Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania donovani

UniProt:

A0A3Q8IA36_LEIDO

TriTrypDb:

LdCL_150015100 , LDHU3_15.1240

Length:

514

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IA36

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IA36

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	356	360	PF00656	0.359
CLV_NRD_NRD_1	106	108	PF00675	0.368
CLV_NRD_NRD_1	252	254	PF00675	0.445
CLV_NRD_NRD_1	324	326	PF00675	0.476
CLV_NRD_NRD_1	361	363	PF00675	0.392
CLV_NRD_NRD_1	482	484	PF00675	0.461
CLV_NRD_NRD_1	98	100	PF00675	0.387
CLV_PCSK_FUR_1	322	326	PF00082	0.465
CLV_PCSK_KEX2_1	105	107	PF00082	0.401
CLV_PCSK_KEX2_1	251	253	PF00082	0.446
CLV_PCSK_KEX2_1	322	324	PF00082	0.470
CLV_PCSK_KEX2_1	482	484	PF00082	0.516
CLV_PCSK_KEX2_1	71	73	PF00082	0.563
CLV_PCSK_PC1ET2_1	71	73	PF00082	0.485
CLV_PCSK_SKI1_1	107	111	PF00082	0.467
CLV_PCSK_SKI1_1	125	129	PF00082	0.288
CLV_PCSK_SKI1_1	212	216	PF00082	0.481
CLV_PCSK_SKI1_1	344	348	PF00082	0.428
DEG_APCC_DBOX_1	250	258	PF00400	0.446
DEG_ODPH_VHL_1	130	141	PF01847	0.424
DEG_SCF_FBW7_1	273	280	PF00400	0.391
DEG_SCF_FBW7_1	415	420	PF00400	0.506
DEG_SPOP_SBC_1	162	166	PF00917	0.711
DEG_SPOP_SBC_1	3	7	PF00917	0.629
DOC_CDC14_PxL_1	128	136	PF14671	0.435
DOC_CYCLIN_RxL_1	209	218	PF00134	0.510
DOC_CYCLIN_RxL_1	223	234	PF00134	0.353
DOC_MAPK_FxFP_2	406	409	PF00069	0.472
DOC_MAPK_gen_1	362	370	PF00069	0.375
DOC_PP1_RVXF_1	200	206	PF00149	0.436
DOC_PP1_RVXF_1	293	299	PF00149	0.321
DOC_PP1_RVXF_1	34	40	PF00149	0.463
DOC_PP1_RVXF_1	475	482	PF00149	0.357
DOC_PP2B_LxvP_1	134	137	PF13499	0.475
DOC_PP2B_LxvP_1	463	466	PF13499	0.401
DOC_PP4_FxxP_1	406	409	PF00568	0.472
DOC_USP7_MATH_1	161	165	PF00917	0.725
DOC_USP7_MATH_1	2	6	PF00917	0.669
DOC_USP7_MATH_1	260	264	PF00917	0.493
DOC_USP7_MATH_1	271	275	PF00917	0.487
DOC_USP7_MATH_1	402	406	PF00917	0.442
DOC_USP7_MATH_1	445	449	PF00917	0.580
DOC_USP7_MATH_1	499	503	PF00917	0.670
DOC_USP7_MATH_2	351	357	PF00917	0.387
DOC_WW_Pin1_4	141	146	PF00397	0.765
DOC_WW_Pin1_4	149	154	PF00397	0.718
DOC_WW_Pin1_4	195	200	PF00397	0.445
DOC_WW_Pin1_4	269	274	PF00397	0.532
DOC_WW_Pin1_4	282	287	PF00397	0.505
DOC_WW_Pin1_4	397	402	PF00397	0.425
DOC_WW_Pin1_4	413	418	PF00397	0.492
LIG_14-3-3_CanoR_1	111	119	PF00244	0.396
LIG_14-3-3_CanoR_1	202	211	PF00244	0.472
LIG_14-3-3_CanoR_1	226	231	PF00244	0.360
LIG_14-3-3_CanoR_1	24	32	PF00244	0.398
LIG_14-3-3_CanoR_1	384	390	PF00244	0.402
LIG_14-3-3_CanoR_1	91	95	PF00244	0.472
LIG_APCC_ABBA_1	228	233	PF00400	0.481
