LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3Q8IAA0_LEIDO
TriTrypDb:
LdBPK_190900.1 , LdCL_190014400 , LDHU3_19.1100
Length:
806

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IAA0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IAA0

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 604 608 PF00656 0.648
CLV_C14_Caspase3-7 712 716 PF00656 0.626
CLV_NRD_NRD_1 120 122 PF00675 0.644
CLV_NRD_NRD_1 133 135 PF00675 0.658
CLV_NRD_NRD_1 144 146 PF00675 0.688
CLV_NRD_NRD_1 167 169 PF00675 0.656
CLV_NRD_NRD_1 580 582 PF00675 0.673
CLV_NRD_NRD_1 585 587 PF00675 0.644
CLV_NRD_NRD_1 610 612 PF00675 0.818
CLV_NRD_NRD_1 646 648 PF00675 0.582
CLV_NRD_NRD_1 9 11 PF00675 0.707
CLV_PCSK_FUR_1 583 587 PF00082 0.656
CLV_PCSK_KEX2_1 120 122 PF00082 0.637
CLV_PCSK_KEX2_1 167 169 PF00082 0.656
CLV_PCSK_KEX2_1 186 188 PF00082 0.535
CLV_PCSK_KEX2_1 325 327 PF00082 0.691
CLV_PCSK_KEX2_1 336 338 PF00082 0.589
CLV_PCSK_KEX2_1 453 455 PF00082 0.524
CLV_PCSK_KEX2_1 582 584 PF00082 0.713
CLV_PCSK_KEX2_1 585 587 PF00082 0.699
CLV_PCSK_KEX2_1 610 612 PF00082 0.818
CLV_PCSK_PC1ET2_1 186 188 PF00082 0.595
CLV_PCSK_PC1ET2_1 325 327 PF00082 0.691
CLV_PCSK_PC1ET2_1 336 338 PF00082 0.589
CLV_PCSK_PC1ET2_1 453 455 PF00082 0.524
CLV_PCSK_PC1ET2_1 582 584 PF00082 0.695
CLV_PCSK_PC7_1 581 587 PF00082 0.677
CLV_PCSK_SKI1_1 339 343 PF00082 0.663
CLV_PCSK_SKI1_1 529 533 PF00082 0.527
CLV_PCSK_SKI1_1 591 595 PF00082 0.673
CLV_PCSK_SKI1_1 86 90 PF00082 0.511
DEG_APCC_DBOX_1 718 726 PF00400 0.652
DEG_SPOP_SBC_1 563 567 PF00917 0.668
DOC_CYCLIN_yCln2_LP_2 408 411 PF00134 0.557
DOC_CYCLIN_yCln2_LP_2 639 645 PF00134 0.560
DOC_MAPK_DCC_7 767 775 PF00069 0.510
DOC_MAPK_gen_1 167 175 PF00069 0.651
DOC_MAPK_gen_1 336 343 PF00069 0.578
DOC_MAPK_gen_1 364 374 PF00069 0.611
DOC_MAPK_gen_1 647 658 PF00069 0.625
DOC_MAPK_MEF2A_6 168 177 PF00069 0.712
DOC_MAPK_MEF2A_6 767 775 PF00069 0.510
DOC_PP1_RVXF_1 394 400 PF00149 0.485
DOC_PP2B_LxvP_1 307 310 PF13499 0.646
DOC_PP2B_LxvP_1 408 411 PF13499 0.557
DOC_PP2B_LxvP_1 68 71 PF13499 0.564
DOC_PP2B_LxvP_1 682 685 PF13499 0.629
DOC_USP7_MATH_1 202 206 PF00917 0.685
DOC_USP7_MATH_1 226 230 PF00917 0.690
DOC_USP7_MATH_1 329 333 PF00917 0.647
DOC_USP7_MATH_1 413 417 PF00917 0.701
DOC_USP7_MATH_1 472 476 PF00917 0.651
DOC_USP7_MATH_1 551 555 PF00917 0.650
DOC_USP7_MATH_1 562 566 PF00917 0.624
DOC_USP7_MATH_1 575 579 PF00917 0.621
DOC_USP7_MATH_1 593 597 PF00917 0.638
DOC_USP7_MATH_1 618 622 PF00917 0.699
DOC_USP7_MATH_1 627 631 PF00917 0.546
DOC_USP7_MATH_1 652 656 PF00917 0.626
DOC_USP7_MATH_1 733 737 PF00917 0.597
DOC_WW_Pin1_4 1 6 PF00397 0.657
