2OG-Fe(II)_oxygenase_superfamily_putative/Pfam:PF 13532

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

2OG-Fe(II) oxygenase superfamily, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IAB8_LEIDO

TriTrypDb:

LdBPK_160360.1 , LdCL_160008500 , LDHU3_16.0430

Length:

368

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	3
GO:0016020	membrane	2	2

Expansion

Sequence features

A0A3Q8IAB8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IAB8

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006259	DNA metabolic process	4	12
GO:0006281	DNA repair	5	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0006950	response to stress	2	12
GO:0006974	DNA damage response	4	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0033554	cellular response to stress	3	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0046483	heterocycle metabolic process	3	12
GO:0050896	response to stimulus	1	12
GO:0051716	cellular response to stimulus	2	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:0006304	DNA modification	5	1
GO:0009451	RNA modification	5	1
GO:0016070	RNA metabolic process	5	1
GO:0035510	DNA dealkylation	6	1
GO:0035511	obsolete oxidative DNA demethylation	4	1
GO:0035513	oxidative RNA demethylation	4	1
GO:0035552	oxidative single-stranded DNA demethylation	5	1
GO:0043412	macromolecule modification	4	1
GO:0044728	obsolete DNA methylation or demethylation	6	1
GO:0070988	demethylation	2	1
GO:0070989	oxidative demethylation	3	1
GO:0080111	DNA demethylation	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0016491	oxidoreductase activity	2	12
GO:0051213	dioxygenase activity	3	12
GO:0005488	binding	1	1
GO:0005506	iron ion binding	6	1
GO:0008198	ferrous iron binding	7	1
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	3	1
GO:0016706	2-oxoglutarate-dependent dioxygenase activity	4	1
GO:0032451	demethylase activity	2	1
GO:0035514	DNA demethylase activity	3	1
GO:0035515	oxidative RNA demethylase activity	3	1
GO:0035516	oxidative DNA demethylase activity	4	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1
GO:0046914	transition metal ion binding	5	1
GO:0140097	catalytic activity, acting on DNA	3	1
GO:0140098	catalytic activity, acting on RNA	3	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	109	113	PF00656	0.464
CLV_NRD_NRD_1	13	15	PF00675	0.489
CLV_NRD_NRD_1	149	151	PF00675	0.206
CLV_NRD_NRD_1	18	20	PF00675	0.473
CLV_PCSK_KEX2_1	13	15	PF00082	0.467
CLV_PCSK_KEX2_1	17	19	PF00082	0.451
CLV_PCSK_KEX2_1	4	6	PF00082	0.402
CLV_PCSK_KEX2_1	44	46	PF00082	0.495
CLV_PCSK_PC1ET2_1	4	6	PF00082	0.389
CLV_PCSK_PC1ET2_1	44	46	PF00082	0.402
CLV_PCSK_PC7_1	13	19	PF00082	0.489
CLV_PCSK_SKI1_1	138	142	PF00082	0.208
CLV_PCSK_SKI1_1	263	267	PF00082	0.267
CLV_PCSK_SKI1_1	49	53	PF00082	0.454
CLV_PCSK_SKI1_1	74	78	PF00082	0.482
DEG_APCC_DBOX_1	262	270	PF00400	0.368
DEG_SPOP_SBC_1	127	131	PF00917	0.440
DOC_CDC14_PxL_1	81	89	PF14671	0.305
DOC_MAPK_gen_1	166	175	PF00069	0.450
DOC_MAPK_gen_1	44	52	PF00069	0.520
DOC_PP2B_LxvP_1	280	283	PF13499	0.475
DOC_PP4_FxxP_1	258	261	PF00568	0.432
DOC_PP4_FxxP_1	352	355	PF00568	0.479
DOC_USP7_MATH_1	203	207	PF00917	0.466
DOC_USP7_MATH_1	222	226	PF00917	0.511
DOC_USP7_MATH_1	261	265	PF00917	0.476
LIG_14-3-3_CanoR_1	138	143	PF00244	0.399
LIG_14-3-3_CanoR_1	157	162	PF00244	0.456
LIG_14-3-3_CanoR_1	303	311	PF00244	0.368
LIG_14-3-3_CanoR_1	38	46	PF00244	0.452
LIG_BIR_II_1	1	5	PF00653	0.397
