DUF4833 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IAB9_LEIDO

TriTrypDb:

LdBPK_210940.1 , LdCL_210014400 , LDHU3_21.1100

Length:

384

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IAB9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IAB9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	218	222	PF00656	0.412
CLV_C14_Caspase3-7	334	338	PF00656	0.313
CLV_NRD_NRD_1	122	124	PF00675	0.440
CLV_NRD_NRD_1	261	263	PF00675	0.538
CLV_PCSK_KEX2_1	121	123	PF00082	0.420
CLV_PCSK_KEX2_1	261	263	PF00082	0.538
CLV_PCSK_KEX2_1	354	356	PF00082	0.313
CLV_PCSK_KEX2_1	88	90	PF00082	0.381
CLV_PCSK_PC1ET2_1	354	356	PF00082	0.313
CLV_PCSK_PC1ET2_1	88	90	PF00082	0.381
CLV_PCSK_SKI1_1	10	14	PF00082	0.440
DEG_SPOP_SBC_1	278	282	PF00917	0.598
DOC_CKS1_1	35	40	PF01111	0.389
DOC_MAPK_gen_1	10	20	PF00069	0.407
DOC_PP4_FxxP_1	26	29	PF00568	0.358
DOC_USP7_MATH_1	175	179	PF00917	0.519
DOC_USP7_MATH_1	278	282	PF00917	0.638
DOC_USP7_MATH_1	29	33	PF00917	0.406
DOC_USP7_UBL2_3	345	349	PF12436	0.396
DOC_WW_Pin1_4	144	149	PF00397	0.391
DOC_WW_Pin1_4	159	164	PF00397	0.473
DOC_WW_Pin1_4	267	272	PF00397	0.650
DOC_WW_Pin1_4	34	39	PF00397	0.425
LIG_14-3-3_CanoR_1	261	266	PF00244	0.591
LIG_14-3-3_CanoR_1	288	298	PF00244	0.702
LIG_BIR_II_1	1	5	PF00653	0.564
LIG_BRCT_BRCA1_1	15	19	PF00533	0.380
LIG_FHA_1	149	155	PF00498	0.381
LIG_FHA_1	300	306	PF00498	0.743
LIG_FHA_1	317	323	PF00498	0.463
LIG_FHA_1	76	82	PF00498	0.315
LIG_FHA_2	280	286	PF00498	0.758
LIG_FHA_2	291	297	PF00498	0.612
LIG_FHA_2	332	338	PF00498	0.296
LIG_FHA_2	372	378	PF00498	0.300
LIG_FHA_2	9	15	PF00498	0.443
LIG_LIR_Apic_2	226	230	PF02991	0.359
LIG_LIR_Apic_2	23	29	PF02991	0.420
LIG_LIR_Apic_2	32	38	PF02991	0.513
LIG_LIR_Gen_1	164	172	PF02991	0.479
LIG_LIR_Gen_1	236	245	PF02991	0.416
LIG_LIR_Gen_1	363	372	PF02991	0.272
LIG_LIR_Nem_3	16	22	PF02991	0.371
LIG_LIR_Nem_3	164	169	PF02991	0.475
LIG_LIR_Nem_3	226	231	PF02991	0.381
LIG_LIR_Nem_3	236	241	PF02991	0.371
LIG_LIR_Nem_3	243	247	PF02991	0.411
LIG_LIR_Nem_3	363	367	PF02991	0.300
LIG_Pex14_1	227	231	PF04695	0.365
LIG_RPA_C_Fungi	256	268	PF08784	0.494
LIG_SH2_CRK	35	39	PF00017	0.535
LIG_SH2_CRK	357	361	PF00017	0.313
LIG_SH2_PTP2	364	367	PF00017	0.272
LIG_SH2_SRC	250	253	PF00017	0.325
LIG_SH2_SRC	364	367	PF00017	0.272
LIG_SH2_STAP1	77	81	PF00017	0.319
LIG_SH2_STAT5	109	112	PF00017	0.365
LIG_SH2_STAT5	117	120	PF00017	0.418
LIG_SH2_STAT5	234	237	PF00017	0.352
LIG_SH2_STAT5	250	253	PF00017	0.498
LIG_SH2_STAT5	347	350	PF00017	0.318
LIG_SH2_STAT5	364	367	PF00017	0.313
LIG_SH2_STAT5	65	68	PF00017	0.412
LIG_SH2_STAT5	77	80	PF00017	0.330
LIG_SH3_3	176	182	PF00018	0.472
LIG_SH3_3	227	233	PF00018	0.371
LIG_SH3_3	236	242	PF00018	0.297
LIG_SH3_3	246	252	PF00018	0.223
LIG_SUMO_SIM_anti_2	131	137	PF11976	0.381
LIG_SUMO_SIM_anti_2	324	334	PF11976	0.295
LIG_SUMO_SIM_anti_2	339	344	PF11976	0.218
LIG_SUMO_SIM_par_1	324	334	PF11976	0.313
