Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3Q8IA94_LEIDO

TriTrypDb:

LdBPK_210520.1 , LdCL_210010000 , LDHU3_21.0560

Length:

912

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IA94

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IA94

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	114	118	PF00656	0.666
CLV_C14_Caspase3-7	439	443	PF00656	0.804
CLV_C14_Caspase3-7	515	519	PF00656	0.779
CLV_NRD_NRD_1	170	172	PF00675	0.634
CLV_NRD_NRD_1	294	296	PF00675	0.800
CLV_NRD_NRD_1	391	393	PF00675	0.859
CLV_NRD_NRD_1	439	441	PF00675	0.812
CLV_NRD_NRD_1	49	51	PF00675	0.720
CLV_NRD_NRD_1	541	543	PF00675	0.658
CLV_NRD_NRD_1	584	586	PF00675	0.644
CLV_NRD_NRD_1	61	63	PF00675	0.609
CLV_NRD_NRD_1	620	622	PF00675	0.767
CLV_NRD_NRD_1	726	728	PF00675	0.751
CLV_PCSK_KEX2_1	170	172	PF00082	0.634
CLV_PCSK_KEX2_1	294	296	PF00082	0.800
CLV_PCSK_KEX2_1	390	392	PF00082	0.856
CLV_PCSK_KEX2_1	584	586	PF00082	0.644
CLV_PCSK_KEX2_1	61	63	PF00082	0.613
CLV_PCSK_KEX2_1	620	622	PF00082	0.767
CLV_PCSK_KEX2_1	726	728	PF00082	0.751
CLV_PCSK_PC7_1	616	622	PF00082	0.737
CLV_PCSK_SKI1_1	248	252	PF00082	0.721
CLV_PCSK_SKI1_1	363	367	PF00082	0.736
CLV_PCSK_SKI1_1	436	440	PF00082	0.816
CLV_PCSK_SKI1_1	51	55	PF00082	0.626
CLV_PCSK_SKI1_1	616	620	PF00082	0.744
CLV_PCSK_SKI1_1	808	812	PF00082	0.694
CLV_Separin_Metazoa	285	289	PF03568	0.764
DEG_APCC_DBOX_1	279	287	PF00400	0.754
DEG_SCF_FBW7_2	558	563	PF00400	0.780
DOC_CDC14_PxL_1	901	909	PF14671	0.548
DOC_CKS1_1	339	344	PF01111	0.746
DOC_CKS1_1	670	675	PF01111	0.740
DOC_MAPK_gen_1	294	301	PF00069	0.794
DOC_MAPK_gen_1	838	847	PF00069	0.750
DOC_MAPK_MEF2A_6	188	197	PF00069	0.682
DOC_MAPK_MEF2A_6	825	833	PF00069	0.709
DOC_PP2B_LxvP_1	786	789	PF13499	0.727
DOC_PP2B_LxvP_1	93	96	PF13499	0.716
DOC_PP2B_PxIxI_1	190	196	PF00149	0.682
DOC_PP4_FxxP_1	858	861	PF00568	0.552
DOC_PP4_MxPP_1	231	234	PF00568	0.733
DOC_USP7_MATH_1	2	6	PF00917	0.755
DOC_USP7_MATH_1	227	231	PF00917	0.732
DOC_USP7_MATH_1	351	355	PF00917	0.766
DOC_USP7_MATH_1	377	381	PF00917	0.798
DOC_USP7_MATH_1	395	399	PF00917	0.562
DOC_USP7_MATH_1	49	53	PF00917	0.680
DOC_USP7_MATH_1	505	509	PF00917	0.643
DOC_USP7_MATH_1	519	523	PF00917	0.639
DOC_USP7_MATH_1	529	533	PF00917	0.784
DOC_USP7_MATH_1	660	664	PF00917	0.836
DOC_USP7_MATH_1	809	813	PF00917	0.804
DOC_USP7_MATH_1	821	825	PF00917	0.620
DOC_USP7_UBL2_3	217	221	PF12436	0.519
DOC_USP7_UBL2_3	895	899	PF12436	0.553
DOC_WW_Pin1_4	182	187	PF00397	0.645
DOC_WW_Pin1_4	338	343	PF00397	0.743
DOC_WW_Pin1_4	45	50	PF00397	0.703
DOC_WW_Pin1_4	556	561	PF00397	0.861
DOC_WW_Pin1_4	60	65	PF00397	0.613
