DoxX family membrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF4499), putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IAC8_LEIDO

TriTrypDb:

LdBPK_211090.1 , LdCL_210015900 , LDHU3_21.1290

Length:

203

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0005635	nuclear envelope	4	1
GO:0005783	endoplasmic reticulum	5	1
GO:0031967	organelle envelope	3	1
GO:0031975	envelope	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A0A3Q8IAC8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IAC8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	83	85	PF00675	0.591
CLV_PCSK_KEX2_1	6	8	PF00082	0.543
CLV_PCSK_KEX2_1	83	85	PF00082	0.645
CLV_PCSK_PC1ET2_1	6	8	PF00082	0.543
CLV_PCSK_PC7_1	79	85	PF00082	0.588
CLV_PCSK_SKI1_1	160	164	PF00082	0.398
CLV_PCSK_SKI1_1	6	10	PF00082	0.544
CLV_PCSK_SKI1_1	79	83	PF00082	0.652
DEG_APCC_DBOX_1	37	45	PF00400	0.359
DEG_SPOP_SBC_1	22	26	PF00917	0.594
DOC_CYCLIN_RxL_1	61	70	PF00134	0.387
DOC_CYCLIN_yCln2_LP_2	39	45	PF00134	0.398
DOC_MAPK_MEF2A_6	34	43	PF00069	0.521
DOC_PP1_RVXF_1	144	150	PF00149	0.445
DOC_PP2B_LxvP_1	39	42	PF13499	0.398
DOC_PP2B_LxvP_1	66	69	PF13499	0.398
DOC_USP7_MATH_1	21	25	PF00917	0.745
DOC_WW_Pin1_4	10	15	PF00397	0.740
DOC_WW_Pin1_4	171	176	PF00397	0.362
LIG_14-3-3_CanoR_1	146	155	PF00244	0.520
LIG_Actin_WH2_2	68	85	PF00022	0.412
LIG_BIR_III_4	60	64	PF00653	0.366
LIG_FHA_1	188	194	PF00498	0.433
LIG_FHA_1	91	97	PF00498	0.484
LIG_GBD_Chelix_1	45	53	PF00786	0.428
LIG_Pex14_2	145	149	PF04695	0.581
LIG_PTB_Apo_2	49	56	PF02174	0.398
LIG_SH2_SRC	40	43	PF00017	0.398
LIG_SH2_STAT5	40	43	PF00017	0.384
LIG_SH2_STAT5	71	74	PF00017	0.392
LIG_SH3_2	2	7	PF14604	0.686
LIG_SH3_3	89	95	PF00018	0.452
MOD_CDK_SPxxK_3	171	178	PF00069	0.383
MOD_CK1_1	25	31	PF00069	0.714
MOD_GlcNHglycan	123	126	PF01048	0.343
MOD_GSK3_1	147	154	PF00069	0.526
MOD_GSK3_1	187	194	PF00069	0.383
MOD_GSK3_1	21	28	PF00069	0.562
MOD_GSK3_1	6	13	PF00069	0.761
MOD_N-GLC_1	151	156	PF02516	0.381
MOD_NEK2_1	104	109	PF00069	0.337
MOD_NEK2_1	119	124	PF00069	0.289
MOD_NEK2_1	155	160	PF00069	0.424
MOD_NEK2_1	162	167	PF00069	0.419
MOD_NEK2_1	187	192	PF00069	0.423
MOD_OFUCOSY	144	151	PF10250	0.449
MOD_PIKK_1	168	174	PF00454	0.363
MOD_PKA_1	6	12	PF00069	0.768
MOD_PKA_2	187	193	PF00069	0.466
MOD_PKA_2	6	12	PF00069	0.740
MOD_Plk_1	104	110	PF00069	0.378
MOD_Plk_1	151	157	PF00069	0.581
MOD_Plk_4	104	110	PF00069	0.382
MOD_ProDKin_1	10	16	PF00069	0.736
MOD_ProDKin_1	171	177	PF00069	0.362
MOD_SUMO_rev_2	3	8	PF00179	0.779
TRG_DiLeu_BaLyEn_6	172	177	PF01217	0.317
TRG_ENDOCYTIC_2	40	43	PF00928	0.392
TRG_ER_diArg_1	82	84	PF00400	0.394
TRG_ER_diLys_1	200	203	PF00400	0.499

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7P5	Leptomonas seymouri	46%	100%
A0A0S4IZY4	Bodo saltans	34%	100%
A0A0S4J009	Bodo saltans	28%	100%
A0A1X0NXR6	Trypanosomatidae	37%	100%
A0A3R7KU69	Trypanosoma rangeli	35%	100%
A4HBU7	Leishmania braziliensis	67%	98%
D0A1C5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9AGV3	Leishmania infantum	99%	100%
E9AV69	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4QCB2	Leishmania major	93%	100%