Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IA72_LEIDO

TriTrypDb:

LdBPK_150560.1 , LdCL_150010700 , LDHU3_15.0710

Length:

675

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	10
GO:0042995	cell projection	2	10
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0110165	cellular anatomical entity	1	11
GO:0120025	plasma membrane bounded cell projection	3	10
GO:0005815	microtubule organizing center	2	1
GO:0035253	ciliary rootlet	2	1
GO:0036064	ciliary basal body	3	1
GO:0097542	ciliary tip	2	1
GO:0016020	membrane	2	1

Expansion

Sequence features

A0A3Q8IA72

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IA72

Function

Biological processes
Term	Name	Level	Count
GO:0003341	cilium movement	4	11
GO:0007017	microtubule-based process	2	11
GO:0007018	microtubule-based movement	3	11
GO:0009987	cellular process	1	11
GO:0016043	cellular component organization	3	11
GO:0022607	cellular component assembly	4	11
GO:0036158	outer dynein arm assembly	7	11
GO:0043933	protein-containing complex organization	4	11
GO:0065003	protein-containing complex assembly	5	11
GO:0070286	axonemal dynein complex assembly	6	11
GO:0071840	cellular component organization or biogenesis	2	11

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	344	348	PF00656	0.575
CLV_C14_Caspase3-7	395	399	PF00656	0.760
CLV_C14_Caspase3-7	525	529	PF00656	0.598
CLV_NRD_NRD_1	152	154	PF00675	0.429
CLV_NRD_NRD_1	229	231	PF00675	0.481
CLV_NRD_NRD_1	275	277	PF00675	0.691
CLV_NRD_NRD_1	35	37	PF00675	0.515
CLV_NRD_NRD_1	425	427	PF00675	0.496
CLV_NRD_NRD_1	429	431	PF00675	0.438
CLV_NRD_NRD_1	45	47	PF00675	0.487
CLV_NRD_NRD_1	660	662	PF00675	0.556
CLV_NRD_NRD_1	668	670	PF00675	0.586
CLV_PCSK_KEX2_1	14	16	PF00082	0.460
CLV_PCSK_KEX2_1	152	154	PF00082	0.429
CLV_PCSK_KEX2_1	229	231	PF00082	0.510
CLV_PCSK_KEX2_1	236	238	PF00082	0.540
CLV_PCSK_KEX2_1	274	276	PF00082	0.688
CLV_PCSK_KEX2_1	35	37	PF00082	0.498
CLV_PCSK_KEX2_1	425	427	PF00082	0.492
CLV_PCSK_KEX2_1	429	431	PF00082	0.435
CLV_PCSK_KEX2_1	45	47	PF00082	0.466
CLV_PCSK_KEX2_1	662	664	PF00082	0.650
CLV_PCSK_KEX2_1	668	670	PF00082	0.666
CLV_PCSK_KEX2_1	86	88	PF00082	0.481
CLV_PCSK_PC1ET2_1	14	16	PF00082	0.460
CLV_PCSK_PC1ET2_1	236	238	PF00082	0.487
CLV_PCSK_PC1ET2_1	662	664	PF00082	0.658
CLV_PCSK_PC1ET2_1	86	88	PF00082	0.460
CLV_PCSK_PC7_1	425	431	PF00082	0.478
CLV_PCSK_SKI1_1	221	225	PF00082	0.468
CLV_PCSK_SKI1_1	229	233	PF00082	0.460
CLV_PCSK_SKI1_1	307	311	PF00082	0.457
CLV_PCSK_SKI1_1	350	354	PF00082	0.560
CLV_PCSK_SKI1_1	430	434	PF00082	0.445
CLV_PCSK_SKI1_1	496	500	PF00082	0.568
CLV_PCSK_SKI1_1	52	56	PF00082	0.576
DEG_APCC_DBOX_1	23	31	PF00400	0.502
DEG_APCC_DBOX_1	641	649	PF00400	0.564
DEG_SCF_TRCP1_1	607	612	PF00400	0.526
DOC_CYCLIN_RxL_1	425	435	PF00134	0.628
DOC_CYCLIN_yCln2_LP_2	287	293	PF00134	0.416
DOC_MAPK_gen_1	13	21	PF00069	0.527
DOC_MAPK_gen_1	242	249	PF00069	0.561
DOC_MAPK_gen_1	298	306	PF00069	0.571
DOC_MAPK_gen_1	323	332	PF00069	0.558
DOC_MAPK_gen_1	425	433	PF00069	0.647