DOC_WW_Pin1_4	669	674	PF00397	0.806
DOC_WW_Pin1_4	678	683	PF00397	0.757
DOC_WW_Pin1_4	713	718	PF00397	0.780
LIG_14-3-3_CanoR_1	235	243	PF00244	0.789
LIG_14-3-3_CanoR_1	248	257	PF00244	0.555
LIG_14-3-3_CanoR_1	327	337	PF00244	0.792
LIG_14-3-3_CanoR_1	573	580	PF00244	0.709
LIG_14-3-3_CanoR_1	67	75	PF00244	0.627
LIG_14-3-3_CanoR_1	676	682	PF00244	0.820
LIG_BIR_II_1	1	5	PF00653	0.754
LIG_BIR_III_2	518	522	PF00653	0.769
LIG_BIR_III_2	544	548	PF00653	0.678
LIG_BRCT_BRCA1_1	803	807	PF00533	0.700
LIG_CtBP_PxDLS_1	547	551	PF00389	0.671
LIG_FHA_1	105	111	PF00498	0.722
LIG_FHA_1	13	19	PF00498	0.709
LIG_FHA_1	288	294	PF00498	0.772
LIG_FHA_1	499	505	PF00498	0.790
LIG_FHA_1	553	559	PF00498	0.742
LIG_FHA_1	589	595	PF00498	0.744
LIG_FHA_1	670	676	PF00498	0.673
LIG_FHA_1	700	706	PF00498	0.606
LIG_FHA_1	741	747	PF00498	0.743
LIG_FHA_1	809	815	PF00498	0.692
LIG_FHA_1	848	854	PF00498	0.676
LIG_FHA_2	277	283	PF00498	0.758
LIG_FHA_2	437	443	PF00498	0.803
LIG_FHA_2	683	689	PF00498	0.739
LIG_FHA_2	735	741	PF00498	0.731
LIG_FHA_2	75	81	PF00498	0.738
LIG_FHA_2	866	872	PF00498	0.671
LIG_Integrin_RGD_1	516	518	PF01839	0.645
LIG_LIR_Apic_2	856	861	PF02991	0.643
LIG_LIR_Gen_1	130	139	PF02991	0.686
LIG_LIR_Gen_1	140	149	PF02991	0.533
LIG_LIR_Gen_1	19	27	PF02991	0.644
LIG_LIR_Gen_1	213	223	PF02991	0.650
LIG_LIR_Gen_1	252	261	PF02991	0.729
LIG_LIR_Gen_1	470	481	PF02991	0.643
LIG_LIR_Gen_1	866	875	PF02991	0.589
LIG_LIR_Nem_3	130	135	PF02991	0.699
LIG_LIR_Nem_3	140	144	PF02991	0.527
LIG_LIR_Nem_3	145	149	PF02991	0.471
LIG_LIR_Nem_3	19	24	PF02991	0.652
LIG_LIR_Nem_3	246	250	PF02991	0.754
LIG_LIR_Nem_3	252	257	PF02991	0.653
LIG_LIR_Nem_3	451	457	PF02991	0.624
LIG_LIR_Nem_3	470	476	PF02991	0.644
LIG_LIR_Nem_3	866	870	PF02991	0.602
LIG_LIR_Nem_3	885	889	PF02991	0.391
LIG_PDZ_Class_2	907	912	PF00595	0.650
LIG_Pex14_1	173	177	PF04695	0.611
LIG_Pex14_2	247	251	PF04695	0.659
LIG_SH2_CRK	14	18	PF00017	0.707
LIG_SH2_CRK	141	145	PF00017	0.667
LIG_SH2_CRK	146	150	PF00017	0.616
LIG_SH2_CRK	473	477	PF00017	0.639
LIG_SH2_NCK_1	473	477	PF00017	0.639
LIG_SH2_SRC	409	412	PF00017	0.624
LIG_SH2_SRC	71	74	PF00017	0.674
LIG_SH2_STAP1	14	18	PF00017	0.707
LIG_SH2_STAP1	21	25	PF00017	0.591
LIG_SH2_STAP1	590	594	PF00017	0.823
LIG_SH2_STAP1	654	658	PF00017	0.706
LIG_SH2_STAP1	71	75	PF00017	0.673
LIG_SH2_STAT5	14	17	PF00017	0.709
LIG_SH2_STAT5	409	412	PF00017	0.737
LIG_SH2_STAT5	590	593	PF00017	0.764
LIG_SH2_STAT5	865	868	PF00017	0.626
LIG_SH3_2	401	406	PF14604	0.723
LIG_SH3_3	184	190	PF00018	0.647
LIG_SH3_3	266	272	PF00018	0.677
LIG_SH3_3	336	342	PF00018	0.823
