DnaJ domain containing protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DnaJ domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IA51_LEIDO

TriTrypDb:

LdBPK_190070.1 , LdCL_190005700 , LDHU3_19.0080

Length:

432

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IA51

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IA51

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0005488	binding	1	1
GO:0008270	zinc ion binding	6	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1
GO:0046914	transition metal ion binding	5	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	296	300	PF00656	0.551
CLV_NRD_NRD_1	104	106	PF00675	0.677
CLV_NRD_NRD_1	157	159	PF00675	0.536
CLV_NRD_NRD_1	179	181	PF00675	0.479
CLV_NRD_NRD_1	190	192	PF00675	0.527
CLV_NRD_NRD_1	214	216	PF00675	0.479
CLV_NRD_NRD_1	266	268	PF00675	0.496
CLV_NRD_NRD_1	302	304	PF00675	0.534
CLV_NRD_NRD_1	375	377	PF00675	0.591
CLV_NRD_NRD_1	388	390	PF00675	0.528
CLV_NRD_NRD_1	398	400	PF00675	0.487
CLV_NRD_NRD_1	69	71	PF00675	0.586
CLV_PCSK_FUR_1	214	218	PF00082	0.490
CLV_PCSK_KEX2_1	157	159	PF00082	0.565
CLV_PCSK_KEX2_1	178	180	PF00082	0.478
CLV_PCSK_KEX2_1	189	191	PF00082	0.481
CLV_PCSK_KEX2_1	214	216	PF00082	0.503
CLV_PCSK_KEX2_1	258	260	PF00082	0.505
CLV_PCSK_KEX2_1	265	267	PF00082	0.457
CLV_PCSK_KEX2_1	302	304	PF00082	0.561
CLV_PCSK_KEX2_1	336	338	PF00082	0.532
CLV_PCSK_KEX2_1	377	379	PF00082	0.626
CLV_PCSK_KEX2_1	387	389	PF00082	0.565
CLV_PCSK_KEX2_1	398	400	PF00082	0.494
CLV_PCSK_KEX2_1	59	61	PF00082	0.342
CLV_PCSK_KEX2_1	69	71	PF00082	0.449
CLV_PCSK_PC1ET2_1	178	180	PF00082	0.490
CLV_PCSK_PC1ET2_1	216	218	PF00082	0.643
CLV_PCSK_PC1ET2_1	258	260	PF00082	0.575
CLV_PCSK_PC1ET2_1	336	338	PF00082	0.572
CLV_PCSK_PC1ET2_1	377	379	PF00082	0.576
CLV_PCSK_PC1ET2_1	59	61	PF00082	0.342
CLV_PCSK_PC7_1	175	181	PF00082	0.589
CLV_PCSK_PC7_1	185	191	PF00082	0.589
CLV_PCSK_PC7_1	210	216	PF00082	0.598
CLV_PCSK_PC7_1	65	71	PF00082	0.649
CLV_PCSK_SKI1_1	108	112	PF00082	0.627
CLV_PCSK_SKI1_1	200	204	PF00082	0.599
CLV_PCSK_SKI1_1	210	214	PF00082	0.598
CLV_PCSK_SKI1_1	416	420	PF00082	0.540
CLV_PCSK_SKI1_1	65	69	PF00082	0.636
CLV_Separin_Metazoa	211	215	PF03568	0.503
DEG_Nend_UBRbox_2	1	3	PF02207	0.628
DOC_CYCLIN_RxL_1	22	35	PF00134	0.317
DOC_USP7_MATH_1	101	105	PF00917	0.612
DOC_USP7_MATH_1	418	422	PF00917	0.523
DOC_USP7_MATH_1	84	88	PF00917	0.657
DOC_USP7_MATH_1	91	95	PF00917	0.612
DOC_USP7_UBL2_3	225	229	PF12436	0.500
DOC_WW_Pin1_4	123	128	PF00397	0.669
DOC_WW_Pin1_4	85	90	PF00397	0.623
LIG_14-3-3_CanoR_1	108	116	PF00244	0.620
LIG_14-3-3_CanoR_1	137	145	PF00244	0.655
LIG_14-3-3_CanoR_1	365	372	PF00244	0.702
LIG_Actin_WH2_2	401	418	PF00022	0.530
LIG_APCC_ABBA_1	30	35	PF00400	0.294
LIG_FHA_1	367	373	PF00498	0.646
LIG_FHA_1	399	405	PF00498	0.534
LIG_FHA_1	422	428	PF00498	0.670
LIG_FHA_2	142	148	PF00498	0.639
LIG_FHA_2	366	372	PF00498	0.691
LIG_FHA_2	51	57	PF00498	0.402
LIG_FHA_2	66	72	PF00498	0.658
LIG_LIR_Gen_1	234	242	PF02991	0.541
