LeishMANIAdb
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Hypothetical_protein_conserved

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Hypothetical_protein_conserved
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3Q8IA62_LEIDO
TriTrypDb:
LdBPK_201760.1 , LdCL_200022500 , LDHU3_20.2150
Length:
121

Annotations

Annotations by Jardim et al.

Vesicle mediated transport, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0016020 membrane 2 11
GO:0110165 cellular anatomical entity 1 11

Expansion

Sequence features

A0A3Q8IA62
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IA62

Function

Biological processes
Term Name Level Count
GO:0009987 cellular process 1 6
GO:0016043 cellular component organization 3 6
GO:0022607 cellular component assembly 4 6
GO:0043933 protein-containing complex organization 4 6
GO:0065003 protein-containing complex assembly 5 6
GO:0070070 proton-transporting V-type ATPase complex assembly 7 6
GO:0070071 proton-transporting two-sector ATPase complex assembly 6 6
GO:0070072 vacuolar proton-transporting V-type ATPase complex assembly 8 6
GO:0071840 cellular component organization or biogenesis 2 6
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_PCSK_SKI1_1 93 97 PF00082 0.359
DEG_SCF_FBW7_1 35 41 PF00400 0.630
DOC_CKS1_1 35 40 PF01111 0.562
DOC_PP1_RVXF_1 91 97 PF00149 0.540
DOC_USP7_MATH_1 38 42 PF00917 0.622
DOC_WW_Pin1_4 34 39 PF00397 0.577
DOC_WW_Pin1_4 40 45 PF00397 0.540
LIG_BIR_II_1 1 5 PF00653 0.721
LIG_FHA_1 86 92 PF00498 0.337
LIG_GBD_Chelix_1 28 36 PF00786 0.430
LIG_LIR_Gen_1 49 58 PF02991 0.300
LIG_LIR_Nem_3 49 53 PF02991 0.300
LIG_PCNA_PIPBox_1 54 63 PF02747 0.220
LIG_Pex14_1 75 79 PF04695 0.312
MOD_CK1_1 2 8 PF00069 0.725
MOD_CK1_1 40 46 PF00069 0.558
MOD_GlcNHglycan 97 100 PF01048 0.382
MOD_GSK3_1 34 41 PF00069 0.637
MOD_NEK2_1 82 87 PF00069 0.298
MOD_PIKK_1 101 107 PF00454 0.665
MOD_PKA_2 112 118 PF00069 0.754
MOD_PKA_2 2 8 PF00069 0.635
MOD_ProDKin_1 34 40 PF00069 0.574
TRG_ER_diLys_1 116 121 PF00400 0.688

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HT94 Leptomonas seymouri 71% 100%
A0A0S4JU45 Bodo saltans 55% 69%
A0A1X0NXN8 Trypanosomatidae 55% 100%
A0A3R7KJJ5 Trypanosoma rangeli 54% 100%
A4HZ13 Leishmania infantum 100% 100%
C9ZIL6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 48% 100%
E9AIM7 Leishmania braziliensis 82% 100%
E9AUW0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
Q4QCM2 Leishmania major 93% 100%
V5B8F5 Trypanosoma cruzi 54% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS