60s Acidic ribosomal family protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

60S acidic ribosomal protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IA63_LEIDO

TriTrypDb:

LdBPK_150430.1 , LdCL_150009100 , LdCL_150009200 , LDHU3_15.0520 , LDHU3_15.0530

Length:

108

Annotations

Annotations by Jardim et al.

Ribosomal Protein, 60S acidic ribosomal

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 5, no: 3
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	8
GO:0032991	protein-containing complex	1	9
GO:0043226	organelle	2	8
GO:0043228	non-membrane-bounded organelle	3	8
GO:0043229	intracellular organelle	3	8
GO:0043232	intracellular non-membrane-bounded organelle	4	8
GO:0110165	cellular anatomical entity	1	8
GO:1990904	ribonucleoprotein complex	2	9
GO:0015934	large ribosomal subunit	4	1
GO:0022625	cytosolic large ribosomal subunit	5	1
GO:0044391	ribosomal subunit	3	1

Expansion

Sequence features

A0A3Q8IA63

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IA63

Function

Biological processes
Term	Name	Level	Count
GO:0006414	translational elongation	5	9
GO:0008152	metabolic process	1	9
GO:0009058	biosynthetic process	2	9
GO:0009059	macromolecule biosynthetic process	4	9
GO:0009987	cellular process	1	9
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	9
GO:0043170	macromolecule metabolic process	3	9
GO:0044237	cellular metabolic process	2	9
GO:0044249	cellular biosynthetic process	3	9
GO:0044260	obsolete cellular macromolecule metabolic process	3	9
GO:0071704	organic substance metabolic process	2	9
GO:1901576	organic substance biosynthetic process	3	9
GO:0002181	cytoplasmic translation	5	1
GO:0006412	translation	4	1
GO:0006518	peptide metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0019538	protein metabolic process	3	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043043	peptide biosynthetic process	5	1
GO:0043603	amide metabolic process	3	1
GO:0043604	amide biosynthetic process	4	1
GO:0044238	primary metabolic process	2	1
GO:0044271	cellular nitrogen compound biosynthetic process	4	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901566	organonitrogen compound biosynthetic process	4	1

Molecular functions
Term	Name	Level	Count
GO:0003735	structural constituent of ribosome	2	9
GO:0005198	structural molecule activity	1	9
GO:0005488	binding	1	1
GO:0008047	enzyme activator activity	3	1
GO:0019207	kinase regulator activity	3	1
GO:0019209	kinase activator activity	4	1
GO:0019887	protein kinase regulator activity	4	1
GO:0030234	enzyme regulator activity	2	1
GO:0030295	protein kinase activator activity	5	1
GO:0043021	ribonucleoprotein complex binding	3	1
GO:0044877	protein-containing complex binding	2	1
GO:0098772	molecular function regulator activity	1	1
GO:0140677	molecular function activator activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	21	25	PF00656	0.395
DOC_USP7_MATH_1	48	52	PF00917	0.523
DOC_USP7_MATH_1	78	82	PF00917	0.669
LIG_BRCT_BRCA1_1	59	63	PF00533	0.546
LIG_FHA_1	1	7	PF00498	0.502
LIG_FHA_2	19	25	PF00498	0.433
LIG_LIR_Gen_1	9	17	PF02991	0.460
LIG_LIR_Nem_3	101	107	PF02991	0.540
LIG_LIR_Nem_3	9	13	PF02991	0.484
LIG_SH2_CRK	10	14	PF00017	0.517
LIG_SH2_STAP1	10	14	PF00017	0.455
LIG_TRAF2_1	90	93	PF00917	0.584
MOD_CK1_1	18	24	PF00069	0.569
MOD_GlcNHglycan	15	18	PF01048	0.492
MOD_GlcNHglycan	63	66	PF01048	0.385
MOD_GlcNHglycan	80	83	PF01048	0.430
MOD_GSK3_1	18	25	PF00069	0.533
MOD_GSK3_1	57	64	PF00069	0.576
MOD_NEK2_1	13	18	PF00069	0.507
MOD_NEK2_1	6	11	PF00069	0.467
MOD_PKA_2	61	67	PF00069	0.473
MOD_SUMO_for_1	90	93	PF00179	0.506
TRG_ENDOCYTIC_2	10	13	PF00928	0.475

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2K6	Leptomonas seymouri	67%	100%
A0A1X0NTR3	Trypanosomatidae	60%	100%
A0A3R7KRR7	Trypanosoma rangeli	61%	100%
A1XQU7	Sus scrofa	39%	95%
A4H3L0	Leishmania braziliensis	47%	100%
A4H3L1	Leishmania braziliensis	47%	100%
A4HWD9	Leishmania infantum	100%	100%
E9AI48	Leishmania braziliensis	81%	99%
E9AQ39	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	99%
H2E5X2	Penicillium crustosum	47%	100%
O01359	Oscheius tipulae	40%	96%
O23095	Arabidopsis thaliana	41%	96%
O46313	Leishmania peruviana	47%	100%
P05318	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	39%	100%
P05386	Homo sapiens	42%	95%
P08570	Drosophila melanogaster	41%	96%
P17476	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	43%	99%
P17477	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	41%	98%
P18660	Gallus gallus	38%	95%
P19944	Rattus norvegicus	42%	95%
P22684	Dictyostelium discoideum	37%	96%
P26643	Trypanosoma cruzi	62%	99%
P29763	Chlamydomonas reinhardtii	45%	100%
P47955	Mus musculus	40%	95%
P49148	Alternaria alternata	43%	98%
P52855	Zea mays	47%	99%
Q49KL9	Penicillium brevicompactum	44%	100%
Q4QFE2	Leishmania major	97%	100%
Q56K14	Bos taurus	42%	95%
Q8LCW9	Arabidopsis thaliana	39%	96%
Q8LEQ0	Arabidopsis thaliana	39%	96%
Q9HFQ6	Candida albicans	47%	100%
Q9UU78	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	43%	99%