Rix1 complex component

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IA81_LEIDO

TriTrypDb:

LdBPK_150690.1 , LdCL_150012000 , LDHU3_15.0880

Length:

476

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IA81

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IA81

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	337	341	PF00656	0.791
CLV_C14_Caspase3-7	391	395	PF00656	0.748
CLV_NRD_NRD_1	122	124	PF00675	0.555
CLV_NRD_NRD_1	209	211	PF00675	0.609
CLV_NRD_NRD_1	257	259	PF00675	0.643
CLV_NRD_NRD_1	286	288	PF00675	0.640
CLV_NRD_NRD_1	290	292	PF00675	0.697
CLV_PCSK_FUR_1	207	211	PF00082	0.604
CLV_PCSK_KEX2_1	203	205	PF00082	0.600
CLV_PCSK_KEX2_1	209	211	PF00082	0.609
CLV_PCSK_KEX2_1	257	259	PF00082	0.643
CLV_PCSK_KEX2_1	286	288	PF00082	0.640
CLV_PCSK_KEX2_1	290	292	PF00082	0.697
CLV_PCSK_PC1ET2_1	203	205	PF00082	0.600
CLV_PCSK_PC1ET2_1	286	288	PF00082	0.640
CLV_PCSK_SKI1_1	383	387	PF00082	0.810
CLV_PCSK_SKI1_1	445	449	PF00082	0.648
CLV_Separin_Metazoa	99	103	PF03568	0.604
DOC_CYCLIN_yCln2_LP_2	113	119	PF00134	0.530
DOC_MAPK_gen_1	290	300	PF00069	0.709
DOC_PP2B_LxvP_1	113	116	PF13499	0.542
DOC_PP2B_LxvP_1	88	91	PF13499	0.707
DOC_PP4_FxxP_1	87	90	PF00568	0.717
DOC_PP4_MxPP_1	112	115	PF00568	0.554
DOC_USP7_MATH_1	211	215	PF00917	0.508
DOC_USP7_MATH_1	397	401	PF00917	0.742
DOC_USP7_MATH_1	421	425	PF00917	0.670
DOC_USP7_MATH_1	434	438	PF00917	0.549
DOC_WW_Pin1_4	240	245	PF00397	0.822
DOC_WW_Pin1_4	35	40	PF00397	0.708
DOC_WW_Pin1_4	404	409	PF00397	0.768
DOC_WW_Pin1_4	430	435	PF00397	0.782
DOC_WW_Pin1_4	80	85	PF00397	0.721
LIG_14-3-3_CanoR_1	187	195	PF00244	0.507
LIG_14-3-3_CanoR_1	445	450	PF00244	0.720
LIG_Actin_WH2_2	434	452	PF00022	0.746
LIG_BIR_III_2	431	435	PF00653	0.705
LIG_BRCT_BRCA1_1	452	456	PF00533	0.801
LIG_FHA_1	116	122	PF00498	0.525
LIG_FHA_1	311	317	PF00498	0.800
LIG_FHA_1	444	450	PF00498	0.710
LIG_FHA_1	465	471	PF00498	0.658
LIG_FHA_2	450	456	PF00498	0.755
LIG_LIR_Apic_2	86	90	PF02991	0.667
LIG_LIR_Gen_1	384	393	PF02991	0.730
LIG_LIR_Gen_1	41	50	PF02991	0.794
LIG_LIR_Nem_3	179	184	PF02991	0.516
LIG_LIR_Nem_3	381	385	PF02991	0.713
LIG_LIR_Nem_3	41	45	PF02991	0.703
LIG_SH2_CRK	181	185	PF00017	0.498
LIG_SH2_CRK	358	362	PF00017	0.634
LIG_SH2_CRK	42	46	PF00017	0.773
LIG_SH2_GRB2like	364	367	PF00017	0.717
LIG_SH2_NCK_1	42	46	PF00017	0.797
LIG_SH2_SRC	364	367	PF00017	0.704
LIG_SH2_STAT5	358	361	PF00017	0.711
LIG_SH3_3	139	145	PF00018	0.662
LIG_SH3_3	222	228	PF00018	0.724
LIG_SH3_3	325	331	PF00018	0.758
LIG_SH3_3	340	346	PF00018	0.609
