Myo-inositol-1 phosphatase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

myo-inositol-1 phosphatase, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IA90_LEIDO

TriTrypDb:

LdBPK_150940.1 , LdCL_150014900 , LDHU3_15.1220

Length:

473

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IA90

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IA90

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	7
GO:0006066	alcohol metabolic process	3	7
GO:0006629	lipid metabolic process	3	5
GO:0006644	phospholipid metabolic process	4	5
GO:0006650	glycerophospholipid metabolic process	5	5
GO:0006661	phosphatidylinositol biosynthetic process	6	5
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0008152	metabolic process	1	7
GO:0008610	lipid biosynthetic process	4	5
GO:0008654	phospholipid biosynthetic process	5	5
GO:0009056	catabolic process	2	7
GO:0009058	biosynthetic process	2	5
GO:0009987	cellular process	1	7
GO:0016311	dephosphorylation	5	7
GO:0019637	organophosphate metabolic process	3	7
GO:0019751	polyol metabolic process	4	7
GO:0043647	inositol phosphate metabolic process	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0044249	cellular biosynthetic process	3	5
GO:0044255	cellular lipid metabolic process	3	5
GO:0044262	obsolete cellular carbohydrate metabolic process	3	7
GO:0044281	small molecule metabolic process	2	7
GO:0044282	small molecule catabolic process	3	7
GO:0045017	glycerolipid biosynthetic process	4	5
GO:0046164	alcohol catabolic process	4	7
GO:0046174	polyol catabolic process	5	7
GO:0046434	organophosphate catabolic process	4	7
GO:0046474	glycerophospholipid biosynthetic process	5	5
GO:0046486	glycerolipid metabolic process	4	5
GO:0046488	phosphatidylinositol metabolic process	6	5
GO:0046838	obsolete phosphorylated carbohydrate dephosphorylation	4	7
GO:0046854	phosphatidylinositol phosphate biosynthetic process	7	5
GO:0046855	obsolete inositol phosphate dephosphorylation	5	7
GO:0071545	inositol phosphate catabolic process	5	7
GO:0071704	organic substance metabolic process	2	7
GO:0090407	organophosphate biosynthetic process	4	5
GO:1901575	organic substance catabolic process	3	7
GO:1901576	organic substance biosynthetic process	3	5
GO:1901615	organic hydroxy compound metabolic process	3	7
GO:1901616	organic hydroxy compound catabolic process	4	7
GO:0006020	inositol metabolic process	4	1
GO:0007165	signal transduction	2	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0065007	biological regulation	1	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	6
GO:0008934	inositol monophosphate 1-phosphatase activity	8	6
GO:0016787	hydrolase activity	2	6
GO:0016788	hydrolase activity, acting on ester bonds	3	6
GO:0016791	phosphatase activity	5	6
GO:0042578	phosphoric ester hydrolase activity	4	6
GO:0052745	inositol phosphate phosphatase activity	6	6
GO:0052832	inositol monophosphate 3-phosphatase activity	8	5
GO:0052833	inositol monophosphate 4-phosphatase activity	8	5
GO:0052834	inositol monophosphate phosphatase activity	7	6
GO:0005488	binding	1	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	160	162	PF00675	0.302
CLV_NRD_NRD_1	357	359	PF00675	0.306
CLV_NRD_NRD_1	48	50	PF00675	0.383
CLV_PCSK_KEX2_1	356	358	PF00082	0.274
CLV_PCSK_KEX2_1	47	49	PF00082	0.407
CLV_PCSK_PC1ET2_1	47	49	PF00082	0.407
CLV_PCSK_SKI1_1	114	118	PF00082	0.363
CLV_Separin_Metazoa	373	377	PF03568	0.363
DEG_APCC_DBOX_1	370	378	PF00400	0.363
DEG_Kelch_Keap1_1	15	20	PF01344	0.515
DEG_SCF_FBW7_1	168	175	PF00400	0.363
DEG_SPOP_SBC_1	11	15	PF00917	0.603
DOC_CKS1_1	124	129	PF01111	0.292
DOC_CKS1_1	169	174	PF01111	0.302
DOC_CKS1_1	231	236	PF01111	0.568
DOC_CKS1_1	257	262	PF01111	0.632
DOC_CKS1_1	6	11	PF01111	0.570
DOC_CYCLIN_yCln2_LP_2	375	381	PF00134	0.363
DOC_CYCLIN_yCln2_LP_2	431	437	PF00134	0.363
DOC_MAPK_gen_1	108	115	PF00069	0.270
DOC_MAPK_gen_1	161	168	PF00069	0.302
DOC_MAPK_gen_1	89	98	PF00069	0.465
DOC_MAPK_HePTP_8	158	170	PF00069	0.302
DOC_MAPK_MEF2A_6	108	115	PF00069	0.302
DOC_MAPK_MEF2A_6	161	170	PF00069	0.302
DOC_MAPK_MEF2A_6	371	379	PF00069	0.363
DOC_PP1_RVXF_1	37	43	PF00149	0.413
DOC_PP2B_LxvP_1	375	378	PF13499	0.363
DOC_PP4_FxxP_1	334	337	PF00568	0.363
DOC_USP7_MATH_1	11	15	PF00917	0.603
DOC_USP7_MATH_1	264	268	PF00917	0.645
DOC_USP7_MATH_1	276	280	PF00917	0.488
DOC_USP7_MATH_1	327	331	PF00917	0.310
DOC_WW_Pin1_4	123	128	PF00397	0.292
DOC_WW_Pin1_4	168	173	PF00397	0.302
DOC_WW_Pin1_4	206	211	PF00397	0.363
DOC_WW_Pin1_4	230	235	PF00397	0.577
DOC_WW_Pin1_4	256	261	PF00397	0.635
DOC_WW_Pin1_4	278	283	PF00397	0.612
DOC_WW_Pin1_4	289	294	PF00397	0.533
DOC_WW_Pin1_4	346	351	PF00397	0.298
DOC_WW_Pin1_4	5	10	PF00397	0.626
LIG_14-3-3_CanoR_1	179	183	PF00244	0.302
LIG_BIR_II_1	1	5	PF00653	0.622
LIG_CtBP_PxDLS_1	434	438	PF00389	0.307
LIG_EVH1_1	256	260	PF00568	0.635
LIG_FHA_1	117	123	PF00498	0.268
LIG_FHA_1	131	137	PF00498	0.332
LIG_FHA_1	169	175	PF00498	0.302
LIG_FHA_1	209	215	PF00498	0.693
LIG_FHA_1	238	244	PF00498	0.667
LIG_FHA_1	251	257	PF00498	0.556
LIG_FHA_1	290	296	PF00498	0.730
LIG_FHA_1	327	333	PF00498	0.342
LIG_FHA_1	439	445	PF00498	0.286
LIG_FHA_1	59	65	PF00498	0.460
LIG_FHA_1	79	85	PF00498	0.290
LIG_FHA_2	231	237	PF00498	0.591
LIG_Integrin_isoDGR_2	315	317	PF01839	0.302
LIG_LIR_Apic_2	401	406	PF02991	0.302
LIG_LIR_Gen_1	129	139	PF02991	0.302
LIG_LIR_Gen_1	302	312	PF02991	0.306
LIG_LIR_Nem_3	129	135	PF02991	0.302
LIG_LIR_Nem_3	262	268	PF02991	0.772
LIG_LIR_Nem_3	302	307	PF02991	0.306
LIG_Pex14_2	464	468	PF04695	0.366
LIG_SH2_SRC	403	406	PF00017	0.302
LIG_SH2_STAP1	102	106	PF00017	0.363
LIG_SH2_STAP1	132	136	PF00017	0.302
LIG_SH2_STAT3	160	163	PF00017	0.363
LIG_SH2_STAT3	199	202	PF00017	0.307
LIG_SH2_STAT5	132	135	PF00017	0.302
LIG_SH2_STAT5	403	406	PF00017	0.302
LIG_SH3_3	121	127	PF00018	0.296
LIG_SH3_3	132	138	PF00018	0.313
LIG_SH3_3	166	172	PF00018	0.302
LIG_SH3_3	204	210	PF00018	0.342
LIG_SH3_3	211	217	PF00018	0.668
LIG_SH3_3	228	234	PF00018	0.499
LIG_SH3_3	254	260	PF00018	0.651
LIG_Sin3_3	184	191	PF02671	0.307
LIG_SUMO_SIM_anti_2	2	8	PF11976	0.673
LIG_SUMO_SIM_par_1	209	215	PF11976	0.582
LIG_TRAF2_1	447	450	PF00917	0.286
LIG_UBA3_1	303	308	PF00899	0.363
MOD_CK1_1	15	21	PF00069	0.443
MOD_CK1_1	281	287	PF00069	0.612
MOD_CK1_1	4	10	PF00069	0.625
MOD_CK2_1	19	25	PF00069	0.433
MOD_CK2_1	340	346	PF00069	0.292
MOD_GlcNHglycan	14	17	PF01048	0.579
MOD_GlcNHglycan	175	178	PF01048	0.302
MOD_GlcNHglycan	219	222	PF01048	0.611
MOD_GlcNHglycan	278	281	PF01048	0.606
MOD_GlcNHglycan	61	64	PF01048	0.695
MOD_GlcNHglycan	78	81	PF01048	0.352
MOD_GSK3_1	1	8	PF00069	0.624
MOD_GSK3_1	11	18	PF00069	0.523
MOD_GSK3_1	126	133	PF00069	0.320
MOD_GSK3_1	152	159	PF00069	0.302
MOD_GSK3_1	168	175	PF00069	0.302
MOD_GSK3_1	206	213	PF00069	0.344
MOD_GSK3_1	219	226	PF00069	0.508
MOD_GSK3_1	272	279	PF00069	0.748
MOD_GSK3_1	384	391	PF00069	0.302
MOD_GSK3_1	414	421	PF00069	0.286
MOD_GSK3_1	54	61	PF00069	0.458
MOD_GSK3_1	78	85	PF00069	0.302
MOD_N-GLC_1	75	80	PF02516	0.250
MOD_NEK2_1	1	6	PF00069	0.623
MOD_NEK2_1	173	178	PF00069	0.302
MOD_NEK2_1	212	217	PF00069	0.568
MOD_NEK2_1	223	228	PF00069	0.652
MOD_NEK2_1	235	240	PF00069	0.595
MOD_NEK2_1	58	63	PF00069	0.497
MOD_NEK2_2	54	59	PF00069	0.440
MOD_PIKK_1	445	451	PF00454	0.329
MOD_PIKK_1	82	88	PF00454	0.302
MOD_PKA_2	178	184	PF00069	0.302
MOD_PKA_2	91	97	PF00069	0.348
MOD_Plk_1	130	136	PF00069	0.302
MOD_Plk_1	19	25	PF00069	0.433
MOD_Plk_1	364	370	PF00069	0.437
MOD_Plk_1	439	445	PF00069	0.292
MOD_Plk_4	130	136	PF00069	0.298
MOD_Plk_4	141	147	PF00069	0.294
MOD_Plk_4	19	25	PF00069	0.507
MOD_Plk_4	291	297	PF00069	0.588
MOD_Plk_4	327	333	PF00069	0.319
MOD_Plk_4	414	420	PF00069	0.346
MOD_Plk_4	439	445	PF00069	0.298
MOD_Plk_4	91	97	PF00069	0.307
MOD_ProDKin_1	123	129	PF00069	0.292
MOD_ProDKin_1	168	174	PF00069	0.302
MOD_ProDKin_1	206	212	PF00069	0.363
MOD_ProDKin_1	230	236	PF00069	0.578
MOD_ProDKin_1	256	262	PF00069	0.634
MOD_ProDKin_1	278	284	PF00069	0.613
MOD_ProDKin_1	289	295	PF00069	0.527
MOD_ProDKin_1	346	352	PF00069	0.298
MOD_ProDKin_1	5	11	PF00069	0.625
MOD_SUMO_rev_2	71	79	PF00179	0.310
TRG_DiLeu_BaEn_1	450	455	PF01217	0.363
TRG_DiLeu_BaEn_4	372	378	PF01217	0.292
TRG_ENDOCYTIC_2	132	135	PF00928	0.302
TRG_ENDOCYTIC_2	467	470	PF00928	0.428
TRG_ER_diArg_1	355	358	PF00400	0.292
TRG_ER_diArg_1	48	50	PF00400	0.394
TRG_NES_CRM1_1	20	32	PF08389	0.319
TRG_Pf-PMV_PEXEL_1	241	245	PF00026	0.621
TRG_Pf-PMV_PEXEL_1	39	43	PF00026	0.427
TRG_Pf-PMV_PEXEL_1	97	101	PF00026	0.329

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZI7	Leptomonas seymouri	56%	100%
A4H860	Leishmania braziliensis	76%	99%
A4HWI6	Leishmania infantum	99%	100%
E9AQ87	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QF96	Leishmania major	90%	99%