Phytanoyl-CoA dioxygenase (PhyH)/2OG-Fe(II) oxygenase superfamily, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

2OG-Fe(II) oxygenase superfamily, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IA78_LEIDO

TriTrypDb:

LdBPK_160050.1 , LdCL_160005400 , LDHU3_16.0050

Length:

317

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	1
GO:0016020	membrane	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2

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Expansion

Sequence features

A0A3Q8IA78

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IA78

Function

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Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0018126	protein hydroxylation	5	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018208	peptidyl-proline modification	6	1
GO:0018401	peptidyl-proline hydroxylation to 4-hydroxy-L-proline	7	1
GO:0019511	peptidyl-proline hydroxylation	6	1
GO:0019538	protein metabolic process	3	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004656	procollagen-proline 4-dioxygenase activity	5	1
GO:0005488	binding	1	12
GO:0005506	iron ion binding	6	12
GO:0016491	oxidoreductase activity	2	12
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	3	12
GO:0016706	2-oxoglutarate-dependent dioxygenase activity	4	1
GO:0019798	procollagen-proline dioxygenase activity	4	1
GO:0019842	vitamin binding	3	12
GO:0030246	carbohydrate binding	2	12

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	289	293	PF00656	0.531
CLV_C14_Caspase3-7	36	40	PF00656	0.537
CLV_NRD_NRD_1	303	305	PF00675	0.357
DEG_APCC_KENBOX_2	211	215	PF00400	0.287
DEG_Nend_Nbox_1	1	3	PF02207	0.559
DOC_CKS1_1	29	34	PF01111	0.477
DOC_MAPK_HePTP_8	175	187	PF00069	0.280
DOC_MAPK_MEF2A_6	178	187	PF00069	0.280
DOC_PP4_FxxP_1	29	32	PF00568	0.470
DOC_USP7_MATH_1	33	37	PF00917	0.341

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCX6	Leptomonas seymouri	79%	100%
A0A0S4JJ67	Bodo saltans	41%	90%
A0A1X0NZK5	Trypanosomatidae	59%	100%
A0A3R7K694	Trypanosoma rangeli	57%	100%
A4H8D1	Leishmania braziliensis	83%	100%
A4HWQ3	Leishmania infantum	100%	100%
C9ZPS8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	100%
E9AQG0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4QF16	Leishmania major	97%	100%
V5D783	Trypanosoma cruzi	57%	83%

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