LIG_SH3_3	398	404	PF00018	0.760
LIG_SH3_3	667	673	PF00018	0.807
LIG_SH3_3	7	13	PF00018	0.729
LIG_SH3_3	704	710	PF00018	0.812
LIG_SUMO_SIM_anti_2	282	288	PF11976	0.753
LIG_SUMO_SIM_par_1	374	380	PF11976	0.781
LIG_SUMO_SIM_par_1	656	663	PF11976	0.616
LIG_TRAF2_1	279	282	PF00917	0.758
LIG_TRFH_1	208	212	PF08558	0.567
LIG_TYR_ITIM	139	144	PF00017	0.548
LIG_UBA3_1	434	441	PF00899	0.627
LIG_WW_3	232	236	PF00397	0.814
MOD_CDC14_SPxK_1	185	188	PF00782	0.614
MOD_CDC14_SPxK_1	48	51	PF00782	0.680
MOD_CDC14_SPxK_1	681	684	PF00782	0.739
MOD_CDK_SPK_2	45	50	PF00069	0.649
MOD_CDK_SPxK_1	182	188	PF00069	0.613
MOD_CDK_SPxK_1	45	51	PF00069	0.686
MOD_CDK_SPxK_1	678	684	PF00069	0.745
MOD_CDK_SPxxK_3	338	345	PF00069	0.746
MOD_CDK_SPxxK_3	60	67	PF00069	0.686
MOD_CDK_SPxxK_3	669	676	PF00069	0.743
MOD_CK1_1	246	252	PF00069	0.758
MOD_CK1_1	551	557	PF00069	0.840
MOD_CK1_1	60	66	PF00069	0.699
MOD_CK1_1	680	686	PF00069	0.845
MOD_CK1_1	716	722	PF00069	0.824
MOD_CK1_1	732	738	PF00069	0.520
MOD_CK1_1	74	80	PF00069	0.568
MOD_CK1_1	816	822	PF00069	0.746
MOD_CK1_1	843	849	PF00069	0.615
MOD_CK2_1	124	130	PF00069	0.692
MOD_CK2_1	276	282	PF00069	0.761
MOD_CK2_1	328	334	PF00069	0.693
MOD_CK2_1	546	552	PF00069	0.850
MOD_CK2_1	66	72	PF00069	0.735
MOD_CK2_1	865	871	PF00069	0.665
MOD_CMANNOS	154	157	PF00535	0.676
MOD_GlcNHglycan	127	130	PF01048	0.606
MOD_GlcNHglycan	318	321	PF01048	0.788
MOD_GlcNHglycan	323	326	PF01048	0.748
MOD_GlcNHglycan	331	334	PF01048	0.624
MOD_GlcNHglycan	379	382	PF01048	0.747
MOD_GlcNHglycan	397	400	PF01048	0.626
MOD_GlcNHglycan	419	423	PF01048	0.624
MOD_GlcNHglycan	442	445	PF01048	0.790
MOD_GlcNHglycan	485	489	PF01048	0.633
MOD_GlcNHglycan	506	510	PF01048	0.738
MOD_GlcNHglycan	531	534	PF01048	0.861
MOD_GlcNHglycan	57	60	PF01048	0.699
MOD_GlcNHglycan	594	597	PF01048	0.866
MOD_GlcNHglycan	650	653	PF01048	0.693
MOD_GlcNHglycan	68	71	PF01048	0.595
MOD_GlcNHglycan	691	695	PF01048	0.818
MOD_GlcNHglycan	734	737	PF01048	0.757
MOD_GlcNHglycan	758	761	PF01048	0.667
MOD_GlcNHglycan	803	806	PF01048	0.752
MOD_GSK3_1	120	127	PF00069	0.740
MOD_GSK3_1	235	242	PF00069	0.718
MOD_GSK3_1	436	443	PF00069	0.727
MOD_GSK3_1	45	52	PF00069	0.721
MOD_GSK3_1	520	527	PF00069	0.744
MOD_GSK3_1	548	555	PF00069	0.800
MOD_GSK3_1	588	595	PF00069	0.806
MOD_GSK3_1	62	69	PF00069	0.641
MOD_GSK3_1	676	683	PF00069	0.824
MOD_GSK3_1	716	723	PF00069	0.758
MOD_GSK3_1	725	732	PF00069	0.679
MOD_GSK3_1	809	816	PF00069	0.757
MOD_GSK3_1	843	850	PF00069	0.659
MOD_LATS_1	674	680	PF00433	0.779
MOD_N-GLC_1	125	130	PF02516	0.612
MOD_N-GLC_1	448	453	PF02516	0.622
MOD_N-GLC_1	556	561	PF02516	0.822