DOC_MAPK_gen_1	45	55	PF00069	0.603
DOC_MAPK_MEF2A_6	242	251	PF00069	0.592
DOC_USP7_MATH_1	206	210	PF00917	0.525
DOC_USP7_MATH_1	352	356	PF00917	0.603
DOC_USP7_MATH_1	367	371	PF00917	0.565
DOC_USP7_MATH_1	615	619	PF00917	0.778
DOC_USP7_UBL2_3	140	144	PF12436	0.434
DOC_USP7_UBL2_3	195	199	PF12436	0.522
DOC_WW_Pin1_4	286	291	PF00397	0.697
DOC_WW_Pin1_4	520	525	PF00397	0.641
DOC_WW_Pin1_4	572	577	PF00397	0.802
DOC_WW_Pin1_4	582	587	PF00397	0.739
LIG_14-3-3_CanoR_1	105	113	PF00244	0.604
LIG_14-3-3_CanoR_1	15	19	PF00244	0.609
LIG_14-3-3_CanoR_1	152	156	PF00244	0.429
LIG_14-3-3_CanoR_1	257	263	PF00244	0.710
LIG_14-3-3_CanoR_1	264	269	PF00244	0.761
LIG_14-3-3_CanoR_1	279	288	PF00244	0.627
LIG_14-3-3_CanoR_1	496	505	PF00244	0.525
LIG_14-3-3_CanoR_1	63	68	PF00244	0.610
LIG_Actin_WH2_2	37	54	PF00022	0.561
LIG_Actin_WH2_2	85	103	PF00022	0.582
LIG_CaM_IQ_9	27	42	PF13499	0.627
LIG_CtBP_PxDLS_1	586	590	PF00389	0.587
LIG_FHA_1	299	305	PF00498	0.583
LIG_FHA_1	502	508	PF00498	0.536
LIG_FHA_1	582	588	PF00498	0.693
LIG_FHA_1	6	12	PF00498	0.509
LIG_FHA_2	155	161	PF00498	0.464
LIG_FHA_2	333	339	PF00498	0.496
LIG_FHA_2	4	10	PF00498	0.725
LIG_GLEBS_BUB3_1	521	529	PF00400	0.597
LIG_IRF3_LxIS_1	247	252	PF10401	0.569
LIG_IRF3_LxIS_1	471	478	PF10401	0.601
LIG_LIR_Gen_1	154	162	PF02991	0.428
LIG_LIR_Gen_1	301	311	PF02991	0.480
LIG_LIR_Gen_1	355	364	PF02991	0.571
LIG_LIR_Gen_1	538	546	PF02991	0.406
LIG_LIR_Nem_3	154	158	PF02991	0.428
LIG_LIR_Nem_3	301	306	PF02991	0.450
LIG_LIR_Nem_3	355	360	PF02991	0.501
LIG_LIR_Nem_3	418	422	PF02991	0.691
LIG_LIR_Nem_3	538	542	PF02991	0.405
LIG_NRBOX	456	462	PF00104	0.538
LIG_PDZ_Class_3	670	675	PF00595	0.669
LIG_SH2_CRK	419	423	PF00017	0.674
LIG_SH2_STAP1	155	159	PF00017	0.389
LIG_SH2_STAT5	303	306	PF00017	0.553
LIG_SH2_STAT5	470	473	PF00017	0.559
LIG_SH3_3	543	549	PF00018	0.696
LIG_SUMO_SIM_anti_2	504	509	PF11976	0.514
LIG_TRAF2_1	106	109	PF00917	0.467
LIG_TRAF2_1	252	255	PF00917	0.643
LIG_TRAF2_1	523	526	PF00917	0.602
LIG_TRAF2_1	670	673	PF00917	0.636
LIG_TRAF2_1	72	75	PF00917	0.562
LIG_TYR_ITIM	417	422	PF00017	0.633
MOD_CK1_1	269	275	PF00069	0.700
MOD_CK1_1	280	286	PF00069	0.709
MOD_CK1_1	486	492	PF00069	0.648
MOD_CK1_1	567	573	PF00069	0.779
MOD_CK1_1	585	591	PF00069	0.809
MOD_CK1_1	605	611	PF00069	0.661
MOD_CK1_1	649	655	PF00069	0.518
MOD_CK2_1	154	160	PF00069	0.463
MOD_CK2_1	171	177	PF00069	0.479
MOD_CK2_1	249	255	PF00069	0.593
MOD_CK2_1	3	9	PF00069	0.735
MOD_CK2_1	332	338	PF00069	0.491
MOD_CK2_1	352	358	PF00069	0.619
MOD_CK2_1	520	526	PF00069	0.587
MOD_CK2_1	532	538	PF00069	0.601
MOD_CK2_1	667	673	PF00069	0.638
MOD_GlcNHglycan	122	127	PF01048	0.505
MOD_GlcNHglycan	195	198	PF01048	0.509
MOD_GlcNHglycan	268	271	PF01048	0.763
MOD_GlcNHglycan	283	286	PF01048	0.756
MOD_GlcNHglycan	369	372	PF01048	0.631
MOD_GlcNHglycan	381	384	PF01048	0.676
MOD_GlcNHglycan	387	390	PF01048	0.728
MOD_GlcNHglycan	477	480	PF01048	0.574
MOD_GlcNHglycan	484	488	PF01048	0.614
MOD_GlcNHglycan	496	499	PF01048	0.651
MOD_GlcNHglycan	567	570	PF01048	0.737
