LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3Q8IA95_LEIDO
TriTrypDb:
LdBPK_160370.1 * , LdCL_160008600 , LDHU3_16.0440
Length:
687

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IA95
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IA95

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 114 116 PF00675 0.703
CLV_NRD_NRD_1 247 249 PF00675 0.756
CLV_NRD_NRD_1 440 442 PF00675 0.761
CLV_NRD_NRD_1 586 588 PF00675 0.682
CLV_NRD_NRD_1 63 65 PF00675 0.670
CLV_NRD_NRD_1 92 94 PF00675 0.642
CLV_PCSK_KEX2_1 114 116 PF00082 0.703
CLV_PCSK_KEX2_1 247 249 PF00082 0.727
CLV_PCSK_KEX2_1 440 442 PF00082 0.761
CLV_PCSK_KEX2_1 586 588 PF00082 0.678
CLV_PCSK_KEX2_1 63 65 PF00082 0.670
CLV_PCSK_SKI1_1 401 405 PF00082 0.704
CLV_PCSK_SKI1_1 420 424 PF00082 0.469
CLV_PCSK_SKI1_1 435 439 PF00082 0.618
CLV_PCSK_SKI1_1 44 48 PF00082 0.628
CLV_PCSK_SKI1_1 481 485 PF00082 0.789
CLV_PCSK_SKI1_1 490 494 PF00082 0.668
CLV_Separin_Metazoa 398 402 PF03568 0.658
DEG_Nend_UBRbox_2 1 3 PF02207 0.675
DEG_SPOP_SBC_1 203 207 PF00917 0.701
DOC_CYCLIN_RxL_1 487 497 PF00134 0.618
DOC_CYCLIN_yCln2_LP_2 672 678 PF00134 0.556
DOC_MAPK_gen_1 93 103 PF00069 0.756
DOC_MAPK_MEF2A_6 269 276 PF00069 0.646
DOC_PP1_RVXF_1 542 549 PF00149 0.562
DOC_PP2B_LxvP_1 221 224 PF13499 0.657
DOC_PP4_FxxP_1 548 551 PF00568 0.582
DOC_SPAK_OSR1_1 8 12 PF12202 0.546
DOC_USP7_MATH_1 118 122 PF00917 0.726
DOC_USP7_MATH_1 147 151 PF00917 0.767
DOC_USP7_MATH_1 174 178 PF00917 0.650
DOC_USP7_MATH_1 203 207 PF00917 0.701
DOC_USP7_MATH_1 210 214 PF00917 0.608
DOC_USP7_MATH_1 367 371 PF00917 0.746
DOC_USP7_MATH_1 38 42 PF00917 0.575
DOC_USP7_MATH_1 464 468 PF00917 0.695
DOC_USP7_MATH_1 558 562 PF00917 0.762
DOC_USP7_MATH_2 386 392 PF00917 0.685
DOC_WW_Pin1_4 143 148 PF00397 0.704
DOC_WW_Pin1_4 240 245 PF00397 0.789
DOC_WW_Pin1_4 289 294 PF00397 0.757
DOC_WW_Pin1_4 435 440 PF00397 0.839
DOC_WW_Pin1_4 446 451 PF00397 0.680
DOC_WW_Pin1_4 494 499 PF00397 0.765
DOC_WW_Pin1_4 503 508 PF00397 0.671
DOC_WW_Pin1_4 513 518 PF00397 0.567
DOC_WW_Pin1_4 547 552 PF00397 0.724
DOC_WW_Pin1_4 574 579 PF00397 0.768
DOC_WW_Pin1_4 580 585 PF00397 0.689
DOC_WW_Pin1_4 595 600 PF00397 0.649
DOC_WW_Pin1_4 616 621 PF00397 0.753
DOC_WW_Pin1_4 681 686 PF00397 0.737
DOC_WW_Pin1_4 88 93 PF00397 0.693
LIG_14-3-3_CanoR_1 26 35 PF00244 0.563
LIG_14-3-3_CanoR_1 269 275 PF00244 0.653
LIG_14-3-3_CanoR_1 277 285 PF00244 0.452
LIG_14-3-3_CanoR_1 389 397 PF00244 0.758