LIG_BRCT_BRCA1_1	230	234	PF00533	0.408
LIG_EH1_1	201	209	PF00400	0.408
LIG_FHA_1	147	153	PF00498	0.475
LIG_FHA_1	194	200	PF00498	0.428
LIG_FHA_1	26	32	PF00498	0.437
LIG_FHA_2	279	285	PF00498	0.463
LIG_FHA_2	286	292	PF00498	0.435
LIG_LIR_Apic_2	130	136	PF02991	0.418
LIG_LIR_Gen_1	156	165	PF02991	0.465
LIG_LIR_Gen_1	243	250	PF02991	0.498
LIG_LIR_Gen_1	278	287	PF02991	0.467
LIG_LIR_Gen_1	307	318	PF02991	0.424
LIG_LIR_Nem_3	156	161	PF02991	0.451
LIG_LIR_Nem_3	243	249	PF02991	0.498
LIG_LIR_Nem_3	278	282	PF02991	0.451
LIG_LIR_Nem_3	3	9	PF02991	0.379
LIG_LIR_Nem_3	307	313	PF02991	0.498
LIG_LIR_Nem_3	324	329	PF02991	0.511
LIG_LIR_Nem_3	80	84	PF02991	0.311
LIG_LYPXL_yS_3	188	191	PF13949	0.498
LIG_PCNA_PIPBox_1	195	204	PF02747	0.408
LIG_SH2_CRK	133	137	PF00017	0.529
LIG_SH2_CRK	246	250	PF00017	0.424
LIG_SH2_SRC	133	136	PF00017	0.450
LIG_SH2_STAP1	144	148	PF00017	0.501
LIG_SH2_STAP1	246	250	PF00017	0.433
LIG_SH2_STAT3	192	195	PF00017	0.408
LIG_SH2_STAT5	279	282	PF00017	0.432
LIG_SH2_STAT5	300	303	PF00017	0.424
LIG_SH2_STAT5	79	82	PF00017	0.357
LIG_SH3_1	17	23	PF00018	0.573
LIG_SH3_3	17	23	PF00018	0.558
LIG_SH3_3	188	194	PF00018	0.482
LIG_SH3_3	47	53	PF00018	0.516
LIG_TRAF2_1	66	69	PF00917	0.487
LIG_TYR_ITIM	199	204	PF00017	0.243
MOD_CK1_1	215	221	PF00069	0.318
MOD_CK1_1	306	312	PF00069	0.219
MOD_CK2_1	278	284	PF00069	0.323
MOD_CK2_1	285	291	PF00069	0.277
MOD_CK2_1	62	68	PF00069	0.738
MOD_CK2_1	9	15	PF00069	0.569
MOD_CK2_1	92	98	PF00069	0.302
MOD_GlcNHglycan	112	115	PF01048	0.363
MOD_GlcNHglycan	162	165	PF01048	0.399
MOD_GlcNHglycan	230	233	PF01048	0.388
MOD_GlcNHglycan	251	254	PF01048	0.243
MOD_GlcNHglycan	263	266	PF01048	0.243
MOD_GlcNHglycan	64	67	PF01048	0.689
MOD_GSK3_1	138	145	PF00069	0.464
MOD_GSK3_1	156	163	PF00069	0.355
MOD_GSK3_1	224	231	PF00069	0.243
MOD_GSK3_1	261	268	PF00069	0.344
MOD_GSK3_1	302	309	PF00069	0.405
MOD_NEK2_1	224	229	PF00069	0.311
MOD_NEK2_1	235	240	PF00069	0.301
MOD_NEK2_1	77	82	PF00069	0.403
MOD_PIKK_1	235	241	PF00454	0.388
MOD_PKA_2	156	162	PF00069	0.311
MOD_PKA_2	302	308	PF00069	0.187
MOD_PKA_2	37	43	PF00069	0.521
MOD_PKB_1	155	163	PF00069	0.288
MOD_Plk_1	215	221	PF00069	0.277
MOD_Plk_2-3	278	284	PF00069	0.268
MOD_Plk_2-3	285	291	PF00069	0.287
MOD_Plk_2-3	37	43	PF00069	0.432
MOD_Plk_4	171	177	PF00069	0.315
MOD_Plk_4	203	209	PF00069	0.285
MOD_Plk_4	306	312	PF00069	0.269
MOD_SUMO_rev_2	37	46	PF00179	0.391
TRG_DiLeu_BaEn_1	42	47	PF01217	0.434
TRG_DiLeu_LyEn_5	42	47	PF01217	0.434
TRG_ENDOCYTIC_2	158	161	PF00928	0.340
TRG_ENDOCYTIC_2	188	191	PF00928	0.302
TRG_ENDOCYTIC_2	201	204	PF00928	0.202
TRG_ENDOCYTIC_2	246	249	PF00928	0.266
TRG_ENDOCYTIC_2	279	282	PF00928	0.335
TRG_ENDOCYTIC_2	326	329	PF00928	0.388
TRG_ER_diArg_1	165	168	PF00400	0.301
TRG_ER_diArg_1	17	19	PF00400	0.552
TRG_ER_diArg_1	292	295	PF00400	0.311
TRG_Pf-PMV_PEXEL_1	271	275	PF00026	0.337
TRG_Pf-PMV_PEXEL_1	356	360	PF00026	0.568

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAG0	Leptomonas seymouri	73%	86%
A0A0S4IYK4	Bodo saltans	48%	95%
A0A1X0PAI9	Trypanosomatidae	50%	100%
A0A3R7NC97	Trypanosoma rangeli	49%	90%
A4H8G0	Leishmania braziliensis	82%	100%
A4HWT4	Leishmania infantum	100%	100%
C9ZLP0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9AQJ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4QEY5	Leishmania major	95%	100%
Q54N08	Dictyostelium discoideum	26%	94%
Q9SA98	Arabidopsis thaliana	28%	100%
V5BRD6	Trypanosoma cruzi	51%	98%