Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IA76_LEIDO

TriTrypDb:

LdBPK_210110.1 , LdCL_210006000 , LDHU3_21.0120

Length:

285

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A0A3Q8IA76

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IA76

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	109	111	PF00675	0.546
CLV_NRD_NRD_1	143	145	PF00675	0.370
CLV_NRD_NRD_1	223	225	PF00675	0.585
CLV_PCSK_KEX2_1	108	110	PF00082	0.551
CLV_PCSK_KEX2_1	223	225	PF00082	0.585
CLV_PCSK_SKI1_1	145	149	PF00082	0.523
CLV_PCSK_SKI1_1	22	26	PF00082	0.468
CLV_PCSK_SKI1_1	264	268	PF00082	0.622
CLV_PCSK_SKI1_1	28	32	PF00082	0.474
CLV_PCSK_SKI1_1	46	50	PF00082	0.384
CLV_PCSK_SKI1_1	55	59	PF00082	0.419
DEG_MDM2_SWIB_1	89	96	PF02201	0.664
DEG_Nend_UBRbox_2	1	3	PF02207	0.683
DEG_SPOP_SBC_1	229	233	PF00917	0.742
DOC_CKS1_1	159	164	PF01111	0.709
DOC_CYCLIN_RxL_1	10	21	PF00134	0.625
DOC_MAPK_gen_1	264	272	PF00069	0.470
DOC_MAPK_MEF2A_6	129	136	PF00069	0.576
DOC_MAPK_MEF2A_6	244	253	PF00069	0.430
DOC_PP1_RVXF_1	242	249	PF00149	0.423
DOC_PP1_RVXF_1	44	51	PF00149	0.579
DOC_USP7_MATH_1	139	143	PF00917	0.612
DOC_USP7_MATH_1	192	196	PF00917	0.775
DOC_USP7_MATH_1	230	234	PF00917	0.776
DOC_USP7_MATH_1	265	269	PF00917	0.430
DOC_WW_Pin1_4	158	163	PF00397	0.708
LIG_14-3-3_CanoR_1	22	30	PF00244	0.679
LIG_14-3-3_CanoR_1	264	270	PF00244	0.435
LIG_14-3-3_CanoR_1	279	284	PF00244	0.530
LIG_14-3-3_CanoR_1	46	51	PF00244	0.659
LIG_Actin_WH2_2	242	258	PF00022	0.502
LIG_AP2alpha_2	105	107	PF02296	0.669
LIG_Clathr_ClatBox_1	133	137	PF01394	0.576
LIG_FHA_1	121	127	PF00498	0.686
LIG_FHA_1	19	25	PF00498	0.638
LIG_FHA_1	89	95	PF00498	0.590
LIG_FHA_2	162	168	PF00498	0.705
LIG_FHA_2	216	222	PF00498	0.768
LIG_GBD_Chelix_1	246	254	PF00786	0.500
LIG_GBD_Chelix_1	262	270	PF00786	0.599
LIG_LIR_Gen_1	91	100	PF02991	0.686
LIG_LIR_Nem_3	56	61	PF02991	0.694
LIG_LIR_Nem_3	91	96	PF02991	0.669
LIG_NRBOX	245	251	PF00104	0.502
LIG_PCNA_PIPBox_1	30	39	PF02747	0.646
LIG_PDZ_Class_2	280	285	PF00595	0.526
LIG_Pex14_2	107	111	PF04695	0.740
LIG_Pex14_2	124	128	PF04695	0.672
LIG_Pex14_2	89	93	PF04695	0.658
LIG_Pex3_1	246	257	PF04882	0.423
LIG_SH2_STAT3	151	154	PF00017	0.707
LIG_SH2_STAT3	209	212	PF00017	0.765
LIG_SH2_STAT5	85	88	PF00017	0.542
LIG_SH3_3	186	192	PF00018	0.701
LIG_TRAF2_1	164	167	PF00917	0.675
LIG_WRC_WIRS_1	47	52	PF05994	0.663
MOD_CDK_SPxxK_3	158	165	PF00069	0.708
MOD_CK1_1	200	206	PF00069	0.758
MOD_CK2_1	161	167	PF00069	0.648
MOD_CK2_1	215	221	PF00069	0.767
MOD_Cter_Amidation	142	145	PF01082	0.361
MOD_GlcNHglycan	141	144	PF01048	0.487
MOD_GlcNHglycan	194	197	PF01048	0.499
MOD_GlcNHglycan	2	5	PF01048	0.423
MOD_GlcNHglycan	203	206	PF01048	0.541
MOD_GlcNHglycan	232	235	PF01048	0.569
MOD_GlcNHglycan	68	71	PF01048	0.381
MOD_GlcNHglycan	78	82	PF01048	0.383
MOD_GSK3_1	18	25	PF00069	0.649
MOD_GSK3_1	197	204	PF00069	0.754
MOD_GSK3_1	211	218	PF00069	0.694
MOD_LATS_1	44	50	PF00433	0.670
MOD_NEK2_1	270	275	PF00069	0.476
MOD_NEK2_1	36	41	PF00069	0.621
MOD_NEK2_2	120	125	PF00069	0.638
MOD_PIKK_1	150	156	PF00454	0.700
MOD_PIKK_1	211	217	PF00454	0.819
MOD_PIKK_1	22	28	PF00454	0.741
MOD_PKA_2	113	119	PF00069	0.649
MOD_PKA_2	215	221	PF00069	0.831
MOD_PKB_1	112	120	PF00069	0.615
MOD_Plk_1	171	177	PF00069	0.689
MOD_Plk_4	184	190	PF00069	0.674
MOD_Plk_4	265	271	PF00069	0.446
MOD_ProDKin_1	158	164	PF00069	0.710
TRG_ER_diArg_1	107	110	PF00400	0.742
TRG_Pf-PMV_PEXEL_1	22	26	PF00026	0.476

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4B3	Leptomonas seymouri	48%	80%
A4HBK4	Leishmania braziliensis	76%	100%
A4HZL1	Leishmania infantum	100%	100%
E9AUX3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QCK9	Leishmania major	93%	100%