DOC_WW_Pin1_4 161 166 PF00397 0.709
DOC_WW_Pin1_4 198 203 PF00397 0.692
DOC_WW_Pin1_4 204 209 PF00397 0.708
DOC_WW_Pin1_4 271 276 PF00397 0.737
DOC_WW_Pin1_4 296 301 PF00397 0.617
DOC_WW_Pin1_4 351 356 PF00397 0.636
DOC_WW_Pin1_4 376 381 PF00397 0.683
DOC_WW_Pin1_4 402 407 PF00397 0.596
DOC_WW_Pin1_4 434 439 PF00397 0.595
DOC_WW_Pin1_4 564 569 PF00397 0.702
DOC_WW_Pin1_4 573 578 PF00397 0.635
DOC_WW_Pin1_4 594 599 PF00397 0.585
LIG_14-3-3_CanoR_1 104 110 PF00244 0.569
LIG_14-3-3_CanoR_1 194 204 PF00244 0.648
LIG_14-3-3_CanoR_1 282 291 PF00244 0.736
LIG_14-3-3_CanoR_1 337 342 PF00244 0.688
LIG_14-3-3_CanoR_1 673 682 PF00244 0.625
LIG_14-3-3_CanoR_1 723 729 PF00244 0.667
LIG_14-3-3_CanoR_1 755 761 PF00244 0.579
LIG_Actin_WH2_2 462 479 PF00022 0.502
LIG_Actin_WH2_2 753 769 PF00022 0.564
LIG_BRCT_BRCA1_1 654 658 PF00533 0.639
LIG_eIF4E_1 465 471 PF01652 0.492
LIG_FHA_1 151 157 PF00498 0.701
LIG_FHA_1 23 29 PF00498 0.556
LIG_FHA_1 352 358 PF00498 0.624
LIG_FHA_1 466 472 PF00498 0.530
LIG_FHA_1 92 98 PF00498 0.618
LIG_FHA_2 112 118 PF00498 0.597
LIG_FHA_2 147 153 PF00498 0.625
LIG_FHA_2 53 59 PF00498 0.449
LIG_FHA_2 550 556 PF00498 0.641
LIG_FHA_2 597 603 PF00498 0.701
LIG_FHA_2 73 79 PF00498 0.501
LIG_LIR_Apic_2 707 711 PF02991 0.641
LIG_LIR_Gen_1 21 31 PF02991 0.578
LIG_LIR_Gen_1 246 255 PF02991 0.705
LIG_LIR_Nem_3 19 23 PF02991 0.724
LIG_LIR_Nem_3 246 250 PF02991 0.701
LIG_LIR_Nem_3 786 792 PF02991 0.588
LIG_LYPXL_SIV_4 45 53 PF13949 0.538
LIG_MYND_1 406 410 PF01753 0.553
LIG_MYND_3 693 697 PF01753 0.665
LIG_NRBOX 465 471 PF00104 0.492
LIG_PTAP_UEV_1 299 304 PF05743 0.635
LIG_PTAP_UEV_1 4 9 PF05743 0.653
LIG_SH2_CRK 103 107 PF00017 0.563
LIG_SH2_CRK 23 27 PF00017 0.582
LIG_SH2_NCK_1 87 91 PF00017 0.547
LIG_SH2_SRC 46 49 PF00017 0.542
LIG_SH2_SRC 791 794 PF00017 0.587
LIG_SH2_STAP1 46 50 PF00017 0.573
LIG_SH2_STAP1 526 530 PF00017 0.543
LIG_SH2_STAT5 268 271 PF00017 0.682
LIG_SH2_STAT5 283 286 PF00017 0.516
LIG_SH2_STAT5 465 468 PF00017 0.539
LIG_SH2_STAT5 708 711 PF00017 0.635
LIG_SH2_STAT5 791 794 PF00017 0.587
LIG_SH3_1 400 406 PF00018 0.576
LIG_SH3_2 381 386 PF14604 0.698
LIG_SH3_2 5 10 PF14604 0.652
LIG_SH3_3 2 8 PF00018 0.654
LIG_SH3_3 267 273 PF00018 0.621
LIG_SH3_3 297 303 PF00018 0.675
LIG_SH3_3 378 384 PF00018 0.692
LIG_SH3_3 400 406 PF00018 0.576
LIG_SH3_3 688 694 PF00018 0.534
LIG_SH3_3 766 772 PF00018 0.579
LIG_SUMO_SIM_anti_2 528 535 PF11976 0.511
LIG_SUMO_SIM_anti_2 602 607 PF11976 0.636
LIG_SUMO_SIM_anti_2 630 638 PF11976 0.582
LIG_SUMO_SIM_par_1 24 29 PF11976 0.563
LIG_SUMO_SIM_par_1 724 730 PF11976 0.546
LIG_SUMO_SIM_par_1 771 777 PF11976 0.516