LIG_14-3-3_CanoR_1 441 450 PF00244 0.741
LIG_14-3-3_CanoR_1 533 537 PF00244 0.619
LIG_14-3-3_CanoR_1 568 574 PF00244 0.678
LIG_14-3-3_CanoR_1 96 104 PF00244 0.675
LIG_Actin_WH2_2 263 279 PF00022 0.629
LIG_BIR_III_4 627 631 PF00653 0.725
LIG_BRCT_BRCA1_1 12 16 PF00533 0.561
LIG_BRCT_BRCA1_1 664 668 PF00533 0.715
LIG_Clathr_ClatBox_1 353 357 PF01394 0.630
LIG_deltaCOP1_diTrp_1 19 24 PF00928 0.593
LIG_FHA_1 124 130 PF00498 0.668
LIG_FHA_1 131 137 PF00498 0.681
LIG_FHA_1 203 209 PF00498 0.692
LIG_FHA_1 216 222 PF00498 0.540
LIG_FHA_1 27 33 PF00498 0.573
LIG_FHA_1 271 277 PF00498 0.637
LIG_FHA_1 323 329 PF00498 0.680
LIG_FHA_1 460 466 PF00498 0.750
LIG_FHA_1 554 560 PF00498 0.752
LIG_FHA_1 97 103 PF00498 0.710
LIG_FHA_2 25 31 PF00498 0.577
LIG_FHA_2 347 353 PF00498 0.587
LIG_FHA_2 443 449 PF00498 0.743
LIG_FHA_2 468 474 PF00498 0.765
LIG_FHA_2 521 527 PF00498 0.745
LIG_FHA_2 595 601 PF00498 0.734
LIG_FHA_2 60 66 PF00498 0.725
LIG_Integrin_RGD_1 137 139 PF01839 0.693
LIG_LIR_Gen_1 163 171 PF02991 0.701
LIG_LIR_Gen_1 27 35 PF02991 0.357
LIG_LIR_Gen_1 540 549 PF02991 0.620
LIG_LIR_Gen_1 7 17 PF02991 0.631
LIG_LIR_LC3C_4 352 356 PF02991 0.614
LIG_LIR_LC3C_4 98 103 PF02991 0.715
LIG_LIR_Nem_3 163 167 PF02991 0.711
LIG_LIR_Nem_3 27 31 PF02991 0.349
LIG_LIR_Nem_3 298 304 PF02991 0.530
LIG_LIR_Nem_3 41 46 PF02991 0.456
LIG_LIR_Nem_3 478 483 PF02991 0.771
LIG_LIR_Nem_3 540 545 PF02991 0.663
LIG_LIR_Nem_3 7 12 PF02991 0.588
LIG_PCNA_PIPBox_1 374 383 PF02747 0.709
LIG_Pex14_1 24 28 PF04695 0.591
LIG_Pex14_1 39 43 PF04695 0.397
LIG_Pex14_2 43 47 PF04695 0.612
LIG_SH2_CRK 164 168 PF00017 0.707
LIG_SH2_CRK 480 484 PF00017 0.791
LIG_SH2_CRK 49 53 PF00017 0.656
LIG_SH2_CRK 542 546 PF00017 0.674
LIG_SH2_PTP2 321 324 PF00017 0.558
LIG_SH2_STAP1 28 32 PF00017 0.567
LIG_SH2_STAP1 381 385 PF00017 0.678
LIG_SH2_STAP1 542 546 PF00017 0.674
LIG_SH2_STAT5 119 122 PF00017 0.758
LIG_SH2_STAT5 28 31 PF00017 0.573
LIG_SH2_STAT5 321 324 PF00017 0.623
LIG_SH3_3 195 201 PF00018 0.776
LIG_SH3_3 311 317 PF00018 0.638
LIG_SH3_3 419 425 PF00018 0.663
LIG_SH3_3 436 442 PF00018 0.638
LIG_SH3_3 476 482 PF00018 0.768
LIG_SH3_3 485 491 PF00018 0.600
LIG_SH3_3 548 554 PF00018 0.675
LIG_SH3_4 70 77 PF00018 0.693
LIG_SUMO_SIM_anti_2 352 357 PF11976 0.626
LIG_SUMO_SIM_anti_2 98 106 PF11976 0.683
LIG_SUMO_SIM_par_1 352 357 PF11976 0.626
LIG_SUMO_SIM_par_1 520 526 PF11976 0.678
LIG_SUMO_SIM_par_1 555 561 PF11976 0.716
LIG_SUMO_SIM_par_1 98 106 PF11976 0.702
