LeishMANIAdb
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Phytanoyl-CoA dioxygenase (PhyH)/2OG-Fe(II) oxygenase superfamily, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Phytanoyl-CoA dioxygenase (PhyH)/2OG-Fe(II) oxygenase superfamily, putative
Gene product:
2OG-Fe(II) oxygenase superfamily, putative
Species:
Leishmania donovani
UniProt:
A0A3Q8IA78_LEIDO
TriTrypDb:
LdBPK_160050.1 , LdCL_160005400 , LDHU3_16.0050
Length:
317

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005783 endoplasmic reticulum 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 2
GO:0016020 membrane 2 1

Expansion

Sequence features

A0A3Q8IA78
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IA78

Function

Biological processes
Term Name Level Count
GO:0006807 nitrogen compound metabolic process 2 1
GO:0008152 metabolic process 1 1
GO:0018126 protein hydroxylation 5 1
GO:0018193 peptidyl-amino acid modification 5 1
GO:0018208 peptidyl-proline modification 6 1
GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline 7 1
GO:0019511 peptidyl-proline hydroxylation 6 1
GO:0019538 protein metabolic process 3 1
GO:0036211 protein modification process 4 1
GO:0043170 macromolecule metabolic process 3 1
GO:0043412 macromolecule modification 4 1
GO:0044238 primary metabolic process 2 1
GO:0071704 organic substance metabolic process 2 1
GO:1901564 organonitrogen compound metabolic process 3 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 12
GO:0005488 binding 1 12
GO:0005506 iron ion binding 6 12
GO:0016491 oxidoreductase activity 2 12
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 3 12
GO:0019842 vitamin binding 3 12
GO:0030246 carbohydrate binding 2 12
GO:0031406 carboxylic acid binding 4 12
GO:0031418 L-ascorbic acid binding 3 12
GO:0036094 small molecule binding 2 12
GO:0043167 ion binding 2 12
GO:0043168 anion binding 3 12
GO:0043169 cation binding 3 12
GO:0043177 organic acid binding 3 12
GO:0046872 metal ion binding 4 12
GO:0046914 transition metal ion binding 5 12
GO:0048029 monosaccharide binding 3 12
GO:0051213 dioxygenase activity 3 12
GO:0097159 organic cyclic compound binding 2 12
GO:1901363 heterocyclic compound binding 2 12
GO:0004656 procollagen-proline 4-dioxygenase activity 5 1
GO:0016706 2-oxoglutarate-dependent dioxygenase activity 4 1
GO:0019798 procollagen-proline dioxygenase activity 4 1
GO:0031543 peptidyl-proline dioxygenase activity 3 1
GO:0031545 peptidyl-proline 4-dioxygenase activity 4 1
GO:0140096 catalytic activity, acting on a protein 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 289 293 PF00656 0.531
CLV_C14_Caspase3-7 36 40 PF00656 0.537
CLV_NRD_NRD_1 303 305 PF00675 0.357
DEG_APCC_KENBOX_2 211 215 PF00400 0.287
DEG_Nend_Nbox_1 1 3 PF02207 0.559
DOC_CKS1_1 29 34 PF01111 0.477
DOC_MAPK_HePTP_8 175 187 PF00069 0.280
DOC_MAPK_MEF2A_6 178 187 PF00069 0.280
DOC_PP4_FxxP_1 29 32 PF00568 0.470
DOC_USP7_MATH_1 33 37 PF00917 0.341
DOC_WW_Pin1_4 262 267 PF00397 0.475
DOC_WW_Pin1_4 28 33 PF00397 0.510
LIG_14-3-3_CanoR_1 115 120 PF00244 0.492