LIG_TRAF2_1	168	171	PF00917	0.359
LIG_TYR_ITIM	362	367	PF00017	0.272
LIG_UBA3_1	247	256	PF00899	0.357
MOD_CK1_1	159	165	PF00069	0.413
MOD_CK1_1	260	266	PF00069	0.624
MOD_CK1_1	270	276	PF00069	0.706
MOD_CK1_1	281	287	PF00069	0.626
MOD_CK1_1	371	377	PF00069	0.313
MOD_CK1_1	8	14	PF00069	0.469
MOD_CK2_1	113	119	PF00069	0.415
MOD_CK2_1	131	137	PF00069	0.407
MOD_CK2_1	290	296	PF00069	0.678
MOD_CK2_1	338	344	PF00069	0.349
MOD_CK2_1	371	377	PF00069	0.359
MOD_CK2_1	8	14	PF00069	0.452
MOD_GlcNHglycan	144	147	PF01048	0.397
MOD_GlcNHglycan	199	202	PF01048	0.652
MOD_GlcNHglycan	210	213	PF01048	0.702
MOD_GlcNHglycan	272	275	PF01048	0.606
MOD_GlcNHglycan	319	322	PF01048	0.529
MOD_GlcNHglycan	7	10	PF01048	0.522
MOD_GlcNHglycan	91	94	PF01048	0.413
MOD_GSK3_1	109	116	PF00069	0.491
MOD_GSK3_1	144	151	PF00069	0.422
MOD_GSK3_1	20	27	PF00069	0.487
MOD_GSK3_1	256	263	PF00069	0.587
MOD_GSK3_1	273	280	PF00069	0.548
MOD_GSK3_1	299	306	PF00069	0.619
MOD_GSK3_1	30	37	PF00069	0.368
MOD_GSK3_1	317	324	PF00069	0.544
MOD_GSK3_1	371	378	PF00069	0.313
MOD_N-GLC_1	290	295	PF02516	0.568
MOD_N-GLC_1	303	308	PF02516	0.517
MOD_NEK2_1	136	141	PF00069	0.428
MOD_NEK2_1	18	23	PF00069	0.268
MOD_NEK2_1	299	304	PF00069	0.588
MOD_NEK2_1	368	373	PF00069	0.288
MOD_NEK2_1	44	49	PF00069	0.380
MOD_NEK2_1	5	10	PF00069	0.521
MOD_PIKK_1	30	36	PF00454	0.433
MOD_PIKK_1	83	89	PF00454	0.382
MOD_PK_1	24	30	PF00069	0.377
MOD_PK_1	261	267	PF00069	0.539
MOD_PKA_1	261	267	PF00069	0.539
MOD_PKA_2	260	266	PF00069	0.587
MOD_Plk_1	131	137	PF00069	0.522
MOD_Plk_1	175	181	PF00069	0.461
MOD_Plk_1	24	30	PF00069	0.517
MOD_Plk_1	303	309	PF00069	0.580
MOD_Plk_1	325	331	PF00069	0.289
MOD_Plk_1	338	344	PF00069	0.228
MOD_Plk_2-3	131	137	PF00069	0.381
MOD_Plk_4	113	119	PF00069	0.447
MOD_Plk_4	131	137	PF00069	0.584
MOD_Plk_4	150	156	PF00069	0.394
MOD_Plk_4	223	229	PF00069	0.409
MOD_Plk_4	325	331	PF00069	0.320
MOD_Plk_4	338	344	PF00069	0.348
MOD_ProDKin_1	144	150	PF00069	0.391
MOD_ProDKin_1	159	165	PF00069	0.473
MOD_ProDKin_1	267	273	PF00069	0.650
MOD_ProDKin_1	34	40	PF00069	0.421
MOD_SUMO_for_1	360	363	PF00179	0.355
MOD_SUMO_rev_2	171	175	PF00179	0.402
MOD_SUMO_rev_2	350	356	PF00179	0.315
MOD_SUMO_rev_2	377	383	PF00179	0.271
TRG_ENDOCYTIC_2	364	367	PF00928	0.302
TRG_ER_diArg_1	121	123	PF00400	0.420
TRG_ER_diArg_1	45	48	PF00400	0.411
TRG_ER_diArg_1	49	52	PF00400	0.460
TRG_ER_diLys_1	381	384	PF00400	0.416
TRG_NES_CRM1_1	339	352	PF08389	0.262

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3J1	Leptomonas seymouri	35%	100%
A0A0N0P3Y3	Leptomonas seymouri	61%	100%
A0A3Q8IF47	Leishmania donovani	35%	100%
A4HZM6	Leishmania infantum	35%	94%
A4HZM7	Leishmania infantum	99%	100%
E9AV54	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	96%
E9AV55	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	94%
Q4QCC6	Leishmania major	34%	91%
Q4QCC7	Leishmania major	94%	100%