RNA_binding_protein_putative/GeneDB:LmjF.19.0300

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA binding protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IA61_LEIDO

TriTrypDb:

LdBPK_190290.1 , LdCL_190007900 , LDHU3_19.0330

Length:

313

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 18
NetGPI	no	yes: 0, no: 18

Cellular components
Term	Name	Level	Count
GO:0020022	acidocalcisome	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IA61

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IA61

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	12
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0003824	catalytic activity	1	2
GO:0004842	ubiquitin-protein transferase activity	4	2
GO:0016740	transferase activity	2	2
GO:0019787	ubiquitin-like protein transferase activity	3	2
GO:0140096	catalytic activity, acting on a protein	2	2
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	211	213	PF00675	0.690
CLV_PCSK_KEX2_1	211	213	PF00082	0.690
CLV_PCSK_KEX2_1	40	42	PF00082	0.613
CLV_PCSK_KEX2_1	96	98	PF00082	0.566
CLV_PCSK_PC1ET2_1	40	42	PF00082	0.448
CLV_PCSK_PC1ET2_1	96	98	PF00082	0.566
CLV_PCSK_SKI1_1	149	153	PF00082	0.482
CLV_PCSK_SKI1_1	159	163	PF00082	0.407
CLV_PCSK_SKI1_1	167	171	PF00082	0.407
CLV_PCSK_SKI1_1	192	196	PF00082	0.583
CLV_PCSK_SKI1_1	64	68	PF00082	0.491
DEG_Nend_UBRbox_1	1	4	PF02207	0.654
DOC_MAPK_gen_1	230	240	PF00069	0.475
DOC_MAPK_MEF2A_6	233	240	PF00069	0.394
DOC_PP1_RVXF_1	275	282	PF00149	0.457
DOC_PP2B_LxvP_1	154	157	PF13499	0.565
DOC_PP2B_PxIxI_1	235	241	PF00149	0.445
DOC_PP4_FxxP_1	281	284	PF00568	0.458
DOC_USP7_MATH_1	150	154	PF00917	0.467
DOC_USP7_MATH_1	157	161	PF00917	0.381
DOC_USP7_MATH_1	23	27	PF00917	0.623
DOC_USP7_UBL2_3	267	271	PF12436	0.571
DOC_WW_Pin1_4	138	143	PF00397	0.537
DOC_WW_Pin1_4	174	179	PF00397	0.622
LIG_14-3-3_CanoR_1	159	165	PF00244	0.564
LIG_14-3-3_CanoR_1	167	172	PF00244	0.599
LIG_14-3-3_CanoR_1	64	69	PF00244	0.560
LIG_APCC_ABBA_1	42	47	PF00400	0.395
LIG_APCC_ABBAyCdc20_2	41	47	PF00400	0.396
LIG_BRCT_BRCA1_1	117	121	PF00533	0.406
LIG_FHA_1	150	156	PF00498	0.462
LIG_FHA_1	65	71	PF00498	0.546
LIG_FHA_2	161	167	PF00498	0.524
LIG_KLC1_Yacidic_2	83	88	PF13176	0.438
LIG_LIR_Apic_2	280	284	PF02991	0.461
LIG_LIR_Nem_3	106	111	PF02991	0.561
LIG_LIR_Nem_3	249	255	PF02991	0.404
LIG_PCNA_yPIPBox_3	158	167	PF02747	0.475
LIG_SH2_PTP2	108	111	PF00017	0.525
LIG_SH2_SRC	131	134	PF00017	0.554
LIG_SH2_SRC	77	80	PF00017	0.545
LIG_SH2_STAP1	257	261	PF00017	0.421
LIG_SH2_STAP1	52	56	PF00017	0.423
LIG_SH2_STAP1	77	81	PF00017	0.426
LIG_SH2_STAT3	52	55	PF00017	0.422
LIG_SH2_STAT5	108	111	PF00017	0.486
LIG_SH2_STAT5	131	134	PF00017	0.423
LIG_SH2_STAT5	243	246	PF00017	0.405
LIG_SH2_STAT5	86	89	PF00017	0.486
LIG_SH3_1	173	179	PF00018	0.565
LIG_SH3_3	173	179	PF00018	0.659
LIG_SH3_5	284	288	PF00018	0.594
LIG_TRAF2_1	298	301	PF00917	0.602
LIG_TRAF2_1	80	83	PF00917	0.429
MOD_CK1_1	144	150	PF00069	0.495
MOD_CK1_1	160	166	PF00069	0.445
MOD_CK2_1	127	133	PF00069	0.547
MOD_CK2_1	23	29	PF00069	0.676
MOD_GlcNHglycan	220	224	PF01048	0.612
MOD_GlcNHglycan	25	28	PF01048	0.538
MOD_GSK3_1	115	122	PF00069	0.419
MOD_GSK3_1	140	147	PF00069	0.549
MOD_GSK3_1	188	195	PF00069	0.688
MOD_LATS_1	190	196	PF00433	0.585
MOD_N-GLC_1	157	162	PF02516	0.448
MOD_N-GLC_1	200	205	PF02516	0.733
MOD_N-GLC_1	246	251	PF02516	0.529
MOD_N-GLC_1	35	40	PF02516	0.525
MOD_N-GLC_2	266	268	PF02516	0.555
MOD_N-GLC_2	272	274	PF02516	0.587
MOD_NEK2_1	45	50	PF00069	0.487
MOD_NEK2_2	157	162	PF00069	0.428
MOD_OFUCOSY	244	250	PF10250	0.419
MOD_PIKK_1	35	41	PF00454	0.581
MOD_PKA_2	124	130	PF00069	0.535
MOD_PKA_2	45	51	PF00069	0.573
MOD_Plk_1	157	163	PF00069	0.455
MOD_Plk_1	200	206	PF00069	0.631
MOD_Plk_2-3	119	125	PF00069	0.432
MOD_Plk_4	127	133	PF00069	0.505
MOD_Plk_4	150	156	PF00069	0.431
MOD_Plk_4	160	166	PF00069	0.419
MOD_Plk_4	45	51	PF00069	0.596
MOD_ProDKin_1	138	144	PF00069	0.528
MOD_ProDKin_1	174	180	PF00069	0.625
MOD_SUMO_for_1	229	232	PF00179	0.613
MOD_SUMO_rev_2	95	104	PF00179	0.552
TRG_DiLeu_BaEn_4	61	67	PF01217	0.391
TRG_ENDOCYTIC_2	108	111	PF00928	0.454
TRG_Pf-PMV_PEXEL_1	64	69	PF00026	0.536

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1I4	Leptomonas seymouri	30%	79%
A0A0N1PG85	Leptomonas seymouri	71%	99%
A0A0S4KEK3	Bodo saltans	29%	96%
A0A0S4KMM7	Bodo saltans	37%	82%
A0A1X0P6E1	Trypanosomatidae	39%	95%
A0A3R7RSV6	Trypanosoma rangeli	44%	100%
A0A3S7WVD2	Leishmania donovani	30%	80%
A4H9Y7	Leishmania braziliensis	80%	100%
A4H9Y8	Leishmania braziliensis	32%	100%
A4HY39	Leishmania infantum	31%	100%
A4HY52	Leishmania infantum	100%	100%
D0A0F3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
D0A0F7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	72%
E9ARY1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
E9ARY2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
Q4QDJ1	Leishmania major	97%	100%
V5BWY8	Trypanosoma cruzi	42%	100%