LIG_APCC_ABBA_1	371	376	PF00400	0.414
LIG_APCC_ABBAyCdc20_2	212	218	PF00400	0.392
LIG_EVH1_1	134	138	PF00568	0.487
LIG_FHA_1	237	243	PF00498	0.430
LIG_FHA_1	325	331	PF00498	0.518
LIG_FHA_1	352	358	PF00498	0.416
LIG_FHA_1	39	45	PF00498	0.417
LIG_FHA_2	111	117	PF00498	0.404
LIG_FHA_2	215	221	PF00498	0.402
LIG_FXI_DFP_1	216	220	PF00024	0.533
LIG_GBD_Chelix_1	246	254	PF00786	0.394
LIG_Integrin_isoDGR_2	293	295	PF01839	0.324
LIG_LIR_Apic_2	405	409	PF02991	0.469
LIG_LIR_Gen_1	185	196	PF02991	0.460
LIG_LIR_Gen_1	217	227	PF02991	0.397
LIG_LIR_Gen_1	345	351	PF02991	0.422
LIG_LIR_Gen_1	65	73	PF02991	0.473
LIG_LIR_Nem_3	185	191	PF02991	0.467
LIG_LIR_Nem_3	206	211	PF02991	0.350
LIG_LIR_Nem_3	345	349	PF02991	0.426
LIG_LIR_Nem_3	405	411	PF02991	0.505
LIG_LIR_Nem_3	420	425	PF02991	0.509
LIG_LIR_Nem_3	65	70	PF02991	0.457
LIG_LYPXL_yS_3	408	411	PF13949	0.573
LIG_MYND_1	132	136	PF01753	0.473
LIG_MYND_1	487	491	PF01753	0.700
LIG_PCNA_PIPBox_1	380	389	PF02747	0.418
LIG_PDZ_Class_3	509	514	PF00595	0.505
LIG_Pex14_1	39	43	PF04695	0.365
LIG_Pex14_2	342	346	PF04695	0.394
LIG_Pex14_2	406	410	PF04695	0.538
LIG_SH2_CRK	188	192	PF00017	0.527
LIG_SH2_NCK_1	266	270	PF00017	0.347
LIG_SH2_SRC	133	136	PF00017	0.424
LIG_SH2_SRC	43	46	PF00017	0.362
LIG_SH2_SRC	462	465	PF00017	0.411
LIG_SH2_STAP1	238	242	PF00017	0.434
LIG_SH2_STAP1	451	455	PF00017	0.539
LIG_SH2_STAT3	177	180	PF00017	0.558
LIG_SH2_STAT5	133	136	PF00017	0.517
LIG_SH2_STAT5	231	234	PF00017	0.451
LIG_SH2_STAT5	238	241	PF00017	0.343
LIG_SH2_STAT5	249	252	PF00017	0.349
LIG_SH2_STAT5	43	46	PF00017	0.362
LIG_SH2_STAT5	455	458	PF00017	0.397
LIG_SH2_STAT5	462	465	PF00017	0.336
LIG_SH2_STAT5	86	89	PF00017	0.419
LIG_SH3_3	129	135	PF00018	0.499
LIG_SH3_3	148	154	PF00018	0.710
LIG_SH3_3	193	199	PF00018	0.545
LIG_SH3_3	310	316	PF00018	0.390
LIG_SH3_3	481	487	PF00018	0.523
LIG_SUMO_SIM_par_1	137	144	PF11976	0.533
LIG_SUMO_SIM_par_1	353	359	PF11976	0.480
LIG_TRAF2_1	169	172	PF00917	0.725
LIG_TRAF2_1	184	187	PF00917	0.490
LIG_TRFH_1	128	132	PF08558	0.451
LIG_WRC_WIRS_1	278	283	PF05994	0.550
LIG_WRC_WIRS_1	403	408	PF05994	0.479
LIG_WRC_WIRS_1	410	415	PF05994	0.533
MOD_CDK_SPxxK_3	141	148	PF00069	0.511
MOD_CDK_SPxxK_3	195	202	PF00069	0.440
MOD_CK1_1	144	150	PF00069	0.614
MOD_CK1_1	164	170	PF00069	0.715
MOD_CK1_1	282	288	PF00069	0.438
MOD_CK1_1	503	509	PF00069	0.679
MOD_CK1_1	84	90	PF00069	0.466
MOD_CK2_1	166	172	PF00069	0.671
MOD_CK2_1	385	391	PF00069	0.391
MOD_CK2_1	499	505	PF00069	0.716
MOD_CK2_1	506	512	PF00069	0.739