MOD_GlcNHglycan	607	610	PF01048	0.635
MOD_GlcNHglycan	617	620	PF01048	0.668
MOD_GlcNHglycan	624	627	PF01048	0.631
MOD_GSK3_1	147	154	PF00069	0.496
MOD_GSK3_1	168	175	PF00069	0.488
MOD_GSK3_1	277	284	PF00069	0.716
MOD_GSK3_1	494	501	PF00069	0.588
MOD_GSK3_1	572	579	PF00069	0.734
MOD_GSK3_1	581	588	PF00069	0.697
MOD_GSK3_1	603	610	PF00069	0.685
MOD_GSK3_1	615	622	PF00069	0.595
MOD_LATS_1	492	498	PF00433	0.628
MOD_N-GLC_1	3	8	PF02516	0.690
MOD_N-GLC_1	63	68	PF02516	0.646
MOD_NEK2_1	193	198	PF00069	0.385
MOD_NEK2_1	232	237	PF00069	0.465
MOD_NEK2_1	249	254	PF00069	0.502
MOD_NEK2_1	3	8	PF00069	0.630
MOD_NEK2_1	332	337	PF00069	0.500
MOD_NEK2_1	475	480	PF00069	0.562
MOD_NEK2_1	55	60	PF00069	0.566
MOD_NEK2_1	85	90	PF00069	0.443
MOD_PIKK_1	168	174	PF00454	0.474
MOD_PIKK_1	249	255	PF00454	0.597
MOD_PIKK_1	455	461	PF00454	0.459
MOD_PIKK_1	486	492	PF00454	0.661
MOD_PIKK_1	496	502	PF00454	0.550
MOD_PK_1	14	20	PF00069	0.481
MOD_PK_1	264	270	PF00069	0.512
MOD_PK_1	63	69	PF00069	0.611
MOD_PKA_1	14	20	PF00069	0.467
MOD_PKA_2	104	110	PF00069	0.619
MOD_PKA_2	14	20	PF00069	0.610
MOD_PKA_2	151	157	PF00069	0.429
MOD_PKA_2	280	286	PF00069	0.713
MOD_PKA_2	667	673	PF00069	0.701
MOD_PKB_1	279	287	PF00069	0.656
MOD_PKB_1	305	313	PF00069	0.580
MOD_PKB_1	321	329	PF00069	0.586
MOD_Plk_1	122	128	PF00069	0.585
MOD_Plk_1	307	313	PF00069	0.469
MOD_Plk_1	339	345	PF00069	0.578
MOD_Plk_1	63	69	PF00069	0.635
MOD_Plk_2-3	104	110	PF00069	0.552
MOD_Plk_4	14	20	PF00069	0.527
MOD_Plk_4	154	160	PF00069	0.458
MOD_Plk_4	283	289	PF00069	0.473
MOD_Plk_4	596	602	PF00069	0.739
MOD_ProDKin_1	286	292	PF00069	0.690
MOD_ProDKin_1	520	526	PF00069	0.641
MOD_ProDKin_1	572	578	PF00069	0.804
MOD_ProDKin_1	582	588	PF00069	0.739
MOD_SUMO_for_1	204	207	PF00179	0.460
MOD_SUMO_for_1	72	75	PF00179	0.588
MOD_SUMO_rev_2	207	213	PF00179	0.504
MOD_SUMO_rev_2	43	51	PF00179	0.523
MOD_SUMO_rev_2	638	648	PF00179	0.591
TRG_DiLeu_BaEn_1	186	191	PF01217	0.545
TRG_DiLeu_BaEn_2	107	113	PF01217	0.554
TRG_DiLeu_BaEn_3	227	233	PF01217	0.513
TRG_ENDOCYTIC_2	155	158	PF00928	0.428
TRG_ENDOCYTIC_2	303	306	PF00928	0.462
TRG_ENDOCYTIC_2	419	422	PF00928	0.677
TRG_ER_diArg_1	151	153	PF00400	0.428
TRG_ER_diArg_1	229	231	PF00400	0.574
TRG_ER_diArg_1	274	276	PF00400	0.693
TRG_ER_diArg_1	304	307	PF00400	0.534
TRG_ER_diArg_1	34	36	PF00400	0.519
TRG_ER_diArg_1	429	431	PF00400	0.459
TRG_ER_diArg_1	44	46	PF00400	0.495
TRG_NLS_MonoExtN_4	659	665	PF00514	0.564
TRG_Pf-PMV_PEXEL_1	111	115	PF00026	0.562
TRG_Pf-PMV_PEXEL_1	221	225	PF00026	0.508
TRG_Pf-PMV_PEXEL_1	429	434	PF00026	0.444

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PF92	Leptomonas seymouri	67%	100%
A0A0S4JUS3	Bodo saltans	30%	100%
A0A1X0NV64	Trypanosomatidae	39%	96%
A0A422NLI6	Trypanosoma rangeli	40%	100%
A4H826	Leishmania braziliensis	81%	100%
C9ZNZ5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	93%
E9AQ51	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QFD1	Leishmania major	93%	100%
V5BBE7	Trypanosoma cruzi	42%	100%