MOD_N-GLC_1	814	819	PF02516	0.734
MOD_NEK2_1	177	182	PF00069	0.615
MOD_NEK2_1	580	585	PF00069	0.796
MOD_NEK2_1	813	818	PF00069	0.734
MOD_NEK2_2	227	232	PF00069	0.714
MOD_NEK2_2	49	54	PF00069	0.553
MOD_PIKK_1	2	8	PF00454	0.674
MOD_PIKK_1	442	448	PF00454	0.829
MOD_PIKK_1	602	608	PF00454	0.862
MOD_PIKK_1	720	726	PF00454	0.830
MOD_PKA_1	440	446	PF00069	0.835
MOD_PKA_1	726	732	PF00069	0.758
MOD_PKA_2	104	110	PF00069	0.711
MOD_PKA_2	287	293	PF00069	0.767
MOD_PKA_2	49	55	PF00069	0.713
MOD_PKA_2	498	504	PF00069	0.615
MOD_PKA_2	572	578	PF00069	0.645
MOD_PKA_2	588	594	PF00069	0.593
MOD_PKA_2	66	72	PF00069	0.574
MOD_PKA_2	725	731	PF00069	0.756
MOD_PKA_2	837	843	PF00069	0.810
MOD_PKB_1	621	629	PF00069	0.713
MOD_Plk_1	2	8	PF00069	0.685
MOD_Plk_1	418	424	PF00069	0.717
MOD_Plk_1	448	454	PF00069	0.622
MOD_Plk_1	624	630	PF00069	0.740
MOD_Plk_1	71	77	PF00069	0.709
MOD_Plk_1	843	849	PF00069	0.664
MOD_Plk_4	120	126	PF00069	0.710
MOD_Plk_4	449	455	PF00069	0.769
MOD_Plk_4	740	746	PF00069	0.757
MOD_Plk_4	751	757	PF00069	0.490
MOD_Plk_4	762	768	PF00069	0.484
MOD_Plk_4	809	815	PF00069	0.742
MOD_Plk_4	95	101	PF00069	0.642
MOD_ProDKin_1	182	188	PF00069	0.644
MOD_ProDKin_1	338	344	PF00069	0.745
MOD_ProDKin_1	45	51	PF00069	0.702
MOD_ProDKin_1	556	562	PF00069	0.860
MOD_ProDKin_1	60	66	PF00069	0.612
MOD_ProDKin_1	669	675	PF00069	0.810
MOD_ProDKin_1	678	684	PF00069	0.758
MOD_ProDKin_1	713	719	PF00069	0.781
MOD_SUMO_for_1	216	219	PF00179	0.510
MOD_SUMO_rev_2	158	163	PF00179	0.660
MOD_SUMO_rev_2	213	223	PF00179	0.724
MOD_SUMO_rev_2	522	532	PF00179	0.647
MOD_SUMO_rev_2	635	643	PF00179	0.690
TRG_DiLeu_BaEn_1	282	287	PF01217	0.749
TRG_DiLeu_BaEn_1	536	541	PF01217	0.638
TRG_DiLeu_BaEn_3	19	25	PF01217	0.593
TRG_DiLeu_BaEn_4	158	164	PF01217	0.666
TRG_DiLeu_BaLyEn_6	273	278	PF01217	0.770
TRG_ENDOCYTIC_2	14	17	PF00928	0.709
TRG_ENDOCYTIC_2	141	144	PF00928	0.651
TRG_ENDOCYTIC_2	146	149	PF00928	0.627
TRG_ENDOCYTIC_2	208	211	PF00928	0.484
TRG_ENDOCYTIC_2	21	24	PF00928	0.594
TRG_ENDOCYTIC_2	254	257	PF00928	0.720
TRG_ENDOCYTIC_2	473	476	PF00928	0.643
TRG_ENDOCYTIC_2	886	889	PF00928	0.713
TRG_ER_diArg_1	169	171	PF00400	0.631
TRG_ER_diArg_1	293	295	PF00400	0.788
TRG_ER_diArg_1	390	392	PF00400	0.856
TRG_ER_diArg_1	619	621	PF00400	0.853
TRG_ER_diArg_1	789	792	PF00400	0.668
TRG_Pf-PMV_PEXEL_1	28	33	PF00026	0.599
TRG_Pf-PMV_PEXEL_1	877	881	PF00026	0.572

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HBP4	Leishmania braziliensis	59%	99%
A4HZ45	Leishmania infantum	99%	100%
E9AV13	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
Q4QCG9	Leishmania major	88%	100%