MOD_GlcNHglycan	157	160	PF01048	0.727
MOD_GlcNHglycan	166	169	PF01048	0.606
MOD_GlcNHglycan	282	285	PF01048	0.546
MOD_GlcNHglycan	302	305	PF01048	0.372
MOD_GlcNHglycan	457	462	PF01048	0.418
MOD_GlcNHglycan	46	49	PF01048	0.477
MOD_GlcNHglycan	492	495	PF01048	0.662
MOD_GSK3_1	139	146	PF00069	0.621
MOD_GSK3_1	162	169	PF00069	0.665
MOD_GSK3_1	214	221	PF00069	0.421
MOD_GSK3_1	269	276	PF00069	0.402
MOD_GSK3_1	409	416	PF00069	0.544
MOD_GSK3_1	495	502	PF00069	0.709
MOD_N-GLC_1	300	305	PF02516	0.348
MOD_N-GLC_2	467	469	PF02516	0.377
MOD_N-GLC_2	90	92	PF02516	0.449
MOD_NEK2_1	155	160	PF00069	0.717
MOD_NEK2_1	300	305	PF00069	0.403
MOD_NEK2_1	342	347	PF00069	0.555
MOD_NEK2_2	385	390	PF00069	0.425
MOD_PIKK_1	182	188	PF00454	0.459
MOD_PIKK_1	445	451	PF00454	0.587
MOD_PKA_1	324	330	PF00069	0.568
MOD_PKA_2	110	116	PF00069	0.396
MOD_PKA_2	203	209	PF00069	0.271
MOD_PKA_2	23	29	PF00069	0.411
MOD_PKA_2	324	330	PF00069	0.598
MOD_PKA_2	90	96	PF00069	0.445
MOD_PKB_1	105	113	PF00069	0.397
MOD_PKB_1	202	210	PF00069	0.360
MOD_PKB_1	322	330	PF00069	0.582
MOD_Plk_1	260	266	PF00069	0.522
MOD_Plk_1	457	463	PF00069	0.372
MOD_Plk_1	84	90	PF00069	0.404
MOD_Plk_2-3	353	359	PF00069	0.364
MOD_Plk_4	226	232	PF00069	0.359
MOD_Plk_4	260	266	PF00069	0.563
MOD_Plk_4	418	424	PF00069	0.497
MOD_Plk_4	84	90	PF00069	0.373
MOD_ProDKin_1	141	147	PF00069	0.765
MOD_ProDKin_1	149	155	PF00069	0.720
MOD_ProDKin_1	195	201	PF00069	0.441
MOD_ProDKin_1	269	275	PF00069	0.536
MOD_ProDKin_1	282	288	PF00069	0.493
MOD_ProDKin_1	397	403	PF00069	0.431
MOD_ProDKin_1	413	419	PF00069	0.486
TRG_ENDOCYTIC_2	176	179	PF00928	0.502
TRG_ENDOCYTIC_2	188	191	PF00928	0.414
TRG_ENDOCYTIC_2	386	389	PF00928	0.513
TRG_ENDOCYTIC_2	408	411	PF00928	0.707
TRG_ENDOCYTIC_2	67	70	PF00928	0.430
TRG_ER_diArg_1	105	107	PF00400	0.415
TRG_ER_diArg_1	148	151	PF00400	0.555
TRG_ER_diArg_1	202	205	PF00400	0.431
TRG_ER_diArg_1	250	253	PF00400	0.385
TRG_ER_diArg_1	322	325	PF00400	0.528
TRG_ER_diArg_1	481	483	PF00400	0.454
TRG_NES_CRM1_1	220	234	PF08389	0.405
TRG_NLS_MonoExtC_3	361	366	PF00514	0.389
TRG_Pf-PMV_PEXEL_1	240	244	PF00026	0.499
TRG_Pf-PMV_PEXEL_1	252	256	PF00026	0.397

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3J4	Leptomonas seymouri	71%	98%
A0A1X0NTX1	Trypanosomatidae	48%	100%
A4H863	Leishmania braziliensis	85%	98%
A4HWI8	Leishmania infantum	99%	100%
C9ZXV9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9AQ89	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QF94	Leishmania major	96%	100%
V5AMI4	Trypanosoma cruzi	49%	99%