60S ribosomal protein L6

Quick info Annotations Localization Phosphorylation Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

60S ribosomal protein L6, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IAA6_LEIDO

TriTrypDb:

LdCL_150016100 , LdCL_330013200 , LDHU3_15.1350 , LDHU3_33.1080

Length:

195

Annotations

Annotations by Jardim et al.

Ribosomal Protein, 60S ribosomal L6

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	yes	yes: 4
Forrest at al. (procyclic)	yes	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 24

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	15
GO:0032991	protein-containing complex	1	17
GO:0043226	organelle	2	15
GO:0043228	non-membrane-bounded organelle	3	15
GO:0043229	intracellular organelle	3	15
GO:0043232	intracellular non-membrane-bounded organelle	4	15
GO:0110165	cellular anatomical entity	1	16
GO:1990904	ribonucleoprotein complex	2	17
GO:0005737	cytoplasm	2	1
GO:0015934	large ribosomal subunit	4	2
GO:0022625	cytosolic large ribosomal subunit	5	2
GO:0044391	ribosomal subunit	3	2

Phosphorylation

Amastigote: 117

Expansion

Sequence features

A0A3Q8IAA6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IAA6

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	17
GO:0006518	peptide metabolic process	4	17
GO:0006807	nitrogen compound metabolic process	2	17
GO:0008152	metabolic process	1	17
GO:0009058	biosynthetic process	2	17
GO:0009059	macromolecule biosynthetic process	4	17
GO:0009987	cellular process	1	17
GO:0019538	protein metabolic process	3	17
GO:0034641	cellular nitrogen compound metabolic process	3	17
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	17
GO:0043043	peptide biosynthetic process	5	17
GO:0043170	macromolecule metabolic process	3	17
GO:0043603	amide metabolic process	3	17
GO:0043604	amide biosynthetic process	4	17
GO:0044237	cellular metabolic process	2	17
GO:0044238	primary metabolic process	2	17
GO:0044249	cellular biosynthetic process	3	17
GO:0044260	obsolete cellular macromolecule metabolic process	3	17
GO:0044271	cellular nitrogen compound biosynthetic process	4	17
GO:0071704	organic substance metabolic process	2	17
GO:1901564	organonitrogen compound metabolic process	3	17
GO:1901566	organonitrogen compound biosynthetic process	4	17
GO:1901576	organic substance biosynthetic process	3	17
GO:0000027	ribosomal large subunit assembly	7	2
GO:0002181	cytoplasmic translation	5	2
GO:0016043	cellular component organization	3	2
GO:0022607	cellular component assembly	4	2
GO:0022618	ribonucleoprotein complex assembly	6	2
GO:0043933	protein-containing complex organization	4	2
GO:0065003	protein-containing complex assembly	5	2
GO:0071826	ribonucleoprotein complex subunit organization	5	2
GO:0071840	cellular component organization or biogenesis	2	2

