG_ER_diArg_1	618	620	PF00400	0.532
TRG_ER_diArg_1	622	624	PF00400	0.568
TRG_NES_CRM1_1	271	283	PF08389	0.465
TRG_Pf-PMV_PEXEL_1	114	119	PF00026	0.471
TRG_Pf-PMV_PEXEL_1	180	185	PF00026	0.504

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4A3	Leptomonas seymouri	49%	100%
A4H8J6	Leishmania braziliensis	74%	100%
A4HWX1	Leishmania infantum	100%	100%
E9AQN3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4QEU5	Leishmania major	91%	100%