LIG_TRAF2_1 150 153 PF00917 0.716
LIG_TRAF2_1 189 192 PF00917 0.700
LIG_TRAF2_1 523 526 PF00917 0.695
LIG_TRAF2_1 72 75 PF00917 0.752
MOD_CDK_SPK_2 435 440 PF00069 0.752
MOD_CDK_SPK_2 446 451 PF00069 0.614
MOD_CDK_SPK_2 88 93 PF00069 0.605
MOD_CDK_SPxK_1 435 441 PF00069 0.805
MOD_CDK_SPxK_1 513 519 PF00069 0.740
MOD_CDK_SPxK_1 580 586 PF00069 0.670
MOD_CDK_SPxK_1 88 94 PF00069 0.692
MOD_CDK_SPxxK_3 240 247 PF00069 0.787
MOD_CDK_SPxxK_3 580 587 PF00069 0.648
MOD_CDK_SPxxK_3 595 602 PF00069 0.638
MOD_CK1_1 231 237 PF00069 0.749
MOD_CK1_1 289 295 PF00069 0.765
MOD_CK1_1 361 367 PF00069 0.659
MOD_CK1_1 446 452 PF00069 0.785
MOD_CK1_1 456 462 PF00069 0.708
MOD_CK1_1 467 473 PF00069 0.657
MOD_CK1_1 496 502 PF00069 0.729
MOD_CK1_1 512 518 PF00069 0.590
MOD_CK1_1 560 566 PF00069 0.687
MOD_CK1_1 639 645 PF00069 0.683
MOD_CK1_1 88 94 PF00069 0.723
MOD_CK2_1 147 153 PF00069 0.719
MOD_CK2_1 24 30 PF00069 0.589
MOD_CK2_1 346 352 PF00069 0.643
MOD_CK2_1 467 473 PF00069 0.709
MOD_CK2_1 520 526 PF00069 0.695
MOD_CK2_1 560 566 PF00069 0.749
MOD_CK2_1 59 65 PF00069 0.730
MOD_CK2_1 594 600 PF00069 0.736
MOD_DYRK1A_RPxSP_1 435 439 PF00069 0.749
MOD_GlcNHglycan 12 15 PF01048 0.590
MOD_GlcNHglycan 120 123 PF01048 0.738
MOD_GlcNHglycan 149 152 PF01048 0.814
MOD_GlcNHglycan 175 179 PF01048 0.711
MOD_GlcNHglycan 212 215 PF01048 0.746
MOD_GlcNHglycan 278 281 PF01048 0.689
MOD_GlcNHglycan 293 296 PF01048 0.520
MOD_GlcNHglycan 36 39 PF01048 0.454
MOD_GlcNHglycan 363 366 PF01048 0.707
MOD_GlcNHglycan 369 372 PF01048 0.605
MOD_GlcNHglycan 455 458 PF01048 0.720
MOD_GlcNHglycan 560 563 PF01048 0.775
MOD_GlcNHglycan 676 679 PF01048 0.654
MOD_GlcNHglycan 83 86 PF01048 0.695
MOD_GlcNHglycan 87 90 PF01048 0.713
MOD_GSK3_1 118 125 PF00069 0.660
MOD_GSK3_1 143 150 PF00069 0.693
MOD_GSK3_1 166 173 PF00069 0.694
MOD_GSK3_1 174 181 PF00069 0.636
MOD_GSK3_1 210 217 PF00069 0.668
MOD_GSK3_1 228 235 PF00069 0.785
MOD_GSK3_1 287 294 PF00069 0.758
MOD_GSK3_1 322 329 PF00069 0.674
MOD_GSK3_1 34 41 PF00069 0.584
MOD_GSK3_1 363 370 PF00069 0.672
MOD_GSK3_1 431 438 PF00069 0.730
MOD_GSK3_1 442 449 PF00069 0.731
MOD_GSK3_1 453 460 PF00069 0.670
MOD_GSK3_1 467 474 PF00069 0.631
MOD_GSK3_1 492 499 PF00069 0.760
MOD_GSK3_1 502 509 PF00069 0.652
MOD_GSK3_1 553 560 PF00069 0.699
MOD_GSK3_1 568 575 PF00069 0.692
MOD_GSK3_1 81 88 PF00069 0.659
MOD_GSK3_1 92 99 PF00069 0.607
MOD_N-GLC_1 228 233 PF02516 0.748
MOD_N-GLC_1 270 275 PF02516 0.591
