Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IAB6_LEIDO

TriTrypDb:

LdBPK_151290.1 , LdCL_150018200 , LDHU3_15.1600

Length:

545

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 19
NetGPI	no	yes: 0, no: 19

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	1
GO:0020023	kinetoplast	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IAB6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IAB6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	148	152	PF00656	0.464
CLV_C14_Caspase3-7	300	304	PF00656	0.534
CLV_C14_Caspase3-7	449	453	PF00656	0.481
CLV_NRD_NRD_1	101	103	PF00675	0.460
CLV_NRD_NRD_1	120	122	PF00675	0.380
CLV_NRD_NRD_1	14	16	PF00675	0.647
CLV_NRD_NRD_1	339	341	PF00675	0.390
CLV_NRD_NRD_1	410	412	PF00675	0.612
CLV_NRD_NRD_1	520	522	PF00675	0.556
CLV_NRD_NRD_1	531	533	PF00675	0.530
CLV_NRD_NRD_1	536	538	PF00675	0.505
CLV_PCSK_KEX2_1	120	122	PF00082	0.505
CLV_PCSK_KEX2_1	14	16	PF00082	0.633
CLV_PCSK_KEX2_1	410	412	PF00082	0.623
CLV_PCSK_KEX2_1	531	533	PF00082	0.570
CLV_PCSK_KEX2_1	536	538	PF00082	0.554
CLV_PCSK_KEX2_1	75	77	PF00082	0.464
CLV_PCSK_PC1ET2_1	75	77	PF00082	0.480
CLV_PCSK_PC7_1	532	538	PF00082	0.570
CLV_PCSK_SKI1_1	246	250	PF00082	0.415
CLV_PCSK_SKI1_1	325	329	PF00082	0.556
CLV_PCSK_SKI1_1	341	345	PF00082	0.324
CLV_PCSK_SKI1_1	346	350	PF00082	0.385
CLV_PCSK_SKI1_1	353	357	PF00082	0.436
CLV_PCSK_SKI1_1	411	415	PF00082	0.605
CLV_PCSK_SKI1_1	481	485	PF00082	0.773
CLV_Separin_Metazoa	528	532	PF03568	0.544
DEG_APCC_DBOX_1	154	162	PF00400	0.492
DEG_APCC_DBOX_1	345	353	PF00400	0.402
DEG_SPOP_SBC_1	27	31	PF00917	0.492
DOC_CYCLIN_RxL_1	350	359	PF00134	0.416
DOC_CYCLIN_yClb1_LxF_4	220	226	PF00134	0.382
DOC_MAPK_FxFP_2	366	369	PF00069	0.569
DOC_MAPK_gen_1	102	110	PF00069	0.506
DOC_MAPK_gen_1	14	20	PF00069	0.522
DOC_MAPK_MEF2A_6	398	406	PF00069	0.605
DOC_PP2B_LxvP_1	355	358	PF13499	0.426
DOC_PP2B_LxvP_1	52	55	PF13499	0.606
DOC_PP4_FxxP_1	366	369	PF00568	0.569
DOC_PP4_FxxP_1	80	83	PF00568	0.493
DOC_USP7_MATH_1	2	6	PF00917	0.546
DOC_USP7_MATH_1	267	271	PF00917	0.533
DOC_USP7_MATH_1	297	301	PF00917	0.751
DOC_USP7_MATH_1	489	493	PF00917	0.623
DOC_USP7_MATH_1	504	508	PF00917	0.558
DOC_USP7_MATH_2	57	63	PF00917	0.532
DOC_USP7_UBL2_3	328	332	PF12436	0.614
DOC_USP7_UBL2_3	468	472	PF12436	0.666
DOC_WW_Pin1_4	254	259	PF00397	0.486
DOC_WW_Pin1_4	493	498	PF00397	0.598
DOC_WW_Pin1_4	8	13	PF00397	0.513
LIG_14-3-3_CanoR_1	26	32	PF00244	0.590
LIG_14-3-3_CanoR_1	340	348	PF00244	0.509
LIG_14-3-3_CanoR_1	35	41	PF00244	0.688