Molecular functions
Term	Name	Level	Count
GO:0003735	structural constituent of ribosome	2	17
GO:0005198	structural molecule activity	1	17
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	2
GO:0005488	binding	1	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	12	14	PF00675	0.644
CLV_NRD_NRD_1	20	22	PF00675	0.529
CLV_NRD_NRD_1	29	31	PF00675	0.421
CLV_NRD_NRD_1	49	51	PF00675	0.282
CLV_NRD_NRD_1	77	79	PF00675	0.309
CLV_PCSK_FUR_1	47	51	PF00082	0.422
CLV_PCSK_KEX2_1	12	14	PF00082	0.742
CLV_PCSK_KEX2_1	49	51	PF00082	0.416
CLV_PCSK_KEX2_1	77	79	PF00082	0.309
CLV_PCSK_PC1ET2_1	12	14	PF00082	0.744
CLV_PCSK_PC7_1	45	51	PF00082	0.425
CLV_PCSK_SKI1_1	132	136	PF00082	0.344
CLV_PCSK_SKI1_1	14	18	PF00082	0.605
CLV_PCSK_SKI1_1	179	183	PF00082	0.370
DOC_CKS1_1	100	105	PF01111	0.470
DOC_MAPK_gen_1	45	54	PF00069	0.429
DOC_MAPK_RevD_3	63	78	PF00069	0.435
DOC_PP4_FxxP_1	106	109	PF00568	0.541
DOC_USP7_MATH_1	3	7	PF00917	0.708
DOC_USP7_UBL2_3	132	136	PF12436	0.503
DOC_USP7_UBL2_3	139	143	PF12436	0.639
DOC_USP7_UBL2_3	14	18	PF12436	0.609
DOC_WW_Pin1_4	141	146	PF00397	0.481
DOC_WW_Pin1_4	20	25	PF00397	0.596
DOC_WW_Pin1_4	99	104	PF00397	0.565
LIG_14-3-3_CanoR_1	179	185	PF00244	0.621
LIG_14-3-3_CanoR_1	30	38	PF00244	0.445
LIG_BIR_II_1	1	5	PF00653	0.758
LIG_BIR_III_4	168	172	PF00653	0.621
LIG_FHA_1	96	102	PF00498	0.509
LIG_FHA_2	113	119	PF00498	0.604
LIG_FHA_2	87	93	PF00498	0.515
LIG_LIR_Apic_2	104	109	PF02991	0.517
LIG_LIR_Gen_1	23	34	PF02991	0.591
LIG_LIR_Nem_3	23	29	PF02991	0.539
LIG_SH2_CRK	26	30	PF00017	0.557
LIG_SH2_CRK	71	75	PF00017	0.509
LIG_SH2_SRC	83	86	PF00017	0.533
LIG_SH2_STAT5	177	180	PF00017	0.533
LIG_SH2_STAT5	26	29	PF00017	0.633
LIG_SH2_STAT5	83	86	PF00017	0.515
LIG_SH3_3	62	68	PF00018	0.590
LIG_SH3_3	97	103	PF00018	0.470
LIG_SUMO_SIM_par_1	61	66	PF11976	0.453
LIG_UBA3_1	161	167	PF00899	0.508
MOD_CK1_1	180	186	PF00069	0.509
MOD_CK1_1	20	26	PF00069	0.549
MOD_CK1_1	6	12	PF00069	0.687
MOD_CK1_1	95	101	PF00069	0.532
MOD_CK2_1	112	118	PF00069	0.523
MOD_Cter_Amidation	140	143	PF01082	0.329
MOD_Cter_Amidation	47	50	PF01082	0.428
MOD_GlcNHglycan	5	8	PF01048	0.673
MOD_GlcNHglycan	65	68	PF01048	0.435
MOD_GSK3_1	20	27	PF00069	0.593
MOD_GSK3_1	91	98	PF00069	0.526
MOD_NEK2_1	1	6	PF00069	0.772
MOD_NEK2_1	29	34	PF00069	0.549
MOD_NEK2_1	63	68	PF00069	0.416
MOD_NEK2_2	177	182	PF00069	0.509
MOD_PKA_1	135	141	PF00069	0.569
MOD_PKA_1	17	23	PF00069	0.606
MOD_PKA_2	29	35	PF00069	0.521
MOD_Plk_1	24	30	PF00069	0.580
MOD_Plk_1	91	97	PF00069	0.548
MOD_Plk_2-3	92	98	PF00069	0.591
MOD_ProDKin_1	141	147	PF00069	0.481
MOD_ProDKin_1	20	26	PF00069	0.594
MOD_ProDKin_1	99	105	PF00069	0.565
MOD_SUMO_for_1	109	112	PF00179	0.510
TRG_ENDOCYTIC_2	26	29	PF00928	0.559
TRG_ENDOCYTIC_2	71	74	PF00928	0.509
TRG_ER_diArg_1	46	49	PF00400	0.423
TRG_ER_diArg_1	76	78	PF00400	0.509

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HT06	Leptomonas seymouri	91%	100%
A0A0S4JL50	Bodo saltans	74%	98%
A0A0S4JLI9	Bodo saltans	74%	98%
A0A1D8PCX8	Candida albicans (strain SC5314 / ATCC MYA-2876)	45%	100%
A0A1X0NVD8	Trypanosomatidae	78%	100%
A0A1X0P118	Trypanosomatidae	79%	99%
A0A3R7KR31	Trypanosoma rangeli	77%	100%
A0A3R7LKV1	Trypanosoma rangeli	77%	100%
A4H873	Leishmania braziliensis	94%	100%
A4HLB2	Leishmania braziliensis	94%	100%
A4HWJ8	Leishmania infantum	100%	100%
D0A4T4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	76%	100%
E9AQ99	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
E9B3Q4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
P05739	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	41%	100%
P0DJ56	Tetrahymena thermophila (strain SB210)	41%	100%
P34091	Mesembryanthemum crystallinum	41%	83%
P47991	Caenorhabditis elegans	40%	90%
P79071	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	41%	100%
Q02326	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	41%	100%
Q02878	Homo sapiens	39%	68%
Q2YGT9	Sus scrofa	39%	69%
Q4Q4D3	Leishmania major	97%	100%
Q4QF84	Leishmania major	96%	100%
Q54D63	Dictyostelium discoideum	44%	83%
Q58DQ3	Bos taurus	39%	68%
Q6QMZ4	Chinchilla lanigera	39%	68%
Q9C9C5	Arabidopsis thaliana	38%	84%
Q9C9C6	Arabidopsis thaliana	37%	84%