LIG_TRAF2_1 677 680 PF00917 0.688
LIG_TRAF2_1 75 78 PF00917 0.566
LIG_UBA3_1 105 110 PF00899 0.570
MOD_CDC14_SPxK_1 383 386 PF00782 0.694
MOD_CDK_SPxK_1 161 167 PF00069 0.649
MOD_CDK_SPxK_1 380 386 PF00069 0.696
MOD_CDK_SPxxK_3 161 168 PF00069 0.712
MOD_CK1_1 147 153 PF00069 0.691
MOD_CK1_1 198 204 PF00069 0.673
MOD_CK1_1 207 213 PF00069 0.631
MOD_CK1_1 227 233 PF00069 0.665
MOD_CK1_1 246 252 PF00069 0.560
MOD_CK1_1 260 266 PF00069 0.555
MOD_CK1_1 3 9 PF00069 0.717
MOD_CK1_1 319 325 PF00069 0.654
MOD_CK1_1 379 385 PF00069 0.690
MOD_CK1_1 404 410 PF00069 0.597
MOD_CK1_1 517 523 PF00069 0.523
MOD_CK1_1 56 62 PF00069 0.582
MOD_CK1_1 576 582 PF00069 0.657
MOD_CK1_1 596 602 PF00069 0.564
MOD_CK1_1 621 627 PF00069 0.609
MOD_CK1_1 637 643 PF00069 0.514
MOD_CK1_1 660 666 PF00069 0.646
MOD_CK1_1 674 680 PF00069 0.576
MOD_CK1_1 727 733 PF00069 0.664
MOD_CK2_1 111 117 PF00069 0.594
MOD_CK2_1 193 199 PF00069 0.654
MOD_CK2_1 549 555 PF00069 0.637
MOD_CK2_1 627 633 PF00069 0.595
MOD_CK2_1 661 667 PF00069 0.620
MOD_CK2_1 674 680 PF00069 0.557
MOD_CK2_1 72 78 PF00069 0.574
MOD_CMANNOS 399 402 PF00535 0.586
MOD_DYRK1A_RPxSP_1 573 577 PF00069 0.696
MOD_GlcNHglycan 187 190 PF01048 0.617
MOD_GlcNHglycan 20 23 PF01048 0.430
MOD_GlcNHglycan 221 224 PF01048 0.774
MOD_GlcNHglycan 229 232 PF01048 0.706
MOD_GlcNHglycan 291 294 PF01048 0.677
MOD_GlcNHglycan 300 303 PF01048 0.567
MOD_GlcNHglycan 319 322 PF01048 0.588
MOD_GlcNHglycan 32 35 PF01048 0.475
MOD_GlcNHglycan 414 418 PF01048 0.664
MOD_GlcNHglycan 5 8 PF01048 0.853
MOD_GlcNHglycan 523 526 PF01048 0.532
MOD_GlcNHglycan 542 546 PF01048 0.419
MOD_GlcNHglycan 55 58 PF01048 0.538
MOD_GlcNHglycan 62 65 PF01048 0.462
MOD_GlcNHglycan 623 626 PF01048 0.714
MOD_GlcNHglycan 629 632 PF01048 0.589
MOD_GlcNHglycan 664 667 PF01048 0.669
MOD_GlcNHglycan 742 745 PF01048 0.512
MOD_GSK3_1 146 153 PF00069 0.686
MOD_GSK3_1 18 25 PF00069 0.615
MOD_GSK3_1 198 205 PF00069 0.689
MOD_GSK3_1 207 214 PF00069 0.624
MOD_GSK3_1 26 33 PF00069 0.485
MOD_GSK3_1 312 319 PF00069 0.662
MOD_GSK3_1 337 344 PF00069 0.668
MOD_GSK3_1 351 358 PF00069 0.540
MOD_GSK3_1 376 383 PF00069 0.651
MOD_GSK3_1 513 520 PF00069 0.457
MOD_GSK3_1 52 59 PF00069 0.540
MOD_GSK3_1 563 570 PF00069 0.657
MOD_GSK3_1 581 588 PF00069 0.593
MOD_GSK3_1 637 644 PF00069 0.503
MOD_GSK3_1 657 664 PF00069 0.508
MOD_GSK3_1 671 678 PF00069 0.569
MOD_GSK3_1 761 768 PF00069 0.566
MOD_LATS_1 793 799 PF00433 0.613
MOD_N-GLC_1 618 623 PF02516 0.552
MOD_NEK2_1 105 110 PF00069 0.570
MOD_NEK2_1 634 639 PF00069 0.621
MOD_NEK2_1 750 755 PF00069 0.465
MOD_NEK2_2 472 477 PF00069 0.470
MOD_NEK2_2 724 729 PF00069 0.547