LIG_LIR_Gen_1	5	12	PF02991	0.293
LIG_LIR_Nem_3	118	123	PF02991	0.538
LIG_LIR_Nem_3	133	139	PF02991	0.702
LIG_LIR_Nem_3	234	239	PF02991	0.554
LIG_LIR_Nem_3	41	47	PF02991	0.319
LIG_LIR_Nem_3	5	10	PF02991	0.293
LIG_PCNA_PIPBox_1	244	253	PF02747	0.492
LIG_Pex14_2	145	149	PF04695	0.504
LIG_RPA_C_Fungi	261	273	PF08784	0.534
LIG_SH2_CRK	51	55	PF00017	0.294
LIG_SH2_CRK	7	11	PF00017	0.308
LIG_SH2_NCK_1	236	240	PF00017	0.518
LIG_SH2_SRC	236	239	PF00017	0.591
LIG_SH2_STAP1	169	173	PF00017	0.501
LIG_SH2_STAP1	63	67	PF00017	0.452
LIG_SH2_STAT5	7	10	PF00017	0.401
LIG_SH3_3	83	89	PF00018	0.640
LIG_TRAF2_1	330	333	PF00917	0.643
LIG_TRAF2_1	338	341	PF00917	0.636
LIG_TRAF2_1	361	364	PF00917	0.629
MOD_CK1_1	126	132	PF00069	0.719
MOD_CK1_1	141	147	PF00069	0.605
MOD_CK1_1	421	427	PF00069	0.651
MOD_CK2_1	141	147	PF00069	0.570
MOD_CK2_1	365	371	PF00069	0.726
MOD_GlcNHglycan	128	131	PF01048	0.642
MOD_GlcNHglycan	391	397	PF01048	0.672
MOD_GlcNHglycan	420	423	PF01048	0.529
MOD_GlcNHglycan	60	63	PF01048	0.418
MOD_N-GLC_1	365	370	PF02516	0.579
MOD_NEK2_1	10	15	PF00069	0.408
MOD_PIKK_1	253	259	PF00454	0.556
MOD_PKA_1	398	404	PF00069	0.536
MOD_PKA_2	282	288	PF00069	0.628
MOD_PKA_2	366	372	PF00069	0.637
MOD_PKA_2	398	404	PF00069	0.528
MOD_Plk_1	392	398	PF00069	0.668
MOD_Plk_4	5	11	PF00069	0.397
MOD_ProDKin_1	123	129	PF00069	0.671
MOD_ProDKin_1	85	91	PF00069	0.627
MOD_SUMO_for_1	165	168	PF00179	0.596
MOD_SUMO_for_1	324	327	PF00179	0.637
MOD_SUMO_for_1	410	413	PF00179	0.619
MOD_SUMO_rev_2	218	227	PF00179	0.574
MOD_SUMO_rev_2	299	308	PF00179	0.488
MOD_SUMO_rev_2	327	335	PF00179	0.521
MOD_SUMO_rev_2	402	410	PF00179	0.580
MOD_SUMO_rev_2	428	432	PF00179	0.614
TRG_DiLeu_BaEn_4	263	269	PF01217	0.548
TRG_DiLeu_BaEn_4	339	345	PF01217	0.606
TRG_ENDOCYTIC_2	236	239	PF00928	0.484
TRG_ENDOCYTIC_2	51	54	PF00928	0.297
TRG_ENDOCYTIC_2	6	9	PF00928	0.295
TRG_ER_diArg_1	156	158	PF00400	0.655
TRG_ER_diArg_1	189	191	PF00400	0.557
TRG_ER_diArg_1	213	215	PF00400	0.498
TRG_ER_diArg_1	265	267	PF00400	0.466
TRG_ER_diArg_1	301	303	PF00400	0.581
TRG_ER_diArg_1	376	379	PF00400	0.711
TRG_ER_diArg_1	387	389	PF00400	0.543
TRG_ER_diArg_1	397	399	PF00400	0.497
TRG_NLS_MonoCore_2	104	109	PF00514	0.651
TRG_Pf-PMV_PEXEL_1	249	253	PF00026	0.540
TRG_Pf-PMV_PEXEL_1	259	263	PF00026	0.456
TRG_Pf-PMV_PEXEL_1	266	270	PF00026	0.424
TRG_Pf-PMV_PEXEL_1	342	347	PF00026	0.622
TRG_Pf-PMV_PEXEL_1	378	382	PF00026	0.543

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0G8	Leptomonas seymouri	71%	100%
A0A0S4IRH8	Bodo saltans	44%	97%
A0A0S4J1C8	Bodo saltans	28%	93%
A0A0S4JH45	Bodo saltans	25%	100%
A0A1X0P7B2	Trypanosomatidae	50%	97%
A0A3R7MIW9	Trypanosoma rangeli	51%	97%
A4H9W5	Leishmania braziliensis	90%	100%
D0A0C8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	98%
E9AGR0	Leishmania infantum	100%	100%
E9ARV9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
Q4QDL3	Leishmania major	97%	100%
V5BWX2	Trypanosoma cruzi	50%	97%