LIG_Actin_WH2_2	401	416	PF00022	0.639
LIG_Clathr_ClatBox_1	162	166	PF01394	0.387
LIG_deltaCOP1_diTrp_1	117	122	PF00928	0.603
LIG_deltaCOP1_diTrp_1	400	406	PF00928	0.553
LIG_FHA_1	20	26	PF00498	0.727
LIG_FHA_1	340	346	PF00498	0.336
LIG_FHA_1	47	53	PF00498	0.706
LIG_FHA_2	128	134	PF00498	0.455
LIG_FHA_2	232	238	PF00498	0.327
LIG_FHA_2	372	378	PF00498	0.549
LIG_GBD_Chelix_1	384	392	PF00786	0.416
LIG_LIR_Gen_1	109	119	PF02991	0.449
LIG_LIR_Gen_1	141	150	PF02991	0.672
LIG_LIR_Gen_1	156	165	PF02991	0.270
LIG_LIR_Gen_1	218	226	PF02991	0.375
LIG_LIR_Gen_1	400	408	PF02991	0.523
LIG_LIR_Nem_3	109	115	PF02991	0.515
LIG_LIR_Nem_3	141	146	PF02991	0.583
LIG_LIR_Nem_3	156	162	PF02991	0.287
LIG_LIR_Nem_3	218	222	PF02991	0.392
LIG_LIR_Nem_3	400	406	PF02991	0.504
LIG_NRBOX	351	357	PF00104	0.514
LIG_PCNA_yPIPBox_3	90	103	PF02747	0.459
LIG_Pex14_2	207	211	PF04695	0.560
LIG_SH2_CRK	112	116	PF00017	0.515
LIG_SH2_CRK	143	147	PF00017	0.523
LIG_SH2_CRK	159	163	PF00017	0.243
LIG_SH2_CRK	219	223	PF00017	0.407
LIG_SH2_GRB2like	219	222	PF00017	0.412
LIG_SH2_GRB2like	276	279	PF00017	0.546
LIG_SH2_STAP1	112	116	PF00017	0.445
LIG_SH2_STAP1	159	163	PF00017	0.386
LIG_SH2_STAP1	219	223	PF00017	0.407
LIG_SH2_STAP1	276	280	PF00017	0.547
LIG_SH2_STAT3	444	447	PF00017	0.532
LIG_SH2_STAT5	180	183	PF00017	0.489
LIG_SH2_STAT5	242	245	PF00017	0.402
LIG_SH3_1	252	258	PF00018	0.403
LIG_SH3_3	252	258	PF00018	0.463
LIG_SH3_3	422	428	PF00018	0.610
LIG_SH3_3	48	54	PF00018	0.727
LIG_SH3_3	506	512	PF00018	0.577
LIG_SUMO_SIM_par_1	371	377	PF11976	0.451
LIG_SUMO_SIM_par_1	383	389	PF11976	0.451
LIG_TRAF2_1	333	336	PF00917	0.616
LIG_TRAF2_1	358	361	PF00917	0.519
LIG_TYR_ITIM	110	115	PF00017	0.577
LIG_WRC_WIRS_1	128	133	PF05994	0.626
MOD_CDC14_SPxK_1	11	14	PF00782	0.473
MOD_CDK_SPxK_1	8	14	PF00069	0.509
MOD_CDK_SPxxK_3	8	15	PF00069	0.493
MOD_CK1_1	176	182	PF00069	0.564
MOD_CK1_1	270	276	PF00069	0.552
MOD_CK1_1	283	289	PF00069	0.526
MOD_CK1_1	290	296	PF00069	0.438
MOD_CK1_1	31	37	PF00069	0.782
MOD_CK1_1	339	345	PF00069	0.487
MOD_CK1_1	493	499	PF00069	0.773
MOD_CK2_1	127	133	PF00069	0.642
MOD_CK2_1	330	336	PF00069	0.637
MOD_CK2_1	371	377	PF00069	0.553
MOD_CK2_1	489	495	PF00069	0.602
MOD_Cter_Amidation	100	103	PF01082	0.462
MOD_GlcNHglycan	270	273	PF01048	0.528
MOD_GlcNHglycan	294	297	PF01048	0.742
MOD_GlcNHglycan	299	302	PF01048	0.746
MOD_GlcNHglycan	305	308	PF01048	0.701
MOD_GlcNHglycan	311	314	PF01048	0.568
MOD_GlcNHglycan	41	44	PF01048	0.590
MOD_GlcNHglycan	415	418	PF01048	0.498
MOD_GlcNHglycan	448	451	PF01048	0.609