MOD_PIKK_1 202 208 PF00454 0.672
MOD_PIKK_1 329 335 PF00454 0.688
MOD_PIKK_1 341 347 PF00454 0.573
MOD_PIKK_1 355 361 PF00454 0.529
MOD_PIKK_1 567 573 PF00454 0.685
MOD_PIKK_1 671 677 PF00454 0.699
MOD_PIKK_1 761 767 PF00454 0.600
MOD_PK_1 224 230 PF00069 0.613
MOD_PK_1 337 343 PF00069 0.685
MOD_PKA_1 581 587 PF00069 0.677
MOD_PKA_2 144 150 PF00069 0.621
MOD_PKA_2 193 199 PF00069 0.626
MOD_PKA_2 585 591 PF00069 0.671
MOD_PKA_2 652 658 PF00069 0.631
MOD_PKB_1 337 345 PF00069 0.664
MOD_PKB_1 583 591 PF00069 0.654
MOD_Plk_1 496 502 PF00069 0.621
MOD_Plk_1 541 547 PF00069 0.578
MOD_Plk_1 666 672 PF00069 0.667
MOD_Plk_1 733 739 PF00069 0.594
MOD_Plk_2-3 152 158 PF00069 0.582
MOD_Plk_4 22 28 PF00069 0.724
MOD_Plk_4 243 249 PF00069 0.693
MOD_Plk_4 404 410 PF00069 0.597
MOD_Plk_4 465 471 PF00069 0.678
MOD_Plk_4 641 647 PF00069 0.621
MOD_Plk_4 774 780 PF00069 0.595
MOD_Plk_4 795 801 PF00069 0.554
MOD_ProDKin_1 1 7 PF00069 0.655
MOD_ProDKin_1 161 167 PF00069 0.710
MOD_ProDKin_1 198 204 PF00069 0.692
MOD_ProDKin_1 271 277 PF00069 0.734
MOD_ProDKin_1 296 302 PF00069 0.618
MOD_ProDKin_1 351 357 PF00069 0.632
MOD_ProDKin_1 376 382 PF00069 0.686
MOD_ProDKin_1 402 408 PF00069 0.604
MOD_ProDKin_1 434 440 PF00069 0.593
MOD_ProDKin_1 564 570 PF00069 0.701
MOD_ProDKin_1 573 579 PF00069 0.634
MOD_ProDKin_1 594 600 PF00069 0.582
MOD_SUMO_for_1 177 180 PF00179 0.716
MOD_SUMO_for_1 216 219 PF00179 0.660
MOD_SUMO_for_1 250 253 PF00179 0.711
MOD_SUMO_rev_2 179 188 PF00179 0.610
MOD_SUMO_rev_2 554 562 PF00179 0.676
TRG_DiLeu_BaEn_1 528 533 PF01217 0.512
TRG_DiLeu_BaEn_1 93 98 PF01217 0.550
TRG_DiLeu_BaEn_2 369 375 PF01217 0.624
TRG_DiLeu_BaEn_4 679 685 PF01217 0.680
TRG_DiLeu_BaLyEn_6 101 106 PF01217 0.559
TRG_ENDOCYTIC_2 103 106 PF00928 0.551
TRG_ENDOCYTIC_2 23 26 PF00928 0.600
TRG_ER_diArg_1 583 586 PF00400 0.656
TRG_NES_CRM1_1 683 697 PF08389 0.540
TRG_NLS_Bipartite_1 120 138 PF00514 0.646
TRG_NLS_Bipartite_1 323 340 PF00514 0.686
TRG_NLS_MonoCore_2 322 327 PF00514 0.592
TRG_NLS_MonoExtC_3 322 327 PF00514 0.592
TRG_NLS_MonoExtC_3 580 585 PF00514 0.653
TRG_NLS_MonoExtN_4 142 149 PF00514 0.587
TRG_NLS_MonoExtN_4 323 328 PF00514 0.636
TRG_NLS_MonoExtN_4 335 340 PF00514 0.635
TRG_NLS_MonoExtN_4 581 586 PF00514 0.655
TRG_Pf-PMV_PEXEL_1 509 513 PF00026 0.595
TRG_Pf-PMV_PEXEL_1 534 538 PF00026 0.477

Homologs

Protein Taxonomy Sequence identity Coverage
A4HA46 Leishmania braziliensis 70% 100%
A4HYB2 Leishmania infantum 99% 100%
E9AS45 Leishmania mexicana (strain MHOM/GT/2001/U1103) 85% 100%
Q4QDC1 Leishmania major 90% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS