Reverse transcriptase (RNA-dependent DNA polymerase), putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3Q8IA53_LEIDO

TriTrypDb:

LdBPK_201590.1 , LdCL_200020700 , LdCL_200022000

Length:

107

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 2
NetGPI	no	yes: 0, no: 2

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IA53

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IA53

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0003964	RNA-directed DNA polymerase activity	5	2
GO:0016740	transferase activity	2	2
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	2
GO:0016779	nucleotidyltransferase activity	4	2
GO:0034061	DNA polymerase activity	4	2
GO:0140097	catalytic activity, acting on DNA	3	2
GO:0140640	catalytic activity, acting on a nucleic acid	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	3	5	PF00675	0.677
CLV_NRD_NRD_1	73	75	PF00675	0.638
CLV_PCSK_KEX2_1	3	5	PF00082	0.677
CLV_PCSK_SKI1_1	8	12	PF00082	0.657
DEG_APCC_DBOX_1	3	11	PF00400	0.662
DEG_Nend_UBRbox_2	1	3	PF02207	0.594
DOC_MAPK_DCC_7	63	71	PF00069	0.623
DOC_MAPK_gen_1	3	11	PF00069	0.662
DOC_MAPK_MEF2A_6	3	11	PF00069	0.662
DOC_MAPK_NFAT4_5	4	12	PF00069	0.658
DOC_PP4_FxxP_1	40	43	PF00568	0.568
DOC_USP7_MATH_1	61	65	PF00917	0.658
LIG_14-3-3_CanoR_1	60	69	PF00244	0.637
LIG_DLG_GKlike_1	3	10	PF00625	0.663
LIG_FHA_1	95	101	PF00498	0.687
LIG_LIR_Apic_2	37	43	PF02991	0.533
LIG_MYND_1	57	61	PF01753	0.663
LIG_NRBOX	6	12	PF00104	0.655
LIG_NRP_CendR_1	106	107	PF00754	0.765
LIG_SH2_CRK	23	27	PF00017	0.660
LIG_SH3_1	51	57	PF00018	0.668
LIG_SH3_3	10	16	PF00018	0.668
LIG_SH3_3	19	25	PF00018	0.550
LIG_SH3_3	51	57	PF00018	0.668
LIG_SUMO_SIM_anti_2	67	73	PF11976	0.609
LIG_SUMO_SIM_par_1	24	30	PF11976	0.649
MOD_CK1_1	96	102	PF00069	0.698
MOD_GSK3_1	94	101	PF00069	0.645
MOD_NEK2_1	93	98	PF00069	0.667
MOD_PIKK_1	77	83	PF00454	0.644
MOD_PKA_1	3	9	PF00069	0.664
MOD_PKA_2	3	9	PF00069	0.664
MOD_PKA_2	62	68	PF00069	0.639
MOD_PKA_2	94	100	PF00069	0.678
TRG_DiLeu_BaLyEn_6	5	10	PF01217	0.653
TRG_ENDOCYTIC_2	23	26	PF00928	0.661

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A381MI35	Leishmania infantum	99%	100%