MOD_NEK2_1 204 209 PF00069 0.690
MOD_NEK2_1 270 275 PF00069 0.643
MOD_NEK2_1 276 281 PF00069 0.566
MOD_NEK2_1 287 292 PF00069 0.473
MOD_NEK2_1 346 351 PF00069 0.613
MOD_NEK2_1 430 435 PF00069 0.784
MOD_NEK2_1 471 476 PF00069 0.780
MOD_NEK2_1 492 497 PF00069 0.773
MOD_NEK2_1 502 507 PF00069 0.628
MOD_NEK2_1 532 537 PF00069 0.689
MOD_NEK2_1 585 590 PF00069 0.761
MOD_NEK2_1 87 92 PF00069 0.732
MOD_PIKK_1 326 332 PF00454 0.666
MOD_PKA_1 440 446 PF00069 0.759
MOD_PKA_2 276 282 PF00069 0.658
MOD_PKA_2 346 352 PF00069 0.643
MOD_PKA_2 388 394 PF00069 0.682
MOD_PKA_2 440 446 PF00069 0.814
MOD_PKA_2 532 538 PF00069 0.606
MOD_PKA_2 567 573 PF00069 0.680
MOD_PKA_2 585 591 PF00069 0.745
MOD_PKA_2 92 98 PF00069 0.740
MOD_Plk_1 270 276 PF00069 0.584
MOD_Plk_2-3 473 479 PF00069 0.723
MOD_Plk_4 204 210 PF00069 0.704
MOD_Plk_4 270 276 PF00069 0.636
MOD_Plk_4 506 512 PF00069 0.611
MOD_Plk_4 532 538 PF00069 0.718
MOD_ProDKin_1 143 149 PF00069 0.699
MOD_ProDKin_1 240 246 PF00069 0.787
MOD_ProDKin_1 289 295 PF00069 0.755
MOD_ProDKin_1 435 441 PF00069 0.839
MOD_ProDKin_1 446 452 PF00069 0.680
MOD_ProDKin_1 494 500 PF00069 0.767
MOD_ProDKin_1 503 509 PF00069 0.671
MOD_ProDKin_1 513 519 PF00069 0.565
MOD_ProDKin_1 547 553 PF00069 0.726
MOD_ProDKin_1 574 580 PF00069 0.769
MOD_ProDKin_1 595 601 PF00069 0.740
MOD_ProDKin_1 616 622 PF00069 0.753
MOD_ProDKin_1 681 687 PF00069 0.742
MOD_ProDKin_1 88 94 PF00069 0.692
MOD_SUMO_rev_2 398 406 PF00179 0.652
MOD_SUMO_rev_2 598 604 PF00179 0.724
MOD_SUMO_rev_2 65 72 PF00179 0.711
TRG_DiLeu_BaLyEn_6 479 484 PF01217 0.785
TRG_DiLeu_BaLyEn_6 488 493 PF01217 0.596
TRG_DiLeu_BaLyEn_6 541 546 PF01217 0.552
TRG_ENDOCYTIC_2 164 167 PF00928 0.714
TRG_ENDOCYTIC_2 28 31 PF00928 0.575
TRG_ENDOCYTIC_2 321 324 PF00928 0.610
TRG_ENDOCYTIC_2 480 483 PF00928 0.791
TRG_ENDOCYTIC_2 542 545 PF00928 0.726
TRG_ER_diArg_1 113 115 PF00400 0.709
TRG_ER_diArg_1 238 241 PF00400 0.779
TRG_ER_diArg_1 246 248 PF00400 0.678
TRG_ER_diArg_1 439 441 PF00400 0.749
TRG_ER_diArg_1 585 587 PF00400 0.677
TRG_ER_diArg_1 655 658 PF00400 0.725
TRG_NLS_MonoExtC_3 92 97 PF00514 0.594
TRG_NLS_MonoExtN_4 92 97 PF00514 0.594
TRG_Pf-PMV_PEXEL_1 481 486 PF00026 0.790

Homologs

Protein Taxonomy Sequence identity Coverage
A4H8G1 Leishmania braziliensis 57% 98%
A4HWT5 Leishmania infantum 100% 100%
E9AQJ3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 82% 99%
Q4QEY4 Leishmania major 91% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS