U1 zinc finger family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

U1 small nuclear ribonucleoprotein C, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IA85_LEIDO

TriTrypDb:

LdBPK_210380.1 , LdCL_210008600 , LDHU3_21.0400

Length:

237

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	4
GO:1990904	ribonucleoprotein complex	2	4
GO:0005654	nucleoplasm	2	1
GO:0005681	spliceosomal complex	3	1
GO:0005689	U12-type spliceosomal complex	4	1
GO:0110165	cellular anatomical entity	1	4
GO:0140513	nuclear protein-containing complex	2	1
GO:0005634	nucleus	5	3
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043231	intracellular membrane-bounded organelle	4	3

Expansion

Sequence features

A0A3Q8IA85

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IA85

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	7
GO:0008270	zinc ion binding	6	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0046914	transition metal ion binding	5	7
GO:0003676	nucleic acid binding	3	4
GO:0097159	organic cyclic compound binding	2	4
GO:1901363	heterocyclic compound binding	2	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	46	48	PF00675	0.537
CLV_NRD_NRD_1	56	58	PF00675	0.544
CLV_NRD_NRD_1	64	66	PF00675	0.503
CLV_PCSK_FUR_1	43	47	PF00082	0.482
CLV_PCSK_KEX2_1	40	42	PF00082	0.496
CLV_PCSK_KEX2_1	45	47	PF00082	0.513
CLV_PCSK_KEX2_1	56	58	PF00082	0.491
CLV_PCSK_KEX2_1	64	66	PF00082	0.475
CLV_PCSK_PC1ET2_1	40	42	PF00082	0.527
CLV_PCSK_PC7_1	41	47	PF00082	0.472
CLV_PCSK_SKI1_1	196	200	PF00082	0.588
DEG_Nend_UBRbox_2	1	3	PF02207	0.669
DOC_MAPK_gen_1	95	103	PF00069	0.460
DOC_PP2B_LxvP_1	169	172	PF13499	0.661
DOC_PP2B_LxvP_1	234	237	PF13499	0.683
DOC_PP2B_PxIxI_1	155	161	PF00149	0.540
DOC_PP2B_PxIxI_1	188	194	PF00149	0.612
DOC_PP4_FxxP_1	175	178	PF00568	0.686
DOC_USP7_MATH_1	102	106	PF00917	0.478
DOC_USP7_MATH_1	179	183	PF00917	0.770
DOC_USP7_MATH_1	206	210	PF00917	0.777
DOC_USP7_MATH_1	222	226	PF00917	0.729
DOC_WW_Pin1_4	144	149	PF00397	0.591
DOC_WW_Pin1_4	185	190	PF00397	0.739
DOC_WW_Pin1_4	209	214	PF00397	0.740
DOC_WW_Pin1_4	49	54	PF00397	0.529
LIG_14-3-3_CanoR_1	224	234	PF00244	0.754
LIG_14-3-3_CanoR_1	86	91	PF00244	0.487
LIG_14-3-3_CanoR_1	98	102	PF00244	0.488
LIG_BRCT_BRCA1_1	200	204	PF00533	0.495
LIG_CaM_NSCaTE_8	90	97	PF13499	0.474
LIG_EVH1_1	169	173	PF00568	0.659
LIG_EVH1_1	175	179	PF00568	0.620
LIG_EVH1_2	171	175	PF00568	0.666
LIG_FHA_1	186	192	PF00498	0.704
LIG_LIR_Gen_1	105	113	PF02991	0.462
LIG_LIR_Gen_1	201	211	PF02991	0.518
LIG_LIR_Gen_1	77	83	PF02991	0.381
LIG_LIR_Nem_3	100	106	PF02991	0.405
LIG_LIR_Nem_3	201	207	PF02991	0.513
LIG_LIR_Nem_3	77	81	PF02991	0.383
LIG_SH2_CRK	107	111	PF00017	0.474
LIG_SH2_NCK_1	107	111	PF00017	0.394
LIG_SH2_STAP1	107	111	PF00017	0.453
LIG_SH2_STAT5	75	78	PF00017	0.384
LIG_SH3_1	168	174	PF00018	0.642
LIG_SH3_3	167	173	PF00018	0.685
LIG_SH3_3	202	208	PF00018	0.635
LIG_SH3_3	212	218	PF00018	0.670
MOD_CDK_SPxxK_3	185	192	PF00069	0.730
MOD_CDK_SPxxK_3	49	56	PF00069	0.526
MOD_CK1_1	209	215	PF00069	0.675
MOD_CK1_1	225	231	PF00069	0.681
MOD_CK2_1	225	231	PF00069	0.685
MOD_CK2_1	32	38	PF00069	0.570
MOD_GlcNHglycan	139	142	PF01048	0.558
MOD_GlcNHglycan	181	184	PF01048	0.670
MOD_GlcNHglycan	2	6	PF01048	0.643
MOD_GlcNHglycan	200	203	PF01048	0.621
MOD_GlcNHglycan	208	211	PF01048	0.609
MOD_GlcNHglycan	23	26	PF01048	0.691
MOD_GlcNHglycan	29	32	PF01048	0.638
MOD_GlcNHglycan	95	98	PF01048	0.477
MOD_GSK3_1	194	201	PF00069	0.565
MOD_GSK3_1	82	89	PF00069	0.402
MOD_GSK3_1	93	100	PF00069	0.610
MOD_N-GLC_1	21	26	PF02516	0.609
MOD_NEK2_1	81	86	PF00069	0.407
MOD_PKA_2	225	231	PF00069	0.720
MOD_PKA_2	97	103	PF00069	0.472
MOD_Plk_4	102	108	PF00069	0.454
MOD_Plk_4	112	118	PF00069	0.361
MOD_Plk_4	194	200	PF00069	0.611
MOD_ProDKin_1	144	150	PF00069	0.590
MOD_ProDKin_1	185	191	PF00069	0.736
MOD_ProDKin_1	209	215	PF00069	0.740
MOD_ProDKin_1	49	55	PF00069	0.528
MOD_SUMO_rev_2	35	42	PF00179	0.538
TRG_ENDOCYTIC_2	106	109	PF00928	0.403
TRG_ENDOCYTIC_2	78	81	PF00928	0.374
TRG_ER_diArg_1	42	45	PF00400	0.501
TRG_ER_diArg_1	46	48	PF00400	0.531
TRG_NES_CRM1_1	108	120	PF08389	0.460
TRG_Pf-PMV_PEXEL_1	57	61	PF00026	0.545

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0S9	Leptomonas seymouri	65%	100%
A4HBN0	Leishmania braziliensis	78%	100%
A4HZ31	Leishmania infantum	100%	100%
D0A1N1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AUZ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	98%
Q4QCI3	Leishmania major	91%	97%