Hypothetical_protein_conserved

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IA91_LEIDO

TriTrypDb:

LdBPK_151480.1 , LdCL_150020100 , LDHU3_15.1800

Length:

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IA91

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IA91

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	65	67	PF00675	0.462
CLV_PCSK_KEX2_1	65	67	PF00082	0.462
CLV_PCSK_SKI1_1	77	81	PF00082	0.609
DEG_SCF_FBW7_1	1	8	PF00400	0.711
DOC_CKS1_1	2	7	PF01111	0.651
DOC_CYCLIN_yClb5_NLxxxL_5	65	73	PF00134	0.553
DOC_MAPK_RevD_3	73	87	PF00069	0.534
DOC_USP7_MATH_1	11	15	PF00917	0.769
DOC_USP7_MATH_1	5	9	PF00917	0.721
DOC_USP7_MATH_1	51	55	PF00917	0.499
DOC_WW_Pin1_4	1	6	PF00397	0.717
DOC_WW_Pin1_4	32	37	PF00397	0.621
LIG_14-3-3_CanoR_1	52	60	PF00244	0.546
LIG_FHA_1	17	23	PF00498	0.743
LIG_FHA_1	26	32	PF00498	0.529
LIG_FHA_2	2	8	PF00498	0.756
LIG_FHA_2	38	44	PF00498	0.598
LIG_LIR_Nem_3	32	37	PF02991	0.601
LIG_LIR_Nem_3	76	82	PF02991	0.549
LIG_SH2_STAT5	82	85	PF00017	0.532
MOD_CK2_1	11	17	PF00069	0.742
MOD_CK2_1	37	43	PF00069	0.640
MOD_GlcNHglycan	23	26	PF01048	0.677
MOD_GlcNHglycan	7	10	PF01048	0.691
MOD_GSK3_1	1	8	PF00069	0.697
MOD_GSK3_1	16	23	PF00069	0.705
MOD_PIKK_1	16	22	PF00454	0.732
MOD_PKA_2	51	57	PF00069	0.605
MOD_ProDKin_1	1	7	PF00069	0.720
MOD_ProDKin_1	32	38	PF00069	0.622
TRG_ER_diArg_1	65	67	PF00400	0.497

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0X5	Leptomonas seymouri	37%	100%
A0A1X0NU10	Trypanosomatidae	33%	84%
A0A3R7K7I4	Trypanosoma rangeli	34%	88%
A4HWN0	Leishmania infantum	100%	100%
E9AI51	Leishmania braziliensis	60%	100%
E9AQD8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4QF37	Leishmania major	86%	100%