LIG_SH3_3	374	380	PF00018	0.692
LIG_SH3_3	420	426	PF00018	0.799
LIG_SH3_3	438	444	PF00018	0.494
LIG_TRAF2_1	214	217	PF00917	0.535
LIG_TRAF2_1	473	476	PF00917	0.679
LIG_WRC_WIRS_1	382	387	PF05994	0.713
MOD_CK1_1	38	44	PF00069	0.696
MOD_CK1_1	381	387	PF00069	0.713
MOD_CK1_1	404	410	PF00069	0.755
MOD_CK1_1	437	443	PF00069	0.678
MOD_CK1_1	59	65	PF00069	0.627
MOD_CK1_1	83	89	PF00069	0.646
MOD_CK2_1	124	130	PF00069	0.599
MOD_CK2_1	211	217	PF00069	0.620
MOD_CK2_1	470	476	PF00069	0.672
MOD_CMANNOS	278	281	PF00535	0.511
MOD_GlcNHglycan	11	14	PF01048	0.818
MOD_GlcNHglycan	159	163	PF01048	0.797
MOD_GlcNHglycan	2	5	PF01048	0.719
MOD_GlcNHglycan	306	309	PF01048	0.716
MOD_GlcNHglycan	31	34	PF01048	0.710
MOD_GlcNHglycan	340	343	PF01048	0.791
MOD_GlcNHglycan	368	372	PF01048	0.736
MOD_GlcNHglycan	399	402	PF01048	0.838
MOD_GlcNHglycan	58	61	PF01048	0.721
MOD_GlcNHglycan	75	78	PF01048	0.743
MOD_GSK3_1	158	165	PF00069	0.806
MOD_GSK3_1	20	27	PF00069	0.796
MOD_GSK3_1	306	313	PF00069	0.723
MOD_GSK3_1	356	363	PF00069	0.810
MOD_GSK3_1	397	404	PF00069	0.719
MOD_GSK3_1	412	419	PF00069	0.753
MOD_GSK3_1	430	437	PF00069	0.690
MOD_GSK3_1	445	452	PF00069	0.715
MOD_GSK3_1	460	467	PF00069	0.621
MOD_LATS_1	122	128	PF00433	0.569
MOD_NEK2_1	103	108	PF00069	0.626
MOD_NEK2_1	24	29	PF00069	0.808
MOD_NEK2_1	338	343	PF00069	0.780
MOD_NEK2_2	281	286	PF00069	0.558
MOD_NEK2_2	434	439	PF00069	0.726
MOD_PIKK_1	416	422	PF00454	0.843
MOD_PKA_1	257	263	PF00069	0.620
MOD_PKA_2	257	263	PF00069	0.667
MOD_PKA_2	449	455	PF00069	0.734
MOD_Plk_4	20	26	PF00069	0.805
MOD_Plk_4	247	253	PF00069	0.671
MOD_Plk_4	40	46	PF00069	0.473
MOD_Plk_4	434	440	PF00069	0.775
MOD_Plk_4	83	89	PF00069	0.721
MOD_ProDKin_1	240	246	PF00069	0.820
MOD_ProDKin_1	35	41	PF00069	0.706
MOD_ProDKin_1	404	410	PF00069	0.770
MOD_ProDKin_1	430	436	PF00069	0.782
MOD_ProDKin_1	80	86	PF00069	0.723
MOD_SUMO_rev_2	190	199	PF00179	0.530
TRG_ENDOCYTIC_2	181	184	PF00928	0.508
TRG_ENDOCYTIC_2	189	192	PF00928	0.497
TRG_ENDOCYTIC_2	382	385	PF00928	0.714
TRG_ENDOCYTIC_2	42	45	PF00928	0.777
TRG_ER_diArg_1	206	209	PF00400	0.624
TRG_ER_diArg_1	289	291	PF00400	0.686
TRG_NLS_MonoCore_2	286	291	PF00514	0.663
TRG_NLS_MonoExtC_3	285	290	PF00514	0.644
TRG_NLS_MonoExtN_4	286	291	PF00514	0.663
TRG_Pf-PMV_PEXEL_1	472	476	PF00026	0.678

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEA5	Leptomonas seymouri	47%	75%
A4H822	Leishmania braziliensis	78%	99%
A4HWG4	Leishmania infantum	100%	100%
E9AQ64	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QFB9	Leishmania major	94%	100%