MOD_GlcNHglycan	476	479	PF01048	0.703
MOD_GlcNHglycan	498	501	PF01048	0.786
MOD_GSK3_1	145	152	PF00069	0.592
MOD_GSK3_1	172	179	PF00069	0.530
MOD_GSK3_1	26	33	PF00069	0.697
MOD_GSK3_1	280	287	PF00069	0.663
MOD_GSK3_1	288	295	PF00069	0.703
MOD_GSK3_1	309	316	PF00069	0.481
MOD_GSK3_1	442	449	PF00069	0.686
MOD_GSK3_1	489	496	PF00069	0.755
MOD_GSK3_1	55	62	PF00069	0.572
MOD_N-GLC_1	46	51	PF02516	0.506
MOD_NEK2_1	110	115	PF00069	0.458
MOD_NEK2_1	25	30	PF00069	0.616
MOD_NEK2_1	280	285	PF00069	0.545
MOD_NEK2_1	413	418	PF00069	0.675
MOD_NEK2_1	443	448	PF00069	0.558
MOD_PIKK_1	110	116	PF00454	0.437
MOD_PIKK_1	443	449	PF00454	0.677
MOD_PKA_2	176	182	PF00069	0.425
MOD_PKA_2	25	31	PF00069	0.609
MOD_PKA_2	339	345	PF00069	0.553
MOD_PKA_2	36	42	PF00069	0.694
MOD_Plk_4	127	133	PF00069	0.552
MOD_Plk_4	176	182	PF00069	0.474
MOD_Plk_4	231	237	PF00069	0.341
MOD_Plk_4	3	9	PF00069	0.542
MOD_Plk_4	64	70	PF00069	0.634
MOD_ProDKin_1	254	260	PF00069	0.491
MOD_ProDKin_1	493	499	PF00069	0.600
MOD_ProDKin_1	8	14	PF00069	0.509
MOD_SUMO_for_1	163	166	PF00179	0.436
TRG_ENDOCYTIC_2	112	115	PF00928	0.423
TRG_ENDOCYTIC_2	143	146	PF00928	0.660
TRG_ENDOCYTIC_2	159	162	PF00928	0.285
TRG_ENDOCYTIC_2	219	222	PF00928	0.411
TRG_ENDOCYTIC_2	433	436	PF00928	0.528
TRG_ENDOCYTIC_2	66	69	PF00928	0.608
TRG_ER_diArg_1	119	121	PF00400	0.463
TRG_ER_diArg_1	13	15	PF00400	0.639
TRG_ER_diArg_1	35	38	PF00400	0.680
TRG_ER_diArg_1	530	532	PF00400	0.554
TRG_NES_CRM1_1	347	361	PF08389	0.413
TRG_NLS_MonoExtC_3	460	465	PF00514	0.535
TRG_NLS_MonoExtN_4	410	415	PF00514	0.726
TRG_Pf-PMV_PEXEL_1	346	351	PF00026	0.333
TRG_Pf-PMV_PEXEL_1	411	415	PF00026	0.503
TRG_Pf-PMV_PEXEL_1	438	442	PF00026	0.672
TRG_Pf-PMV_PEXEL_1	95	100	PF00026	0.456

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P950	Leptomonas seymouri	23%	97%
A0A0N1ILX4	Leptomonas seymouri	60%	100%
A0A0S4JKE9	Bodo saltans	50%	100%
A0A1X0NTZ8	Trypanosomatidae	55%	100%
A0A3S5IRP3	Trypanosoma rangeli	53%	100%
A0A3S7X2J5	Leishmania donovani	26%	100%
A4H889	Leishmania braziliensis	84%	99%
A4HHF5	Leishmania braziliensis	25%	100%
A4HWL2	Leishmania infantum	99%	100%
A4I4K3	Leishmania infantum	25%	100%
C9ZL87	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
C9ZXS8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
E9AE02	Leishmania major	25%	100%
E9ALT0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9AQB9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QF55	Leishmania major	95%	100%
V5B4N1	Trypanosoma cruzi	55%	100%
V5D9T1	Trypanosoma cruzi	24%	100%