LIG_14-3-3_CanoR_1 178 184 PF00244 0.280
LIG_14-3-3_CanoR_1 217 227 PF00244 0.365
LIG_APCC_ABBA_1 163 168 PF00400 0.280
LIG_BIR_III_4 78 82 PF00653 0.501
LIG_BRCT_BRCA1_1 232 236 PF00533 0.292
LIG_CSL_BTD_1 142 145 PF09270 0.364
LIG_FHA_1 180 186 PF00498 0.290
LIG_FHA_1 219 225 PF00498 0.477
LIG_FHA_1 263 269 PF00498 0.483
LIG_FHA_1 67 73 PF00498 0.434
LIG_FHA_2 169 175 PF00498 0.295
LIG_FHA_2 50 56 PF00498 0.469
LIG_LIR_Apic_2 27 32 PF02991 0.485
LIG_LIR_Gen_1 179 187 PF02991 0.280
LIG_LIR_Gen_1 20 30 PF02991 0.357
LIG_LIR_Gen_1 3 8 PF02991 0.467
LIG_LIR_Nem_3 177 183 PF02991 0.285
LIG_LIR_Nem_3 20 26 PF02991 0.340
LIG_LIR_Nem_3 233 239 PF02991 0.320
LIG_LIR_Nem_3 3 7 PF02991 0.475
LIG_LIR_Nem_3 99 105 PF02991 0.353
LIG_REV1ctd_RIR_1 132 141 PF16727 0.313
LIG_SH2_CRK 181 185 PF00017 0.295
LIG_SH2_CRK 239 243 PF00017 0.339
LIG_SH2_CRK 4 8 PF00017 0.484
LIG_SH2_GRB2like 186 189 PF00017 0.275
LIG_SH2_GRB2like 238 241 PF00017 0.313
LIG_SH2_NCK_1 110 114 PF00017 0.475
LIG_SH2_SRC 281 284 PF00017 0.447
LIG_SH2_STAP1 110 114 PF00017 0.367
LIG_SH2_STAP1 181 185 PF00017 0.295
LIG_SH2_STAP1 68 72 PF00017 0.432
LIG_SH2_STAT5 181 184 PF00017 0.291
LIG_SH2_STAT5 186 189 PF00017 0.254
LIG_SH2_STAT5 208 211 PF00017 0.346
LIG_SH2_STAT5 254 257 PF00017 0.273
LIG_SH2_STAT5 68 71 PF00017 0.369
LIG_SUMO_SIM_par_1 170 177 PF11976 0.279
LIG_SUMO_SIM_par_1 33 39 PF11976 0.571
LIG_TRAF2_1 280 283 PF00917 0.374
LIG_TRAF2_1 52 55 PF00917 0.409
MOD_CK1_1 179 185 PF00069 0.295
MOD_CK2_1 49 55 PF00069 0.346
MOD_GlcNHglycan 105 108 PF01048 0.230
MOD_GlcNHglycan 232 235 PF01048 0.328
MOD_GlcNHglycan 86 89 PF01048 0.535
MOD_GSK3_1 24 31 PF00069 0.471
MOD_N-GLC_1 218 223 PF02516 0.313
MOD_N-GLC_2 188 190 PF02516 0.290
MOD_NEK2_1 139 144 PF00069 0.421
MOD_NEK2_1 286 291 PF00069 0.526
MOD_NEK2_2 309 314 PF00069 0.352
MOD_PIKK_1 218 224 PF00454 0.376
MOD_PKA_1 230 236 PF00069 0.374
MOD_PKA_1 304 310 PF00069 0.373
MOD_PKB_1 302 310 PF00069 0.397
MOD_Plk_2-3 168 174 PF00069 0.295
MOD_Plk_4 139 145 PF00069 0.369
MOD_Plk_4 168 174 PF00069 0.295
MOD_Plk_4 179 185 PF00069 0.295
MOD_Plk_4 193 199 PF00069 0.320
MOD_Plk_4 309 315 PF00069 0.439
MOD_Plk_4 66 72 PF00069 0.351
MOD_ProDKin_1 262 268 PF00069 0.475
MOD_ProDKin_1 28 34 PF00069 0.513
MOD_SUMO_rev_2 271 278 PF00179 0.381
MOD_SUMO_rev_2 36 42 PF00179 0.421
TRG_DiLeu_BaEn_1 55 60 PF01217 0.413
TRG_ENDOCYTIC_2 110 113 PF00928 0.457
TRG_ENDOCYTIC_2 181 184 PF00928 0.295
TRG_ENDOCYTIC_2 238 241 PF00928 0.315
TRG_ENDOCYTIC_2 4 7 PF00928 0.493

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PCX6 Leptomonas seymouri 79% 100%
A0A0S4JJ67 Bodo saltans 41% 90%
A0A1X0NZK5 Trypanosomatidae 59% 100%
A0A3R7K694 Trypanosoma rangeli 57% 100%
A4H8D1 Leishmania braziliensis 83% 100%
A4HWQ3 Leishmania infantum 100% 100%
C9ZPS8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 57% 100%
E9AQG0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 95% 100%
Q4QF16 Leishmania major 97% 100%
V5D783 Trypanosoma cruzi 57% 83%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS